Fixed-term

Optometry and Vision Science Research Programmes

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Overview The Centre for Optometry and Vision Science brings together a diverse range of researchers, but all with a focus on clinically relevant vision research employing the best techniques to optimise measurement of visual function and its underpinning structure.  Some areas of research have been summarised below, but we are open to discuss particular ideas or projects potential PhD researchers may have in mind if it is a good fit with our expertise. Refractive error Refractive error results when the eye grows abnormally so that light does not focus accurately on the retina. One increasingly common error of focus, myopia (short-sightedness), tends to increase during school years as the eye continues to grow and can affect a child’s self-image and may impact his/her ability to participate in sports. Our Centre conducts the Northern Ireland Childhood Errors of Refraction (NICER) study, which is the largest longitudinal study in the UK and Ireland to examine how children’s vision, in particular their refractive error, changes through childhood and adolescence. Further work is investigating the influence of how much time children spend studying, playing outside and using smart phones and tablets, and we have ongoing clinical trials investigating optical and pharmaceutical interventions to retard myopia progression. We also have a significant interest in hyperopia and the contribution of the accommodation to overcome lower levels of hyperopia.  We are involved in a large international project investigating the impact of hyperopia on learning in schoolchildren in Zimbabwe. Researchers: Prof. K Saunders, Dr JA Little, Dr J McClelland, Dr S McCullough, Dr K Breslin, Dr L Doyle, Dr E McConnell Novel ophthalmic imaging Our group is currently involved in research to develop novel in-vivo ophthalmic imaging including Binocular Optical Coherence Tomography (OCT) development in collaboration with Moorfields Eye Hospital in London. This technique uses swept source OCT to generate high resolution whole-eye scans of both eyes simultaneously. Its binocular design also enables clinicians to perform objective binocular functional testing including pupillometry and strabismus assessment. The group also uses both retinal and anterior segment OCT imaging to investigate retina in Down syndrome, and to investigate the utility of OCT for biometric analysis and quantifying of cataract magnitude. We are also investigating retinal cone imaging using a narrow angle Heidelberg Retinal Angiograph (HRA) in the ageing eye and in ocular diseases such as glaucoma and diabetes. Researchers: Prof. R. Anderson, Dr P. Mulholland, Dr JA Little, Prof Kathryn Saunders Visual disorders in Special needs Our group has a strong international reputation for investigating visual processing and optical performance of children with developmental disabilities, including Down syndrome, cerebral palsy and Autism Spectrum Disorder. Techniques such as objective photorefraction, higher order aberrations, advanced imaging, electrodiagnostic and clinical techniques have furthered our knowledge and help influence the diagnosis and clinical management of visual disorders in these groups. The Special Education Eyecare (SEE) Project seeks to improve access to eyecare for children with developmental disability, providing more accessible, extended modes of provision for these vulnerable children in order to make a real difference to their educational development and quality of life. Researchers: Prof. K Saunders, Dr JA Little, Dr J McClelland, Dr S McCullough, Dr L Doyle, Dr E McConnell Psychophysical investigation of visual function The group is involved with a number of studies using psychophysical methods to investigation visual function including: Basic psychophysics investigating spatio-temporal interactions across the field of vision and spatial properties of different parallel visual pathways. Development of novel perimetric methods in glaucoma using perimetric stimuli that scale in 3D. The investigation of the role of the macular pigment in human visual performance in the normal eye and diseased eye. Visual acuity chart design using high-pass filtered letters which has led to the development of the Moorfields Acuity Chart (MAC) in collaboration with Moorfields Eye Hospital in London. Researchers: Prof. R. Anderson, Dr P. Mulholland, Dr R Beirne Vision and Driving The group is developing an increasing interest in how visual deficits (acuity, visual field damage, intraocular straylight, low-light sensitivity loss) affects the ability to drive safely. Researchers: Dr J. Little, Prof. R. Anderson, Dr P. Mulholland. Summary Biomedical Science at Ulster University has an outstanding and sustained record of success in research, recognised in the most recent REF2021 to be internationally excellent, world leading and ranked 5th out of 89 UK universities within the category of Allied Health Professions which encompasses the disciplines of biomedical sciences, nursing, nutrition, pharmacy, optometry, health sciences and personalised medicine. Our research is not only producing outputs of world leading quality but also credited with having significant global translation, impacting positively on health professionals, industry, the general public and specific patient groups. We are proud to have externally recognised world-leading research environment which scored 100% 4*rating in REF 2014 and 2021. Biomedical Sciences research activities are currently organised within distinct Research Centres: Diabetes, Food & Health (through Nutrition Innovation Centre for Food and Health (NICHE)), Genomic Medicine, Pharmaceutical Sciences & Practice, Personalised Medicine and Optometry & Vision Science. Multi-disciplinary collaboration between the research groups is strongly encouraged and is widespread with research into, for instance, anti-diabetic and antioncogenic aspects of nutrition, the genomics of vitamin receptors, visual deterioration or cancer, imaging of neovascularisation. Our research investigates the interaction between cardiovascular disease and vision and the impact of health and disease, diet, diabetes on dementia, hypertension, autoimmunity, vascular and inflammatory disease, to name a few. The research groups collaborate both internally and internationally on a range of prioritized multi-disciplinary themes in functional foods, gene-nutrient interactions; pregnancy and early life; healthy ageing, musculoskeletal health; drug discovery and delivery, personalized medicine and genomic medicine. The BMSRI has strong collaborations with regional and global pharmaceutical and diagnostics companies and many of our graduates and postgraduates gain employment in the government bodies, pharma, diagnostics, and health care sectors as well as academia and through self-employment. About The Biomedical Sciences Research Institute (BMSRI) offers a “state-of-the-art” research environment for high profile researchers to undertake internationally agenda setting research in strategically prioritized areas of biomedicine. This research environment within Biomedical Sciences at Ulster has been continually judged as exceptional and world-leading and awarded the highest 100%

