Fixed-term

Do you want to contribute to top quality medical research? The Department of Laboratory Medicine consists of seven divisions that conduct both research and teaching. The department is involved in cutting-edge research in both basic and applied fields. All divisions work in close collaboration with clinics at Karolinska University Hospital. The department’s educational activities contribute to numerous programs and courses within KI’s overall educational offerings. The Division of Clinical Physiology is now seeking a postdoctoral researcher for a fixed-term (full-time) position for approximately 7 months. Your mission Currently there are over 12 million cancer survivors in Europe alone and numbers are still increasing, many cancer survivors suffer from persistent disease and treatment related side effects. We and others have shown that physical activity after a cancer diagnosis leads to maintained physical functioning and quality of life. In addition, epidemiological and animal-model based evidence support the role of exercise to enhance therapeutic efficacy, reduce recurrence and improve survival. In a recent publication, we showed that the immune system, and especially CD8+ T-cells, are instrumental for the anti-neoplastic effects of exercise. The project is part of a HEU supported exercise intervention RCT for patients with cancer. Specifically, the focus of the project will be on linking exercise induced changes in immune function to side effects, disease progression and therapeutic response. To accomplish this, practical flow cytometry and omics analyses will be combined with computer based and prediction machine learning models. The applicant will have access to RCT data, state of the art human exercise facilities, and preclinical labs in an innovative and translational environment. Your profile To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier. We are looking for a candidate with documented experience in data analysis from clinical trials. Previous experience with human physiological assessments, multi-color flow cytometry and functional characterization of immune cells are key requirements. A keen interest in translational science and the ability to interact effectively and work productively in a interprofessional team as well as a good ability to communicate in English is required. Previous teaching experience in statistical analyses is considered a merit. Emphasis will be placed on personal skills, knowledge, and abilities, as well as on documented previous work. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. Location: [Solna, SÖS, Danderyd or Flemingsberg] Application An employment application must contain the following documents in English or Swedish: PhD certificate A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) The application is to be submitted through the Varbi recruitment system. Apply Now

Do you want to contribute to top quality medical research? Overview of the Position The Strategic Research Programme in Diabetes (SRP Diabetes) at Karolinska Institutet is funding a prestigious fellowship programme for postdoctoral research fellows. The Programme is focused on research in diabetes and its comorbidities. With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. As part of this programme, we are looking to recruit 5 outstanding postdoctoral research fellows. Full details on each project and contact information to the PIs can be found at: http://ki.se/en/srp-diabetes/postdoctoral-fellowships Based at Karolinska Institutet, fellows will undertake a cutting-edge research project in a competitive lab and be part of the SRP Diabetes dynamic research environment where several events will be held throughout the year such as high-profile lectures, symposia, internal retreat, etc. giving the fellows lot of opportunities to make new connections both within Karolinska Institutet and internationally within the field of diabetes and metabolism. The fellowships are fully funded, and salary is provided for a 2-year period. It is our intention that the positions will start in the fall 2026, though some flexibility with the start date might be possible. Short running title of project: mTORC1 signalling in insulin resistant human skeletal muscle Research Project: “Mechanistic dysregulation of insulin responsive mTORC1 signalling in insulin resistant human skeletal muscle” Insulin resistance in skeletal muscle is a core defect in type 2 diabetes, resulting in reduced glucose disposal and hyperglycaemia. Insulin resistance is also linked to altered muscle remodelling, reduced metabolic flexibility, and impaired adaptation to diet and exercise. We have recently taken an unbiased approach to deconvolute insulin signalling in skeletal muscle. Specifically, we  applied deep proteomics and phosphoproteomics in human skeletal muscle during fasting and during hyperinsulinaemic euglycaemic clamps in a large, well phenotyped cohort across the insulin sensitivity spectrum. Strikingly, a key and unexpected pattern emerged. Several insulin-stimulated mTORC1 substrates tracked tightly with insulin sensitivity, whereas many AKT substrates remained insulin responsive even in insulin resistant muscle (Cell, 2025). This points to selective uncoupling of insulin signalling to mTORC1 rather than global proximal insulin signalling failure. Thus the aim of this post-doctoral project is to Define an insulin responsive mTORC1 signature in human skeletal muscle across insulin sensitivity. Identify upstream regulators reducing mTORC1 signalling in insulin resistance Test causality in primary human skeletal muscle cells from insulin sensitive and insulin resistant donors. mTORC1 is a central integrator of insulin, nutrients, growth factors, energy status, and cellular stress. It controls translation initiation, ribosomal biogenesis, autophagy, and aspects of intermediary metabolism. In skeletal muscle, mTORC1 also contributes to protein turnover and thus to muscle quality and function. In insulin resistant states, mTORC1 may be altered in two nonexclusive ways. First, insulin may fail to engage mTORC1 due to impaired coupling between AKT and the TSC complex, altered RPTOR based scaffolding, or altered localisation of the complex. Second, stress and nutrient sensing inputs may dominate over insulin input, shifting the operating point of the pathway. In vivo data from human studies that resolve these possibilities are scarce. One of mTOR’s key roles is to regulate protein synthesis. Interestingly we have recently identified reduced expression of TMEM9-AS1 in skeletal muscle from people with type 2 diabetes, a lncRNA that appears necessary for adequate protein synthesis. Key responsibilities of the selected applicant:  Plan, manage and conduct an agreed academic research project and associated activities. Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. Develop research questions, analyse detailed and complex qualitative and/or quantitative data from a variety of sources, and contribute original ideas for new research projects. Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the Principal Investigator. Adapt existing and develop new scientific techniques and experimental protocols to support research. Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews. Formally present your research and represent the research group at internal, national and international conferences and meetings, either with other members of the team or alone. Informally present your research to the group at established meetings. Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques. Selection Criteria Essential  A PhD in a medical/biological subject (to be completed at the latest at the time of the employment decision). The ability to manage your own academic research and associated activities. Excellent team working and collaborative abilites Ability to contribute ideas for new research projects and research income generation. Ability to work with meticulous attention to detail. An enthusiastic interest in diabetes research. Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community. Strong verbal and written communication skills in English. A conscientious and enthusiastic working approach. Excellent planning, organizational and problem-solving skills. Meritorious A strong CV, having published in high impact journals and presented at international meetings. Experience of cell biology and signalling is a merit Each Fellowship is for two years. To be eligible for employment as a post-doctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample

