Fixed-term

Full time, fixed term until 31st December 2028, located on the Camperdown Campus at the School of Life and Environmental Sciences (SOLES) Opportunity to make valuable contributions to research in Metabolic disease Base Salary, level A $105,314 – $116,679 p.a + 17% superannuation  About the opportunity The School of Life and Environmental Sciences (SOLES) is currently seeking a Postdoctoral Researcher in Metabolic Disease and Cell Signalling to carry out independent research, keeping with the aims of the laboratory and the Charles Perkins Centre (CPC). The successful candidate will contribute to projects focused on understanding the molecular and cellular mechanisms underlying metabolic disease, with a particular emphasis on protein trafficking, signalling pathways, membrane transport, proteomics, and systems-level regulation of metabolism. The role will involve the integration of biochemical, molecular, cellular, and in vivo approaches to investigate disease mechanisms and identify novel therapeutic targets. Your key responsibilities will be to: participate in and drive laboratory research programs focused on metabolism and cell signalling carry out independent research aligned with the strategic aims of the laboratory and the CPC coordinate and manage multiple research projects to ensure timely completion of milestones and publications develop, optimise, and apply advanced methodologies in protein biochemistry, molecular biology, proteomics, and cell biology perform mechanistic studies in mammalian cell systems and mouse models design and implement CRISPR/Cas9-based genetic manipulation approaches in cells and animal models conduct biochemical and enzymatic assays to investigate protein function, signalling pathways, and metabolic regulation undertake proteomic and mass spectrometry-based analyses of proteins and signalling networks contribute to screening approaches, including functional and biochemical screening strategies supervise honours, PhD, and postgraduate students and provide mentorship in experimental design and data analysis foster collaborations within the laboratory, CPC, and broader national and international research community present research findings at national and international scientific meetings and publish in high-impact peer-reviewed journal contribute to grant applications and help secure national and international competitive funding disseminate technical expertise and train other laboratory members in specialised methodologies. About you The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. In addition, we are seeking a highly motivated Postdoctoral Researcher with some of the following skills: a PhD (or near completion) in biochemistry, molecular biology, cell biology, metabolism, or related discipline strong expertise in protein biochemistry and molecular mechanisms of cell signalling experience in mammalian cell culture and molecular cloning techniques expertise in CRISPR/Cas9-mediated genome engineering experience with proteomics and mass spectrometry-based approaches experience performing enzyme assays and mechanistic biochemical studies expertise in molecular biology techniques including plasmid design, mutagenesis, and gene expression analysis experience working with mouse models and small animal experimentation would be an advantage. experience in functional screening approaches and/or assay development expertise in fluorescence microscopy and imaging approaches strong analytical and problem-solving skills, including experience analysing complex biological datasets the ability and willingness to work collaboratively within multidisciplinary research teams excellent written and verbal communication skills a strong publication track record relative to career stage experience with quantitative proteomics and/or phosphoproteomics would be an advantage. Pre-employment checks Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment. EEO statement  At the University of Sydney, our shared values include diversity and inclusion and we strive to be a place where everyone can thrive. We are committed to creating a University community which reflects the wider community that we serve. We deliver on this commitment through our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTIQ. We welcome applications from candidates from all backgrounds.  How to apply Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.  Candidates should indicate which level they wish to apply for; however, the selection panel reserves the right to make offers based on its appraisal of the candidate’s skills, experience, and knowledge. For employees of the University or contingent workers, please login into your Workday account and navigate to the Career icon on your Dashboard.  Click on USYD Find Jobs and apply. For a confidential discussion about the role, or if you require reasonable adjustment or any documents in alternate formats, please contact Simon Drew, Recruitment Operations, Human Resources at recruitment.sea@sydney.edu.au © The University of Sydney The University reserves the right not to proceed with any appointment. Click to view the Position Description for this role.  

