Fixed-term

PhD position focused on developing and applying computational and data-driven methods to understand protein structure, function, and interactions

The University of Bayreuth is a research-oriented university with internationally competitive, interdisciplinary focus areas in research and teaching. The Chair of Artificial Intelligence in Protein Science at the University of Bayreuth invites applications for a PhD position at the interface of machine learning, computational biology, and protein science. The position is available from July 2026. The successful candidate will join a highly interdisciplinary research environment focused on developing and applying computational and data-driven methods to understand protein structure, function, and interactions. Remuneration: The position is 65% according to TV-L E13 The position is initially limited to 3 years Your Responsibilities: Investigate fundamental questions in protein science using computational and quantitative approaches, including machine learning methods for protein structure, function, and interactions. Develop and apply computational methods and algorithms, as well as machine learning and deep learning models. Build and maintain software tools, pipelines, and web applications to support research workflows. Conduct systematic literature reviews and communicate research progress regularly to the group. Actively participate in regular group meetings, discussions, and collaborate with team members. Present research findings in diverse academic settings, including seminars, conferences, and workshops. Create high-quality figures and visualizations. Prepare, write, and publish scientific manuscripts arising from your research. Contribute to the tutoring of university-level courses. Mentor bachelor’s and master’s students when appropriate. Your Profile: We are seeking motivated candidates with a strong background at the interface of biology and quantitative sciences. Master’s degree at the interface of molecular biology and quantitative sciences including Bioinformatics, Biophysics, Computational Biology or a related discipline, with a strong academic record. Applicants with a background in Computer Science or Machine Learning are welcome, provided they have demonstrated experience or a strong interest in molecular biosciences. Experience in programming and data analysis, ideally in Python. Familiarity with statistics, biological datasets, and computational analysis methods. Experience with biological databases, omics data, or machine learning approaches is advantageous. Genuine interest in scientific research, with a curious, well-organized, and self-driven mindset. Strong communication and teamwork skills, with an interest in collaborative research and a positive attitude. Very good written and spoken English. Experience working in international or multicultural environments is a plus. What You Can Expect: Exposure to cutting-edge research projects in protein science and methods in machine learning. A secure workplace at a modern university with state-of-the-art research facilities. A constructive and supportive work atmosphere within a friendly, open-minded team. Opportunities for personal and professional development aligned with your career goals, including workshops, training programs, and mentoring. Paid vacation and flexible work arrangements. Support for participation in scientific conferences, networking events, and collaborative projects. Opportunity to contribute to high-impact publications. Opportunities to mentor students and participate in teaching activities, enhancing leadership experience. Diversity & Inclusion The University of Bayreuth values diversity among its staff as an asset and is explicitly committed to gender equality. Women are strongly encouraged to apply. Applicants with children are warmly welcome. The University of Bayreuth is a member of the Best-Practice Club “Family in the University e.V.” and has successfully participated in the HRK audit “Internationalization of Higher Education.” Applicants with disabilities will be given preferential consideration in the case of equal suitability. Your application Application Process: Please submit your application including: CV Academic certificates and transcripts Motivation letter Two letters of recommendation, including names and contact details of referees Via the University of Bayreuth application portal, quoting the password “Protein Science” by 30 June 2026. Please ensure your application clearly reflects your experience and includes concrete examples of relevant skills. Application documents will be handled in accordance with data protection regulations and deleted after the position is filled. If you have any questions, please contact Prof. Dr. Hadeer Elhabashy(Hadeer.elhabashy@uni-bayreuth.de) with the email subject: “PhD Position Inquiry”

PhD position in the field of drug delivery with a focus on immunotherapy.

