Fixed-term

We are seeking an enthusiastic and motivated Research Assistant to join the laboratory of Dr Herzog at the Cambridge Stem Cell Institute, University of Cambridge, located on the Cambridge Biomedical Campus. This is an exciting opportunity to work at the forefront of epigenomics research. You will play a central role in developing and optimising protocols for nucleic acid extraction for existing and novel technical approaches, including single-cell and long-read methodologies, to study ageing of diverse tissues. Your work will have an impact in shaping how these approaches are implemented within the team, working closely with Dr Herzog as well as internal and external collaborators. We are a friendly and supportive team, and we welcome candidates who enjoy technical challenges, take pride in careful and creative science, and are keen to grow and develop within an ambitious research programme. The post is full-time but applications are welcome from those who would like to work flexibly. An ideal candidate will have a degree in a biological science, experience with DNA and/or RNA extraction from tissues as well as with molecular biology techniques (e.g. PCR). You should have excellent organisational and record keeping skills, be able to prioritise and manage own workload and drive projects forward within agreed plans, as well as have strong written and oral communication skills We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. The closing date for applications is 21 June 2026 The interview date for the role is 03 July 2026 and/0r 06 July 2026 Please quote reference PS49757 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

Advanced mRNA therapeutics offer a powerful way to transiently express proteins that can reshape immune signalling in vivo. This role will focus on designing and manufacturing modified mRNAs encoding proteins that modulate IL-6 signalling, and testing their biological activity in cellular and animal models. We are looking to appoint a Research Assistant to work across mRNA therapeutic design, in vitro transcription, lipid nanoparticle formulation, immune signalling assays and in vivo mouse experiments, with the aim of defining whether engineered mRNA medicines can be used to tune IL-6-dependent immune responses for therapeutic benefit. The successful candidate will be expected to work with a high degree of technical independence across the full experimental workflow: design and production of IVT mRNA constructs, capping and polyadenylation, LNP formulation, in vitro testing of IL-6 pathway activity, and in vivo assessment in mouse models. Candidates must have a degree in a relevant biological science The role requires a strong practical understanding of mRNA therapeutic development, IL-6 biology and animal experimentation, including current UK Home Office personal licence authority and demonstrable expertise in mouse handling. The project will suit a technically skilled and scientifically engaged researcher who can move confidently between molecular biology, immunology and in vivo experimentation, and who is able to generate robust, reproducible data in a fast-moving translational research environment. This position also offers the potential for the successful candidate to study for a PhD alongside their employment (subject to the University Admissions policy). Fixed-term: The funds for this post are available for 3 years in the first instance. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Further information about the Toxicology Unit can be found on our website: https://www.mrc-tox.cam.ac.uk Please quote reference PU49864 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint a Research Assistant to join Prof. Edmund Kinji’s group. A world-renowned centre for research, the MRC MBU is a vibrant community focused on the involvement of mitochondria and their dysfunction in an ever-increasing range of human diseases. Additional information can be found at www.mrc-mbu.cam.ac.uk. The Mitochondrial Carriers group investigates how mitochondrial transport processes contribute to cellular homeostasis and how dysfunction of mitochondrial transport steps lead to disease. A key focus is on Citrin Deficiency (CD), a complex metabolic disorder caused by the absence of dysfunction of the mitochondrial aspartate/glutamate carrier (AGC2 or citrin). Our group uses cellular and murine models to uncover the metabolic consequences of CD, aiming to develop new therapeutic strategies. This post is funded by the Citrin Foundation (https://citrinfoundation.org). This is a fixed-term position available until 31 May 2028. We are seeking to recruit an enthusiastic, well-organised person, who will provide general laboratory support, as well as technical support for breading and management of murine models of Citrin Deficiency, and for mammalian cell culture. The post-holder will contribute to a range of molecular, cellular and organismal assays. Attention to detail and meticulous recordkeeping are key elements for this position. The applicant must be a graduate (BSc/MPhil) in a biomedical scientific subject and have prior practical laboratory experience. Experience in handling animal models would be key, while experience in basic molecular biology techniques is desirable. Applicants should include a CV and cover letter detailing why they are suitable for the position and their experience, along with contact information for three professional referees who can be contacted prior to interview. Informal enquiries about this position should be directed to Dr Sotiria Tavoulari (st632@cam.ac.uk). The University of Cambridge is committed, in its pursuit of academic and research excellence, to a pro-active and inclusive approach to equality, which supports and encourages all under-represented groups, promotes an inclusive culture, and values diversity. The MBU is part of the School of Clinical Medicine, which holds an Athena Swan Silver Award and supports an Academic Women’s Forum. The University particularly encourages women and candidates from Black, Asian and Minority Ethnic backgrounds to apply. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. The closing date for applications is: 21st June 2026 The interview date for the role is: To be confirmed Please quote reference SM49850 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