Part time (0.2 FTE), fixed term until December 2027  Exciting opportunity to be a Postdoctoral Research Associate with the School of Medical Sciences   Base Salary starting from $113,400 pro rata + 17% superannuation About the opportunity The School of Medical Sciences is recognised as one of the leading centres for medical science education in the world. With over 100 years of excellence in education, we are proud to be training the next generation of medical scientists who will be leading members of the medical research community with an innovative integrated curriculum. Our team of researchers lead key internationally competitive research from molecules to medicines, from patient to policy across a range of therapeutic areas. We are seeking a Postdoctoral Research Associate to apply and develop their expertise in conducting research that advances the research agenda of the faculty or school. The role involves contributing to research independently or as part of a team, developing scholarly outputs, and supporting collaborative research initiatives within the discipline. Your key responsibilities will be to: conduct research, scholarly or professional activity independently or as part of a team, contributing to discipline knowledge develop and refine independent research skills under the supervision of senior academic staff provide informal mentoring and advice to students within the discipline carry out administrative tasks and contribute to faculty or school meetings contribute to a positive workplace culture in which diversity of thought, collaboration, excellence and achieving outcomes are valued and enabled understand and contribute to furthering the university and faculty or school strategic agenda undertake other duties and contribute to projects appropriate within the classification level as required. About you bachelor’s degree in a relevant field or an equivalent combination of relevant training and experience demonstrated understanding of the subject matter within the discipline experience conducting original research and engaging in scholarly activity a developing research profile in the discipline or area of expertise a developing network of academic, industry and professional partners and stakeholders strong skills in research, planning and organisation, computer literacy, effective presentations, communication and customer service. Pre-employment checks Your employment is conditional upon the successful completion of all pre-employment or background checks required for the role in terms satisfactory to the University. Also, to meet the University’s obligations under the National Higher Education Code to Prevent and Eliminate Gender-Based Violence you will be asked to declare if you have been investigated for, or found to engaged in, sexual harm or gender-based violence in the course of previous employment or in a legal process. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment. EEO statement  At the University of Sydney, our shared values are trust, accountability and excellence and we strive to be a place where everyone can thrive. We are committed to creating a University community that thrives through diversity and reflects the wider community that we serve. We deliver on this through our commitment to diversity and inclusion, evidenced by our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTIQ+. We welcome applications from candidates from all backgrounds.  We are proud to be recognised as an Australian Workplace Equality Index (AWEI) Gold employer. Find out more about our work on diversity and inclusion.  How to apply Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.   For employees of the University or contingent workers, please login into your Workday account and navigate to the Career icon on your Dashboard.  Click on USYD Find Jobs and apply. For a confidential discussion about the role, or if you require reasonable adjustment or any documents in alternate formats, please contact, Ajaypal Singh, Recruitment Operations by email to ajaypal.singh@sydney.edu.au. © The University of Sydney The University reserves the right not to proceed with any appointment. Click to view the Position Description for this role.

PRIMARY DETAIL – Salary Package $120,623 (ACA A.8) plus 17% employer’s superannuation contribution and annual leave loading.– Appointment Type: Full-time, 3 year fixed term role– Build and expend your academic networks and advance your career THE ROLE An exciting opportunity for a Postdoctoral Research Fellow in Extracellular Vesicle Analysis exists in the School of Natural Sciences at Macquarie University, as part of an ARC Discovery Project.  