Fixed-term

Do you want to contribute to top quality medical research?  The Department of Laboratory Medicine consists of seven divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet. Division The Department of Laboratory Medicine consists of seven divisions that conduct both research and teaching. The department is involved in advanced research, encompassing both basic and applied research. All divisions operate in close collaboration with clinicians at the Karolinska University Hospital. The Division of Biomolecular and Cellular Medicine (BCM) focuses on the use of modified biomolecules, cells, and cell products as new therapeutic agents, as well as the identification and study of suitable biomolecular and cellular targets for therapy and diagnostics. The division is also connected to the Karolinska ATMP Center. Our research efforts in the EL Andaloussi lab focus on one of the greatest challenges facing modern therapeutics; the delivery of macromolecules to target cells in vivo. Despite the unprecedented knowledge of diseases and their mechanisms due to advances in biomedical sciences; many promising therapeutic approaches are still clinically unavailable. This is simply because there is no efficient means of delivering these therapeutics to the right organ with the right dose. Our research performance involves developing novel and innovative drug delivery technologies that can carry proteins, RNAs, or gene editors to the target tissues safely and efficiently. Antisense oligonucleotides (ASOs) and siRNAs ´can be designed to suppress expression of any gene, including genes that drive cancer growth. This project focuses on exploiting antibody-oligonucleotide conjugates for selective delivery to prostate cancer cells, with the aim of improving therapeutic response and overcoming resistance. It also seeks to investigate underlying resistance mechanisms using integrative molecular profiling approaches, while maintaining a strong emphasis on translational relevance. Duties As a postdoctoral research scholar, you will work closely with team members to design and implement strategies for targeted delivery of oligonucleotide-based therapeutics, with a focus on antibody-oligonucleotide conjugates. A central aspect of the role will be to screen different antibody-ASO/siRNA conjugates for their ability to suppress growth of prostate cancer cells. This will be done in close collaboration with the chemistry team responsible for conjugate synthesis and optimization. You will establish and optimize experimental workflows to assess the activity and therapeutic impact of these conjugates, including their ability to modulate cellular responses and improve sensitivity to treatment. The work will involve correlating design parameters with functional outcomes in relevant in vitro systems and progressing toward in vivo validation. You will also participate in the design and execution of vivo studies, including xenograft models, to evaluate targeting efficiency and therapeutic efficacy. Entry requirements Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education. We are seeking a highly motivated scientist with a strong background in oligonucleotide conjugate delivery and/or in vivo biodistribution studies. Key areas of expertise: In vitro characterization • Utilize relevant in vitro cancer models to assess targeting specificity, delivery efficiency, and therapeutic activity, including effects on treatment response. • Preferred but not required: Investigate mechanisms of cellular uptake and intracellular trafficking, including development of advanced analytical approaches. In vivo experiments • Extensive hands-on experience in mouse handling, including various administration routes (e.g., IV, IP) and procedures relevant to cancer models. • Experience in evaluating biodistribution and therapeutic molecules in vivo. • Preferred but not required: Experience with xenograft models, toxicity studies, and in vivo imaging (e.g., IVIS, bioluminescence, fluorescence). Molecular and cellular biology expertise • Proficiency in mammalian cell culture and transfection techniques. • Expertise in quantitative assays to evaluate outcomes of in vitro and in vivo studies, such as gene expression analysis (RT-qPCR) and oligonucleotide detection methods (e.g., dPCR, SplintR). • Preferred but not required: Experience with flow cytometry for uptake analysis, single-cell approaches, and transcriptomic profiling (e.g., RNA sequencing, multi-omics). In addition, excellent proficiency in both spoken and written English is essential. We are looking for an energetic and passionate individual who actively contributes to our team and thrives in a collaborative environment. Strong interpersonal and communication skills are required, along with the ability to work independently and manage multiple tasks. The eligible candidate for the above-mentioned Postdoctoral Researcher position should hold a PhD degree dated no more than 7 years before the last date of employment as postdoc. The term can be extended under special circumstances. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global

