Fixed-term

The Opportunity: We are looking for a skilled and motivated postdoctoral researcher to investigate the causes and consequences of sex-differences in recombination rates and landscapes. The award holder will integrate whole-genome, single-cell, and gamete-sequencing approaches from house sparrows in Helgeland in Norway, to understand fine-scale individual variation in recombination, the sex-specific genetic architectures associated with functional variation, and impacts of recombination on individual fertility. The award holder will join Susan Johnston’s lab in the dynamic Institute of Ecology and Evolution, University of Edinburgh, as part of a project funded by the Natural Environmental Research Council (NERC). Applicants must have a PhD (or to be completed in 3 months) in population genetics, quantitative genetics, and/or bioinformatics. The post requires experience in genomic analyses, creativity in problem solving, and strong communication and organisational skills. An understanding of the biology of meiotic recombination and inference methods using sequence and/or pedigree-based approaches is desirable. An overview of the laboratory can be found here: https://sejohnston.com/ and questions should be directed to Susan.Johnston@ed.ac.uk This post is full-time (35 hours per week). View the full job description How to Apply: Please include the following documents in your application: – CV – Cover letter As a valued member of our team, you can expect:  •    A competitive salary.  •    An exciting, positive, creative, challenging and rewarding place to work.  •    To be part of a diverse and vibrant international community. •    Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page and use our reward calculator to discover the value of your pay and benefits. Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages (opens new browser tab). The University may be able to sponsor the employment of international workers in this role.  This will depend on a number of factors specific to the successful applicant.  Key dates to note The closing date for applications is 03.07.2026 Unless stated otherwise the closing time for applications is 11:59pm UK time. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone. Interviews will be held online the week of 13.07.2026 Apply Now

Job Description Grade UE07 £41,064 – £48,822 per annum CSE / Institute of Quantitative Biology, Biochemistry and Biotechnology / School of Biological Sciences Full Time: 35 hours per week Fixed term: 24-months The Opportunity An exciting opportunity to join the lab of Stephen Wallace and research at the interface of biology and chemistry is available. We are seeking highly motivated postdoctoral researchers to develop novel, sustainable and circular biomanufacturing methods. You would become part of a large multidisciplinary friendly team, working as part of a multinational consortium with access to world-class facilities.  Specifically, the candidate would be optimising microbial strains for production of rubber monomers and develop upstream and downstream methods for increased yield of volatile chemicals from sustainable feedstocks.  We value colleagues with drive, determination and a passion for what they do. We are a place where everyone is welcome and offer a range of policies and benefits designed to support you in building the right meaningful flexibility that works for you. A career with us has a range of other benefits that can be tailored to your lifestyle:  Opportunities to develop new skills and broaden your experience  Leading-edge research  Variety every day  Responsibility and autonomy  Excellent benefits and support  This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. We are also open to considering requests for hybrid working (on a non-contractual basis) that combines a mix of remote and regular on-campus working.  View the full job description (opens in a new browser tab)  How to apply Please include the following documents in your application:  – CV  – Cover letter  – Two academic references   As a valued member of our team, you can expect:  A competitive salary.  An exciting, positive, creative, challenging and rewarding place to work.  To be part of a diverse and vibrant international community. Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page(opens in a new tab) and use our reward calculator to discover the value of your pay and benefits.  Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also a Stonewall Proud Employer, actively promoting LGBTQ+ equality.  We welcome applications from all qualified candidates  Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages (opens new browser tab) On this occasion the University will not consider applicants requiring sponsorship for this role. International workers will therefore only be able to take up this role if they can demonstrate an alternative right to work in the UK.  Key dates to note The closing date for applications is 29th June 2026. Unless stated otherwise the closing time for applications is 11:59pm UK time. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.    Apply Now