We are seeking a qualified Research Fellow to join a team with an international reputation for producing high quality research outcomes in the area of innovative spectroscopic tools for EV analysis. The position consists of leading the development of new EV engineering platform for a better understanding of the chirality of EV for an enhanced cellular uptake. The successful candidate will report to Professor Yuling Wang, and will undertake the following responsibilities as a Postdoctoral Research Fellow: Development of highly innovative platform for engineering of chiral extracellular vesicles (EVs) Maintenance and supervision of EV Analysis Facility at Macquarie University Work in supportive, collegiate team environment; Undertake independent research in the area of EV analysis using a serial of spectroscopic tools; Prepare, write, and submit high-quality research manuscripts for publication in peer-reviewed journals; Collaborate with senior staff to actively seek and secure external funding, prepare and submit research proposals to external funding bodies as appropriate; Foster interdisciplinary collaborations within the University and with external partners, including industry where appropriate; Take responsibility for health and safety in the workplace; We very much look forward to hearing from applicants who have demonstrated excellence in their past research, have several of the technical skills required to match the demands of this project, and who are keen to engage in a project that involves collaboration with academic and industry partners. About Us The Faculty of Science and Engineering is a young and dynamic faculty driven by the spirit of discovery. Here we nurture the next generation of science and technology innovators. From a handful of students on the University’s first day, the Faculty now serves over 8,000 students across all our courses. The School of Natural Sciences at Macquarie University was established on 1 January 2022 through the amalgamation of the Departments of Biological Sciences, Molecular Sciences, and Earth and Environmental Sciences. The School is the largest in the Faculty of Science and Engineering and is a vibrant community of educators, researchers and students working across a wide range of biological, biomolecular, biomedical, chemical, environmental and geoscience disciplines. How to Apply To be considered for this position, applicants must address the selection criteria below and attach your CV (including a list of three referees). Essential A PhD in analytical chemistry, bioanalysis, biosensors or a related discipline and/or relevant experience with combination of qualifications and skill; Experience in cell biology and biotechnology Experience in nanomaterials and extracellular vesical research Evidence of research excellence and independence in one or more relevant areas, demonstrated through high-quality peer-reviewed publications; Ability to assist in the supervision of students working on research projects; Experience in project leadership including in an interdisciplinary/ multidisciplinary team, with the ability to design, conduct and analyse research projects; High quality interpersonal, oral and written communication skills to effectively engage with internal and external collaborators Ability for analytical thinking and independent problem solving. Knowledge of WHS principles, commitment to attend relevant training. Candidates must have Valid Australian working rights. A police/criminal history check is required for this role. The Faculty of Science and Engineering at Macquarie University has a goal to increase the engagement of women, Aboriginal and Torres Strait Islander peoples, and people from diverse backgrounds in STEMM roles. Applications are considered holistically, and candidates are encouraged to apply even if their experience does not meet each individual selection criterion. Enquiries:   For enquiries, or a confidential conversation about the role please contact Prof Yuling Wang on yuling.wang@mq.edu.au or +61 2 9850 6914 or Kate Williams, TA Consultant k.williams@mq.edu.au. Applications Close: Monday 6th of July 2026 at 11:59pm (AEST) *** Applications will be reviewed as they are received, and we reserve the right to progress or decline an application prior to the application closing date. We also reserve the right to close the advertisement early if a sufficient number of qualified applicants is received. Why Join Us? Macquarie is a university engaged with the real and often complex problems and opportunities that define our lives. Since our foundation over 60 years ago, we have aspired to be a different type of university. Over the years, we have grown to become the centre of a vibrant local and global community. Connect with us today. We rank amongst the top employers in the Australian Workplace Employers Index, having recently earned a five-star rating in the QS World Rankings with the highest rating for employability. Take a look at the fabulous staff benefits on offer when you work at Macquarie University. Pre-Employment Checks Macquarie University/Health cultivates a workplace defined by safety, ethical conduct, and strong integrity.  Prior to completion of an offer of employment, preferred candidates will be required to participate in a combination of pre-employment checks relevant to the role they have applied for. Your employment is conditional upon the completion and maintenance of all role-required pre-employment or background checks in terms satisfactory to the University/Health.  If you’re already part of the Macquarie Group (MQ University, U@MQ, MQ Health, MGSM), you’ll need to apply through your employee Workday account. To apply for this job: Login to Workday and go to the Careers App > Find Jobs. Applications Close: 06/07/2026 11:59 PM ​A Place Where You BelongAt Macquarie, we believe diversity makes us stronger, inclusion drives our success, and belonging inspires us to do our best work. We are proud to foster a community where different backgrounds, identities, and experiences are valued, and where our people are empowered to thrive through supportive leadership, shared responsibility, and a deep commitment to genuine care and respect for our community. Find out more about our vision for a truly inclusive workplace in our Diversity, Inclusion and

