Fixed-term

Details Pluripotent stem cells (PSCs) are defined by their capacity for self-renewal and differentiation, making them an attractive platform for modelling human tissue formation in vitro. However, generating scalable, uniform differentiated cell types from PSCs remains challenging because of the limited control we have over the cellular environment. While growth factors can direct differentiation, surprisingly little is known about how the dynamics of their application shape cell fate. This project builds directly on our recent work exploring how the application dynamics of agonists activating the all-trans-retinoic acid (atRA) and WNT signalling pathways influence Ntera-2 differentiation. In that work, atRA and CHIR99021 were applied either as pulses or through sustained replenishment at frequencies ranging from 1 to 48 hours, with differentiation tracked using fluorescent labelling of surface markers for loss of pluripotency (TRA-1-60) and pro-neuronal commitment (A2B5), alongside morphological changes. To make these complex experiments possible, we developed an open-source liquid-handling and imaging platform that requires minimal human input and operates at very low cost. The platform can test over 60 conditions in a single experiment and collect data from more than 10 million cells — throughput that would be unfeasible manually. Using it, we showed that atRA dynamics did not significantly alter A2B5 expression, whereas CHIR dynamics had a pronounced effect: pulsed CHIR produced higher A2B5 expression than sustained application, with shorter pulses (≤12 hr) generating circular cells with glial-like morphology and longer pulses (≥18 hr) generating elongated neuron-like cells. These findings demonstrate that not only ligand identity but also the timing and frequency of signalling determine cell fate. The successful applicant will continue and extend this line of research — using and further developing our automated platform to systematically map, model, and optimise the signalling conditions that steer PSCs toward defined neuronal outcomes, and to apply the same framework to other developmental pathways. What the project offers You will work at the interface of stem cell biology, automation, and quantitative image analysis, gaining hands-on experience with open-source robotics, high-throughput live-cell imaging, and data-driven optimisation of differentiation protocols. Candidate profile We welcome applicants with a background in cell/molecular biology, neuroscience, bioengineering, or a related quantitative discipline. An interest in laboratory automation, coding (e.g. Python), or image analysis is an advantage but not essential — enthusiasm for building and troubleshooting experimental systems matters most. Funding Notes This is a self-funded opportunity. Applicants are responsible for securing their own tuition fees and living costs (e.g. through personal funds, scholarships, or sponsorship). Guidance on potential funding schemes can be discussed with the supervisor. References Informal enquiries are strongly encouraged before applying. Please contact Dr Anton Nikolaev (a.nikolaev@sheffield.ac.uk) with a CV and a short statement of interest. Apply Now

The Opportunity:  We are looking for a postdoctoral researcher to study mammalian brain regeneration. The post holder will be part of a Brain Research UK research project between The University of Edinburgh, ETH Zurich and the University of Basel investigating how adult neural stem cells and other glial cells respond to a focal injury and drive tissue regeneration in the spiny mouse – the only mammal known to rebuild complex tissues after substantial damage. The post holder will use single-cell genomics, develop novel brain injury models, and perform cross-species comparisons to pinpoint exactly what sets spiny mice apart from other mammals, including humans, whose regenerative capacity is much more limited. The post holder will be embedded within a highly collaborative team and have outstanding scope to drive discovery at the interface of regeneration and neuroscience, and to make findings with potential to inform new strategies for repairing the human brain.  Your skills and attributes for success:  A PhD in regenerative biology, neurobiology/neuroscience or similar;  Experience in animal work including stereotaxic surgery;  Experimental design experience and expertise;  Strong communication and interpersonal skills;  Commitment to a positive work environment.  This post is full-time (35 hours per week).  View the full job description   How to apply  Please include the following documents in your application:  CV  Cover letter detailing how you meet each of the essential criteria outlined on the job description   We value colleagues with drive, determination, and a passion for what they do. People have always been at the heart of our work. As part of the University, you are a part of our community.  A career with us has a range of other benefits that can be tailored to your lifestyle:   Leading-edge research  Opportunities for publication  Working within one of the world’s leading universities  Contributing to the work and purpose of the University  As a valued member of our team, you can expect:  A competitive salary.  An exciting, positive, creative, challenging and rewarding place to work.  To be part of a diverse and vibrant international community. Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page and use our reward calculator to discover the value of your pay and benefits.  Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.  We welcome applications from all qualified candidates and particularly encourage applications from candidates from traditionally underrepresented backgrounds, as we acknowledge they are currently underrepresented in biomedical research.  Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages. The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.  Key dates to note The closing date for applications is 4 August 2026. Unless stated otherwise, the closing time for applications is 11:59 pm (UK time). If you are applying from outside the UK, the closing time shown on our adverts will automatically adjust to your browser’s local time zone. Apply Now