Do you want to contribute to top quality medical research? The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. Our key words are multidisciplinary, bridging, national and international collaborations. We are now recruiting a research assistant to work in the group of Professor Gunilla Karlsson Hedestam. Your mission You will work with both wet and dry lab tasks to characterize antigen-specific B cell receptor repertoires. The work will focus on generating high-throughput sequence data and analyzing the results with a range of specialized analysis pipelines developed in the group. The work will also include the isolation of monoclonal antibodies from single B cells using RT-PCR, cloning and production of recombinant antibodies in mammalian cells and functional analysis of such antibodies as well as antibody engineering. Your profile Requirements for the position You have recently completed (or will very soon complete) a Master program in Biomedicine or related topic. You have robust experience working with multiplex PCR, next generation sequencing and standard molecular biology approaches applied to the analysis of adaptive immune receptor genes. Meritous Experience with immune repertoire sequencing and expression of recombinant proteins in mammalian cells is an advantage. You are fluent in both written and spoken English, and you are keen to learn different software tools and use basic programming to analyze biological data. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site. Location: Solna Application The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. This is a temporary position. Apply Now

Do you want to contribute to top quality medical research? The division of immunology and respiratory medicine is recruiting a postdoctoral research to the group led by Elisabeth Nyström witch is an interdisciplinary research team investigating how epithelial tissues build and regulate protective barriers. We focus on how intestinal mucus and mucus-producing goblet cells create a dynamic interface between the host and its environment, shaping microbial interactions, molecular exchange, and immune activation. By integrating molecular biology, biochemistry, and physiology, we aim to uncover how mucus is assembled and functions in health and disease. The group is embedded in a collaborative and interdisciplinary environment, with close interactions across immunology, bioinformatics, structural biology, biochemistry, and clinical research, both locally, nationally and internationally. Your mission The project aims to establish and validate a genetic approach to specifically target subtypes of mucus-producing goblet cells in vivo to functionally analyze their role in mucus- and goblet cell-mediated defense mechanisms. Functional analyses include advanced imaging, transcriptomics and proteomics, and ex vivo mucus analysis. Some of these activities may require flexibility in working hours, including work outside standard hours or during weekends. You are expected to independently drive their project forward, while actively engaging with the research group. Collaboration within the team and contribution to the overall lab environment are important parts of the role. Your profile To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier. · PhD in in molecular biology, biochemistry, cell biology, biomedical sciences, or a closely related discipline with a strong experimental component. · Extensive experience in maintaining complex mouse strains and working with genetically modified models, including advanced breeding strategies and inducible genetic systems. · Familiarity with intestinal physiology and biology. Meritorious · Experience of advanced imaging techniques, including confocal imaging of whole tissue · Experience with cell sorting techniques using FACS · Experience with omics-analysis, for example bulk or scRNA-seq, or proteomics · Basic bioinformatics skills and experience handling large datasets. We attach great importance to personal qualities in this recruitment. As a person, you are: • Analytical, structured, and detail-oriented, with a strong commitment to high-quality work and an interest in solving complex research questions. • Self-driven and able to work independently, with the ability to take initiative and move projects forward while seeking input and raising challenges constructively when needed. • Curious and motivated to learn new methods, skills, and concepts, with perseverance and resilience to see projects through to completion. • Collaborative, with good communication skills, and comfortable working in interdisciplinary teams with diverse backgrounds. • Willing to contribute to a positive and well-functioning lab environment. To be eligible for employment as a postdoctor, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered an advantage if you have completed your doctoral degree within the last three years. If there are special reasons, your degree may have been completed earlier. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. Application An employment application must contain the following documents in English or Swedish: PhD certificate A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) The application is to be submitted through the Varbi recruitment system. Apply Now

Do you want to contribute to improving human health? Come and join us at the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm. In the research group led by Laura Baranello, we are particularly interested in the molecular mechanisms defining the crosstalk between transcription, DNA topology and chromatin folding, with the aim to design improved strategies for anti-cancer treatment. We are a young and dynamic research team with a well-established collaborative network. Our lab is located at Biomedicum, a top modern research building with a large repertoire of researchers and access to state-of-the-art infrastructure and facilities. Our group is also associated to the laboratory of Dr. Levens at the National Institutes of Health (US) and Dr. Shiraige at Tokyo University (JP). The candidate will greatly benefit from this interdisciplinary environment, immersion in a highly stimulating and supportive research community, unique infrastructure, a buzzing capital, and scenic nature at your doorstep. Your mission The Baranello Lab – Drawing from our expertise in the fields of topoisomerase and cancer biology, we aim to answer fundamental questions about how