Details Parkinson’s disease is the fastest-growing neurodegenerative disorder, with cases projected to more than double by 2050. No disease-modifying treatment strategies exist to date, and mechanistic insights are urgently needed. This PhD studentship, hosted at University College London (UCL), aims to answer how alpha-synuclein (α-syn) condensates affect synapse biology and trigger early neuronal pathology. Biomolecular condensates are dynamic compartments that assemble through phase separation and have recently been implicated in many processes of cellular organisation, such as at the synapse. Importantly, they are one of the first steps when molecular dysfunction may occur, preceding pathological protein aggregation and neurodegeneration. Leveraging recent discoveries from the host lab on the regulation of α-syn condensates by the presynaptic protein VAMP2, the research programme will focus on the role played by α-syn condensates in the organisation and function of synapses and their contribution to the progression of Parkinson’s disease.  Research Aims and Approach This project integrates advanced human neuronal models, genome engineering, and cutting edge imaging to interrogate α-syn biology at unprecedented resolution. The student will: • Dissect the functional consequences of α-syn condensate formation: Using CRISPR/Cas9 genome editing, a suite of engineered human iPSC lines will be generated to enable precise molecular tracking and manipulation. • Model synaptic dysfunction in human neurons: Differentiation into cortical and dopaminergic neurons will allow interrogation of disease-relevant cell types. • Integrate collaborative approaches: The project will leverage collaborations with experts in synaptic biology, imaging and Parkinson’s disease within UCL and across partner institutions.  Training Environment Through this studentship, the candidate will have access to the highly renowned and multidisciplinary research environment at UCL. The candidate will be able to collaborate with specialists in single-molecule microscopy, synaptic function, and neurodegenerative disorders, among other disciplines, such as biophysics. Candidate Profile Applicants should hold, or expect to obtain, a first-class or high upper second-class Master’s degree (or equivalent) in neuroscience, biochemistry, or a related discipline. A strong interest in synaptic biology, and molecular mechanisms of disease is essential. Experience with iPSC-derived neurons, genome editing, or advanced imaging is advantageous but not required; intellectual curiosity, technical ambition, and a drive to make meaningful contributions to the field are paramount.  Applicants should send their CV and personal statement to biosciences.pgr.admin@ucl.ac.uk using the reference – Lautenschlager Lab PhD 2026 AND complete the UCL application form: https://www.ucl.ac.uk/prospective-students/graduate/research-degrees/neuroscience-physiology-and-pharmacology-mphil-phd Applications are invited for an October 2026 or February 2027 start. Interviews will be held in the week 27th July. For specific project related question please email: j.lautenschlaeger@ucl.ac.uk For application related question please email: biosciences.pgr.admin@ucl.ac.uk Funding Notes This funded PhD studentship is supported by the Royal Society and UCL and includes: A competitive tax-free stipend A contribution to Home tuition fees Access to research and training support  References Agarwal, A.; Chandran, A.; Raza, F.; Ungureanu, I.-M.; Hilcenko, C.; Stott, K.; Bright, N. A.; Morone, N.; Warren, A. J.; Lautenschläger, J. VAMP2 Regulates Phase Separation of α-Synuclein. Nat. Cell Biol. 2024, 26 (8), 1296–1308. https://doi.org/10.1038/s41556-024-01451-6.Chandran, A.; Agarwal, A.; Wang, T.; Amaral, L.; Chaves, S. R.; Outeiro, T. F.; Lautenschläger, J. Dual Effect of α-Synuclein Disease Variants on Condensate Formation. bioRxiv 2025, p 2025.06.06.657340. https://doi.org/10.1101/2025.06.06.657340. Under revision, Nat Commun Apply Now

