Fixed-term

Tackling oxaliplatin drug resistance in colorectal cancer by developing a novel bifunctional prodrug

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 Dr Steven Shnyder,  Dr Goreti Ribeiro Morais,  Prof Rob Falconer Application Deadline: Applications accepted all year round Details Acquired drug resistance is a considerable problem for the treatment of colorectal cancer (CRC), of which oxaliplatin is a key component, with little improvement in the ~65% 5-year survival rate over the past 25 years. Modulation of resistance pathway component expression can maintain tumour drug sensitivity during multiple cycles of treatment, minimising chances of the tumour becoming resistant, and one would ideally want to administer the modulator specifically to the tumour at the same time as the drug. In preliminary cell-based studies we have identified compounds that can reduce resistance to oxaliplatin. We have previously demonstrated that a matrix-metalloproteinase 1 (MT1-MMP) activated peptide-based prodrug can differentially release a drug payload in a CRC xenograft model, and this prodrug platform has flexibility to be applied to other payloads. Aim To develop a bifunctional MT1-MMP-activated peptide prodrug which will minimise acquisition of resistance and improve efficacy of oxaliplatin in CRC patients. Focus Design and development of a prodrug incorporating oxaliplatin and a modulator of the resistance-causing survivin, LQZ-7I, with optimisation of formulation for intravenous administration. Following confirmation of differential tumour release in ex vivo studies, in vitro and in vivo proof-of-concept in CRC resistance models will be evaluated. Who should apply Applicants with a passion for medicinal and/or synthetic chemistry, and cancer drug discovery. Candidates should have, or expect to obtain, a first or good upper second-class degree (or non-UK equivalent) in a chemistry-based subject or an appropriate Master’s degree qualification. We are looking for applicants with evidence of laboratory experience in organic or medicinal chemistry (e.g. a significant research project), with some experience of drug analysis and/or cell-free or in vitro screening assays. How to apply Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account, select ‘Postgraduate Research’ as the course and then use the keywords ‘cancer therapeutics’. Applicants should then specify the project title in the ‘Research Proposal’ section. Enquiries For informal enquiries, please contact s.d.shnyder@bradford.ac.uk.  For further information about the Institute of Cancer Therapeutics Doctoral Training Centre, please contact r.a.falconer1@bradford.ac.uk, or take a look at our website. About the University of Bradford Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities. Positive Action Statement At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students. Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level.  These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies. Funding Notes This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee of £10,000 per year may also apply to this project, in addition to the tuition fees. UK students may be able to apply for a Doctoral Loan from Student Finance for financial support. References Atkinson, J.M et al. Cancer Research, 2010, 70, 6902-6912 (10.1158/0008-5472.CAN-10-1440); Gill, J.H et al. Molecular Pharmaceutics, 2014, 11, 1294−1300 ( DOI: 10.1021/mp400760b )   Apply Now

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

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 Prof Rob Falconer,  Dr Steven Shnyder Application Deadline: Applications accepted all year round Details Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Polysialic acid is aberrantly re-expressed on the surface of many tumours, where it plays a key role in diseases progression and metastasis. It is therefore an attractive anti-cancer target (see Current Cancer Drug Targets, 2012, 12, 925-939). The Institute of Cancer Therapeutics, at the University of Bradford, is focused on the development of novel polyST inhibitors, using computational chemistry to aid compound design. We have developed assays to assess compound inhibition (see Analyst, 2016, 141, 5849-5856) and have utilized tool compounds to show the potential of the approach (see PLoS ONE, 2013, 8, e73366). The wider project benefits from funding from programme funding from Yorkshire Cancer Research and more recently from the Wellcome Trust. The student will join a successful, motivated multidisciplinary team with expertise in medicinal chemistry, pharmacology and drug analysis. The group has a series of hit polyST inhibitors with potential for further development. The project will focus on the synthesis of the next generation of inhibitors, utilising computational chemistry to aid compound design. Training in compound synthesis, purification (including preparative HPLC) and analysis (LC-MS, NMR) will be provided. Synthesised compounds will be evaluated in cell-free HPLC-based enzyme inhibition assay, with the most promising compounds then screened in cell-based assays, all in-house. How to apply Formal applications can be submitted via the University of Bradford web site. Applicants should register an account, select ‘Postgraduate Research’ as the course type and use the keywords ‘cancer therapeutics’. Please include the project title on the Research Proposal section; applicants are not required to supply a research proposal for this project. Informal enquiries are also welcome. About the University of Bradford Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities. Positive Action Statement At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students. Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level.  These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies. Funding Notes This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee of £10,000 also applies to this project, in addition to the tuition fees. UK students may be able to apply for a Doctoral Loan from Student Finance for financial support. Apply Now