The Opportunity: An exciting postdoc position is available to understand the role of autophagy and lysosomal degradation in aging and aging-related diseases.  A postdoctoral research fellow position is available at the laboratory of Chancellor’s Fellow Noor Gammoh, University of Edinburgh. The lab is interested in investigating key events during autophagy initiation, progression, and lysosomal degradation as well as the relevance of autophagy in disease. A current project is available in the lab to uncover molecular events underlying lysosomal degradation of autophagic cargo using a combination of cell biology and biochemical techniques. The lab is seeking to appoint a highly motivated, skilled and dedicated postdoctoral research fellow. The candidate must have completed a PhD degree (or anticipate to obtain one in the near future) and ideally has a good publication record. Experience in basic molecular techniques and excellent technical skills are essential. The candidate should demonstrate an ability to design, execute and interpret experiments, creative thinking, good presentation skills, problem solving, self-motivation and critical analyses.  The lab is located at the Cancer Research UK Scotland Centre which is part of a wider Institute of Genetics and Cancer and supports state-of-the art technologies, collaborative research environment and access to multiple advanced services. Particularly important within the Centre is an ethos of mentoring and nurturing scientists in order to establish the next generation of scientific leaders.  Click here to view a copy of the full job description. Any additional inquiries involving the advertised position are welcomed by email to noor.gammoh@ed.ac.uk. How to apply Please include the following documents in your application: – CV – Cover letter As a valued member of our team, you can expect:  A competitive salary.  An exciting, positive, creative, challenging and rewarding place to work.  To be part of a diverse and vibrant international community. Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page and use our reward calculator to discover the value of your pay and benefits.  Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.  Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages. The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.  Key dates to note The closing date for applications is 7th August 2026. Unless stated otherwise, the closing time for applications is 11:59 pm (UK time). If you are applying from outside the UK, the closing time shown on our adverts will automatically adjust to your browser’s local time zone. Apply Now

Details Applications are invited for a 3-year funded PhD studentship in the Department of Imaging Neuroscience (https://www.in.fil.ion.ucl.ac.uk/) under the supervision of Prof. Peter Kok, PI of the Visual Perception group (https://www.in.fil.ion.ucl.ac.uk/visual-perception). The anticipated start date is 1st February 2027. The Department of Imaging Neuroscience is home to the internationally renowned Functional Imaging Laboratory (FIL), which houses two 3T Siemens Prisma MRI scanners, a 7T Siemens Terra MRI scanner, a SQUID magnetoencephalography (MEG) system, and a dedicated optically-pumped MEG (OP-MEG) scanning suite. Project details The Visual Perception team, led by Prof Peter Kok, uses a combination of state-of-the-art neuroimaging techniques (esp. 7T fMRI and MEG) to shed light on the neural underpinning of our visual perception of the world. A major insight from the past decades is that visual perception is strongly influenced by our prior knowledge and predictions. However, the neural mechanisms underlying this process are largely unknown. A major focus of the Visual Perception team in the coming years will be the role of the hippocampus in supplying predictions to guide visual perception. We plan to investigate the computations taking place in the different hippocampal subfields and the role of hippocampal theta in coordinating predicting and perceiving. We seek a highly motivated individual to join us in exploiting the exciting opportunities afforded by 7T fMRI and MEG to study the neural substrates of visual perception. The successful candidate will undertake high quality research using cutting-edge human neuroimaging, for example, subfield-specific hippocampal and layer-specific cortical responses (using 7T fMRI) and time-resolved decoding of the neural dynamics underlying visual predictions (using MEG and intracranial recordings). For some analyses deep neural networks (DNNs) will be used to probe the representational contents of neural signals. Applicants must have an honours degree (2.1 minimum) in experimental