PRIMARY DETAIL – Salary Package: $114,992 – $124,676 (pro rata 0.5 FTE, 17.5 hours) ( HEW 7.1 – 7.4) plus 17% employer’s superannuation– Appointment Type: Part-time, 0.5 FTE (17.5 hours, 2.5 days per week), fixed term position for 2.5 years– Location: Macquarie University (Wallumattagal Campus, North Ryde) The Role The Australian Proteome Analysis Facility (APAF) is seeking a mass spectrometry expert who is ready to join our Mass Spectrometry team as a Senior Analytical Scientist. APAF is a NATA accredited facility within the Macquarie Analytical and Fabrication Facility (MAFF), providing research support, expertise and services in proteomics to the Australian and international research community. The facility currently hosts significant infrastructure and specialist expertise in mass spectrometry based proteomics and multiomics, RNA mass spectrometry, bioinformatics, mass photometry, amino acid analysis and array technology. This role will be part of the Mass Spectrometry team at APAF, one of the four teams which make up the specialist areas of the facility (Bioinformatics, Mass Spectrometry, Protein Analysis, and Protein Interactions). Reporting to the Mass Spectrometry Technology Manager you will: Develop RNA mass spectrometry analysis workflows and implement small RNA mass spectrometry workflows at APAF; Provide expert technical support to internal and external clients, collaborators and industry partners; Contribute to the research and development of experimental methods, techniques and/or technologies; Implement new analytical procedures, and review and maintain procedures for a specialist stream; Undertake complex instrument troubleshooting and maintain laboratory instruments, equipment and maintenance schedules; Build and maintain relationships with key stakeholders. About Us APAF is part of the Macquarie Analytical and Fabrication Facility (MAFF), a shared research infrastructure facility which sits within the Faculty of Science and Engineering at Macquarie University. APAF is also supported by Bioplatforms Australia (BPA) through funding from the Australian Government National Collaborative Research Infrastructure Strategy (NCRIS), and is proudly accredited by the National Association of Testing Authorities (NATA) in compliance with ISO/IEC 17025. MAFF includes a highly diverse range of analytical instrumentation and research facilities which include (in addition to APAF): the Macquarie University Centre for Analytical Biotechnology (MUCAB), NMR facility, Microscopy Unit, the Macquarie Engineering Technical Services workshop (METS) and the Material Characterisation and Analysis Facility (MCAF). The facility of APAF houses a range of mass spectrometers, including Orbitrap Tribrid Eclipse, Orbitrap Astral, Exploris 480, Sciex 7600s and Waters Cyclic IMS instruments, a TwoMP Mass Photometer, and other state-of-the-art specialist instrumentation. The facility has a team of expert technical staff who manage these instruments and the facilities, as well as analyse samples, develop methods and provide expert data analysis and interpretation. The facility supports research from internal and external clients through access to instrumentation with training and support from the APAF team; and through project work completed as a service by the APAF team. How to Apply To be considered for this position, applicants must address the Selection Criteria below in a separate document or covering letter and upload the document as part of the application process with their curriculum vitae. Required: Degree (preferably a postgraduate degree) in the analytical sciences including in-depth mass spectrometry; Proven experience and expert knowledge of mass spectrometry, instrumentation and data analysis particularly for characterisation of a range of biomolecules; Experience working with scientists and researchers in the execution of project specific mass spec analyses; Experience working with mass spectrometry instrument platforms and interfaced liquid chromatography equipment; Demonstrated experience building, managing and maintaining productive working relationships with key stakeholders, including interacting with scientific clients, collaborators or industry partners; Able to work autonomously and develop novel mass spectrometry centred workflows for the analysis and characterisation of biomolecules; Sound knowledge of workplace health and safety legislation, principles and practices applicable to specialist remit (including hazardous chemicals) in a laboratory environment; Desirable: Knowledge of top-down and native mass spectrometry, mass photometry, or other RNA analysis methods; Knowledge and/or experience in mass spectrometry analysis of mRNA, tRNA, siRNA and its modifications Experience in developing and reporting novel analytical methods, techniques and/or technologies; Experience working in a NATA accredited environment, or similar. The Faculty of Science and Engineering at Macquarie University has a goal to increase the engagement of women, Aboriginal and Torres Strait Islander peoples, and people from diverse backgrounds in STEMM roles. Applications are considered holistically, and candidates are encouraged to apply even if their experience does not meet each individual selection criterion. *This position requires a criminal history and qualifications check. Applications Close: Friday 3rd of July 2026 at 11:59pm (AEST). We reserve the right to progress or decline an application prior to the application closing date. For enquiries, or a confidential conversation about the role please contact Muhammad A. Zenaidee, Technology Manager – muhammad.zenaidee@mq.edu.au. Pre-Employment Checks  Macquarie University cultivates a workplace defined by safety, ethical conduct, and strong integrity. Prior to completion of an offer of employment, preferred candidates will be required to participate in a combination of pre-employment checks relevant to the role they have applied for.  