Heidelberg University is a comprehensive university with a strong research focus and international aspirations. With approximately 32,200 students and 9,540 employees, including numerous leading researchers, it is a globally renowned institution that also has outstanding economic significance for the Rhine-Neckar metropolitan region. The Institute of Pharmacy and Molecular Biotechnology (IPMB) has two open positions in the Department of Pharmaceutical Technology and Biopharmacy, each with a workload of 19.75 hours per week, initially for a fixed term of 3 years, starting on October 1, 2026: Academic employee for doctoral studies (f/m/d) in the field of drug delivery with a focus on immunotherapy. We are looking for a motivated and open-minded individual with a passion for research and teaching. The area of ​​responsibility: Conducting an independent doctoral project in the field of modern drug delivery systems Development and characterization of nanoparticles for the transport of nucleic acids (e.g., mRNA, siRNA) Design and production of innovative biomaterials for the controlled release of nanoparticles Participation in interdisciplinary research projects within the context of the SynthImmune Cluster of Excellence Active participation in the teaching of pharmacy and molecular biotechnology Requirements: Above-average university degree in pharmacy, molecular biotechnology or a comparable field of study Strong motivation for scientific work and the development of own research approaches Commitment and interest in teaching, as well as enjoyment in interacting with students Independent, structured and goal-oriented work style Teamwork skills and very good English skills   Remuneration is based on the TV-L collective agreement. We look forward to receiving your application, which you should submit with the usual documents (CV, certificates, etc.) as a single PDF file by email to the secretariat of the Department of Pharmaceutical Technology and Biopharmacy ( schischka@uni-heidelberg.de ) by July 1, 2026. We will also be happy to provide you with further information about the position at this address.

PhD position for Topical Gene Therapy

Your tasks and responsibilities: Work on the above-mentioned project topic within the framework of scientific research projects Design, plan, and implement project objectives within the respective research project Generate insights for the preparation of a doctoral thesis, ideally aimed at translating research findings into therapies for severe genetic diseases of the lung and skin, as well as supporting the research community Conduct literature research Publish original research findings in peer-reviewed journals in accordance with scientific standards Where applicable, supervise and support undergraduate and Master’s students Contribute to teaching activities Your qualifications: Applicants must have an M.Sc./State examination degree (or equal qualification) in pharmaceutical sciences, biomedical engineering, biochemistry, or a related field with relevant experience Excellent written and spoken German and English skills Experience in (primary) cell culture work and gene therapies is considered an asset   Practical experience in biomolecular methods is considered an asset   High levels of participation in a collaborative team setting, a high degree of self-motivation, time management skills, and an ability to demonstrate creativity and sound judgment will be required Benefits: The position is classified according to the Collective Agreement for the Public Service of the German Federal States (TV-L) in salary group E13. Remuneration is based on individual qualifications and experience and corresponds to 65% of a full-time position. The current TV-L salary table can be found here: https://www.tdl-online.de/tv-l/tarifvertrag.html The position is initially limited to 3 years within the framework of a doctoral qualification. The workplace is located at the LMU Campus Munich-Großhadern within the Department of Pharmaceutical Sciences, with excellent public transport connections. You will work in a modern research environment with close integration into interdisciplinary research networks. LMU Munich stands for excellent research, an international academic environment, and strong support for early-career researchers. People with disabilities who are equally as qualified as other applicants will receive preferential treatment. Contact: For further information, please email: sarah.hedtrich@ubc.ca If interested, please send a curriculum vitae, a motivation letter, and the names of two referees to sarah.hedtrich@ubc.ca by June 30, 2026.