Exploring the potential benefits of novel very long-chain polyunsaturated fatty acid supplements for dry eye

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Summary Dry eye disease (DED) is a chronic, multifactorial condition characterised by tear film instability, hyperosmolarity, and inflammation of the ocular surface (Jones et al., 2025). It is highly prevalent and can significantly impact quality of life. Although current treatments, including artificial tears and topical anti-inflammatory agents, provide relief for some patients, a substantial proportion remain symptomatic, highlighting the need for more effective strategies (Downie & Keller, 2015). N-3 polyunsaturated fatty acids (PUFAs) have previously been investigated as a potential intervention for DED, with human studies suggesting beneficial effects on both signs and symptoms (Downie et al., 2019). More recently, attention has turned to very long chain polyunsaturated fatty acids (VLCPUFAs), a subclass of fatty acids containing hydrocarbon chains of ≥24 carbons. VLCPUFAs are synthesised endogenously from long-chain PUFAs via elongation of very long chain fatty acid (ELOVL) proteins (Agbaga et al., 2010) and are predominantly found in specialised tissues such as the retina, brain, and testis (He et al., 2021). Emerging preclinical evidence suggests that VLCPUFAs play an important role in maintaining ocular health and function (McMahon et al., 2007; Nagaraja et al., 2021). However, their therapeutic potential in dry eye disease has not yet been fully explored. This MRes project aims to investigate the efficacy of a novel VLCPUFA supplement in the management of dry eye disease. The study will evaluate both objective clinical outcomes and subjective patient-reported symptoms, to determine whether VLCPUFAs represent a novel approach to the management of dry eye. Objectives of the research: Conduct a systematic review on the health benefits of very long chain marine-derived lipids and ocular health. Conduct a human intervention study to assess the efficacy of a very long chain polyunsaturated fatty acid supplement on signs and symptoms of dry eye. Methods to be used: A parallel randomized controlled human intervention study will be conducted in adults (18-75 yrs) with dry eye. Participants will be randomly allocated to one of two intervention groups: (I) Very long chain polyunsaturated fatty acids or (ii) a placebo supplement group. Pre and post intervention analysis will include ophthalmic assessment, lifestyle and anthropometric assessments along with the biochemical analysis of human biological samples for markers of inflammation. Statistical analysis of large data sets along with report writing will be integral to its success. Essential criteria Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study. We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction. In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications. Sound understanding of subject area as evidenced by a comprehensive research proposal A comprehensive and articulate personal statement Desirable Criteria If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview. First Class Honours (1st) Degree Practice-based research experience and/or dissemination Experience using research methods or other approaches relevant to the subject domain Publications record appropriate to career stage Experience of presentation of research findings Equal Opportunities The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities. Appointment will be made on merit. Funding and eligibility This opportunity is open to all applicants. The tuition fee for international and EU (excluding ROI) candidates is £19,040 for 2026/27. Studentship funding is available to UK and ROI applicants, as follows: MRes studentships will be available to top ranked candidates to cover tuition fees and a Research Training Support Grant of £900. All applicants to the project will be considered automatically for an MRes studentship. Applicants who do not receive a studentship but meet admission requirements may be offered admission on a self-funded basis. Applicants who already hold an MRes or a doctoral degree or who have been registered on a programme of research leading to the award of an MRes or doctoral degree are NOT eligible to apply for funding. Applicants who hold or who are registered on a taught Master’s degree are eligible to apply. Apply Now

