Position of Research Specialist in Targeted Protein Degradation

Do you want to contribute to top quality medical research?

Karolinska Institutet offers a uniquely collaborative research environment at the interface of fundamental biology and translational medicine. You will conduct studies at the forefront of cancer biology and drug discovery, with opportunities to engage in international collaborations and contribute to projects with clear therapeutic potential. The selected candidate will join the Sangfelt Lab at the Department of Cell and Molecular Biology, Biomedicum, Karolinska Institutet. You will be part of a small, dynamic, and closely knit multinational team located in one of Europe’s most advanced biomedical research facilities.

Description of the subject area

The Research Specialist position focuses on targeted protein degradation, with particular emphasis on replication stress and DNA damage response pathways. The projects integrate molecular and cell biology, biochemistry, genetics, and computational approaches to identify and exploit specific cancer vulnerabilities, and you will play a central role in developing novel therapeutic strategies.

As a Research Specialist, you will be responsible for leading research projects, supervising students and visiting scientists, and working closely with the group leader and senior scientists to maintain a high level of scientific rigor and professionalism within the team.

The ideal candidate has documented experience conducting independent research, taking responsibility for project development within the research area, and demonstrates a strong academic track record, including at least one recent first‑author publication in a high‑impact journal.

Your mission and responsibilities

• Project leadership
• Designing and conducting biochemical and cell‑based high‑throughput screens
• Integrating biophysical, computational, and cell‑based data Independent experimental design, data analysis, and interpretation
• Active participation in a multinational research team and international collaborations

Eligibility requirements

For employment as Research Specialist at Karolinska Institutet, the eligibility requirements stated in the Guidelines for non-teaching positions at Karolinska Institutet are applied in relation to the established profile of employment.

To be eligible, applicants must:
• hold a doctoral degree (PhD) or a foreign degree deemed equivalent
• have demonstrated research expertise with documented senior postdoctoral research experience.

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having a foreign degree deemed equivalent to a Swedish doctoral degree, the applicant must have demonstrated research expertise as well as have documented postdoctoral research experience.

Assessment criteria

The assessment criteria form part of the overall evaluation of the applicant’s eligibility and suitability. All criteria will be assessed collectively.

It is particularly meritorious if the applicant has demonstrated:
• Advanced expertise in ubiquitin ligases and protein degradation pathways
• Strong experience in cancer biology, replication stress, or DNA damage response mechanisms • Independence in method development and execution of complex research projects
• A strong publication record

It is meritorious if the applicant has:
• Experience in leukemia research Experience with scRNA‑seq, ATAC‑seq, CUT&RUN
• Bioinformatics or data‑analysis skills (e.g. R or Python)

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

The employment corresponds to 25% of a full-time position. An increase in the scope may become relevant during the period, in dialogue with the immediate manager and as agreed.Location: Solna

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents:  PhD certificate, resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio.

The application must be submitted through the Varbi recruitment system.