Fixed-term

Project background Living cells such as neurons can be viewed as biological systems with complex, dynamic, and multi-functional behaviors through their billions of years of evolution. Interfacing with living cells using advanced micro-/nano-electronics enables new sensing and actuation opportunities but requires robust biological protocols and stable bioelectronic interfaces. In parallel, biomolecules and their complexes can be probed and controlled using CMOS micro-/nano-electronics, enabling applications such as molecular sensing (DNAs/proteins), surface functionalization, electrochemical reactions, and molecular synthesis. Our ETH IDEAS group has developed many generations of CMOS cellular/molecular platforms with dense arrays of electrodes and multi-modality active pixels for sensing and actuation. Some of these platforms focus on long-term culture and sensing of biological systems, including neurons, human stem-cell-derived cells, and animal-based cells. Others focus on molecular or chemical functionalities, including electrochemical measurements and on-chip molecular processes. Across these diverse projects, a central requirement is bio-experimental expertise in both cellular and molecular/electrochemical workflows. This postdoctoral position supports research across these applications and contributes to the development and operation of CMOS bioelectronics and biosensors at ETH IDEAS group. Job description You will work on the molecular and cellular assays and systems for CMOS bioelectronics and biosensor platforms. Please note that this position is NOT for CMOS electronic circuit research. Research directions and responsibilities include: Long-term culture and maintenance of neurons and other cell-based assays on CMOS integrated circuit (IC) chips Work with human stem-cell-derived cells, animal-based cells, and other cellular systems for extended-time cell culture and interfacing experiments on CMOS Development and maintenance of stable and reproducible cell-microelectrode interfaces on CMOS Design and execution of molecular and electrochemical experiments on CMOS micro-/nano-electrode arrays, including surface functionalization and electrodeposition Implementation of molecular and chemical workflows on CMOS IC chips, including electrochemical reactions and molecular synthesis Biological and molecular characterization using microscopy, fluorescence-based assays, and electrochemical measurements Working closely with CMOS electronics researchers to support experimental design and platform operation Contribution to teaching activities, including lectures, exercises, or laboratory components related to cellular/molecular biology Presentation of results at internal meetings and international conferences Preparation of peer-reviewed publications The position offers scientific freedom to shape experimental workflows and contribute to multiple projects within a highly interdisciplinary research environment at ETH Zurich Profile PhD degree or equivalent in cell biology, molecular biology, neuroscience, chemistry, electrochemistry, bioengineering, biomedical engineering, or closely related disciplines Experience in long-term cell cultures in particular neuronal cultures Experience with cellular assays using human stem-cell-derived cells and/or animal-based cells Strong experimental background in molecular chemistry, electrochemistry, or related chemical systems Experience with bioelectronic platforms, microelectrode arrays, or Organ-on-Chip systems is an advantage Strong interest in interdisciplinary research involving biological and molecular systems on CMOS bioelectronics and biosensors Strong interest in contributing to teaching and mentoring Excellent work ethics, scientific rigor, and ability to build collaborative team cultures Ability to work independently as well as part of a team Excellent organizational skills and high reliability Excellent track record in scientific work, communication, and publications Fluent oral and written communication skills in English are essential We offer New research frontier with highly interdisciplinary nature at the interface of biology, molecular systems, and CMOS bioelectronics/biosensors A collaborative research environment within ETH Zurich and extended partnership with UZH, EPFL, EMPA, PSI, and industry in Switzerland Access to the state-of-the-art biological and chemical laboratories, equipment, and CMOS IC platforms Opportunities to gain teaching experience in an interdisciplinary graduate-level course Support benefits including professional networking and career development opportunities Regular seminars and symposia within the ETH Zurich research ecosystem A fully funded position for an initial period of 1-2 years, with the possibility of extension contingent on performance and available funding chevron_rightWorking, teaching and research at ETH Zurich We value diversity and sustainability In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us – we are consistently working towards a climate-neutral future. Curious? So are we. We look forward to receiving your online application with the following documents: Cover letter outlining your motivation and experience Concise CV Diploma and certificates Five of your best publications Further information about the IDEAS Group can be found on our Website. Questions regarding the position should be directed to ideas-jobs@iis.ee.ethz.ch (no applications). Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. We would like to point out that the pre-selection is carried out by the responsible recruiters and not by artificial intelligence. Apply Now

Project background The systematic monitoring of living organisms, from pathogens and pests to agricultural species and biodiversity is becoming increasingly important to ensure long-term societal well-being. A major challenge in this field is the early, reliable, and efficient detection of disruptive species (e.g. pests or pathogens), enabling timely intervention and informed management decisions. In this project, we are generating a programmable rapid eDNA detection platform, based on CRISPR-Cas reactions, for fast and cost-effective organism detection across diverse environmental settings. Job description We are building the early foundations of a new venture and are looking for a motivated applicant to join the project at a formative stage. The role is designed for someone interested in contributing to the development of a potential spin off, should the project demonstrate traction and should there be strong mutual alignment. The successful candidate will be responsible for collection and processing of eDNA samples from a range of different environments, as well as development, testing, and optimization of molecular reactions and detection methods under both laboratory and field conditions. This includes executing and refining molecular biology workflows, independently troubleshooting experiments, and improving robustness and reproducibility. The role further involves supporting the generation of high-quality, reproducible data suitable for intellectual property (IP) development, regulatory pathways and potential commercial use. The technician will work closely with the project lead to shape technical direction, set priorities, and iteratively refine the platform. Given the applied nature of the project, the position also requires collaboration with external partners and the ability to communicate clearly with various stakeholders as the project matures and demonstrates scientific and commercial viability. Duration: The position is fixed for 12 months (80%). The project is expected to continue within an ETH spin off. Profile Master’s degree in molecular biology, biochemistry, biomedical engineering or related fields Hands-on experience with standard molecular laboratory techniques (e.g. DNA/RNA extractions, PCR, qPCR) Experience in method development and testing protocols under laboratory conditions Ability to work independently, plan and document experiments and execute protocols efficiently Strong interest in translating scientific findings into applications, including IP and commercialization Willingness to engage in broader venture-building activities Industrial or product design experience is an advantage Experience with CRISPR-C as protocols and environmental DNA samples would be a plus Ability to integrate concepts from different disciplines efficiently and adapt to evolving project needs Excellent communication and writing skills (English + one official Swiss language) We offer You will work together with a group of scientists (technicians, graduate students, postdocs and senior scientists) to streamline and optimize experimental procedures in the CRISPR/eDNA research domain. The focus will not only be on basic research, but on applied research fields, offering a variety of projects and opportunities to get involved in. You will work in an international vibrant team with the unique opportunity to continuously refine and expand your interpersonal and methodical skills. A stimulating academic environment at one of the world’s leading technical universities. The opportunity to contribute to impactful projects in favour of biodiversity. Work in an international vibrant team with the unique opportunity to continuously refine and expand your interpersonal and methodical skills. ETH Zurich is one of the world’s leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow. Read more about working at ETH and our benefits for employees. chevron_rightWorking, teaching and research at ETH Zurich We value diversity and sustainability In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us – we are consistently working towards a climate-neutral future. Curious? So are we. We look forward to receiving your online application with the following documents: CV/Resume Cover letter explaining your interest and qualifications Contact information for 2-3 references Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. Further information about the Laboratory of Ecosystem and Landscape Evolution can be found on our website. Questions regarding the position should be directed to Prof. Loïc Pellissier (loic.pellissier@usys.ethz.ch), no applications. Apply Now