Do you want to contribute to top quality medical research? The Integrative Physiology research group at the Department of Molecular Medicine and Surgery at Karolinska Institutet is seeking a highly motivated research assistant to join the group of Professors Juleen R. Zierath and Anna Krook. The research is focused on translational studies on cellular and molecular mechanisms underlying insulin resistance and type 2 diabetes and the positive effects of physical exercise on glucose and lipid metabolism in skeletal muscle. The candidate will join our research group to explore the molecular signal transducers involved in the regulation of glucose transport and to test therapies to restore glucose uptake in skeletal muscle from people with type 2 diabetes. The employment is limited to 1 year. Your mission The candidate will work on understanding skeletal muscle metabolism, with a focus on changes in lipid metabolism. The candidate will join an enthusiastic, collaborative, hardworking and dynamic team. Your profile For this position we are seeking someone witha completed degree in biomedicine/human physiology or medicine. A masters degree in a relevant subject is a merit. Expertise and research experience in the study of cellular metabolism is desired. This includes experience in metabolomics, lipidomics and cell and molecular biology. Expertise and experience in culturing and handling of primary cultures of skeletal muscle, rodent animal handling, with a focus on skeletal muscle is desired. The candidate must be fluent in English, have excellent writing skills and be able to take the lead on projects. Ability to work well in a team is an essential requirement. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site. Location: Solna Application KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T. The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.  Apply Now

Do you want to contribute to improving human health? The Department of Laboratory Medicine at Karolinska Institutet consists of seven divisions and is active in many areas of laboratory medicine to advance human health in both the short and long term. The department has close collaboration with Karolinska University Hospital and conducts advanced basic, clinical, and epidemiological research. It is one of the largest educational departments at Karolinska Institutet. The Division of Clinical Immunology is currently seeking a highly ambitious and motivated postdoctoral researcher to join the research group led by Dr. Sidinh Luc. The research group investigates fundamental mechanisms regulating hematopoietic stem cell (HSC) function and heterogeneity, transformation of normal HSCs into leukemic stem cells and cellular and molecular drivers of leukemia development. The research integrates experimental models, human patient samples, and advanced sequencing technologies, with the aim to bridge basic biology with clinical translation. Your mission  As a postdoctoral researcher you will be responsible to drive research projects with the aim to unravel the mechanisms of leukemia development from diverse hematopoietic stem cells. You will work with animal models including transplantation experiments, human patient samples, high-throughput sequencing and omics approaches, as well as performing some bioinformatics analyses. Success in this role requires a strong desire and curiosity to explore basic research questions with translational potential. You are expected to contribute actively and positively to the research environment through collaboration, engagement, and supervision of students. Entry requirements The candidate applying must have a PhD degree in biomedicine, molecular medicine, molecular biology, gene technology, immunology, stem cell biology or a related discipline. Expertise in some of the following areas is required: experimental hematology, transplantation models, advanced flow cytometry, sequencing based molecular biology (“omics”) and bioinformatics. Emphasis will be placed on personal suitability and compatibility with lab members and the overall research group. Applicants must have excellent communication skills in English, be able to work independently in a self-driven manner, while being able to work collaboratively within the research group. Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site. Location: Flemingsberg Campus, Huddinge Type of scholarship The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable. Choose to work at KI – Ten reasons why Sidinh Luc research group Application process An application must contain the following documents in English or Swedish: A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) Contact details to two references The application is to be submitted on the Varbi recruitment system. Apply Now