psychology, neuroscience, cognitive science or a related discipline, and an MSc in a Neuroscience related discipline is desirable. Experience of conducting cognitive experiments using MEG and/or 7T fMRI is essential, as are strong programming skills (e.g. in Matlab) and experience of analyzing MEG and/or 7T fMRI data, e.g. time-resolved decoding or estimating subfield-specific or layer-specific BOLD responses. Excellent oral and written communication skills, with fluency in English, good inter-personal skills, exceptional attention to detail, and a very high level of consideration and care for research volunteers with ability to build rapport with study participants, are also required. An interest in/experience of studying visual perception is essential. Deadline 31st July 2026. Shortlisted candidates will be interviewed in August. How to apply: Applicants should submit 1) a CV, 2) a 1-page statement detailing why you want to do the PhD, motivation, interest and suitability for the project, 3) a copy of your strongest single piece of academic work (e.g. thesis, publication), and 4) contact details of two referees. Please ensure that each document is clearly labelled with your surname. Please send all documents to Sheila White (sheila.e.white@ucl.ac.uk) by 31st July 2026. Interviews will be held in August 2026. Informal enquiries are welcome to Prof Peter Kok (p.kok@ucl.ac.uk). Funding Notes This is a fully funded 3-year PhD programme, with the starting date anticipated to be 1st February 2027. The studentship is funded by an ERC Consolidator Grant and includes an annual stipend, starting at approximately £26,000 per year. The stipend will be supplemented to compensate for Home tuition fees (approximately £6,400 per year). Overseas tuition fees cannot be covered. The ERC Grant will also cover all research costs and travel and accommodation for attending conferences and workshops. Apply Now

Details A three-year PhD studentship funded by Cure DHDDS is available from 1 October 2026, in the Translational Omics Research Group at the UCL Great Ormond Street Institute of Child Health. This project will define how impaired dolichol biosynthesis disrupts glycosylation, protein handling and cellular quality control in DHDDS deficiency. By measuring these processes dynamically with stable isotope tracers and mass spectrometry, the study aims to convert a poorly understood rare disease into a measurable pathway for biomarker discovery, functional diagnostics and therapeutic target identification. The student will use cutting edge stable isotope tracing, proteomics, lipidomics and state of the art mass spectrometry to build a dynamic cellular model of DHDDS deficiency. This model will track dolichol metabolism, lipid flux, glycoprotein synthesis, protein folding and cellular quality control in real time. During a PhD we aim to create a platform for disease mechanism discovery, new biomarker development, functional diagnostics and future therapeutic testing. The student will work at the interface of rare disease biology, neuronal cell models, iPSC derived organoids, translational omics and therapeutic discovery. The project will be based in a highly active translational omics laboratory of around 25 researchers with expertise in mass spectrometry, proteomics, metabolomics, lipidomics, rare disease diagnostics and biomarker translation. The group has helped deliver major translational programmes including mass spectrometry testing during the COVID 19 pandemic and the development of the first blood test for Parkinson’s disease. Background DHDDS deficiency is a rare and devastating congenital disorder of glycosylation. It affects dolichol biosynthesis, a core biochemical pathway required for normal protein glycosylation. Despite this, patients often do not show the classical transferrin isoelectric focusing pattern that usually reveals defective glycoprotein synthesis in CDG. This creates a major biological and clinical puzzle. The disease is clearly driven by a defect in glycosylation biology yet the standard diagnostic readout can appear relatively normal. This suggests that DHDDS deficiency may cause a more subtle, neuronal specific and dynamic failure of glycosylation, protein folding, trafficking and degradation. These hidden defects may be largely invisible in plasma but highly damaging in neuronal cells. This PhD will tackle that problem directly. By combining stable isotope tracers with high resolution omics and advanced cellular models, the student will measure the movement of metabolites, lipids and proteins through the pathway rather than relying only on static measurements. This will allow the disease process to be watched as it happens. Hypothesis and aims We hypothesise that DHDDS deficiency causes a dynamic failure of dolichol driven glycosylation and protein quality control that is not fully captured by conventional CDG testing. The project will test whether impaired dolichol metabolism disrupts glycoprotein synthesis, protein folding, trafficking and degradation in neuronal and hepatic cell systems. The student will use stable isotope tracers to quantify pathway flux in real time and define the biochemical signature of DHDDS deficiency. The aims are to build a functional cellular model of DHDDS deficiency, identify disease relevant biomarkers, define the hidden mechanisms linking DHDDS dysfunction to neuronal injury and create a platform for testing candidate therapeutic strategies. Research outputs The