Your employment is conditional upon the completion and maintenance of all role-required pre-employment or background checks in terms satisfactory to the University.  If you’re already part of the Macquarie Group (MQ University, U@MQ, MQ Health, MGSM), you’ll need to apply through your employee Workday account. To apply for this job: Login to Workday and go to the Careers App > Find Jobs. Applications Close: 03/07/2026 11:59 PM ​A Place Where You BelongAt Macquarie, we believe diversity makes us stronger, inclusion drives our success, and belonging inspires us to do our best work. We are proud to foster a community where different backgrounds, identities, and experiences are valued, and where our people are empowered to thrive through supportive leadership, shared responsibility, and a deep commitment to genuine care and respect for our community. Find out more about our vision for a truly inclusive workplace in our Diversity, Inclusion and Belonging Framework. Flexible WorkAt Macquarie, we believe by providing flexibility in when, where and how work is done, we can support our staff to manage their personal commitments, while optimising their work performance and contributions to the University. See how we

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. The Opportunity: The Cellular Genomics Programme is seeking a highly motivated staff scientist to lead wet lab work in the Lee-Six group. The group is focused on studying the earliest stages of childhood cancer by investigating the conditions under which cells with particular cancer-driving mutations gain a selective advantage over their healthy neighbours. The applicant will have the opportunity to be embedded in a large community of experimental and computational scientists with access to world-leading computational and experimental facilities at the institute. About the Team: Henry Lee-Six is a paediatric pathology registrar. His previous work has been focused on somatic mutations in normal tissues. He is starting a new group in the Cellular Genomics Programme with the aim of understanding the interplay of somatic mutations and development in childhood cancer. A major goal of the group is to investigate the relative contribution of mutation identity, cell state, and microenvironmental context in determining whether a mutant cell progresses to form a tumour. The group pursues this line of research by studying samples of children’s tumours and normal tissues with cutting-edge spatial transcriptomic platforms coupled to different mutation-calling technologies such as laser capture microdissection and duplex sequencing. These data are used to build models of what determines a cell’s selective advantage, which are in turn queried to suggest perturbations to a cell’s state or microenvironment that might change the relative fitness of a mutant clone. These in silico predictions are then tested in vitro using iPSC and cell-line models. The group is a mixture of wet and dry lab researchers and clinicians and collaborates closely with other teams in the Cellular Genomics Programme and the wider Institute. About the Role: You will use CRISPR-Cas9 to generate genotypes of interest in human iPSC lines, differentiate them into cell states of interest, and characterise their behaviour using a combination of methods, including transcriptomic analysis and functional assays of proliferation and death. In due course you will design and execute more complex culture systems, including co-culture. You will work closely with computational members of the team, and will collaborate with other teams within the Institute and beyond. You will contribute to the day-to-day supervision of students. About you: You are experienced in genetic manipulation and cell culture, and are able to design experiments, work independently, and troubleshoot. You will ideally have experience working with CRISPR manipulation of iPSC lines. You understand key concepts in genomics and are able to work with computational members of the team to improve experimental design and analysis. You are able to contribute to the smooth running of the lab and supervise students. Knowledge, skills and experience required: Technical Skills: PhD in relevant wet-lab subject (e.g. Molecular Biology, Developmental Biology) Post-doctoral experience including proven track record (publications and meetings) in field of expertise Experience using CRISPR editing tools Comprehensive, up to date and in depth understanding of CRISPR-based genetic screening, stem cell culture and differentiation Practical experience in mammalian ES or iPS Competencies