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

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 Prof Rob Falconer,  Prof Paul Loadman Application Deadline: Applications accepted all year round Details Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. The concept behind our technology is that the increased expression and activity of MMPs within the tumour microenvironment, relative to normal tissues, can be exploited to selectively release potent chemotherapeutics from non-toxic peptide conjugates. The result is high levels of the active agent in the tumour and negligible drug levels in ’normal’ tissues. Conjugation of a peptide to the active drug molecule renders it inactive until such time that it is activated by MMPs in the tumour. The MMP then cleaves the peptide, resulting in release of the active drug selectively in the tumour microenvironment. The ICT has already successfully used this technology to improve the therapeutic index of a colchicine derivative (ICT2588), which is now licensed to University of Bradford spin-out company Incanthera plc and received global press coverage at the British Science Festival 2011. ICT2588 is about to enter Phase I clinical trials. The group additionally has strong links with Stanford University (USA), having commercialised an MMP-activated ‘theranostic’ version of ICT2588, which simultaneously allows MRI imaging and cancer therapy. The student will join a successful, motivated multidisciplinary team with expertise in medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics. The project will involve the design, synthesis and biological evaluation of the next generation of MMP-activated prodrugs, with the aim of identifying an agent to progress towards advanced preclinical testing and ultimately the clinic. Specific aims: Synthesis of novel peptide-drug conjugates, utilizing modern automated solid-phase peptide technology and/or Study of the metabolism of synthesized conjugates in tumour and normal tissues in vitro, using LC-MS; In vivo assessment of the most promising compound – pharmacokinetics and efficacy in a mouse model. How to apply Formal applications can be submitted via the University of Bradford web site. Applicants should register an account, select ‘Postgraduate Research’ as the course type and use the keywords ‘cancer therapeutics’. Please include the project title on the Research Proposal section; applicants are not required to supply a research proposal for this project. Informal enquiries are also welcome. About the University of Bradford Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities. Positive Action Statement At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students. Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level.  These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies. Funding Notes This is a self-funded project; applicants will be expected to pay their own fees or have access to suitable third-party funding. In addition to the university’s standard tuition fees, bench fees of £10,000 per year also apply to this project. References Small, 2014, 10, 566-575Molecular Cancer Therapeutics, 2017, 16, 1909-1921Cancer Research, 2010, 70, 6902-6912 At least 2:1 honours degree in Chemistry, Medicinal Chemistry, Pharmacy or related subjects. An MSc in any of these areas is an advantage.For full details of our entry requirements, please visit our website.   Apply Now

Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids

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 Dr Ibrahim Khot,  Prof Anant Paradkar,  Prof David Jayne Application Deadline: Applications accepted all year round Details Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. However, up to 20% of patients develop recurrent disease after treatment. Photodynamic Therapy (PDT) is an emerging anti-cancer treatment method, which can substantially improve the outcomes of treatment in CRC. PDT involves the administration of a photosensitising agent to cancers, followed by the irradiation of light to the cancer growth. This results in the activation of the photosensitising agent, eliciting cell death through the generation of reactive oxygen species and oxidative stress. This project will involve the investigation of PDT in CRC using different in vitro models of CRC. Recently, it has been identified that 2D cell cultures are not adequate and efficient in providing reliable and clinically representative outcomes of treatment. This is due to the limited capacity and application of 2D cell cultures and their lack of representation of clinical cancers. 3D spheroidal cell cultures and more recently, patient-derived organoids have been identified as vastly more improved and better models of CRC to pre-clinically evaluate treatments. In this project, PDT will be evaluated in simple 2D monolayer and more advanced 3D spheroidal cell monocultures and co-cultures of CRC. In our laboratory, we culture patient-derived organoids, directly from CRC patients in Leeds and will be used in this PhD project to study PDT treatments. The candidate will liaise with the colorectal surgery team at St James Hospital to collect and process CRC tissue specimens from theatre into organoids. Organoids will be subjected to PDT and other cancer treatments and interrogated on a molecular level to identify novel markers of chemoresistance. Methods: Cell line and tissue culturing, patient-derived organoid culturing, cell viability assays, fluorescent microscopy, immunofluorescence, immunohistochemistry, western blotting, RT-PCR, single cell analyses, statistical analyses How to apply Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account and select ‘Full-time PhD in Biomedical Science’ as the course, and then specify the project title when prompted. About the University of Bradford Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities. Positive Action Statement At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students. Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level.  These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies. Funding Notes This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee may apply in addition to tuition fees. UK students may be able to apply for a Doctoral Loan from Student Finance for financial support. References Kim, W.S., Khot, M.I., Woo, H.M., Hong, S., Baek, D.H., Maisey, T., Daniels, B., Coletta, P.L., Yoon, B.J., Jayne, D.G. and Park, S.I., 2022. AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy. Nature communications, 13(1), pp.1-11.Khot, M.I., Perry, S.L., Maisey, T., Armstrong, G., Andrew, H., Hughes, T.A., Kapur, N. and Jayne, D.G., 2018. Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer. Photodiagnosis and photodynamic therapy, 23, pp.221-229.Kondo, J., Endo, H., Okuyama, H., Ishikawa, O., Iishi, H., Tsujii, M., Ohue, M. and Inoue, M., 2011. Retaining cell–cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. Proceedings of the National Academy of Sciences, 108(15), pp.6235-6240. Apply Now