project will deliver a stable isotope based cellular model of DHDDS deficiency that can measure dolichol flux, glycoprotein synthesis, protein folding, trafficking and degradation in real time. It will generate new mechanistic insight into why DHDDS patients lack the classical CDG isoelectric focusing pattern and will identify biochemical markers that better reflect disease activity. The work will also create a platform for testing candidate therapies in neuronal, hepatic and iPSC derived organoid systems. Expected outputs include targeted mass spectrometry assays, lipidomic and proteomic datasets, mechanistic pathway models, PhD publications, conference presentations and a translational workflow that could be developed into a future functional diagnostic test. Policy-outputs The policy output is a new model for how ultra rare genetic diseases should be moved beyond diagnosis by sequencing alone. This work could support a shift toward functional biochemical testing in CDG, helping clinicians measure disease activity, monitor treatment response and design biomarker driven trials. In the longer term it could inform NHS rare disease pathways, trial readiness frameworks and orphan therapy development by showing how a hidden cellular defect can be converted into a measurable diagnostic and therapeutic readout About you Applicants should have a keen research interest in metabolism and neurodegeneration but especially in the omic techniques of proteomics and lipidomics. Applicants should have a minimum of an upper second-class UK Bachelor’s degree and/or a Master’s degree (preferably with a merit or distinction) in a biological sciences preferably biochemistry. What we offer This project will be under the supervision of Professor Kevin Mills, Dr Jenny Hällqvist, Dr Wendy Heywood and Professor Philippa Mills. This studentship provides a starting stipend of £23,805 per annum and covers the cost of Home and Overseas tuition fees. The studentship does not cover the costs of the Student Visa application and Immigration Health Surcharge. Funding is not provided for paid parental and medical leave. Unpaid interruptions can be requested and may be supported. How to apply Enquiries regarding the post can be made to Enquiries regarding the post can be made to Professor Kevin Mills (kevin.mills@ucl.ac.uk) To apply, please send a current CV including the contact details of two professional referees as well as a 1-sided A4 cover letter to Professor Kevin Mills (kevin.mills@ucl.ac.uk) Closing date for applications: 30 July 2026. Interview date: 10 August 2026 Applications that are submitted without following the correct application process will not be considered. The successful applicant will then be required to apply to and register on the Child Health research degree to take up the studentship. Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

About the role The Martin-Sancho lab is recruiting a talented and motivated postdoctoral researcher to study early host defences against mosquito-borne and other emergent viruses. What you would be doing The position is funded by the ERC Starting Grant and aims to characterize a novel array of antiviral pathways recently discovered by the lab, initially on dengue and other mosquito-borne viruses. The project will leverage a wide array of approaches including molecular virology, systems biology, functional screening (siRNA and CRISPR), and biochemistry. Experiments will be conducted in CL2 and CL3 laboratory settings. This is an excellent opportunity to contribute to foundational antiviral immunity research, leveraging advanced tools to uncover new immune mechanisms and inform future therapeutic strategies What we are looking for The ideal applicant is highly motivated, passionate about science and works well in a team. You will be expected to drive the project and perform the highest quality research under the guidance of Dr. Martin-Sancho, as well as supervise other researchers in the lab.  Essential requirements: A PhD in virology. *Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £43,863 – £47,223 per annum Expertise with virus infections in CL2 conditions. Expertise with molecular biology, molecular virology, and biochemistry. Experience with cell culture of mammalian cells. Evidence of making significant scientific contributions in the field of virology, including scientific. publication and/or presentations at conferences. Excellent critical and analytical thinking skills. Able to independently design and execute experiments, interpret data and identify follow-up strategies. Excellent verbal and written communication skills to interface with the team and collaborators. To have a highly motivated and detailed-oriented approach. Preferred requirements: Experience with analysis of OMICs and other large datasets. Experience with mammalian primary cells. Experience with siRNA assays and high throughput screening. Experience with virus infections in CL3 conditions. What we can offer you You will join the Martin-Sancho lab (www.martin-sancholab.com) a dynamic and collaborative team at Imperial College London using systems biology to dissect virus-host conflicts and mechanisms of viral disease. Our network includes leading international virology partners, and we place a strong emphasis on scientific growth, collaboration, and career development. The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.  Grow your career: gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression.  