transcription, replication and DNA topology are functionally coordinated in human cells. We use state-of-the-art approaches to assess transcriptomic, epigenomic and replisomic profiles, as well as molecular biology, advanced microscopy and drug screens to understand how topoisomerase regulation affects fundamental nuclear processes (key lab references: Baranello et al. Cell 2016; Wiegard et al. Molecular Cell 2021; Das et al. Molecular Cell 2022; Cameron et al. Science Advances 2023, Cameron et al. Nat Comm 2026). The overall aim is to reveal novel cancer therapy targets and improved strategies for personalized treatment. Recently we have identified a protein complex called “topoisome” in which the oncoprotein MYC recruits and increases the catalytic activities of both Topoisomerase 1 and 2 to promote high rates of transcription (Das et al. Molecular Cell 2022). The successful candidate will play a leading role in a full-time research project funded by the European Research Council, focused to address the functional role of the topoisome during transcription. Specifically we want to study the coordination of the topoisome and the transcriptional machinery. The outcome of this work is predicted to inspire a new strategy to target MYC in cancer, which will be tested in MYC-driven cancer models. This multidisciplinary project involves master biochemistry, master molecular biology, proteomics/genomics, and computational analysis. The postdoc will plan and execute experiments, analyze data, interpret, and present the results, supervise students as well as write scientific articles, initially under partial supervision but with greater independence going forward. Your profile We are looking for a highly motivated, driven and enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player capable of working independently and contribute to a good social environment in the laboratory. The candidate must have a PhD in medical sciences, biochemistry, molecular biology or equivalent. Requirements: Strong expertise in cell and molecular biology Strong expertise in biochemistry Expertise in proteomics and/or genomics Expertise in transcription regulation Expertise in DNA topology Proficiency in scientific programming (e.g., R/Bioconductor, Python, UNIX) Interest in solving intricate scientific questions and willingness to help PhD/master students. Excellent interpersonal and communication skills (in English written and verbal). Emphasis will be also placed on personal suitability, fitting well into the current research group. To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier. What do we offer? Our lab is eager to provide the postdoc with an opportunity to develop and/or apply state-of-the-art methodologies to solve timely biological key questions. Necessary training on Mass Spectrometry, sequencing technologies and computational analysis will be provided. Our aim is to give the candidate the opportunity to become fully independent researcher in interdisciplinary science within years. A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. Location: Stockholm, KI Campus Solna Application An employment application must contain the following documents in English or Swedish: PhD certificate A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A letter describing previous accomplishments, technical expertise and why you want to work with us (no more than one-page, generic letters not accepted) Names and contact details of two scientists for reference letters The application is to be submitted through the Varbi recruitment system. Apply Now

Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required. The research group Dahlin’s team focuses on charting basophil and mast cell differentiation at the single-cell level in health and hematologic diseases. This is performed using state-of-the-art single-cell omics technologies complemented with functional experiments. The current team consists of the principal investigator and four doctoral students, which together cover the areas of experimental research, bioinformatics, and applied mathematics. The group is part of the Division of Immunology and Respiratory Medicine. The doctoral student project and the duties of the doctoral student The differentiation of hematopoietic stem cells into the various blood cell lineages has been described with high precision. However, the basophil differentiation trajectory has yet to be charted in detail. The mission of the doctoral student project is to map basophil differentiation in health and hematologic disease. This includes studies of how progenitor cell fate is regulated at the molecular level during differentiation, and investigations of how disease-associated genetic alterations affect hematopoiesis and basophil development. Key technologies applied to primary samples from healthy subjects and patients with hematologic diseases include FACS sorting, flow cytometry-based analysis, CRISPR-based gene editing, cell culture and cell fate assays, cytochemical staining, and single-cell omics technologies, including transcriptomics and surface epitope profiling. The research is performed in an interdisciplinary setting, with both experimental and computational scientists. It also includes collaborations with clinical departments as well as national and international research groups. The main focus of the doctoral studies is experimental research, though the doctoral student will also be involved in omics data analysis performed together with bioinformaticians and applied mathematicians in the group. Additional duties include participation in daily routines of the research group and the division, such as shared laboratory tasks, administration, and supervision. What do we offer? A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care. Eligibility requirements for doctoral education In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline. It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education. A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you: have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or have acquired substantially equivalent knowledge in some other way in Sweden or abroad.