Fixed-term

Duties  Doctoral education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies Doctoral studies comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period, and result in a corresponding extension of the studies. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration. RNA interference (RNAi) is a critical biological process that regulates gene expression and maintains cellular homeostasis. Disruptions in RNAi pathways are linked to various diseases. The RNAi machinery primarily involves Argonaute (AGO) proteins and microRNAs (miRNAs), which bind to messenger RNAs (mRNAs), leading to mRNA degradation and gene silencing. While the cytoplasmic RNAi mechanisms are well-characterized, recent findings highlight that RNAi also operates within the cell nucleus. In the nucleus, AGO2 plays essential roles during early development but is typically excluded from the nucleus in mature, healthy cells. However, mislocalization of AGO2 to the nucleus has been observed during viral infections, cancer, and aging, often correlated with poor disease progression. This suggests that targeting nuclear AGO2 could offer a novel therapeutic strategy for certain diseases. On the topic we have published: https://pubmed.ncbi.nlm.nih.gov/40219968/ https://pubmed.ncbi.nlm.nih.gov/38994560/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11169490/ https://pubmed.ncbi.nlm.nih.gov/30146314/ https://www.biorxiv.org/content/10.64898/2025.12.12.693770v1.full This PhD project explores how spatial regulation of AGO proteins influences gene regulation in cancer and viral infection. The aim is to understand how compartment-specific RNA silencing contributes to disease and to develop new strategies to restore proper RNAi function in pathological contexts. The project combines molecular and cellular biology with systems-level approaches, including RNA sequencing (RNA-seq), miRNA profiling, PAR-CLIP, and proteomic analyses to investigate gene regulation and RNA–protein interaction networks. Together, these methods will provide mechanistic insight into how RNA silencing pathways are altered in disease and how they can be reprogrammed. We are seeking a highly motivated and curious candidate with a strong background in molecular biology, cell biology, biochemistry, or a related field. The candidate should demonstrate strong experimental skills, independence, critical thinking, and the ability to work collaboratively in an interdisciplinary research environment. Experience in one or more of the following areas is advantageous: • RNA biology and gene regulation • Cell culture and molecular cloning • RNA sequencing (RNA-seq) or small RNA analysis • Protein–RNA interaction methods (e.g., CLIP-based approaches) • Microscopy and subcellular localization studies • Basic bioinformatics or analysis of high-throughput sequencing data • Proteomics or biochemical assays Prior experience in cancer biology, virology, or RNA interference is beneficial but not required. Read more at our homepage: www.sarshadlab.com Eligibility  Doctoral education requires general eligibility and, where appropriate, specific eligibility as set out in the general syllabus for the subject. The general eligibility requirements for doctoral studies are: having completed a degree at second-cycle level, or the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or the acquisition of equivalent knowledge in some other way, either in Sweden or abroad. Specific entry requirements for this subject, according to the general syllabus, are: having successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies. Assessment criteria  The selection of applicants who meet the basic and specific eligibility requirements will be based on the ability to assimilate the doctoral studies. The assessment shall attach particular importance to documented qualifications for: – specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through an academic paper, degree project, scientific journals or the like. Admission and employment  Once you have been admitted to doctoral studies, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at doctoral level for four years. Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell biology. Extent: 100%. First day of employment: as agreed. The University applies a local agreement on salaries for doctoral students. Please note, doctoral studies at the institute of Biomedicine require physical presence to conduct the studies. If the admitted applicant needs a residence permit for higher education to pursue studies in Sweden, the institute has the right to revoke the admission decision if the applicant cannot present a valid residence permit no later than at the start of the studies.   Contact information For more information about the project please contact principal supervisor, Aishe Sarshad, Associate Professor, Institute of Biomedicine, e-mail: aishe.sarshad@gu.se   Unions Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande   Application You can apply to be admitted to doctoral education via the University of Gothenburg’s recruitment portal. It is your responsibility to ensure that the application is complete as per this notice, and that the University receives it by the final application deadline.   You must include the following, in pdf format Personal letter CV Diploma and transcripts showing that you meet with the general entry requirement Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier. For information on what you need to submit in order to fulfill the English