PhD position for Bioengineering Immunocompetent Epithelial (Disease) Models

About us: Prof. Sarah Hedtrich (currently Tier I Canada Research Chair and Associate Professor at the University of British Columbia, Vancouver, Canada) will assume the Chair of Pharmaceutical Biotechnology at LMU Munich in October 2026 and is now recruiting ambitious candidates to help build a dynamic new research lab at the LMU Munich. The Hedtrich’s lab mission is to understand and tackle mechanisms of inflammatory and genetic diseases of human epithelia and translate these insights into meaningful therapeutic strategies. We tackle complex biological questions through highly interdisciplinary approaches, working at the interface of pharmaceutical sciences, biomedical engineering, and medicine in close collaboration with leading experts across fields. We are building a driven, collaborative, and forward-thinking team, and we are looking for curious, motivated individuals who want to make a tangible impact through cutting-edge research. The Hedtrich lab is looking for a motivated PhD student to continue our exciting work on generating immunocompetent epithelial (disease) models, with a focus on secondary lymphoid tissue models and connecting them to complex human-based epithelial models such as the skin. The overall goal of this work is to generate, validate, and application of human epithelial models including organ-on-chip approaches to emulate inflammatory and infectious diseases. Following successful generation, the models will be leveraged to unravel disease-related mechanisms in single state and multi-organ settings. We are looking for you: PhD Student for Bioengineering Immunocompetent Epithelial (Disease) Models (m/f/d) (m/f/x) in München Your tasks and responsibilities: Work on the above-mentioned project topic within the framework of scientific research projects Design, plan, and implement project objectives within the respective research project Generate insights for the preparation of a doctoral thesis Conduct literature research Publish original research findings in peer-reviewed journals in accordance with scientific standards Where applicable, supervise and support undergraduate and Master’s students Contribute to teaching activities Your qualifications: Applicants must have an M.Sc./State examination degree (or equal qualification) in pharmaceutical sciences, biomedical engineering, biochemistry, or a related field with relevant experience Excellent written and spoken German and English skills Experience in bioengineering, cell culture work or standard biomolecular methods is considered an asset   High levels of participation in a collaborative team setting, a high degree of self-motivation, time management skills, and an ability to demonstrate creativity and sound judgment will be required Benefits: The position is classified according to the Collective Agreement for the Public Service of the German Federal States (TV-L) in salary group E13. Remuneration is based on individual qualifications and experience and corresponds to 65% of a full-time position. The current TV-L salary table can be found here. The position is initially limited to three years within the framework of a doctoral qualification. The workplace is located at the LMU Campus Munich-Großhadern within the Department of Pharmaceutical Sciences, with excellent public transport connections. You will work in a modern research environment with close integration into interdisciplinary research networks. LMU Munich stands for excellent research, an international academic environment, and strong support for early-career researchers. People with disabilities who are equally as qualified as other applicants will receive preferential treatment. Contact: For further information, please email: sarah.hedtrich@ubc.ca If interested, please send a curriculum vitae, a motivation letter, and the names of two referees to sarah.hedtrich@ubc.ca by June 30, 2026.

Postdoctoral Researcher position in Evolutionary Genetics

About us: We are recruiting a postdoctoral scientist to join our international research team in Munich. Whether you are completing your PhD or finishing a first postdoc, this fully funded, long-term position offers a great opportunity to make an impact in evolutionary genetic research and establish a career in science. The Wolf lab is located at LMU Munich and Max-Planck Institute of Biological Intelligence (MPI-BI) and maintains close ties to a growing evolutionary genetics community representing the breadth of the field (EvoGenMunich). With the Leibniz Supercomputing Centre (LRZ) and its local partners, we have access to state-of-the art computing facilities. Through our EES Master’s program and our partnership with the MEME program, we are fortunate to attract exceptional talent, giving you the unique opportunity to work alongside passionate, enthusiastic students from around the world. Munich is Bavaria’s capital combining living traditions with a relaxed, high-quality lifestyle. If you enjoy the outdoors, the Alps and many lakes are just a short train or bike ride away. We are looking for you: Postdoctoral Researcher in Evolutionary Genetics (m/f/x) in Munich Your tasks and responsibilities: Research in the lab combines evolutionary theory with field work, lab work and large-scale computational approaches to investigate fundamental evolutionary processes in natural and experimental populations (e.g. 1–3). A central goal is to understand the evolutionary processes and molecular mechanisms involved in adaptation and speciation. We integrate diverse sequence-based datasets (WGS, ATAC-seq, RNA-seq, WGBS, EM-seq) from ancient and modern samples with quantitative phenotypes, which we have begun characterizing using AI-based approaches. Study systems range from yeast to whales with primary focus on vertebrates and current emphasis on avian host–parasite systems such as cuckoos and indigobirds (4, 5). The successful candidate is expected to contribute to the lab’s ongoing research and will have creative freedom to develop complementary research directions aligned with the broader goals of the lab. We are seeking a highly motivated, creative and skilled scientist with a strong background in evolutionary genetics and a passion for understanding the mechanisms that generate biological diversity. The successful candidate has expertise in evolutionary genetic theory and demonstrated proficiency in population genomic, comparative and large-scale -omics data analyses. They will develop and apply innovative computational approaches to existing data sets and will contribute to the design and development of future research directions. Beyond research, the candidate will take an active role in maintaining the lab’s computational infrastructure and contribute to teaching in BSc and MSc courses aligned with the lab’s expertise and research profile (~4 hours per week during the semester). 1. J. W. Poelstra et al., Science. 344, 1410–1414 (2014), 2. C. R. Peart et al., Nat. Ecol. Evol. 4, 1095–1104 (2020), 3. S. Tusso, B. P. S. Nieuwenhuis, B. Weissensteiner, S. Immler, J. B. W. Wolf, Nat. Ecol. Evol. 5, 338–349 (2021), 4. J. Merondun et al., Sci. Adv. 10, eadl5255 (2024), 5. J. Merondun et al., Science. 390, 527–532 (2025) Your qualifications: Applicants holding a PhD with a proven publication record in a relevant field are encouraged to apply. Benefits: Salary according to the Collective Agreement for the Public Service of the states (TV-L E13) Supportive and stimulating research environment with excellent lab facilities Supportive network of mentors and co-supervisors Conferences and lab exchanges Working conditions in the lab allow a good work-life balance. We offer flexible working hours and are generally a family-friendly lab In addition, you can benefit from the various LMU corporate benefits. Also possible in a part-time capacity. People with disabilities who are equally as qualified as other applicants will receive preferential treatment. Contact: Applications including a statement of motivation, a CV and the contact details of at least two references should be sent as a single .pdf file to evolution@bio.lmu.de subject term ‘EvoGen postdoc’ until the 09.07.2026.