Genomic Medicine Research Programmes

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Overview The Genomic Medicine Research Group is focused on using genetic knowledge and cutting-edge technologies to improve our understanding of human disease, with a view to enhancing diagnosis and treatment of complex disorders. Our team of researchers are particularly interested in the role of epigenetics, the function of microRNAs and investigation of genetic mutations which contribute to development of disease. Using a variety of in vitro, in vivo and in silico approaches, a number of overlapping projects in our group are carrying out ground-breaking research into various disease areas, including cancer, eye disease, cardiovascular disease and mental health. Our work utilises state-of-the-art equipment available in the Genomics Core Facility Unit, including instrumentation for flow cytometry, imaging, PCR, sequencing and methylation analysis. We use several unique in vitro and in vivo disease models for our research, and techniques routinely employed in our research include CRISPR/Cas gene editing, gene silencing, DNA methylation analysis and reporter assays. Our cell biology laboratory work is complemented by bioinformatics expertise within the group to perform genome-wide association studies and other analyses of publicly available datasets. Together, the group members have several strategic national and international research collaborations across academia, healthcare and industry, with an exciting track record of research outputs and conference presentations across the globe. Genomic research is absolutely crucial in the drive towards personalized medicine and tailored treatment for disease and the Genomic Medicine Research Group at Ulster are proud to be making a valuable contribution to this effort. Through our work we aim to facilitate translational medical research from laboratory to clinic, thereby helping to fulfil the great promise of genomic medicine. Summary Biomedical Science at Ulster University has an outstanding and sustained record of success in research, recognised in the most recent REF2021 to be internationally excellent, world leading and ranked 5th out of 89 UK universities within the category of Allied Health Professions which encompasses the disciplines of biomedical sciences, nursing, nutrition, pharmacy, optometry, health sciences and personalised medicine. Our research is not only producing outputs of world leading quality but also credited with having significant global translation, impacting positively on health professionals, industry, the general public and specific patient groups. We are proud to have externally recognised world-leading research environment which scored 100% 4*rating in REF 2014 and 2021. Biomedical Sciences research activities are currently organised within distinct Research Centres: Diabetes, Food & Health (through Nutrition Innovation Centre for Food and Health (NICHE)), Genomic Medicine, Pharmaceutical Sciences & Practice, Personalised Medicine and Optometry & Vision Science. Multi-disciplinary collaboration between the research groups is strongly encouraged and is widespread with research into, for instance, anti-diabetic and antioncogenic aspects of nutrition, the genomics of vitamin receptors, visual deterioration or cancer, imaging of neovascularisation. Our research investigates the interaction between cardiovascular disease and vision and the impact of health and disease, diet, diabetes on dementia, hypertension, autoimmunity, vascular and inflammatory disease, to name a few. The research groups collaborate both internally and internationally on a range of prioritized multi-disciplinary themes in functional foods, gene-nutrient interactions; pregnancy and early life; healthy ageing, musculoskeletal health; drug discovery and delivery, personalized medicine and genomic medicine. The BMSRI has strong collaborations with regional and global pharmaceutical and diagnostics companies and many of our graduates and postgraduates gain employment in the government bodies, pharma, diagnostics, and health care sectors as well as academia and through self-employment. About The Biomedical Sciences Research Institute (BMSRI) offers a “state-of-the-art” research environment for high profile researchers to undertake internationally agenda setting research in strategically prioritized areas of biomedicine. This research environment within Biomedical Sciences at Ulster has been continually judged as exceptional and world-leading and awarded the highest 100% ranking within the RAE2008, REF2014 and REF2021. Furthermore, in the Postgraduate Research Experience Survey (PRES) awards, it was ranked 2nd in the UK, with an overall satisfaction rate of 88%. Our research is carried out in well-equipped laboratories allowing the latest methods to be applied to individual projects. Our infrastructure is managed as Core Facility Units (CFUs) with equipment and laboratories dedicated to supporting pre-clinical studies, controlled human trials with expertise in vascular research, advanced molecular bioimaging/microscopy, bioinformatics, cell technologies, cellular biology, chemical analysis, genomics, proteomics/metabolomics (including mass spectrometry & NMR analysis), ocular imaging and psychophysics, transgenics, physiology and pharmacology. The BMSRI research infrastructure also includes centralized resources for: high throughput drug screening in vitro assays, clinical research & human intervention studies/ trials; the use and storage of mammalian cells and tissues; and in vivo studies and animal models that replicate human disease. The BMSRI uses its estate of equipment, specialist laboratories, infrastructure and internationally recognized biomedical expertise to offer clinical & translational services to Academic Researchers and Industrial Business partners. The BMSRI routinely engages in collaborative research with some of the world’s leading pharmaceutical and biomedical companies and through the support of Ulster’s Office of Innovation, the University has established a track record of success in the commercialization of its research outcomes. Research within BMSRI frequently involves collaboration between clinicians, academics and businesses in the life and health sector contributing to the development and launch of innovative health technologies, medical devices, and therapeutics. In addition to high-spec capabilities such as human genome sequencing, flow-cytometry and tissue culture, the close proximity of our research centres to hospitals permits direct access to NHS diagnostic laboratories, Clinical staff, and expertise in research governance and healthcare economics. The expansion of biomedical research during the last 10 years and more has led to the construction of the £14.5M Centre for Molecular Biosciences (CMB) at the Coleraine campus. This expansion in research infrastructure later led to the creation of a number of “virtual” centres of excellence which are housed within the CMB building, i.e., the Centre for Functional Genomics (CFG), the FEI Centre for Advanced Bioimaging (CFAI) and the Centre for Nutrition & Bone Health whose overall aim is to develop a new “all-Ireland” expert research capability focused on nutrition and bone health, particularly targeted at identifying strategies to prevent osteoporosis. Entry requirements Applicants should hold, or expect to obtain, a First or Upper Second

