Fixed-term

The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work as part of an ongoing team project that explores the function of a multi-gene family that has expanded in the genomes of Plasmodium vivax and other related neglected human malaria parasites, and have been highlighted as potential vaccine targets. The project builds on a recent publication that established that these tryptophan-rich antigens (TRAgs) have lipid binding activity (PMID: 37709739), suggesting they may be involved in remodelling membranes. It will use CRISPR/Cas9 genetic modification to knockout and tag multiple TRAg genes in P. knowlesi, as well as work with lines already generated by other team members and explore the function of these genes using a range of cell biological and biochemical assays. This is a short-term position so it will be absolutely essential that the successful candidate has demonstrable experience in culturing and transfecting Plasmodium parasites, with experience working with P. knowlesi particularly desirable. The candidate must also have extensive experience in using molecular biology techniques (eg Gibson assembly) to generate and validate complex genetic manipulation vectors, as well as in relevant cell biology techniques such as immunofluorescence, expansion and live imaging microscopy and flow cytometry. The primary focus will be on carrying out outstanding academic research which will contribute directly to collaborative papers. The project provides substantial scope for innovation, creativity and exercising scientific judgement. You will work as part of a vibrant interdisciplinary team with colleagues in both the Rayner and Deane labs in the Cambridge Institute for Medical Research. You are expected to contribute to that positive team environment, supporting and training others where needed and working together to create the best possible outputs within the time available. The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health. This is a full-time fixed-term post for 1 year from the start date. Informal enquiries to Professor Julian Rayner jcr1003@cam.ac.uk Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Closing Date: 5th August 2026 Interview Date: as soon as possible after application closing date Please quote reference SG50311 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

Applications are invited for a fully funded PhD studentship starting January 2027 in the laboratory of Dr Aakash Mukhopadhyay. Eukaryotic flagella (aka cilia) are remarkable cellular organelles that enable cells to move, sense their environment, and communicate with surrounding tissues. In humans, defects in these structures cause a wide range of diseases, including retinal degeneration, developmental disorders and obesity. Many microbial pathogens also rely on flagella for survival, transmission and host adaptation. Among the most fascinating examples are the trypanosomatid parasites, a group that includes the causative agents of leishmaniasis and sleeping sickness. These parasites possess a specialised flagellum that is essential for motility, environmental sensing and successful progression through multiple hosts including humans. This project will investigate the mechanism of the trypanosome intraflagellar transport (IFT) motors and determine how their architecture supports flagellum assembly and function. You will apply multi-disciplinary approaches from cell biology, parasite genetics, biochemistry and structural biology to uncover fundamental principles governing the function and evolution of these molecular motors. The project will be carried out in the newly established Mukhopadhyay Laboratory, which studies the mechanisms of eukaryotic cilia and flagella. The PI has an established track record in IFT, motors and flagellum function. The project offers an exciting opportunity to address fundamental questions in cell biology while gaining insight into the biology of medically important parasites. The findings are expected to reveal new principles of molecular motor evolution, with broad relevance to both pathogen biology and ciliary/flagellar function across eukaryotes. Closing Date is 31 July 2026 Further information about the course can be found here https://www.postgraduate.study.cam.ac.uk/courses/directory/blpapdpth All applications should be made online via the University’s Applicant Portal https://apply.postgraduate.study.cam.ac.uk/applicant/login?dswid=749 for a PhD in Pathology (BLPA22). A completed application must be submitted by the closing date below. An application is only complete when all supporting documents, including the 2 academic references, are submitted. University Postgraduate Admissions closing dates are 31 July for January start, although it is advisable to apply earlier than this. Please note that there is an application fee of £20 to apply via the Postgraduate Application Portal. It is the applicant’s responsibility to ensure their referees submit their references before the closing date. Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role. The studentships are available to students who qualify for UK HOME FEES ONLY Please check for eligibility details using this website: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status Applicants should hold (or expect to obtain) the equivalent of a UK upper 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. Please quote reference PK49372 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint two post-doctoral Research Associates to join the research group of Prof. Mike Murphy at the MRC Mitochondrial Biology Unit. A world-renowned centre for research, the MRC MBU is a vibrant community focused on the involvement of mitochondria and their dysfunction in an ever-increasing range of human diseases. Additional information can be found at www.mrc-mbu.cam.ac.uk. The successful candidates will carry our work on the chemical biology of mitochondrial function developing and expanding chemical and mass spectrometric analytical techniques in mitochondrial biology in the areas of drug delivery and probe development. You will also be expected to play a major role in the work of the research group, through the conduct of research, introduction of new ideas, dissemination of research results and support and training of others. Candidates will have or be about to receive a PhD in biochemistry, biological chemistry or a related discipline. Candidates with experience in mitochondrial biology, chemical biology, small molecule mass spectrometry and confocal microscopy of mitochondria are encouraged to apply. Informal enquiries about this position should be directed to Professor Mike Murphy (mpm37@cam.ac.uk). This is a fixed term post with funding available from September 1 2026 to 31 August 2029. The University of Cambridge is committed, in its pursuit of academic and research excellence, to a pro-active and inclusive approach to equality, which supports and encourages all under-represented groups, promotes an inclusive culture, and values diversity. The MBU is part of the School of Clinical Medicine, which holds an Athena Swan Silver Award and supports an Academic Women’s Forum. The University particularly encourages women and candidates from Black, Asian and Minority Ethnic backgrounds to apply. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Applicants must have (or be close to obtaining) a PhD. *Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Closing Date: 9th August 2026 Interview Date: to be confirmed Please quote reference SM50294 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