Chemical Laboratory Technician / Biological Laboratory Technician position

The Chair of Functional Beverage Technology (Breselge Lab) at the TUM School of Life Sciences, Campus Weihenstephan, is a research group focusing on functional beverages. The core of this position lies in the analytical characterization of fermentation metabolites, particularly sugars, organic acids, and related compounds, using HPLC- and GC-based as well as complementary analytical methods. Requirement • Completed vocational training as a chemical laboratory assistant, chemical laboratory assistant, biological laboratory assistant, biological laboratory assistant or comparable qualification; alternatively, a completed university degree (B.Sc.) in chemistry, food chemistry, biotechnology or a related field. Practical experience in handling HPLC or GC systems Experience in method development and validation is desirable. • Very good knowledge of sample preparation, calibration and quality assurance • Experience working in a research laboratory (documentation, SOPs, etc.) • Reliable, structured and responsible work ethic Teamwork skills and the ability to work independently Good English skills; German skills are an advantage. Tasks Independent operation and maintenance of HPLC and/or GC analysis systems Development, optimization and documentation of analytical methods for complex fermentation and beverage matrices Sample preparation, measurement, quality assurance and evaluation of analytical data • Establishment and maintenance of SOPs and analytical workflows • Training and instruction of students and research staff in analytical techniques • Support for student internships and research projects • Organization of laboratory operations (safety, documentation, etc.) We offer • Employment remuneration according to the collective agreement for the public service of the Länder (TV-L). • Part-time employment The position is suitable for applicants with severe disabilities. Applicants with severe disabilities will be given preference if they are otherwise essentially equally qualified, capable, and professionally competent. TUM aims to increase the proportion of women on its staff; therefore, applications from women are expressly welcomed. Application We look forward to receiving your cover letter and complete CV. Please send these as a single PDF document to application.fbt@ls.tum.de. The application deadline is July 2, 2026. If you have any questions, please also contact application.fbt@ls.tum.de. The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance. Data Protection Information:When you apply for a position at the Technical University of Munich (TUM), you are submitting personal information. With regard to this personal information, please note the data protection information pursuant to Article 13 of the General Data Protection Regulation (GDPR) concerning the collection and processing of personal data in connection with your application. By submitting your application, you confirm that you have acknowledged the above data protection information of TUM. Contact: application.fbt@ls.tum.de