Exploring the Cardiovascular Health Benefits of Novel Marine Lipids

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Summary This MRes project will focus on the development and investigation of the health benefits of sustainable marine derived lipids. In particular, the project will focus on fish oils derived from certain North Atlantic fish which are naturally rich in the long chain mono-unsaturated fatty acids (LCMUFA) cetoleic acid. LCMUFAs have been linked to improvements in several key risk factors associated with metabolic health including reductions in LDL-cholesterol, total cholesterol, glucose levels as well as enhanced insulin sensitivity. Studies also show an improvement in adipocyte health with a reduction in hypertrophy of the cells and increased levels of the anti-inflammatory and insulin regulating hormone adiponectin. This MRes will investigate the effect of a unique blend of more sustainable marine derived lipids on cardiovascular and metabolic health related outcomes. Objectives of the research: Conduct a systematic review on the health benefits of very long chain marine-derived lipids. Conduct a human intervention study to assess the efficacy of a novel marine lipid blend for improving indicators of cardiovascular and metabolic health related outcomes. Methods to be used: A parallel randomized controlled human intervention study will be conducted in adults (18-65 yrs). Participants will be randomly allocated to one of three intervention groups: (I) Omega-3 supplement group, (ii) Omega 3-9-11 group or (iii) a placebo supplement group. Pre and post intervention analysis will include lifestyle and anthropometric assessment along with the biochemical analysis of human biological samples for markers of cardiovascular health. Statistical analysis of large data sets along with report writing will be integral to its success. Essential criteria Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study. We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction. In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications. Sound understanding of subject area as evidenced by a comprehensive research proposal A comprehensive and articulate personal statement Desirable Criteria If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview. First Class Honours (1st) Degree Practice-based research experience and/or dissemination Experience using research methods or other approaches relevant to the subject domain Publications record appropriate to career stage Experience of presentation of research findings Equal Opportunities The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities. Appointment will be made on merit. Funding and eligibility This opportunity is open to all applicants. The tuition fee for international and EU (excluding ROI) candidates is £19,040 for 2026/27. Studentship funding is available to UK and ROI applicants, as follows: MRes studentships will be available to top ranked candidates to cover tuition fees and a Research Training Support Grant of £900. All applicants to the project will be considered automatically for an MRes studentship. Applicants who do not receive a studentship but meet admission requirements may be offered admission on a self-funded basis. Applicants who already hold an MRes or a doctoral degree or who have been registered on a programme of research leading to the award of an MRes or doctoral degree are NOT eligible to apply for funding. Applicants who hold or who are registered on a taught Master’s degree are eligible to apply. Apply Now

Engineering Long-Lasting Broad-Spectrum Innate Immune Antivirals

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OVERVIEW This project seeks to discover and develop novel means to push the temporal limits of innate antiviral immunity of epithelial and immune cells against emerging viruses with pandemic potential through a combination of computational, cellular and molecular approaches. Viruses continue to be a major global burden to the health and wellbeing of humans, animals, and ecosystems. Emerging zoonotic viruses that spillover from animals into the human population represent a clear future pandemic threat, particularly for respiratory infections, or vector-borne diseases driven by climate change. The diversity and unpredictability of zoonoses are a massive challenge in developing effective, rapid countermeasures. One answer to this problem lies in our own innate immune system that has evolved to quickly defend against myriad viruses. However, due to evolutionary and biological constraints such pathways are poorly optimised for sustained, safe activity. Therefore, this project seeks to overcome these challenges and engineer longterm antiviral immunity in both mucosal and systemic tissues against airborne viruses and arboviruses. You will use cutting-edge computational biology and machine learning tools, combined with molecular genetic manipulation of host cells and viral pathogens like influenza viruses and flaviviruses under high-containment to: i) determine the temporal limits of natural antiviral immune signalling pathways in airway epithelial and immune cells; ii) uncover underlying induced RNA and protein biomarkers of signalling kinetics; and iii) identify genetic and biochemical modifiers of these targets in order to safely enhance their longevity. Research Information PhD Supervisors Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility. Career Prospects Introduction Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields). Employment after the Course Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government. ENTRANCE REQUIREMENTS Graduate The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School. International Students For information on international qualification equivalents, please check the specific information for your country. English Language Requirements Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years). International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes. For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs. If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree. HOW TO APPLY Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply. Find a supervisor If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions. To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here. You might be asked to provide a short outline of your proposal to help us identify potential supervisors. Apply Now

Elucidating the Functional Role of Infection Factors from Entomopathogenic Nematodes