Research Associate at Department of Pharmacology and Toxicology

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Date Posted: 05/22/2026Req ID:48252Faculty/Division: Temerty Faculty of MedicineDepartment: Department of Pharmacology and ToxicologyCampus: St. George (Downtown Toronto)Existing Vacancy: Yes Description: OVERVIEW: The Department of Pharmacology and Toxicology in the Temerty Faculty of Medicine , University of Toronto invites applications for the position of Research Associate to investigate Pharmacokinetic variation in human drug samples.  QUALIFICATIONS: Candidates require a Ph.D. with at least 4 years of research expertise in population and individual pharmacokinetics, quantitative system Pharmacology and Baysesian statistics and have some general programming skills (e.g. PopPK, PBPK, Phoenix, SimCYP and similar software, R). Candidates must also have a strong and long-standing track record of publication and experience in designing, planning, and executing experiments, as well as data analysis, interpretation, quantification, and figure preparation for grants and manuscripts. Candidates will also be involved in supervising students and postdoctoral fellows, preparing manuscripts for submission to peer-reviewed publications/journals, assisting with grant application preparation, and presenting findings at meetings and conferences. Strong orgazational and communication skills are required, as well as the ability to work collaboratively in a large multi-collaborative laboratory.  KEY DUTIES:  Develop and conduct independent research in population pharmacokinetics in animal and human sample sets.  Contribute directly to research via experimental design, execution, interpretation, and write-up.  Liaise with collaborators and assist in the compilation, analysis, and reporting of research findings to researchers within and outside the program.  Prepare manuscripts for submission to peer-reviewed publications/journals.  Present findings at local, national, and international conferences.  Prepare research proposals for submission to granting agencies and report on progress.  Provide general laboratory biosafety and maintenance, including inventories, equipment repair, ordering, and shipping reagents.  Train other lab members.  At all times, the individual will be expected to support the overall research and teaching missions of the lab.  The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.  All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority. Please note: this is an 18-month term position. Closing Date: 07/05/2026,11:59PM ETEmployee Group: Research Associate Personnel Subarea:Research AssocAppointment Type: Grant – Term Schedule: Full-TimePay Scale Group & Hiring Zone: R01 — Research Associates (Limited Term): $53,520 – $100,350Job Category: Research Administration & Teaching Diversity Statement The University of Toronto embraces Diversity and is building a culture of belonging that increases our capacity to effectively address and serve the interests of our global community. We strongly encourage applications from Indigenous Peoples, Black and racialized persons, women, persons with disabilities, and people of diverse sexual and gender identities. We value applicants who have demonstrated a commitment to equity, diversity and inclusion and recognize that diverse perspectives, experiences, and expertise are essential to strengthening our academic mission. As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see http://uoft.me/UP. Accessibility Statement The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission. The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities. If you require any accommodations at any point during the application and hiring process, please contact uoft.careers@utoronto.ca. Apply Now