Do you want to contribute to top quality medical research? Our group at the Division of Neurogeriatrics, Karolinska Institutet, study how mitochondrial function and dynamics influence early disease mechanisms in Alzheimer’s disease. Our team combines advanced cell biology, super-resolution imaging, and in vitro and in vivo models to better understand how brain energy metabolism fails during neurodegeneration. By joining our group, you will gain hands-on experience with cutting-edge neuroscience research in an international and collaborative environment. The position is a full-time fixed-term employment for two years, with a possibility of extension. Your mission This project aims to generate a spatially resolved map of mitochondrial functions, network organization, and dynamics in a 3D model of Alzheimer’s disease. Our ambition is to identify key events that regulate and precede mitochondrial decay during neurodegeneration. The project combines 2D and 3D cell culture systems, confocal and super-resolution live imaging microscopy, high-resolution respirometry, and deep learning-based image analysis. You will be involved in experimental work, data analysis, supervision of junior researchers, and grant writing, while contributing to the collaborative scientific environment of the group. Your profile We are seeking a highly motivated and team-oriented postdoctoral researcher with a background in neuroscience and a strong interest in mitochondrial biology. The successful candidate must have documented experience in advanced fluorescence imaging, including confocal and/or super-resolution microscopy of mitochondria and other relevant organelles such as lipid droplets and lysosomes. Experience with primary neural cultures, brain organoid systems, and image analysis is essential. Strong computational and coding skills are also essential, particularly for microscopy image analysis and handling large datasets. Proficiency in programming languages such as Python or R is expected, and experience with deep learning–based image analysis approaches is highly desirable. The candidate is expected to work independently, perform experiments and data analysis, and actively contribute to the scientific development of the group. Participation in supervision and collaborative projects is also expected. Training in laboratory animal science according to FELASA guidelines (or equivalent) is required. Fluency in written and spoken English is mandatory. To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier. What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. Location: We are located in BioClinicum, KI-Campus Solna. Application An employment application must contain the following documents in English or Swedish: PhD certificate A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) The application is to be submitted through the Varbi recruitment system. The evaluation of applications and recruitment process will begin after the summer break. Apply Now

Do you want to contribute to top quality medical research? We are recruiting a Research Assistant with strong wet- and dry-lab experience in spatial omics, genomics, tissue biology and method development to join Emma Andersson Lab at Karolinska Institutet. You will work at the interface of developmental biology, disease modelling, regeneration, and spatial multiomics methods development, helping to understand how genetic perturbations alter organ development, tissue architecture and cellular identity. The position offers the opportunity to contribute to projects focused on inner-ear development, regeneration and disease-relevant tissue remodelling. You will work closely with experimentalists, computational biologists, core facilities and clinical collaborators, and contribute to the development and application of state-of-the-art single-cell, spatial and multimodal technologies. Your mission You will contribute experimentally and computationally to projects aiming to understand how developing organs acquire their correct cellular identities and architectures, and how these processes are altered in congenital disease, injury, aging and regeneration. Key duties include:  Processing, quality control and analysis of spatial transcriptomics, imaging-based transcriptomics, single-cell/single-nuclei RNA-seq, and possibly mass spectrometry, mass spectrometry imaging and related datasets.  Contributing to developing new spatial and single-cell/single-nuclei multi-omics approaches that connect tissue morphology, gene expression and molecular phenotypes, including integration of spatial transcriptomics with lineage tracing and potentially mass-spectrometry-based readouts. Developing, adapting and troubleshooting experimental workflows for tissue-based omics, including work with mouse models, organoids, CRISPR-engineered cell systems and/or patient-derived material.  Performing data analysis and visualization using R and Python, and working with clinical collaborators to interpret the results.  Supporting reproducible analysis workflows, documentation, data management and preparation of figures, reports, manuscripts and grant material.  Interacting with core facilities and external collaborators, including clinical collaborators.   Your profile Requirements: MSc or PhD (near completion is sufficient) in biotechnology (or closely related). Documented experience with next-generation sequencing technologies, such as single-cell or single-nuclei RNA-seq, spatial transcriptomics and long-read sequencing. Experience with spatial transcriptomics platforms such as Visium, Visium HD, Xenium, RNAscope or related technologies. Ability to analyse biological data independently using R and Python. Excellent collaborative skills and ability to work across wet lab, dry lab, core facilities and clinical/translational environments. Good written and spoken English.  Meriting (strongly advantageous): Medical degree or proven experience in translational research. A strong interest in developmental biology, organogenesis, disease mechanisms, regeneration and/or translational tissue biology. A strong interest in bridging experimental biology, computational analysis and medically relevant disease questions. Experience with one or more of the following: exome sequencing, long-read sequencing, LC-MS, mass spectrometry imaging, cell sorting, flow cytometry, histology and digital pathology. Experience developing, optimizing or troubleshooting new experimental protocols for spatial or single-cell/single-nucleus multi-omics technology development. Experience preparing publication-quality figures, manuscripts, protocols, patents or collaborative reports.  What do we offer? A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site. Location: Solna Application KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T. The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.  Apply Now