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OVERVIEW We have recently demonstrated the power of using the Drosophila model to determine novel parasitic nematode infection factors and elucidate the genetic and functional bases of host anti-nematode defense. This project will use omics together with reverse genetics and functional approaches to reveal original entomopathogenic nematode infection strategies in Drosophila. We aim to understand the infective process of entomopathogenic nematodes (EPNs) and the host’s immune response to infection. Our hypothesis is that EPNs produce proteins which interact with the host immune and metabolic responses to promote pathogenicity during the early stages of insect infection. We have identified three putative virulence factors that are up-regulated early in infection. We will test the hypothesis that these molecules facilitate infection by interfering with the host immune signaling and function and altering its metabolic activity. First, we will determine the combined action of H. bacteriophora candidate virulence factors and P. luminescens infection on the fly innate immune signaling activity and function. Then, we will perform gene knockdown to explore the role of EPN candidate virulence factors on host survival and interaction with the host anti-nematode response. Finally, we will determine the effect of H. bacteriophora candidate virulence factors on lipid metabolism in D. melanogaster. Results from this research will provide critical information on the molecular basis of EPN infection and the nature of nematode molecules that compromise the insect host defense. This information can be used to advance efforts in the biocontrol of agricultural insect pests and vectors of plant and human diseases. Research Information PhD Supervisors Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility. Career Prospects Introduction Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields). Employment after the Course Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government. ENTRANCE REQUIREMENTS Graduate The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School. International Students For information on international qualification equivalents, please check the specific information for your country. English Language Requirements Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years). International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes. For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs. If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree. HOW TO APPLY Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply. Find a supervisor If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions. To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here. You might be asked to provide a short outline of your proposal to help us identify potential supervisors. Apply Now

Beyond antibiotics: the impact of non-antibiotic drugs on the selection of antibiotic resistance in Pseudomonas aeruginosa

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OVERVIEW The goal of this PhD project is to investigate how commonly used non-antibiotic drugs in combination with antibiotics can impact the evolution of antibiotic resistance in Pseudomonas aeruginosa, a high priority pathogen and leading cause of severe hospital-acquired infections. The emergence and spread of multi-drug resistant (MDR) bacterial pathogens, virtually untreatable by antibiotics, poses a fundamental threat to human health. While it has been long-established that treating patients with antibiotics selects for resistant bacteria, recent studies have elucidated that many commonly used non-antibiotic drugs may also have unintended antimicrobial effects, and can impact the development and spread of resistance, despite this not being their intended use. The goal of this PhD project is to investigate how commonly used non-antibiotic drugs in combination with antibiotics can impact the evolution of antibiotic resistance in Pseudomonas aeruginosa, a high priority pathogen and leading cause of severe hospital-acquired infections. The PhD student will develop skills in experimental evolution, high-throughput microbiology, antimicrobial susceptibility testing, whole-genome sequencing and analysis, bacterial genetics, and fitness assays in complex environments. Research Information PhD Supervisors Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility. Career Prospects Introduction Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields). Employment after the Course Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government. ENTRANCE REQUIREMENTS Graduate The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School. International Students For information on international qualification equivalents, please check the specific information for your country. English Language Requirements Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years). International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes. For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs. If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree. HOW TO APPLY Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply. Find a supervisor If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions. To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here. You might be asked to provide a short outline of your proposal to help us identify potential supervisors. Apply Now

Weed Out the Worms – Exploiting Endocannabinoid Biology for Nematode Parasite Control