Postdoctoral Research Fellow – C. elegans Developmental Biology

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Job Category Faculty Non Bargaining Job Title Postdoctoral Research Fellow Department Research | Sugioka | Department of Zoology (Kenji Sugioka) Posting End Date June 18, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date February 29, 2028 The expected salary range of this position is CAD $60,000–70,000 per year plus benefits, depending on qualifications and experience. The Sugioka Lab at the University of British Columbia seeks a postdoctoral researcher in developmental cell biology to study the developmental control of cell division and the cytoskeleton using the C. elegans embryo as a model system. The researcher will work with the supervisor Dr. Kenji Sugioka in the Department of Zoology, Life Sciences Institute at UBC’s Vancouver campus. The postdoctoral researcher will lead projects investigating how cortical flow, concerted actomyosin flow, regulates embryonic morphogenesis, including asymmetric cell division and left-right asymmetry. In the past few years, our lab has identified novel mechanical regulation of cortical flow and its role in asymmetric regulation of cytokinesis (Khor et al., Current Biology, 2025; Hsu et al., Nature Communications, 2023). Building on this work, the successful candidate will investigate the molecular mechanisms and cellular information-processing principles underlying these processes. Work will be developed in close collaboration with the supervisor, with significant opportunity for independent project development. The candidate will use a combination of C. elegans genetics, live imaging, quantitative image analysis, and molecular perturbation approaches. The candidate will also have opportunities to mentor junior researchers and contribute to a vibrant and collaborative research environment. The Sugioka Lab shares space with two other C. elegans research groups, providing strong opportunities for scientific interaction and collaboration. Required qualifications: Ph.D. in Cell Biology, Developmental Biology, Biophysics, Genetics, Molecular Biology, or a related field (PhD students in their final years are also eligible) Strong background in cell biology, developmental biology, or genetics Experience with molecular biology, genetics, live imaging, or image analysis. Strong collaborative skills and effective professional communication. Demonstrated writing skills and evidence of research productivity. Desired qualifications: Experience with C. elegans genetics. Experience with single-cell RNA-seq or other genomics approaches. Experience with quantitative live imaging and computational image analysis. Interest in mentoring undergraduate or graduate students. Desire to contribute to a diverse, inclusive, and collaborative research environment. The position will start on September 1, 2026, or after, and will be based in the Life Sciences Institute at UBC’s Vancouver campus. The expected salary range is CAD $60,000–70,000 per year + benefits, depending on qualifications and experience. Information on benefits is available at www.postdocs.ubc.ca. The initial appointment is 1.5 year(s) in duration, with the possibility of extension contingent on satisfactory work performance and funding availability. Successful applicants will join a dynamic research environment with opportunities to interact with researchers in developmental biology, cell biology, mechanobiology, quantitative biology, and C. elegans genetics at UBC. The position also offers an exceptional training opportunity within the scientific community and quality of life of Vancouver. Applications should be submitted as a single PDF attachment by email to kenji.sugioka@ubc.ca with the subject “Sugioka Lab postdoc application” and file name “LastName.FirstName.pdf”, and should include: A 1-page cover letter stating research interests and key qualifications, CV including contact information for 3 references, and Copies or links for 1–3 writing samples, such as recent peer-reviewed publications. Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as an Indigenous person. Applications will be reviewed as they are received and will continue until a suitable candidate is identified.