* Follow the instructions on the web page Entry requirements (eligibility) for doctoral education. *If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education. B) Specific eligibility requirement You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you: – Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school. Follow the instructions on the web page English language requirements for doctoral education. Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action. (A) and (B) can only be certified by the documentation requirement for doctoral education. Skills and personal qualities Previous experience with experimental work is required. Experience from research projects involving cell biology, molecular biology, immunology, hematology, biotechnology, or related fields is considered an advantage. The successful applicant is motivated, trustworthy, organized, curious and open-minded, and has good collaborative skills. Terms and conditions The doctoral student will be employed on a doctoral studentship maximum 4 years full-time. Application process Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish. Your application must contain the following documents: A personal letter, in Swedish or English, describing why you are interested in the doctoral project. The letter should also include concrete examples of how your knowledge, skills, and previous experience make you suitable for this particular position. Curriculum vitae Degree projects and previous publications, if any Any other documentation showing the desirable skills and personal qualities described above Documents certifying your general eligibility (see A above) Documents certifying your specific eligibility (see B above) Selection A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis. Karolinska Institutet uses the following bases of assessment: – Documented subject knowledge of relevance to the area of research – Analytical skill – Other documented knowledge or experience that may be relevant to doctoral studies in the subject. All applicants will be informed when the recruitment is completed. Charting normal and malignant hematopoiesis – Team Joakim Dahlin Want

Do you want to contribute to better health for all? The Department of Laboratory Medicine comprises six divisions and is active across many areas of Laboratory Medicine to promote human health in short and long term. The department collaborates closely with Karolinska Hospital and engages in advanced basic, clinical, and epidemiological research. It is also one of the largest teaching departments at Karolinska Institutet. The research group of Dr. Ping Chen in the Division of Clinical Chemistry is seeking a postdoctoral fellow with expertise in RNA biology and wet-lab experiments. The Chen lab conducts systems biology to dissect the regulation of RNA diversity in human metabolic diseases, with the goal of advancing diagnostics and therapeutic strategies. The group works closely with multidisciplinary teams, integrating biobank resources, longitudinal clinical data, and multi-omics technologies with innovative computational approaches for biomarker discoveries. A two-year postdoctoral position will be available immediately in the Chen lab. Division The Division of Clinical Chemistry is carrying out research to elucidate the molecular basis of cardiometabolic disease integrating basic science, clinical medicine, and translational approaches. Duties The growing prevalence of obesity is increasing the global burden of metabolic disease. In this position, you will contribute to elucidating cellular and molecular mechanisms underlying obesity and related metabolic disorders, with a primary focus on RNA biology. You will design and perform wet-lab validation of biomarkers and regulatory mechanisms identified through high-throughput transcriptomic data analysis and apply perturbation strategies to link transcriptomic changes to functional phenotypes. You will work with human liver, adipose tissue and blood samples, as well as relevant cellular models. The role also includes maintaining rigorous experimental documentation and reproducible workflows, collaborating with clinical partners, contributing to figures and manuscript preparation, and communicating results through presentations and, where appropriate, through contributions to grant applications. Entry requirements To qualify for this position, applicants must: Hold a PhD in molecular biology, cell biology, immunology/metabolism, genetics, or a related field with strong experimental training. Demonstrate hands-on expertise in molecular biology, particularly in RNA biology, including RT-PCR/RT-qPCR and assay/primer design. Have proven experience with isoform-level validation and quantification (e.g., ddPCR and/or targeted sequencing is strongly advantage). Have solid experience working with relevant experimental systems, including human biopsy-derived material, flow cytometry, and mammalian cell culture, as well as strong skills in experimental design, troubleshooting, and the use of rigorous controls. Have experience with at least one perturbation platform (e.g., siRNA/shRNA, CRISPRi/a/editing, antisense oligonucleotides) and downstream molecular readouts. Be able to work effectively in a collaborative, multidisciplinary environment, with strong communication skills and a proactive, solution-oriented mindset. Demonstrate high motivation and scientific curiosity, with the ability to drive a project forward independently while aligning with group priorities. The following experience is considered an advantage: Amplicon sequencing; RNase R; splice junction assays. RNA–protein interaction assays (e.g., RIP-qPCR, CLIP/eCLIP, RNA pull-down). Experience with immunometabolism models and/or primary immune cell/macrophage systems. Familiarity with single-cell and/or multi-omics data analysis and the ability to translate computational findings into targeted experimental validation plans. Strong publication record and demonstrated manuscript writing skills. Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site. Location:  The position is located within the Department of Laboratory Medicine, KI Campus Flemingsberg within the research group of Dr. Ping Chen at the Division of Clinical Chemistry. Type of scholarship The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable. Application process An application must contain the following documents in English:  Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )  A motivation letter A summary of current work and achievements A complete list of publications The application is to be submitted on the Varbi recruitment system. Apply Now

Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required. The research group Our research delves into how the immune system engages with cancer and why it sometimes struggles to stop tumors from growing. By uncovering the signals and conditions that suppress immune activity inside tumors, we work to develop more effective and finely tuned immunotherapies for patients. We also strive to identify biomarkers that can predict how well an individual will respond to treatment, paving the way for more personalized and precise cancer care. Together, these efforts advance our understanding of how to harness and strengthen the body’s own defences, opening new avenues for transforming cancer treatment. The doctoral student project and the duties of the doctoral student This PhD project explores how natural killer (NK) cells contribute to immune surveillance in solid cancers. Using a combination of patient data, experimental model systems, and modern imaging and computational approaches, the project aims to understand when and how NK cells can effectively target tumor cells, and how this response might be enhanced for future therapies. As a doctoral student, you will receive broad training in cancer immunology and translational research. You will work with patient samples, public datasets, and experimental models, gaining hands-on experience in laboratory methods as well as data analysis. The PhD education also includes coursework, active participation in the research environment, scientific writing, and teaching or supervision of junior students. Over time, you are expected to develop increasing independence, critical thinking skills, and a strong foundation for a future career in academic or translational cancer research. What do we offer? A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care. Eligibility requirements for doctoral education In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline. It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education. A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you: have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or have acquired substantially equivalent knowledge in some other way in Sweden or abroad.* Follow the instructions on the web page Entry requirements (eligibility) for doctoral education. *If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education. B) Specific eligibility requirement You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you: – Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school. Follow the instructions on the web page English language requirements for doctoral education. Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action. (A) and (B) can only be certified by the documentation requirement for doctoral education. Skills and personal qualities We are looking for a curious, well‑organized, and self‑driven candidate who enjoys problem‑solving and teamwork. Good communication skills, basic competence in scientific writing, and a willingness to engage with both experimental and data‑driven research are essential. Applicants should have a strong interest and experience in biomedical research, particularly cancer biology and immunology. Prior experience with laboratory work, data analysis, or experimental research is important. Previous exposure to methods in cell biology, molecular biology, immunology, or bioinformatics is desired. Previous experience in specific methodology including flow cytometry, PCR, ELISA, immunohistochemistry, cell culture of cancer cells, isolation and culture of human primary leukocytes is particularly meritorious. Terms and conditions The doctoral student will be employed on a doctoral studentship maximum 4 years full-time. Application process Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish. Your application must contain the following documents: – A personal letter and a curriculum vitae – Degree projects and previous publications, if any – Any other documentation showing the desirable skills and personal qualities described above – Documents certifying your general eligibility (see A above) – Documents certifying your specific eligibility (see B above) Selection A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis. Karolinska Institutet uses the following bases of assessment: – Documented subject knowledge of relevance to the area of research – Analytical skill – Other documented knowledge or experience that may be relevant to doctoral studies in the subject. All applicants will be informed when the recruitment is completed. Apply at the latest 26th May. Apply Now