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OVERVIEW Parasitic nematodes cause major global health and economic burdens, and long-term control is increasingly threatened by escalating drug resistance. Endocannabinoid (EC) signalling regulates key physiological processes and has become an established therapeutic target in vertebrates. Parasitic nematodes also possess EC signalling pathways that may be important in parasitism. This project will explore the potential of EC signalling as a novel target pathway for nematode parasite control. Exogenous cannabinoids, commonly derived from the cannabis plant, alter sensory perception and affect a range of behaviours. Vertebrates also naturally produce endogenous cannabinoids, known as endocannabinoids (ECs), that are responsible for the modulation of important physiological processes including movement, reproduction, and feeding. Indeed, these pathways are now the target of many new treatments for vertebrate diseases. Invertebrates, including the free-living model nematode Caenorhabditis elegans, also possess functional EC signalling systems, but they appear to display key differences from vertebrates. We know little about the functional biology or importance of the EC system in parasitic nematodes however, bioinformatic evidence suggests that these pathways also differ from vertebrate EC signalling and may offer new opportunities for antiparasitic therapy. This project will exploit genomic resources, functional genomics and tractable parasite models, to define the role and importance of EC signalling in parasitic nematodes. The student will: (i) Identify and prioritise EC signalling candidates in key parasitic nematodes using in silico analyses of genome (BLAST, HMM) and transcriptome (RNASeq analyses) datasets; (ii) functionally interrogate prioritised EC signalling effectors using reverse genetics approaches (RNAi and CRISPR) in tractable nematode parasite models; (iii) validate gene silencing or knockout at the molecular and, where appropriate, proteomic level; (iv) determine the biological consequences of EC signalling disruption using in vitro and in vivo bioassays designed to interrogate nematode behaviour and parasitism. This interdisciplinary project will provide training in bioinformatics, molecular parasitology, functional genomics and experimental biology, while addressing a global challenge. By uncovering the functional importance of nematode EC signalling the work has the potential to reveal new targets for parasite control and reduce the long-term clinical and economic burden of infection. Research Information PhD Supervisors Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility. Career Prospects Introduction Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields). Employment after the Course Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government. ENTRANCE REQUIREMENTS Graduate The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School. International Students For information on international qualification equivalents, please check the specific information for your country. English Language Requirements Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years). International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes. For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs. If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree. HOW TO APPLY Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply. Find a supervisor If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions. To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here. You might be asked to provide a short outline of your proposal to help us identify potential supervisors. Apply Now

Developing a sustainable approach to research in a microbiology laboratory

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Summary Research has a high carbon footprint and hence a sustainable approach has become a necessity (UKRI, 2026) .Thus far the approach has been to deal with the low hanging fruit such as waste disposal, energy savings and procurement (Carrillo-Barragan 2024) but much less time has been spent investigating our actual approach to research, our methods and procedures and how addressing these might lead to a step change towards net zero requirements (Kelly, 2023). The focus on sustainability in laboratories is supported by laboratory accreditation schemes e.g. LEAF (Schell & Burns 2024), but there is less in the way of support for changes in research laboratories. The Microbiology Group in the School of Biomedical Sciences is the ideal test-bed to investigate procedures and