PhD position in Plant Proteomics, Bioinformatics, and Biology

The project: Peptides are short, biologically synthesized chains of amino acids that play central roles in a wide range of physiological processes. They can be arranged as linear chains or cycles, may carry post-translational modifications or stabilizing motifs, and have a variety of important physiological functions. In plants, bioactive peptides have been shown to contribute to cellular communication, coordinated growth, development, and responses to environmental challenges. This PhD project, based at the Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), focuses on uncovering the functional landscape of defense-associated peptides in crop species. The successful candidate will investigate how plant peptidomes adapt and respond to biotic and abiotic stressors, with particular emphasis on pathogen attack, elevated temperatures, and water limitation. Building on prior work in the model organism Arabidopsis thaliana, the project will leverage advanced mass spectrometry-based proteomics approaches to expand peptide discovery and characterization into agriculturally relevant crops. The overarching goal is to generate a molecular understanding of plant defense mechanisms mediated by bioactive peptides, contributing to the crop proteome atlas and enabling future strategies to improve plant resilience. Requirements: Candidates must hold an internationally recognized MSc degree in a life science discipline, such as analytical (bio-)chemistry, plant biology, or omics-related fields. A high interest in understanding technologies in proteomics research using mass spectrometers is expected. Essential skills include proficiency in biological and (bio)chemical concepts and some expertise in performing and analyzing proteomics or related omics experiments. Additional desirable skills include data mining, data integration, and statistical analysis in R or Python. We are looking for self-motivated and broadly interested individuals with a strong sense of responsibility. Flexibility and the ability to work in a fast-paced environment on multiple scientific and infrastructure projects are essential. Good intercultural and interpersonal communication skills, as well as the ability to communicate and present in English, are very important. We aim to recruit individuals with the highest potential, typically from the top 10% of an academic year. Our offer: You will join a young and interdisciplinary team of life scientists and bioinformaticians who use the latest proteomic approaches and equipment to better understand plant biology. TUM is one of the best academic institutions in Germany and offers a stimulating work environment and excellent future perspectives. The position will be available for four years (10/26 – 09/30). Remuneration is in accordance with TV-L E13, depending on the professional qualification. Equal opportunity: TUM aims to increase the proportion of women and therefore expressly welcomes applications from women. The position is also suitable for persons with disabilities, who will be given preference if their suitability, qualifications, and professional performance are otherwise essentially equal. Application process: Applicants should send a dossier containing a motivational statement (max. one page), a curriculum vitae summarizing qualifications and experience, copies of degrees and transcripts of study records, names and the email addresses of two referees as a single PDF document, and no later than 30 June 2026 to Dr. Christina Ludwig (tina.ludwig@tum.de). Online interviews will be conducted with selected candidates, and shortlisted candidates will be invited to an in-person interview in Freising. The successful candidate is asked to start on 1 October 2026. Data Protection Information: When you apply for a position with the Technical University of Munich (TUM), you are submitting personal information. About personal information, please take note of the data protection information on collecting and processing personal data contained in your application in accordance with Article 13 of the General Data Protection Regulation (GDPR). By submitting your application, you confirm that you have acknowledged the above data protection information of TUM. The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance. Data Protection Information:When you apply for a position with the Technical University of Munich (TUM), you are submitting personal information. With regard to personal information, please take note of the Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. (data protection information on collecting and processing personal data contained in your application in accordance with Art. 13 of the General Data Protection Regulation (GDPR)). By submitting your application, you confirm that you have acknowledged the above data protection information of TUM. Kontakt: tina.ludwig@tum.de

PhD position in the field of Brown and White Adipose Tissue Biology

About us Our research group at the Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, investigates the molecular events governing adipogenesis and the resulting heterogeneity of mature adi-pocytes in brown and white adipose tissue. We are seeking a highly motivated doctoral researcher to strengthen our interactive and collaborative team. You will be part of the collaborative research center “BATenergy”, funded by the DFG (TRR333), and team up with biologists, physiologists, nutrition scientists, and doctors applying cutting-edge technologies to dissect a novel signaling axis that drives functional diversity in mature adipocytes. Your profile We are looking for a highly motivated candidate with a Master of Science or equivalent who is eager to carry out a PhD project in academic research. Application For further information or to submit your application (including a cover letter, CV, academic transcripts, and contact details for two referees), please contact: Technical University of Munich,Chair for Molecular Nutritional Medicine,Priv.-Doz. Dr. Tobias Fromme,Gregor-Mendel-Str. 2, 85354 Freising, Germany,Tel. +49 8161 713850,fromme@tum.de, www.mls.ls.tum.de/en/mnm/research-group-fromme, www.tum.de —If you apply in writing, we request that you submit only copies of official documents, as we cannot return your materials after completion of the application process. The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance. Data Protection Information:When you apply for a position at the Technical University of Munich (TUM), you are submitting personal information. With regard to this personal information, please note the data protection information pursuant to Article 13 of the General Data Protection Regulation (GDPR) concerning the collection and processing of personal data in connection with your application. By submitting your application, you confirm that you have acknowledged the above data protection information of TUM. Contact: fromme@tum.de

PhD in the field of amyloid and bio-condensate structural biology by NMR spectroscopy