We are inviting applications for a talented and hard-working Research Assistant to contribute to an exciting Medical Research Council funded translational project with Respiratory Clinician Scientist Dr Akhilesh Jha (https://www.hlri.cam.ac.uk/staff/dr-akhilesh-jha) in collaboration with Professor Clare Bryant (https://www.hlri.cam.ac.uk/staff/professor-clare-bryant) The research project titled “Mechanisms of inflammatory memory in the human respiratory mucosa” will seek to develop unique and innovative human experimental medicine inhaled challenge models for investigating the molecular drivers of immune responses in the lungs of healthy individuals and those with asthma. Further information on the project is available via the UKRI Gateway to Research website: https://gtr.ukri.org/projects?ref=MR%2FY000935%2F1 Recent projects related to the background for this study include: Jha et al, Immunther Adv 2025 (PMID 40201213); Jha et al, JACI 2021 (PMID 32717253); Progatzky, Jha et al, JACI 2019 (PMID 31002833); Jha et al, ERJ, 2019 (PMID 31391224). The project will seek to characterise cellular responses and epigenetic changes that occur in vivo in humans after immune challenge with the Toll-Like Receptor (TLR) agonists and in vitro using primary epithelial cells, as well as co-culture with immune cells such as macrophages. The aim of the research is to develop novel approaches for treating airway inflammation. The work will involve the handling, processing and storing human samples including sputum, bronchoalveolar lavage, respiratory mucosal tissue, epithelial cells and blood. A range of experimental techniques involving primary cell culture including at Air-Liquid Interface (ALI), ELISA, Flow cytometry and preparatory steps for advanced molecular biology tools such as single-cell RNA seq, ATAC-seq and spatial transcriptomics. The position is particularly suited to applicants with experience of handling human samples, molecular biology approaches and tissue culture. They will also contribute to and gain experience in aspects of clinical trials management and will receive training in Good Clinical Practice (GCP) as required (https://www.nihr.ac.uk/career-development/clinical-research-courses-and-support/good-clinical-practice) Candidates are expected to have a BSc or equivalent degree. The position will be based in the Heart and Lung Research Institute (HLRI) (https://www.hlri.cam.ac.uk/) at the core of the Cambridge Biomedical Campus as well as in the NIHR Cambridge Clinical Research Facility (https://www.cambridgecrf.nihr.ac.uk/) based in Cambridge University Hospitals NHS Foundation Trust. Applicants will be expected to work collaboratively and flexibly with colleagues and contribute to a positive, friendly and dynamic research environment. Fixed Term: Funding is available for this position until 27th August 2028. Informal enquiries are welcome and can be sent to Dr Akhilesh Jha (aj580@cam.ac.uk). Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. This appointment also requires a Research Passport application. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Please quote reference RC49804 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

This is an exciting opportunity to work on a GSK-funded, cross-disciplinary project led by Professor Clare Bryant to develop advanced human respiratory epithelial models for Chronic Obstructive Pulmonary Disease (COPD). The successful candidate will join the Cambridge- GSK Translational Immunology Collaboration (GC-TIC), a new translational initiative between Cambridge and GSK focused on renal and respiratory diseases of high unmet medical need. CG-TIC aims to deliver impact to patients while advancing the GSK pipeline and supporting research in Cambridge. This role will contribute to our ongoing research on mechanisms of Chronic Obstructive Pulmonary Disease (COPD). COPD remains an incurable, progressive respiratory disease characterized by persistent airflow limitation and chronic airway inflammation. Historically, the development of effective therapeutics has been constrained by a lack of biomimetic, multi-cellular human models. To address this challenge, you will join a highly collaborative, transdisciplinary team in the lab of Prof. Clare Bryant, comprising biological, medical, and physical scientists dedicated to advancing our customized organ-on-a-chip platforms. Based in the VPD-Heart and Lung Research Institute, located on the Cambridge Biomedical Campus, the ideal candidate will have experience of air-liquid interface culture of primary airway epithelial cell culture models as well as advanced molecular biology skills (CRISP/Cas9 gene editing). We seek a collaborative team player who shares our passion for biomedical discovery and is eager to embrace an integrative scientific challenge with the genuine potential to advance COPD treatment. Informal enquiries regarding this position are welcomed: please contact Prof. Clare Bryant (ceb27@cam.ac.uk). Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Please quote reference RC49883 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

We are seeking an experienced and motivated researcher to work on a Cambridge-GSK Translational Immunology Collaboration (CG-TIC) project. CG-TIC is a new translational initiative between Cambridge and GSK focused on renal and respiratory diseases. It will leverage the world-class capabilities of Cambridge and GSK, targeting diseases of high unmet medical need, with the aim of delivering impact to patients while advancing the GSK pipeline, and supporting research in Cambridge. The successful applicant will be part of the Respiratory Mechanisms of Disease theme and will join the research group of Professor James Nathan, based in the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID) on the Cambridge Biomedical Campus, in collaboration with Professor Michal Minczuk at the MRC Mitochondrial Biology Unit. You will also be part of the CG-TIC and will join a growing team of researchers supporting this collaboration. The work will investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to chronic inflammation in Chronic Obstructive Pulmonary Disease (COPD), using a primary human airway air¿liquid interface (ALI) platform. A central aim is to define how mitochondrial metabolic dysfunction shapes innate immune responses, and to identify the molecular mechanisms by which damaged mtDNA is sensed by the innate immune system. This programme is a close collaboration between the Nathan Laboratory and the Minczuk Group, combining expertise in mitochondrial metabolism and innate immunity with state-of-the-art mitochondrial genome engineering tools, and is conducted in partnership with GSK. The ideal candidate will have a strong background in mitochondrial biology, cell metabolism, or innate immunology, with hands-on experience of primary human cell culture and quantitative molecular biology. Experience with approaches to assess mitochondrial function, mtDNA biology, or innate immune signalling pathways is highly desirable, as is familiarity with genomics or sequencing-based methods. A collaborative outlook and the ability to work effectively across a large academic¿industry partnership, including with the Minczuk Group, GSK, and other CG-TIC researchers, will be essential to success in this role. Informal enquiries regarding this position are welcomed: please contact Prof. James Nathan (jan33@cam.ac.uk). Fixed-term: The funds for this post are available for 2 years in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. The closing date for applications is: 5th July 2026 The interview date for the role is: To be confirmed Please quote reference RC49887 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now