Applications are invited for a Postdoctoral Research Associate position to work on a NERC-funded project investigating the evolutionary dynamics of virus resistance in wild animal populations. The post will be based in the Pathogen Dynamics Unit within the Department of Genetics at the University of Cambridge and be co-supervised by Professor Frank Jiggins and Professor Henrik Salje in collaboration with Prof Jon Slate at the University of Sheffield and Dr Joel Alves at the University of Oxford. The Pathogen Dynamics Unit at the University of Cambridge consists of 15-20 researchers at different stages of their career using experimental, mathematical and computational research to help our understanding of how pathogens spread in populations. This post will work closely with the Slate group, which uses genomics approaches to study the evolution of quantitative traits. The project will consist of the analysis of data from a population of wild rabbits in Australia that have been followed and sampled regularly for 25 years. During this period there have been regular outbreaks of Rabbit Haemorrhagic Disease Virus (RHDV), a highly contagious, often fatal virus. This project will use advanced quantitative genetics and epidemiological modelling to explore the evolution of resistance in the rabbit population and coevolution with the virus. This will include analysing several thousand host genomes from the 25-year period allowing us to investigate the evolution of host immunity from a quantitative genetic perspective. The project promises to provide fundamental insight into our understanding of disease ecology and evolution by exploring the interplay between host immunity and virus across long timeframes. The applicant will have strong quantitative skills. The project will require the development of computationally intensive models and analysis of large genomic datasets, and therefore applicants should have experience in coding and a good understanding of probability, likelihoods and Bayesian analysis. Key responsibilities: Develop models that integrate different data types (e.g., serology, epidemiological data, genomic data, demography) to understand the immune dynamics. Applying quantitative genetics approaches to a wild population. Analysis of genomic data. Write-up findings in manuscripts Work with study partners and researchers generating genomic data in the laboratory Present findings at conferences, external and internal meetings Be an active member of the Pathogen Dynamics Unit, including contributing to wider group discussions Supervision of students/Interns working in support of the research group The position is offered on a fixed term basis for an initial period of 12 months in the first instance to start from September 2026 or later, subject to negotiation at interview stage. Please note, the role will require periods of time at Institut Pasteur (Paris, France), where Professor Salje will be partially based from September 2026. The timing and duration of these research visits is flexible and will be agreed with the successful applicant. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Informal enquiries are welcomed and should be directed to Professor Frank Jiggins fmj1001@cam.ac.uk Please quote reference PC49820 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

Applications are invited for an enthusiastic and highly motivated Postdoctoral Research Associate to join the laboratory of Professor Amanda Sferruzzi-Perri in the Department of Physiology, Development and Neuroscience (PDN) at the University of Cambridge. The Sferruzzi-Perri Laboratory investigates the aetiology of pregnancy complications and the regulation of fetal and placental development within broader physiological and environmental contexts. The group employs integrative approaches, combining environmental mouse models and human pregnancy studies with advanced molecular, cellular, and physiological techniques. The Role The successful applicant will join a team investigating the maternal gut¿placental¿fetal axis in the context of gestational Environmental Enteric Dysfunction (EED). This project aims to address a significant knowledge gap using novel mouse models of gestational EED and by testing innovative biotherapies designed to mitigate adverse pregnancy outcomes. The research will integrate in vivo physiological assessments with structural, functional, and molecular analyses of tissues to determine how maternal intestinal dysfunction influences fetal development through gut-derived metabolic and inflammatory signals acting on the placenta. About You Applicants should hold, or be close to completing, a PhD in a relevant field, with a strong background in pregnancy and/or metabolic physiology research. You will have: A proven track record of research productivity, with the ability to lead and complete complementary projects independently. Experience with malnutrition, immune activation, and/or infection-based mouse models. A strong understanding of inflammation, metabolic pathways, and pregnancy physiology. Expertise in rodent experimentation techniques, including in vivo Doppler ultrasound and metabolic assays. Experience with advanced molecular approaches, including transcriptomic, proteomic, and metabolomic analyses. Skills in bioinformatics, histological analysis, and the integration of complex multi-modal datasets. Please see the Further Particulars for more information. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant, moving to Research Associate upon confirmation of your PhD award. Fixed-term: The funds for this post are available for 18 months in the first instance. Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. To apply for this post, please submit a CV and a motivation letter detailing why you want to be part of this project and how your knowledge, skills and experience match the requirements of the role. Please also describe what you would bring to the group and why this post would be an ideal fit for your career plan. We also need the contact details for two people who can provide a professional reference, one of which should be your most recent line manager. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form. Closing date: midnight on 28th June 2026. Please quote reference PM49745 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