The Reif group at the Bavarian NMR Center (BNMRZ) at the TU Munich is looking for a PhD student to work on the characterization of amyloid fibrils, protein condensates and liquid liquid phase separation (LLPS) using a combination of solution- and MAS solid-state NMR spectroscopy. The position is available immediately. Membraneless organelles (such as nucleoli, nuclear speckles, stress granules etc.) are vital for living organisms. These biomolecular condensates are formed by multi-domain proteins that are involved in multi-valent interactions. Condensate formation implies both protein-protein and protein-RNA interactions, involving prion-like low complexity regions and RNA binding domains. The delicate balance between liquid-liquid phase separation (LLPS) and amyloid fibril formation requires tight regulation. This can be achieved by chaperones, posttranslational modifications, small molecules and/or metals that affect this balance and either yield disintegration or rigidification of protein liquid droplets into β-strand rich protein fibrils. It is the aim of the PhD project to better understand the mechanisms that modulate the equilibrium between amyloid fibril and granule formation in the cell on a structural basis. Protein systems under investigation involve stress granule (SG) associated factors, the Alzheimer’s disease Aβ peptide, the diabetes type II related human islet amyloid polypeptide (hIAPP/amylin), light chain antibody domains involved in AL-amyloidosis and serum amyloid A (SAA) involved in AA-amyloidosis. We employ solution- and MAS solid-state NMR to characterize these systems. In addition, we use low resolution biophysical methods such as fluorescence microscopy, ThT aggregation assays, CD spectroscopy, electron microscopy and dynamic light scattering (DLS). Interested candidates should have a background in biochemistry and biophysical methods to characterize protein misfolding. References– Pradhan T, Sarkar R, Meighen-Berger KM, Feige MJ, Zacharias M, Reif B (2023) Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain protein FOR005. Nature Comm. 14:e3755; doi: 10.1038/s41467-023-39280-0.– Rodina N, Hornung S, Sarkar R, Suladze S, Peters C, Schmid PWN, Niu Z, Haslbeck M, Buchner J, Kapurniotu A, Reif B (2024) Modulation of Alzheimer’s Disease Aβ40 Fibril Polymorphism by the Small Heat Shock Protein αB-Crystallin. J.Am. Chem. Soc. 146, 19077; doi: 10.1021/jacs.4c03504– Suladze S, Sarkar R, Rodina N, Bokvist K, Krewinkel M, Scheps D, Nagel N, Bardiaux B, Reif B (2024) Atomic resolution structure of full-length human insulin fibrils. Proc. Natl. Acad. Sci. USA 121, e2401458121; doi: 10.1073/pnas.2401458121– Suladze S, Sustay Martinez C, Rodriguez Camargo DC, Engler J, Rodina N, Sarkar R, Zacharias M, Reif B (2024) Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation. J.Am. Chem. Soc. 146, 13783; doi: 10.1021/jacs.3c14233 General InformationFor further information, please see our web page: https://www.bio.nat.tum.de/ocb/home/. Our group is integrated into the Bavarian NMR Center (www.bnmrz.org) at the Technical University Munich and is associated with the Institute of Structural Biology (www.helmholtz-munich.de/en/stb) at the Helmholtz-Zentrum München (HMGU). Labs are located in the Bavarian NMR Center at Campus Garching, and are used together with the groups of Profs. Michael Sattler, Franz Hagn and Steffen Glaser. In addition to a high-end NMR facility, our group has direct access on campus to an X-ray crystallography facility, as well as to a cryo-EM platform equipped with a Selectrix X imaging filter and a modern Falcon 4i direct electron detector enabling cutting-edge single-particle analysis and in situ cryo-electron tomography. While working at BNMRZ, you participate in the scientific seminars organized by the BNMRZ, and the STB. Membraneless organelles (such as nucleoli, nuclear speckles, stress granules , etc.) are essential for living organisms. These biomolecular condensates are formed by multi-domain proteins involved in multivalent interactions. Condensation formation relies on both protein-protein and protein-RNA interactions, involving prion-like regions of low complexity as well as RNA-binding domains. The delicate balance between liquid-liquid phase separation (LLPS) and amyloid fibril formation requires precise regulation. This can be achieved by chaperones, post-translational modifications, small molecules, and/or metals that influence this balance, leading either to the disintegration or solidification of liquid protein droplets into β-strand-rich protein fibrils. The aim of this doctoral project is to gain a better structural understanding of the mechanisms that modulate the balance between the formation of amyloid fibrils and granules in cells. The protein systems under investigation include factors associated with stress granules (SG), the Aβ peptide (Alzheimer’s disease), the human islet amyloid polypeptide (hIAPP/amylin) associated with type 2 diabetes, antibody light chain domains (involved in AL amyloidosis), and serum amyloid A (SAA; involved in AA amyloidosis). We use solution-based and MAS solid-state NMR spectroscopy to characterize these systems. In addition, we employ lower-resolution biophysical methods such as fluorescence microscopy, ThT aggregation assays, CD spectroscopy, electron microscopy, and dynamic light scattering (DLS). Interested candidates should have knowledge of biochemistry and biophysical methods for characterizing protein misfolding. References– Pradhan T, Sarkar R, Meighen-Berger KM, Feige MJ, Zacharias M, Reif B (2023) Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain protein FOR005. Nature Comm. 14:e3755; doi: 10.1038/s41467-023-39280-0. – Rodina N, Hornung S, Sarkar R, Suladze S, Peters C, Schmid PWN, Niu Z, Haslbeck M, Buchner J, Kapurniotu A, Reif B (2024) Modulation of Alzheimer’s Disease Aβ40 Fibril Polymorphism by the Small Heat Shock Protein αB-Crystallin. J.Am. Chem. Soc. 146, 19077; doi: 10.1021/jacs.4c03504– Suladze S, Sarkar R, Rodina N, Bokvist K, Krewinkel M, Scheps D, Nagel N, Bardiaux B, Reif B (2024) Atomic resolution structure of full-length human insulin fibrils. Proc. Natl. Acad. Sci. USA 121, e2401458121; doi: 10.1073/pnas.2401458121– Suladze S, Sustay Martinez C, Rodriguez Camargo DC, Engler J, Rodina N, Sarkar R, Zacharias M, Reif B (2024) Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation. J.Am. Chem. Soc. 146, 13783; doi: 10.1021/jacs.3c14233 General InformationFurther information can be found on our website: https://www.bio.nat.tum.de/ocb/home/. Our research group is integrated into the Bavarian NMR Center (www.bnmrz.org) at the Technical University of Munich and associated with the Institute of Structural Biology (www.helmholtz-munich.de/en/stb) at the Helmholtz Center Munich (HMGU). The laboratories are located in the Bavarian NMR Center on the Garching campus and are shared with the research groups of Professors Michael Sattler, Franz Hagn, and Steffen Glaser. In addition to a state-of-the-art NMR facility, our group has direct access on campus to an X-ray