approaches. It is a self-contained unit of the Northern Centre for Food Innovation and Health (NICHE) with technical staff, academic staff, post-docs and PhD researchers working in close proximity to their desk/office space. The Microbiology Group also hosts a significant number of undergraduate and MSc students during the academic year along with Visiting Researchers. This interdisciplinary MRes project will involve the student examining research procedures with the use of psychology methodologies to identify ways of working and how these can be refined and or replaced. This project will be of interest to students who are seeking a career in project delivery in the sustainability sphere in the context of Bioscience/Psychology Research. This proposal aligns with the University’s strategic plan – People, Place and Partnership: Delivering Sustainable Futures for All, the DfE sectoral plans for achieving low carbon/net zero (Skills and Workforce Development) and the Programme for Government 2024-2027 – Grow a Globally Competitive and Sustainable Economy. It aligns with the Causeway Coast and Glens Growth Deals’ Centre for Food and Drug Discovery (CCFD) where NICHE is a significant contributor. Objectives of the research: Conduct a review of sustainable practices in Microbiological Research Identify procedures and approaches to Microbiological Research in a typical laboratory Provide recommendations to refine and/or replace procedures and approaches in Microbiological Research Methods to be used: For the successful applicant.. The project will involve a period of observation in the Microbiology Group Training will be provided in the preparation of an ethics application to perform research There will be an opportunity to train in the collection and analysis of data There may be the opportunity to conduct a workshop/conduct focus groups and/or interviews with stakeholders Skills required of applicant: Applicants should have a degree in Biomedical Science, Psychology or a related area and should have achieved at least a 2.1. A background in microbiology and/or an interest in sustainability would be an advantage but full training will be available to the successful applicant. Essential criteria Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study. We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction. In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications. Sound understanding of subject area as evidenced by a comprehensive research proposal A comprehensive and articulate personal statement Desirable Criteria If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview. First Class Honours (1st) Degree Practice-based research experience and/or dissemination Experience using research methods or other approaches relevant to the subject domain Sound understanding of subject area as evidenced by a comprehensive research proposal Publications record appropriate to career stage Experience of presentation of research findings Equal Opportunities The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities. Appointment will be made on merit. Funding and eligibility This opportunity is open to all applicants. The tuition fee for international and EU (excluding ROI) candidates is £19,040 for 2026/27. Studentship funding is available to UK and ROI applicants, as follows: MRes studentships will be available to top ranked candidates to cover tuition fees and a Research Training Support Grant of £900. All applicants to the project will be considered automatically for an MRes studentship. Applicants who do not receive a studentship but meet admission requirements may be offered admission on a self-funded basis. Applicants who already hold an MRes or a doctoral degree or who have been registered on a programme of research leading to the award of an MRes or doctoral degree are NOT eligible to apply for funding. Applicants who hold or who are registered on a taught Master’s degree are eligible to apply. Recommended reading UKRI https://www.ukri.org/who-we-are/policies-standards-and-data/corporate-policies-and-standards/environmental-sustainability/ Carrillo-Barragan P. (2024) Clean your own house first: integrating sustainability into microbiology labs. FEMS Microbiol Ecol. 17;100(7):fiae084. doi: 10.1093/femsec/fiae084. Kelly FJ (2023) How can we reduce biomedical research’s carbon footprint?. PLOS Biology 21(11): e3002363. https://doi.org/10.1371/journal.pbio.3002363 Schell, BR, Bruns, N (2024) Lab sustainability programs LEAF and My Green Lab®: impact, user experience & suitability. RSC Sustainability 2(11) 3383-3396 doi: https://doi.org/10.1039/d4su00387j