Do you want to contribute to top-quality medical research? Do you want to be part of developing next-generation models to understand the development, function and diseases of the skeleton and joints? At the Growth and Cartilage Biology Group at the Center for Molecular Medicine (CMM), Karolinska Institutet, we are looking for a postdoctoral fellow with solid experience in advanced in vitro studies of bone and cartilage cells. You will be part of an international and dynamic research environment with strong national and international collaborations and the opportunity to conduct cutting-edge research in skeletal biology and regenerative medicine. Your role Our research aims to understand the molecular and cellular mechanisms that regulate skeletal growth, cartilage development and tissue homeostasis, as well as how these processes are affected in genetic skeletal diseases and degenerative joint diseases. As a postdoctoral fellow, you will have a leading role in projects that focus on: Development and use of advanced in vitro models for bone and cartilage formation. Studies of stem cell differentiation into chondrocytes and osteoblasts. Analysis of mechanotransduction and cellular mechanosensing in skeletal and cartilage tissue. Establishment and optimization of 2D and 3D cell culture systems, organoid models and biomaterial-based models. Molecular and cellular characterization using modern methods in cell biology, molecular biology and omics technologies. Planning, implementation, analysis and presentation of research results and supervision of students and junior researchers. You are expected to run your own research projects while working closely with other members of the research group and our national and international partners. Who are you? To be employed as a postdoctoral researcher, a doctoral degree or equivalent foreign degree is required. The degree must be completed no later than the time the employment decision is made. It is an advantage if the doctoral degree has been completed within the last three years. We are looking for a highly motivated and independent researcher with: Claim Doctoral degree in cell biology, developmental biology, tissue engineering, biomedicine or a related field. Documented experience in culturing and characterizing bone and/or cartilage cells. Extensive experience with in vitro models of cell differentiation. Documented experience in advanced cell biology and molecular biology methods. Scientific productivity documented through publications in international journals. Very good ability to communicate in English, both verbally and in writing.  Meritorious Experience in research on mechanosensing, mechanotransduction or biomechanical regulation of cell function. Experience with 3D cell cultures, organoids or biomaterial-based model systems. Experience with analytical methods such as RNA sequencing, single-cell technologies or proteomics. Experience in microscopy, image analysis and quantitative cellular analyses. Experience in supervising students or younger researchers. Great emphasis will be placed on scientific proficiency, independence, problem-solving skills and collaboration skills. What do we offer? A creative, international, inspiring environment filled with expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Here we conduct successful medical research and have the largest range of medical education in Sweden. At KI you will meet researchers with different research areas working together. It is this cross-border collaboration that contributes to KI’s world-leading position in research. Several of the people you meet in healthcare are educated at KI. A close relationship with the healthcare sector is important for creating education and research of the highest quality. As a university, Karolinska Institutet is also a government agency. This means that as an employee you receive good benefits through our collective agreement. Location: Center for Molecular Medicine (CMM), Karolinska Institutet, Solna Application The application must consist of the following documents, written in English or Swedish: Proof of doctoral degree A complete CV including date of public defense, title of thesis, previous academic positions, academic title, current position, academic awards and committee work A complete list of publications A summary of current work (maximum one page) KI applies individual and differentiated salary setting according to our collective agreements RALS and RALS-T.  Applications must be made via the Varbi recruitment system.   Apply Now