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Where environmental stress tolerance meets biotechnology – understanding Cereblon E3 ubiquitin ligase function during stress responses and targeted protein degradation in plants

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,80 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline.   Plants use ubiquitination to regulate cellular function more than any other group of

Identification of novel mitochondrial mechanisms in cellular homeostasis

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline.  Molecular dissection of the protein kinase PINK1 and ubiquitin ligase Parkin has revealed a highly conserved mitochondrial quality control pathway found in nearly every cell type including neurons. Upon mitochondrial damage, activation of PINK1 and Parkin leads to ubiquitin-dependent removal of damaged mitochondria by autophagy (mitophagy). The intramitochondrial mechanisms

Post transcriptional control of the segmentation clock and somitogenesis

Funding – BBSRC funded 4year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline During early embryogenesis, segments (somites) are formed during a process called somitogenesis. These somites will go on to form the bones and muscles of the skeleton. The timing of the segmentation process

New tools to study plant parasite effectors at the interaction interface

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline Plant parasites form close associations with their host plants and deliver suites of effector molecules, including proteins, inside their host essential for infection or infestation. Effector repertoires (proteins) have been identified for a wide range of plant parasites, including fungi, oomycetes, bacteria, nematodes and more recently herbivorous insects. Importantly,

How does cell size control cell fate? – studying cell fate specification in the developing nervous system

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline We all have started as a single cell, the egg, yet our bodies consist of hundreds of different cell types. This raises the question of how this cell type diversity is established. In this project you will study asymmetric cell division1, a process in which a single division generates

How does dysregulated Ser-Arg Protein Kinase (SRPK) signalling cause Alzheimer’s disease?

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline The focus of our lab is on dissecting neurological functions of the Ser-Arg Protein Kinases (SRPK) kinase family and its downstream signalling pathways. SRPK was   originally identified as a splicing factor kinase, but recent findings have implicated SRPK in various neurological disorders, including Alzheimer’s disease (AD). Indeed, SRPK2

Understanding the genetic and molecular basis of complex glycan metabolism by the human gut microbiota

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline Understanding the genetic and molecular basis of complex glycan metabolism by the human gut microbiota The human gut is colonised by trillions of microbes collectively termed the human gut microbiota (HGM) that play a vital role in human health and disease. They contribute to human nutrition by metabolising otherwise

Odour-Based Detection and Discrimination of Microorganisms: Integrating Electronic Nose Technologies with Machine Learning

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline  Planet Earth is estimated to harbour up to one trillion microbial species [1]. Collectively, these microorganisms encode an enormous diversity of genes, many of which produce enzymes with unique metabolic capabilities. A single individual human microbiome (community of bacteria) contains over 46 million unique bacterial genes in the gut

Why does the B cell antibody response wane with ageing?

Funding – BBSRC funded 4year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline.  B lymphocytes (B cells) are key cells of the adaptive immune system producing antibodies which bind to pathogens such as viruses and bacteria and targeting them for destruction. Short-lived and long-lived antibody producing B cells provide rapid and durable protection against infection and B cells play a vital role in

Targeting proteasome assembly to uncover cancer vulnerabilities

Funding – BBSRC funded 4 year studentship, providing tuition fees, training/research costs and an annual stipend at the UKRI rate, currently £21,805 Start Date – September 2027 Applicants are expected to have a degree (equivalent of Honours or Masters) in a relevant discipline.  Cancer cells must continually remove damaged and unwanted proteins to sustain rapid growth and survive cellular stress. This creates a strong dependence on the proteasome, the molecular machinery responsible for much of the cell’s controlled protein degradation. Although drugs that block proteasome activity have transformed   treatment for some

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