As a member of research staff you have 10 development days to use to develop your skills and explore your career prospects  Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).  Further information This position will be full-time (35 h/w) for an initial two years, with funding available for a possible further three years depending on the project progress. Interviews will take place in early August 2026. If you require any further details about the role, please contact: laura.martin-sancho@imperial.ac.uk Available documents Attached documents are available under links. Clicking a document link will initialize its download. download: Research Associate in Virology JD.pdf download: Employee Benefits Booklet.pdf Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above. We reserve the right to close the advert prior to the closing date stated, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment. If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help. Apply Now

About the role We are looking for a talented and highly motivated Research Assistant to join an exciting project investigating the molecular basis of epigenetic dysregulation in acute myeloid leukaemia (AML). The successful candidate will work in the laboratory of Dr. Shuchi Agrawal Singh on a project focused on understanding how aberrant function of chromatin complexes drives drug resistance in AML. This role, funded by the Academy of Medical Sciences, offers an excellent opportunity to contribute to cutting-edge translational cancer research within a collaborative and supportive research environment. We strongly encourage applications from candidates who are interested in pursuing a future PhD, as this role will provide research experience prior to doctoral study in a translational cancer research environment. What you would be doing You will be performing molecular and cellular biology experiments, including cell culture, CRISPR-based approaches, chromatin and gene expression analyses, microscopy, proteomics, and chromatin-based assays. You will work with sequencing-based datasets and contributing to bioinformatics analysis and interpretation of data, and support the development and optimisation of new experimental protocols You will have the opportunity to presenting findings at meetings within the laboratory and external, as well as contributing to manuscripts and collaborative research activities. You will also be involved in other ongoing projects within the Agrawal Singh laboratory and assist in the training of junior staff members. What we are looking for You should have a first / masters degree (or equivalent) in a relevant biological or biomedical science discipline. You should have previous experience working in a research laboratory. You should also have knowledge of basic cancer cell biology and general laboratory practices. Experience in bioinformatics and specific techniques, such as chromatin biology and confocal imaging, is desirable, but training will be provided. What we can offer you The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity. Grow your career: gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression. Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes). Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing. Further information This is full-time post available to start from 1 November 2026, and fixed term until 31 December 2027. If you have any further details about the role, please contact Dr. Shuchi Agrawal Singh (s.agrawal-singh@imperial.ac.uk) Available documents Attached documents are available under links. Clicking a document link will initialize its download. download: Job Description Research Assistant.pdf download: Employee Benefits Booklet – V.2026.pdf Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above. We reserve the right to close the advert prior to the closing date stated, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment. If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help. Apply Now

About the role The Department of Metabolism, Digestion and Reproduction invites applications for an Assistant Professor post in Cell Biology. You will work closely with academic and research staff within the Section of Cell Biology and Functional Genomics at the Division of Diabetes, Endocrinology, and Metabolism, as well as across the wider Department and Faculty.   You will have a strong research interest and an excellent upwards trajectory in diabetes research, focused on the study of pancreatic islets and/or other relevant cell systems, to establish an independent research programme in areas including, but not limited to, cell signalling, regulation of gene expression, novel therapeutic targets and/or regenerative medicine, to complement the Section’s portfolio of research in both basic and translational cell biology of diabetes and metabolism.  