Applications are invited for a Research Assistant or Assistant/Associate role in the lab of Dr. Heather Machado, jointly in the Departments of Pathology and Genetics, University of Cambridge. Appointment will be made on the basis of successful candidate’s experience and education. The Machado Lab studies how tumour and immune cells co-evolve during cancer progression. We combine approaches from evolutionary genetics with single-cell genomic, transcriptomic and multiomic datasets to address fundamental questions in cancer immunology, including when anti-tumour immune responses arise, how inflammation reshapes those responses, and how immune cells evolve during immunotherapy. We are seeking a computational biologist or genomicist to analyse single-cell genomic and transcriptomic datasets to investigate the somatic evolution of T cell responses to cancer. The successful applicant will have experience analysing genomic and/or multiomic data, along with excellent written and oral communication skills, strong organisational skills, and the ability to work both independently and collaboratively in a multidisciplinary environment. Relevant analytical approaches may include variant calling, artefact filtering, mutational signature analysis, phylogenetic inference, mutational timing analysis, and selection analysis. Fixed-term: The post is available for one year in the first instance starting September 2026 or as soon as possible thereafter and subject to a 6-month probationary period. Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. Please ensure that you upload your Curriculum Vitae (CV), a motivation letter detailing project and career development plans and include a publications list in the upload section of the online application. Please provide contact details, including an email address for two referees. At least one of your referees should be someone who is familiar with your work in your primary research field. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application. Appointment at the Research Associate level is dependent on the award of a PhD. Those who have submitted but not yet received their PhD will be appointed at the Research Assistant level, Grade 5 (£34,610- £35,608), which will be amended to Research Associate, Grade 7 (£37,694- £46,049) once the award of the PhD has been confirmed. The Department of Pathology is a very active research and teaching department in the School of Biological Sciences. We offer modern laboratory spaces, flow cytometry, imaging, histology, proteomics and sequencing facilities in the centre of Cambridge. We host an external seminar series as well as internal talks, journal clubs, and a Departmental annual symposium. There are approximately 40 research groups spanning a wide array of disciplines, including infectious and genetic diseases, immunology and cancer biology. Additional information can be found at https://www.path.cam.ac.uk/research We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our Department. Informal enquiries and requests for further information are very welcome and should be addressed to Dr Heather Machado hem48@cam.ac.uk. If you have any queries regarding the application process, please contact: hr@path.cam.ac.uk Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please quote reference PK49372 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now

We are looking for a motivated and skilled Research Assistant to join Dr Herzog’s laboratory at the Cambridge Stem Cell Institute, University of Cambridge, located on the Cambridge Biomedical Campus. You will play a central role in an exciting research programme focused on epigenetics and ageing, contributing to cutting-edge research involving innovative haematopoietic stem cell (HSC) cultures, gene editing, and the establishment of standardised workflows in close collaboration with our research partners. This role offers a unique opportunity to shape the technical foundations of a growing research programme in stem cell biology and gene therapy within a collaborative and supportive research environment. We are a friendly and supportive team, and we welcome candidates who enjoy technical challenges, take pride in careful and creative science, and are keen to grow and develop within an ambitious research programme. The post is full-time but applications are welcome from those who would like to work flexibly. An ideal candidate will have a degree in a biological science, experience primary cell culture, including stem or progenitor cells, as well as molecular biology techniques and CRISPR-based gene editing. You should have excellent organisational and record keeping skills, be able to prioritise and manage own workload and drive projects forward within agreed plans, as well as have strong written and oral communication skills. We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. The closing date for applications is 21 June 2026 The interview date for the role is 03 July 2026 and/0r 06 July 2026 Please quote reference PS49758 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply Now