and Behaviours: Ability to test, implement and troubleshoot new approaches and techniques Excellent communication skills Proven ability to work effectively within a team Self-motivated, able to be independent and organised Good attention to detail and record keeping for sample and experimental tracking An ability to lead and inspire others to achieve scientific projects Demonstrates inclusivity and respect for all Other Information: For further role details, please see role profile. Salary per annum (dependent upon skills and experience): £45,788-£54,397 Application Process: Please apply with your CV and a Cover letter outlining how you meet the criteria set out above and in the role profile. Closing Date: 2nd July 2026 Interviews will take place mid-end of July 2026. Hybrid Working at Wellcome Sanger: We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible. Equality, Diversity and Inclusion: We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks: LGBTQ+, Parents and Carers, Disability, Gender Equity and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others. We believe people do their best work when they can be their authentic selves. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive. Apply Now

Overall purpose: To work within the group of Dr Manu Hegde at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at understanding protein biosynthesis and quality control. For cells to function properly, newly synthesised proteins must be accurately delivered to their correct cellular destinations and, in many cases, assembled with other proteins into larger complexes. Our group investigates the molecular mechanisms underlying these processes, together with the pathways that detect and resolve errors in protein maturation. In particular, we are interested in how cells recognise and clear aberrant proteins, including unassembled subunits of multi-protein complexes. Defects in these and related quality control pathways are associated with numerous human diseases, including neurodegeneration and cancer, highlighting their essential role in maintaining cellular homeostasis. Main duties/key responsibilities: •    To undertake research aimed at understanding the molecular mechanisms of protein quality control.•    To perform a range of support duties that may include:      o    Maintaining cell lines in culture      o    Assisting with CRISPR-Cas9 genetic screens in mammalian cells      o    Generating tools and reagents to support the project•    To present information on research progress and outcomes within the group and the LMB.•    To contribute to the smooth running of the research group, including the effective use of resources, as well as taking responsibility for communal reagents and facilities. •    To contribute to the production of research reports and publications.•    To plan and manage your experimental work within the project along with your supervisor and other members of the project team.•    To ensure the research is carried in accordance with good practice and in compliance with local polices and legal requirements. Working relationships: You will report to Manu Hegde and Eszter Zavodszky and will interact and collaborate with Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary. Person requirements Academic qualifications: Essential: Bachelor’s degree or equivalent in a relevant subject, such as biology, biochemistry, biotechnology, or genetics. Desirable: Masters degree or equivalent relevant experience. Previous work experience required: Essential:•    Basic understanding of molecular and cell biology.•    Experience of basic tissue culture skills/techniques (e.g. splitting cells, sterile culture technique). Desirable:•    Previous experience in genetic screening.•    Experimental techniques relevant to the role, which could include (but not limited to):     o    Flow cytometry     o    Western blotting     o    Next generation sequencing•    Previous experience with bioinformatics and data analysis. Knowledge and experience: Creativity and initiativeEssential: •    Ability to plan and carry out experiments, collate and analyse data.•    Understanding of lab health and safety. Desirable: •    Experience of general lab management, including purchasing consumables and preparing communal reagents according to established protocols.•    Ability to troubleshoot challenges and suggest new approaches. Independent workingEssential: Proven skills in working independently and as part of a team with minimal supervision; good judgment in assessing when to ask for support. Desirable: Can independently advance existing techniques and implement new methods. Personal skills / behaviours / qualities: Essential:•    Able to work collaboratively and harmoniously as part of a team.•    Well organised and reliable, with exceptional record-keeping.•    Flexible and able to adapt to changing priorities. Corporate/Local responsibilities & requirements You must at all times carry out your responsibilities with due regard to the: •    MRC Code of Conduct•    MRC Equality and Diversity policy•    UKRI Health and Safety policy•    UKRI Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal.  Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.   The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.  About Us UKRI – UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world’s most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at www.ukri.org. Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme.  For more details, visit benefits of working for UKRI. How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit ‘How we support EDI in the workforce’. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. How to apply Online applications only preferred for this role. Please submit a CV and covering letter which clearly outlines how you fulfil the criteria specified along with your motivation for UKRI and the role. Ensure that the job reference number is included in the filename description of each document uploaded. Note that failure to address the above criteria or submit an application without a covering letter may result in the application not being considered. Assessment will only