Human Tissue Technician

Job details When you work for the University of Lancashire, you’ll be part of a thriving community of talent that’s united in a common commitment to transform lives. We do this by delivering an outstanding educational experience and creating prosperity and opportunity in the communities we serve. Whatever your role, you’ll be playing a vital part in helping us achieve our vision. About the role: The University of Lancashire wishes to recruit a Human Tissue Technician to join our Technical Services team who provide support to the wide variety of laboratories and Clinical facilities at our Preston campus. The successful candidate will primarily be focused on supporting research within our state of the art laboratories based in Preston. You will help coordinate and undertake maintenance and configuration of equipment and relevant software. As well as help with the introduction of new technologies, procedures and practices and be familiar with biological instrumentation.  About you: The ideal candidate will have experience of working within a human tissue biobank, including sample storage maintenance and knowledge of legal requirements. You will have an undergraduate degree in a Biology related subject or equivalent experiential learning. Candidates should be practical with a keen interest in science and technology supported by great customer service skills. The ability to adapt knowledge and experience to support staff and students across the wide range of subject disciplines we support would be a distinct advantage. Candidates must also have good verbal and written communication skills. Applicants need to meet all essential criteria on the person specification to be considered for interview. This position is based in Preston. Use of AI in applications: We want to understand your genuine interest in the role and artificial intelligence can be a useful tool to support your application. However, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience and the written elements of your application should accurately reflect your own communication style. Applications that rely too heavily on AI tools can appear generic and lack the detail we need to assess your skills and experience. We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible. What we can offer you: We have a fantastic package of rewards and lifestyle benefits – from an attractive annual leave entitlement to access to a comprehensive employee benefits platform which includes a 24/7 online GP. Our people are our most important asset. We’ll encourage you to make the most of your talents and continually develop your skills and knowledge. As well as realising your career ambitions, you’ll be making a positive difference to other people’s lives. Apply Now

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