Research Associate – Airway Inflammation and Translational Medicine

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Job Category Faculty Non Bargaining Job Title Research Associate Department Thamboo Research Lab Otolaryngology | Department of Surgery | Faculty of Medicine (Andrew Thamboo) Posting End Date June 22, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date July 31, 2027 The expected pay for this position is $76,128 per year. JOB SUMMARY The Research Associate is responsible for initiating and leading research projects, leading research communications and arrangements, and interacting with the sponsors/ collaborators and advising team members as part of the Sinus Clinic at St. Paul’s Hospital and the Centre for Heart Lung Innovation (HLI). The incumbent will design and lead and liaise with Dr. Thamboo as the Principal investigator (PI), study sponsors, and collaborators as well as team members regarding project progress and deliverables. The incumbent will join faculty, students, and staff engaged in innovative, leading edge research, education and community service on university and hospital campuses across BC. Together, we aim to create knowledge and advance learning that will make a vital contribution to the health of individuals and communities, locally, nationally and internationally.  ORGANIZATIONAL STATUS The UBC Faculty of Medicine Department of Surgery educates students at the undergraduate, graduate and postgraduate levels, and pursues research to make innovative advancements in knowledge and practice to improve health.  The Department consists of more than 600 physicians, surgeons, scientists and educators and over 60 administrative, research and technical staff in nine divisions distributed across British Columbia.  Specialty training programs are offered in Cardiac Surgery, General Surgery, Neurosurgery, Otolaryngology, Pediatric Surgery, Plastic Surgery, Radiation Oncology, Thoracic Surgery and Vascular Surgery.  The Department is also home to the Branch for International Surgical Care.   The Research Associate reports directly to the Principal Investigator, Dr. Andrew Thamboo.  The incumbent liaises with Research Technicians and trainees in the Thamboo laboratory and in the Core Facilities at HLI and Sinus Centre at UBC. The Research Associate supports, trains and provides functional direction to Undergraduate, Graduate, and Postgraduate students as well as other staff working in the lab.   WORK PERFORMED Establish, implement and lead research projects, including designing and performing experiments related to “Unified Airway Hypothesis” and Inflammatory respiratory tract diseases Develop and implement clinical research study protocols, including operational plans, timelines, and logistics for studies involving human participants Manage and coordinate industry-sponsored and basic science collaborative research projects, ensuring alignment with project priorities and timelines Manage the development and improvement of Standard Operating Procedures (SOP) to support the clinical research workflows Design research methodology including questions and approaches for clinical and basic science research projects; critically review the literature on a regular basis Direct the organization, inventory, and maintenance of research data and collected clinical samples Coordinate new infrastructure purchase, delivery and installation; organize calendaring systems for shared infrastructure Analysis and coordinate presentations of complex data in meetings, conferences and publications Lead and perform grant application activities, including searching funding opportunities, preparing and submitting the application packages and leading further communications with collaborators and grant agencies Manage the team research related purchasing and budget and liaise with funding agencies and HLI/UBC staff to coordinate financial reportin Liaise with other academic and industrial collaborators to report on the research project, the milestones, and collection of data Liaise with the Research Ethics Board to write applications, obtain approval for multiple projects, and oversee compliance with approved protocols Advise technical staff and faculty members on experimental techniques, design and SOPs Train undergraduate, Co-Op, and graduate students in performing experiments and provide direction with associated tasks Perform PBMC isolation, RNA extraction (Bulk and ScRNA), and genetic analyses on RNA and DNA samples obtained from human airway specimens Perform flow cytometry and fluorescence activated cell sorting on labelled PBMC or airway cells Maintain and monitor infrastructure required for efficient airway studies Perform and prioritize other research-related responsibilities, as required by the PI WORKING CONDITIONS The position is based in the Sinus Clinic at St. Paul’s Hospital and Dr. Thamboo laboratory within the Centre for Heart Lung Innovation (HLI). CONSEQUENCE OF ERROR/JUDGEMENT The incumbent may have access to confidential data.  The quality of work performed will determine the success of future projects and funding.  Exercising poor judgment and lack of appropriate consultation with research team members and supervisors can adversely affect the viability and validity of research projects or programs, and may compromise the UBC Division’s and Department’s ability to secure grant-based funding for future research projects. SUPERVISION RECEIVED The Research Associate reports directly to the Principal Investigator, Dr. Andrew Thamboo through formal weekly Research meetings, weekly lab group meetings, and other communications. SUPERVISION GIVEN No formal supervision, however the incumbent will train and act as a resource for faculty, staff, and students on specific techniques, procedures and processes. QUALIFICATIONS PhD in Biology, Immunology, Biochemistry, Molecular Biology, or relevant discipline plus a minimum of 3 years’ related experience, or an equivalent combination of training and experience, is required. Up-to-date experience in research performing relevant techniques to “Unified Airway Hypothesis” and airway inflammatory diseases. This includes: Molecular & Protein Analysis: ELISA, multiplex cytokine assays, RT-qPCR, gene expression profiling, Bulk RNA-seq and single-cell RNA-seq, Proteomics, immunoassays, and biomarker discovery Cellular & Immunology Techniques: Flow cytometry and immune phenotyping, Primary airway epithelial cell culture, Air–liquid interface (ALI) models, PBMC isolation and immune cell functional assays, Co-culture and ex vivo tissue models Advanced / High-Tech Approaches: Single-cell multi-omics (scRNA-seq, CITE-seq), Spatial transcriptomics High-dimensional cytometry (CyTOF / spectral flow), High-content imaging and automated microscopy Clinical & Translational Techniques: Human biospecimen processing (blood, sputum, BAL, tissue), Biobanking and longitudinal sample analysis, Inflammatory endotyping and biomarker validation, Patient-reported outcomes and clinical correlation Experience developing study protocols and coordinating clinical and translational research logistics Demonstrated experience contributing to successful competitive grant applications, including proposal development, budget coordination, and submission management Excellent organizational and project management skills with the ability to prioritize multiple projects and meet deadlines deadlines along with an outstanding level of accuracy and attention to detail Ability to exercise tact, discretion and confidentiality  Strong attention to detail and commitment to