What you would be doing You will work in a vibrant environment and will be expected to make a significant contribution to diabetes research as well as to undertake undergraduate and graduate teaching responsibilities in this broad area, with opportunities for leadership roles within education. In addition, you will demonstrate a strong contribution to both research and teaching, with a growing national/international presence in the fields of cell biology and diabetes, including by securing external funding and delivering successful research outcomes. What we are looking for You will be expected to demonstrate the following key requirements: PhD in related field or equivalent High level analytical capacity Evidence of a growing national reputation and expertise in the field of cell biology and diabetes research A sustained track record in delivering successful research outcomes Ability to attract external research funding Evidence of published research results Contribution to teaching A full list of responsibilities and essential requirements can be found in the attached Job description. What we can offer you The opportunity to continue your career at a world-leading institution and be part of our mission to use science for humanity. Grow in your career with tailored training programmes for academic staff including dedicated support with navigating your career and managing research as well as a transparent promotion process. Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes). Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources designed to support your personal and professional wellbeing. Please see our Further Particulars for more information about the College and the benefits available to staff. Further information Closing date: Tuesday, 4 August 2026, 23:59 hours Midnight BST Interviews to be held on Tuesday, 25 August 2026. For informal enquiries, please contact Dr Alejandra Tomas, Head of Section of Cell Biology and Functional Genomics (a.tomas-catala@imperial.ac.uk). For further information on the Section of Cell Biology and Functional Genomics please visit its webpage: Cell Biology and Functional Genomics | Faculty of Medicine | Imperial College London If you experience any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help. The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see About Imperial research | Research | Imperial College London The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. Animal research | Research | Imperial College London We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion. Available documents Attached documents are available under links. Clicking a document link will initialize its download. download: Job Description_AP in Cell Biology.pdf download: Employee Benefits Booklet – V.02.2026.pdf Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above. We reserve the right to close the advert prior to the closing date stated, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment. If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help. Apply Now

The University of Cambridge wishes to appoint a talented postdoctoral research associate to join the research groups of Prof Patrick Chinnery, Prof Rita Horvath and Dr Jelle van den Ameele at the Department of Clinical Neurosciences and the John Van Geest Brain Repair Centre. The position is part of a collaborative Wellcome Discovery Award, to characterise novel cellular models of mitochondrial disease, and use genetic screening approaches to characterise novel nuclear modifiers of disease progression. The focus of your work will be on studying how nuclear and mitochondrial DNA defects lead to tissue specific clinical presentations. You will use cutting-edge technologies, including functional studies on neuronal and muscle stem cells and human organoids. RNA sequencing and other omics technologies will be performed to identify the molecular mechanism of mitochondrial diseases and other rare neurological diseases in children and adults. The over-arching aim of the research group is to develop new treatments for mitochondrial diseases and other inherited rare neuromuscular diseases using a combination of genomic, cell biology and specialized mitochondrial assays. You will have access to a team of experienced bioinformaticians, but have the opportunity to be trained and perform independent in-depth bioinformatic analysis. You will have access to clinical samples from the MitoCamb (https://mitocamb.medschl.cam.ac.uk/) neurogenetics clinic, to apply and translate novel technology and insights towards a human disease context. We anticipate this work will lead to high-profile publications based on our track-record: Nature Str Mol Biol 2026 PMID: 41922875; Science 2025 PMID: 41066576; Nature Medicine 2024 PIMID 8745010; Nat Comm 2023 PMID: 36823193, Cell 2023 PMID: 36827974; Nature 2022 PMID: 36198798. Candidates are expected to be independent, highly motivated, and keen to work collaboratively with wet-lab and computational biologists within and outside the research groups. In addition to their own research, there will be opportunities for training and career development, and supervision of junior researchers. The role will be located within the Horvath Group in the John Van Geest Brain Repair Centre on the Cambridge Biomedical Campus, with state-of-the-art facilities available to group members. The lab and the wider University of Cambridge are committed, in their pursuit of academic and research excellence, to a pro-active and inclusive approach to equality, which supports and encourages all under-represented groups, promotes an inclusive culture, and values diversity. Flexible working will be considered. Lab websites: Horvath Group: https://www.horvathlab-cam.co.uk/ John Van Geest Centre for Brain Repair: https://www-neurosciences.medschl.cam.ac.uk/ Cambridge Clinical Mitochondrial Research team: https://www-neurosciences.medschl.cam.ac.uk/mitocamb/ Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Please quote reference RR50158 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now