School of Life SciencesJawaharlal Nehru UniversityNew Delhi Applications are invited for the post of Junior Research Fellow (JRF) (one) in Sleep Research Laboratory in the School of Life Sciences, JNU, under the SERB-funded project titled “Targeting Epigenetic HAT Inhibition and Sleep Restriction as Potential Tools for Altering Traumatic Memories.” The candidate will be selected strictly as per the guidelines issued by the SERB, Government of India Essential Qualifications for JRF:1. M.Sc., or M.Phil. degree in Life Sciences or related field with at least 1 year of experience in Neuroscience with NETorB.Tech/M.Tech degree (having a neuroscience background) with GATE Duration of the project: one year Last Date for sending application: July 31st, 2026 Application along with resume can be sent to the postal address:Dr. Sushil Jha,Project Investigator,Room 208, SLS, JNUNew Delhi-110067Ore-mail to: sushilkjha[at]mail[dot]jnu[dot]ac[dot]in

Overall purpose: To work within the group of Dr Anne Bertolotti at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at studying phosphatases and kinases controlling the integrated stress response. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors. The project will express and purify phosphatase and kinase complexes and aims to solve their structures using a combination of approaches, which primarily includes cryoEM, and crystallography (with the support of LMB facilities). You may also conduct functional studies. Main duties: •    To undertake research aimed at solving structures of phosphatases and kinases.•    To identify, develop and apply a broad range of techniques to pursue the research objectives.•    To present scientific work at seminars within the laboratory and at external meetings.•    To contribute to laboratory-wide discussions on developments within the field. •    To draft scientific papers, and contribute to the overall preparation of research for publication.•    To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.•    To assist in the training of PhD students and other members of the LMB. Key responsibilities: Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor. To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project. To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required. To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities. To enhance your research and generic skills through a tailored development programme. Working relationships: You will report to Dr Anne Bertolotti and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary. Additional information: This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:•    MRC training courses.•    External training and personal development courses.•    One-to-one training with your Supervisor and other Scientists. You will commit to undertaking the following:•    Developing and following a personal development plan.•    Attending training courses.•    Identifying additional training which will support you to develop your career. Person Specification Academic qualifications: These should include a PhD in biochemistry/structural biology or due to complete PhD within 6 months. Technical skills and expertise: Essential:Experience of and ability to perform techniques relevant to the project. Experience in structural biology including CryoEM is essential. Experience in protein expression and purification in diverse systems is essential. Desirable:• An interest in signalling and/or stress response/protein quality control.• An interest in protein phosphorylation.• An interest in enzymology and small molecule inhibitors. Track record of research: This will include achievements, and contributions to published papers. Other relevant evidence of: •    Commitment.•    Originality.•    Ability to communicate.•    Working with others. Additional information: You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown. Applicants are required to submit a cover letter and CV. Corporate Responsibilities You must at all times carry out your responsibilities with due regard to the UKRI: •    Code of Conduct•    Equality, Diversity and Inclusion policy•    Health and Safety policy•    Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal.  Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.   The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment. About Us UKRI – UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world’s most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at www.ukri.org. Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme.  For more details, visit benefits of working for UKRI. How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit ‘How we support EDI in the workforce’. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the