Assistant Professor, Computational Oncology and Single Cell Genomics

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Job Category Faculty Bargaining Job Title Assistant Professor, Computational Oncology and Single Cell Genomics Department Black Laboratory | Department of Urologic Sciences | Faculty of Medicine (Peter Black) Posting End Date June 22, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date Ongoing The expected pay for this position is $10,000/month At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career. ​​​​​​   The Department of Urologic Sciences at The University of British Columbia (UBC) invites applications for a full‑time, research focused faculty position in computational oncology at the rank of Assistant Professor, Grant Tenure Track. The Department of Urologic Sciences (DUS), part of the UBC Faculty of Medicine, strives to develop and deliver programs of excellence in key areas of urology. With a robust and active clinical and research faculty, the Department is a leader in education, patient care and research. The successful candidate will also be appointed as Senior Research Scientist in the Vancouver Prostate Centre and Centre for Urologic Oncology of the M.H. Mohseni Institute of Urologic Sciences providing access to cutting-edge facilities and collaborative research networks, opportunities for leadership in translational science, and a vibrant academic community committed to improving patient outcomes through innovation and evidence-based practice. Reporting to the Head of the UBC Department of Urologic Sciences, the successful candidate will develop and lead an independent research program in computational oncology, centred on new quantitative and machine-learning methods that integrate single-cell genomics and spatial profiling to study cancer evolution, therapy resistance, and immune escape in urologic cancers (especially prostate, bladder and kidney cancer). The program will draw on expertise in probabilistic modeling and causal machine learning, phylogenetic and evolutionary inference, clonal dynamics, and immune-tumour interactions, and will emphasize rigorous uncertainty quantification and reproducible, scalable analysis of large multi-omics datasets. The successful candidate will be expected to work closely with clinical and experimental collaborators to translate computational findings into testable hypotheses, biomarkers, and decision-relevant insights. The successful candidate will be expected to participate in the teaching activities of the Department, as well as provide mentorship and training to undergraduate, graduate, and postgraduate learners. The incumbent will also be expected to provide service to the University and broader academic community, including peer review, committee participation, and initiative development. They will work collaboratively across disciplines to advance strategic initiatives for the Department and Faculty. The successful candidate will contribute to fostering an environment that promotes inclusivity and embodies values of respect, integrity, compassion, collaboration, and equity. The successful candidate will have demonstrated evidence of ability in teaching and scholarly activity, and will have PhD in Computational Biology, Bioinformatics, or a closely related field, with a demonstrated focus on quantitative modeling of cancer evolution and clonal dynamics using single-cell whole genome sequencing and/or longitudinal patient or experimental data. Research expertise in causal machine learning, computational modeling, and single-cell multi-omics. Experience modeling mechanism of genome structural dynamics in clinical cohorts of patients with cancer. Proven ability to develop novel computational methodologies, including Bayesian generative models, phylogenetic inference tools, and algorithms for multimodal data integration. Demonstrated history of collaboration with clinicians and experimentalists, including work on patient-linked cohorts or translationally relevant experimental systems. Prior experience teaching computational statistics, Bayesian analysis, and software engineering In addition, the successful candidate will demonstrate a willingness to respect diverse perspectives, including perspectives in conflict with one’s own, and a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion. The expected salary for this position is $120,000 per annum in addition to startup funding. The Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate. At UBC, in addition to a generous benefit package and highly valued pension plan, faculty members also have access to a comprehensive range of leaves, services, resources and career development opportunities. For more information, please visit: https://hr.ubc.ca/working-ubc. An application package should include: a letter of application with a detailed curriculum vitae that addresses (i) scholarly, professional and creative work, (ii) teaching (including summary of academic and/ or clinical teaching), (iii) administrative service and experience fostering collaboration across partners, and (iv) a brief statement of your previous, current or envisioned contributions to advancing anti-racism, equity, diversity, decolonization, Indigenization and inclusion in an academic, professional, or community context; publications record; and three reference letters   Applications should be submitted to: Karen du Plessis Administrative Manager Department of Urologic Sciences, UBC Subject: UBC Recruitment – Assistant Professor in Computational Oncology & Single Cell Genomics Email: dus.hr@ubc.ca Should you have any queries around this position, please contact Karen du Plessis, Admin Manager at karen.duplessis@ubc.ca.   Review of applications will begin on June 22, 2026 and continue until the position is filled. The anticipated start date for this position is November 1, 2026 or upon a date to be mutually agreed. We invite applications from qualified candidates who share our commitment to employment equity and inclusive excellence, and we welcome applications from candidates belonging to historically, persistently, or systemically marginalized groups: Indigenous (First Nation, Métis, Inuit) Peoples, racialized persons, persons with disabilities, women, 2SLGBTQIA+ people, and trans and non-binary people. The University is committed to creating and maintaining an inclusive and equitable work environment for all members of its workforce. An inclusive work environment presumes an environment where differences are appreciated, recognized, and integrated into current structures, planning, and decision-making modes. Within this hiring process we are committed to creating an inclusive and equitable process for all candidates (including but not limited to people with disabilities).  Confidential accommodations are available on request. Please contact Karen du Plessis via email at karen.duplessis@ubc.ca. If you have any questions regarding accommodations or accessibility during the recruitment and hiring