The University of Gothenburg tackles society’s challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. Doctoral position in Medical Science Project title: Targeting astrocytes to improve outcome in CNS diseases The Department of Clinical Neuroscience is located at the Institute of Neuroscience and Physiology at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg. We are at the forefront of groundbreaking research in neurology, neurosurgery, clinical neurophysiology, ophthalmology, rehabilitation medicine, and experimental neuroscience, working closely with Sahlgrenska University Hospital. Our department offers educational programs for future physicians, biomedical analysts, occupational therapists, physiotherapists, and speech therapists, along with specialized commissioned courses in collaboration with the Department of Neurology at Sahlgrenska University Hospital. Join our innovative team of researchers who are constantly pushing the boundaries of science. Are you ready to be part of something extraordinary? General information about being a doctoral student at the University of Gothenburg can be found on the university’s doctoral student pages https://www.gu.se/en/doctoral-studies Duties  Doctoral education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies Project: We and others showed that astrocytes are involved in many processes in the CNS ranging from the establishment and maintenance of neuronal synapses and regulation of synaptic transmission, to neuroprotection and control of regenerative responses. These findings identify astrocytes as a major factor in the maintenance of brain health and a central element in many neurological diseases, making them a novel therapeutic target. We and others previously demonstrated that reactive gliosis, while beneficial in many neurological conditions, can in some disease contexts become maladaptive, with severe consequences for the CNS function. We hypothesize that the maladaptive response of reactive astrocytes is the driver of some neurodegenerative disorders. The project aims to address cellular and molecular mechanisms of astrocyte malfunction and provide the basis for designing future treatment strategies for neurodegenerative conditions involving maladaptive astrocyte reactivity. The student will use mouse disease models, perform behavioral assessment of sensorimotor functions, and apply state-of-the-art tissue and omics analyses. Taking advantage of a strong collaborative network of national and international experts, this PhD project will contribute to the understanding of the role of astrocytes in selected CNS diseases, and has the potential to accelerate the development of new treatments to improve outcome. We are looking for a highly motivated candidate, preferentially with very well documented experience in molecular and cellular biology laboratory work. The candidate should have medical, clinical or biological background, strong interest in neuroscience, a drive to advance the understanding of the molecular mechanisms of human disease, and excellent oral and written communication skills in English. Doctoral studies comprises four years of full-time study, and leads to a doctoral degree. Eligibility  Doctoral education requires general eligibility and, where appropriate, specific eligibility as set out in the general syllabus for the subject. The general eligibility requirements for doctoral studies are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad. Specific entry requirements for this subject, according to the general syllabus, are: having successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies. Assessment criteria  The selection of applicants who meet the basic and specific eligibility requirements will be based on the ability to assimilate the doctoral studies. The assessment shall attach particular importance to documented qualifications for: – specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through an academic paper, degree project, scientific journals or the like. Admission and employment  Once you have been admitted to doctoral studies, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at doctoral level for four years. Location: Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience. Extent: 100%. First day of employment: as agreed. The University applies a local agreement on salaries for doctoral students. Please note, doctoral studies at the Institute of Neuroscience and Physiology requires physical presence to conduct the studies. If the admitted applicant needs a residence permit for higher education to pursue studies in Sweden, the Institute of Neuroscience and Physiology has the right to revoke the admission decision if the applicant cannot present a valid residence permit no later than at the start of the studies.  Contact information For more information about the project please contact principal supervisor, Milos Pekny, Professor, Institute of Neuroscience and Physiology, e-mail: milos.pekny@neuro.gu.se Unions Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande     Application You can apply to be admitted to doctoral education via the University of Gothenburg’s recruitment portal. It is your responsibility to ensure that the application is complete as per this notice, and that the University receives it by the final application deadline. You must include the following, in pdf format Personal letter CV Diploma and transcripts showing that you meet with the general entry requirement Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies

Do you want to contribute to improving human health? Join a leading research team dedicated to understanding how mitochondrial DNA (mtDNA) gene expression affect mitochondrial function in disease and ageing. At the Division of Molecular Metabolism, we combine fundamental basic scientific research with clinical perspectives in a collaborative and well-equipped environment. We are currently looking for 1–2 highly motivated postdoctoral researchers to join the research group of Nils-Göran Larsson. Our group values scientific curiosity and careful experimentation. We welcome motivated researchers eager to explore mitochondrial biology in depth and contribute to advancing the field. Division The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is located at the modern Biomedicum laboratory building at Solna campus of Karolinska Institutet. Our research encompasses basic scientific approaches to understand the regulation of mitochondrial function and its control of metabolism as well as biochemical and genetic studies of patients with inherited mitochondrial diseases. We use biochemistry, molecular biology and a set of elaborate genetic mouse (Mus musculus) models to study molecular regulation of mitochondrial function. We also have access to cell lines and tissues from patients with mitochondrial disease for human validation of results. Modern -omics techniques, including single cell proteomics, play an important role in our analyses. We offer an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory. https://ki.se/en/mbb/research-division-of-molecular-metabolism https://ki.se/en/mbb/nils-goran-larsson-group Duties Mitochondria are central to cellular metabolism, and mitochondrial dysfunction is implicated in a wide range of human diseases and in the ageing process. The postdoctoral researcher will independently pursue a main project and will be involved in collaborative efforts on other research projects within the group. The ongoing projects in the group include the organization and regulation of the mitochondrial genome, mechanisms controlling mitochondrial gene expression and maintenance, the role of mitochondria in ageing, and how mitochondrial dysfunction cause mitochondrial disease phenotypes and contributes to metabolic disorders, immune responses and cancer. The work will employ biochemical, molecular and cell biological approaches, various omics technologies, and advanced genetic models. Entry requirements Applications are invited from enthusiastic and motivated individuals with a PhD in molecular biology or genetics. We are interested in individuals with experience in biochemistry, molecular biology, mouse genetics and different -omics methods. Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to pursue his/her own research project and to contribute to ongoing collaborative projects. Personal suitability is of great importance when evaluating the applicants. Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site. Location: Biomedicum, Solna Type of scholarship The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable. Application process An application must contain the following documents in English or Swedish: A complete resumé (max 2 pages) A complete list of publications A personal motivation letter, explaining your research interest (max 1 page) Contact information of at least two references The application is to be submitted on the Varbi recruitment system. Want to make a difference? Join us and contribute to better health for all Apply Now