Identification of Neuropeptide-gated Ion Channels in Nematode Parasites

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OVERVIEW Neurotransmitter-gated ion channels represent well-established anthelmintic targets, yet many ion channel families remain underexploited for nematode parasite control. There is evidence for a neuropeptide-gated chloride channel in the somatic muscle of the gastrointestinal parasite Ascaris suum, however the constitutive proteins have not yet been identified. The recent surge in both the quality and scale of nematode genomic and transcriptomic datasets, in combination with the experimental tractability of A. suum, offer a novel vantage point to search for nematode neuropeptide-gated ion channel subunit encoding genes. There are >100 neurotransmitter gated ion channel encoding subunits in the A. suum genome. This project will employ bioinformatic and physiology approaches to aid the identification of specific ion channel subunits that are most likely to constitute a neuropeptide-gated ion channel. In this approach, the student will utilise the available phylogenetic, genomic and tissue-specific transcriptomic data to develop a pipeline for the identification of genes that encode nematode neuropeptide-gated chloride channels (potential novel anthelmintic targets), and validate candidate proteins through muscle-based physiology / electrophysiology tools. Specifically this project will: (i) Employ a BLAST- and Hidden Markov Model-based pipeline to identify candidate ion channel subunit encoding genes across phylum Nematoda; (ii) Screen candidate proteins for domains/motifs that support their designation as putative neuropeptide-gated chloride channel subunits; (iii) Exploit available nematode tissue-specific RNAseq datasets to identify putative targets that are highly expressed in muscle tissues, and (iv) use reverse genetics and physiology to validate candidate proteins key nematode species. This project has the potential to uncover a novel neuropeptide-gated ion channel for chemotherapeutic exploitation in parasitic nematodes. The project will be part of an international collaboration that offers opportunities for lab-exchange and training. The student and will also receive local training from a Senior Postdoctoral Researcher (Dr Ciaran McCoy, QUB). Research Information PhD Supervisors Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility. Career Prospects Introduction Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields). Employment after the Course Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government. ENTRANCE REQUIREMENTS Graduate The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School. International Students For information on international qualification equivalents, please check the specific information for your country. English Language Requirements Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years). International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes. For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs. If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree. HOW TO APPLY Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply. Find a supervisor If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions. To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here. You might be asked to provide a short outline of your proposal to help us identify potential supervisors. Apply Now

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