Research Associate-II Hallam Lab

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Job Category Faculty Non Bargaining Job Title Research Associate-II Hallam Lab Department Research | Hallam | Department of Microbiology | Faculty of Science (Steven Hallam) Posting End Date June 26, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date June 30, 2027 The expected salary range for this position is $80,000 – $100,000 per annum. Job Summary:The Department of Microbiology and Immunology at the University of British Columbia’s Vancouver campus is seeking a full-time Research Associate. This position is housed within the Hallam Lab, a highly interdisciplinary research group engaged in transformative science at the interface of microbial ecology, biological engineering, bioinformatics, and sustainability science. The Research Associate-II will play a pivotal role in contributing to active research projects involving large sample collections, environmental genomic library screening, and the design and testing of engineered living materials for wide-ranging industrial applications, while overseeing laboratory operations related to research and training activities to ensure the lab runs safely, efficiently, and in full compliance with institutional requirements.   Organizational Status:The Research Associate-II reports to Prof. Steven Hallam (Principal Investigator) and works closely with the leadership team (Research Associate I and Project Manager), postdocs, students, and other staff.   Key Responsibilities:The Research Associate-II will combine technical expertise with administrative leadership, with responsibilities including:   Research and Scientific Contributions Designing and conducting independent research, contributing to publications, reports, and grant funded research activities within the lab. Supporting active research projects involving large sample collections, environmental genomic library screening, and the design and testing of engineered living materials for wide-ranging industrial applications. Coordinating sample submission and biobanking procedures as well as data access and transfer from outside service providers in collaboration with trainees and other staff. Maintaining collections of samples, constructs, and other biological resources in consultation with the UBC Biobank. Coordinating with external collaborators, core facilities, and service providers to support research and operational activities. Supporting collaborative and legacy projects to preserve and extend the scientific contributions of trainees including graduate students and postdocs. Providing day-to-day leadership and mentorship to students, postdocs, and staff in contemporary lab practices and research techniques. Organizing and hosting weekly laboratory meetings.   Laboratory Leadership and Research Operations Overseeing day-to-day laboratory operations. Monitoring laboratory operations to proactively identify gaps, inefficiencies, or risks, and implement improvements. Ensuring strict adherence to biological and chemical safety regulations. Ensuring alignment of lab operations with departmental and UBC policies and mandates. Maintaining laboratory inventories and developing or updating standard operating procedures for lab protocols and equipment using eLab information management software. Managing ordering and procurement, including timely payment processing, purchase tracking, and communication with vendors regarding technical requirements and shipping. Managing the inventory and life cycle of all laboratory equipment (installation, certification, maintenance, repairs and decommissioning). Administering the laboratory’s operating financial accounts and credit card statements, including monitoring expenditures, reconciling accounts, and supporting budget tracking, in consultation with Project Manager. Organize annual laboratory cleaning events to increase lab safety and efficiency. Coordinating equipment maintenance as indicated by the manufacturer. Implement sustainable practices in the laboratory to reduce waste and environmental impact supporting the UBC 2030 Climate Action Plan. Providing lab access, orientation, and operational support to student design teams including iGEM and BIOMOD design teams. Coordinating on-boarding and off-boarding of personnel, including training, institutional access, protocol compliance, and knowledge transfer of data and research outputs. Coordinating social and team-building activities to foster a positive lab culture.   Consequence of Error/Judgment:Delays or errors in procurement or payment processing may disrupt laboratory experiments and project timelines, affecting the ability to deliver high-quality results on schedule. Failure to adhere to biological and chemical safety protocols could increase safety risks, result in regulatory intervention, and potentially lead to the suspension of laboratory activities. Errors in communication may negatively affect collaboration within the group and harm the reputation of the Hallam Lab.   Supervision Received:The Research Associate II reports directly to Prof. Hallam and works collaboratively with the Project Manager and Research Associate-I to support the strategic alignment of laboratory activities. The position exercises independent judgment within defined areas of responsibility, with guidance from the PI on strategic decisions, financial approvals, and interactions with departmental and other university offices.   Supervision Given:The Research Associate-II provides mentorship to students and postdocs and other staff in operational and technical tasks. The position coordinates laboratory-wide activities and exercises judgment in balancing operational requirements, strategic priorities, and equitable allocation of resources in close collaboration with the leadership team.   Minimum Qualifications: PhD in molecular biology, genetics, environmental microbiology, biological engineering, or other relevant STEM disciplines. Minimum of 6 years of hands-on laboratory experience, including molecular biology techniques. Strong record of research accomplishments. Excellent communication, problem-solving, and organizational skills. Demonstrated ability to work effectively with multidisciplinary teams, senior-level academics, researchers, and university administration. Strong leadership skills, judgment, discretion, and work ethic. Ability to manage multiple processes in parallel while adjusting to contingencies Preferred Qualifications: Self-motivated, detail-oriented, and proactive. Experience developing and maintaining cooperative relationships with multidisciplinary groups and leadership personnel. Knowledge of internal UBC administrative and financial processes. Previous lab management or administrative experience.