About us  The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.  The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.  About the role We are seeking a highly motivated postdoctoral researcher to lead an ambitious project aimed at reconstructing the cell-type-specific connectome of the mouse hypothalamus. You will combine viral tracing, spatial transcriptomics, and computational analysis to uncover how molecularly defined hypothalamic neuronal populations are interconnected to control instinctive behaviours and physiological states. To achieve this, the project will implement BRISC (Barcoded Rabies In Situ Connectomics), a recently developed method that combines barcoded rabies tracing with in situ sequencing to map long-range synaptic connectivity at high throughput and cellular resolution. The resulting datasets will link neuronal identity, spatial organization, and connectivity across hypothalamic circuits. The project will involve close interaction with computational and experimental collaborators and offers the opportunity to work at the interface of systems neuroscience, spatial transcriptomics, and data science. The Research Group The Kohl lab uses a multidisciplinary strategy, ranging from in vivo calcium imaging and in vivo / ex vivo electrophysiology to behavioural profiling, viral circuit tracing and molecular approaches to investigate the neuronal and circuit-level mechanisms by which physiological states alter information processing in the brain. Further details can be found at www.kohl-lab.org. Our team currently includes four postdocs, three PhD students, three research scientists, and one MSc student. We are committed to maintaining a supportive and collaborative research environment, and we particularly value collegiality and open scientific discussion. This project will involve close collaboration with the neighbouring Znamenskiy lab, which is developing in situ connectomics approaches for high-throughput reconstruction of neural circuits (e.g. https://www.biorxiv.org/content/10.1101/2025.07.16.665048v1). What you will be doing You will: Lead an independent and ambitious research project aligned with the aims outlined above. Develop and implement custom viral tracing and spatial transcriptomics workflows, including experimental pipelines, data acquisition, and analysis. Generate, analyse, and interpret high-quality datasets Establish and maintain close collaborations with computational and experimental researchers within and beyond the institute. Scientific and technical support for group members Data management and analysis, writing up of manuscripts Presenting at scientific meetings Guiding PHDs in their research Please click here for full job description About you You will have: PhD in Neuroscience or a related field or in the final stages of PhD submission* Experience with viral tracing, circuit neuroscience, systems neuroscience, or related approaches* Strong analytical, quantitative, and coding skills (particularly in Python) * Experience handling and analysing large-scale biological datasets* Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings Minimum criteria* About Working at the Crick Our values   Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture. We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.  We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.  We are collegial. We show respect for one another, work cooperatively and support the wider community.  At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we’ll make reasonable adjustments if you need them – just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: karen.au@crick.ac.uk Find out more about life at the Crick. What will you receive?   At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:  Visas: Applicants for this role will be eligible for sponsorship to work in the UK  Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.  Pension Scheme: Defined contribution pension with employer contributions of up to 16%.  Health & Well-being:  24/7 GP consultation services.  Occupational health services and mental health support programs.  Eye care vouchers and discounted healthcare plans.  Work-Life Balance:  Back-up care for dependents.  Childcare support allowance.  Annual leave purchase options.  Crick Networks offering diverse groups’ support, community and inclusive social events. Perks:  Discounted gym memberships, bike-to-work scheme, and shopping discounts.  Subsidised on-site restaurant and social spaces for team interaction.  Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.   Apply Now