Associate Professor, Organoid 3D Cancer Modeling

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Job Category Faculty Bargaining Job Title Associate Professor, Organoid 3D Cancer Modeling Department Department of Urologic Sciences | Faculty of Medicine | Provost and VP Academic (Peter Black) Posting End Date June 26, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date Ongoing The expected pay for this position is $13,333.34/month Associate Professor, Grant Tenure| Department of Urologic Sciences At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career. ​​​​​​   The Department of Urologic Sciences at The University of British Columbia (UBC) invites applications for a full-time faculty position at the rank of Associate Professor, grant tenure. The Department of Urologic Sciences (DUS), part of the UBC Faculty of Medicine, was founded on July 1, 2006. The DUS strives to develop and deliver programs of excellence in key areas of urology. With a robust and active clinical faculty, the Department is a leader in education, clinical care and research. Reporting to the Head of the UBC Department of Urologic Sciences, the successful candidate will lead a research program focused on aging, metabolism, and development of innovative three-dimensional (3D) models of urologic cancers using fresh human tissue, including organoid and stem/progenitor cell-driven approaches. The ideal candidate will also bring recognized expertise in metabolomics to complement these research areas. These models will be used to investigate disease progression, treatment resistance, and enable large-scale drug testing. The successful candidate will be expected to participate in the teaching activities of the Department, as well as provide mentorship and training to undergraduate, graduate, and postgraduate learners. The incumbent will also be expected to provide service to the University and the broader academic and professional community. They will work collaboratively in diverse groups to bring forward strategic initiatives for the Department and the Faculty. The successful candidate will contribute to fostering an environment that promotes inclusivity and embodies values of respect, integrity, compassion, collaboration, and equity. Equity, diversity, inclusion, and justice are essential to academic excellence, as well as to fostering an inclusive community for voices that have been historically underrepresented or discouraged. The successful candidate will have demonstrated evidence of successful teaching and ability to supervise and mentor graduate students, a growing body of productive scholarly activity, and must be willing to participate in the affairs of the Department and the University. They will have: ·         A PhD (or equivalent) in a relevant field. ·         Demonstrated expertise in prostate cancer biology, including aging, plasticity, and metabolism. ·         Experience in developing 3D disease models using fresh human tissue. ·         Experience in academic mentorship and supervision. ·         Preferred qualifications include: ·         A strong publication record and potential for securing external research funding. ·         Experience in collaborative research and interdisciplinary initiatives. In addition, the successful candidate will demonstrate a willingness to respect diverse perspectives, including perspectives in conflict with one’s own, and a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion. The expected salary for this position is $160,000 per annum. The Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate. At UBC, in addition to a generous benefit package and highly valued pension plan, faculty members also have access to a comprehensive range of leaves, services, resources and career development opportunities. For more information, please visit: https://hr.ubc.ca/working-ubc. An application package should include: a letter of application with a detailed curriculum vitae that addresses (i) scholarly, professional and creative work, (ii) teaching (including summary of academic and/ or clinical teaching), (iii) administrative service and experience fostering collaboration across partners, and (iv) a brief statement of your current or previous contributions to advancing anti-racism, equity, diversity, decolonization, Indigenization and inclusion in an academic, professional, or community context; publications record; and names of four arm’s length references Applications should be submitted to: Karen du Plessis Administrative Manager Department of Urologic Sciences, UBC Subject: UBC Recruitment – Associate Professor in Organoid 3D Cancer Modeling Email: dus.hr@ubc.ca Should you have any queries around this position, please contact Admin Manager at karen.duplessis@ubc.ca. Review of applications will begin on June 28, 2026 and continue until the position is filled. The anticipated start date for this position is January 1, 2027 or upon a date to be mutually agreed. We invite applications from qualified candidates who share our commitment to employment equity and inclusive excellence, and we welcome applications from candidates belonging to historically, persistently, or systemically marginalized groups: Indigenous (First Nation, Métis, Inuit) Peoples, racialized persons, persons with disabilities, women, 2SLGBTQIA+ people, and trans and non-binary people. The University is committed to creating and maintaining an inclusive and equitable work environment for all members of its workforce. An inclusive work environment presumes an environment where differences are appreciated, recognized, and integrated into current structures, planning, and decision-making modes. Within this hiring process we are committed to creating an inclusive and equitable process for all candidates (including but not limited to people with disabilities).  Confidential accommodations are available on request. Please contact DUS Administrative Manager, Karen du Plessis via email at karen.duplessis@ubc.ca. ]If you have any questions regarding accommodations or accessibility during the recruitment and hiring process or for more information and support, please visit UBC’s Centre for Workplace Accessibility website at https://hr.ubc.ca/health-and-wellbeing/workplace-accessibility/centre-workplace-accessibility or contact the Centre at workplace.accessibility@ubc.ca. With gratitude, we acknowledge that the University of British Columbia Faculty of Medicine and its distributed programs, which include four university academic campuses, are located on traditional, ancestral and unceded territories of First Nations Peoples and communities around the province. Our Vision: To Transform Health for Everyone. Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both

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