Fixed-term

The Opportunity: Cancer Grand Challenges – from DNA damage to the mechanisms of mutagenesis We are looking to employ a post-doctoral researcher to join the group of Professor Martin Taylor at the Institute of Genetics and Cancer (IGC), working to understand the mechanisms that drive mutagenesis. In this post you will be a key member of the international Cancer Grand Challenges CAUSE team mechanistically relating DNA damage to the mutations it generates. This is pioneering research in a highly collaborative international team embedded within a well-supported, collegiate and enthusiastic research group. This specific role is will drive the development and application of technologies to enrich for and map DNA damage and modifications within the human genome. You will explore how that damage is processed leading to repair, mutagenesis or damage tolerance. Within the IGC you will be co-supervised by biochemist Dr Tom Deegan. The successful candidate will have experience in molecular biology and nucleic acid manipulation along with core biochemistry techniques including protein purification. You will have ownership of your own projects and work closely with experts in the analysis of high-throughput sequencing and mass-spectrometry data, familiarity with such platforms would be an advantage. The post holder will have many opportunities for multidisciplinary collaborative working both within the IGC and with CAUSE partners based at the Sanger Institute, Hubrecht Institute, Harvard University, University of San Diego and University of Minnesota. The wider Cancer Grand Challenge community will also provide excellent opportunities for training, professional and network development. Applicants must have a PhD in molecular biology, biochemistry or a related discipline for appointment at Research Associate level. Applicants close to completion of their PhDs will also be considered where experience is directly relevant. Please see the job description and person specification document associated with this advert for the full list of criteria. This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. Initially a 24-month contract is offered, with the possibility of extension. View the full job description How to apply Please include the following documents in your application: – CV – either narrative or structured. – Cover letter explaining your fit for the role, the science that excites you how you think this role could help realise your aspirations. The University of Edinburgh is a world-class organisation. We look for the best in the field across all disciplines and provide a working environment where academics can develop their careers and passion for their chosen subject area. The University isn’t just any employer. We are part of a local community and a contributor to global thinking, progress and research. In Edinburgh, you are in one of the world’s most attractive cities with active arts and social sectors, while working in a University that has made significant contributions to society, medicine, physics and teaching for over four centuries. Our people have helped create the modern world and are working on more ground-breaking technologies and practices. As a valued member of our team, you can expect:  A competitive salary. An exciting, positive, creative, challenging and rewarding place to work. To be part of a diverse and vibrant international community. Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page and use our reward calculator to discover the value of your pay and benefits. Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. We welcome applications from all qualified candidates and aim to make appointments only on the criteria of merit and evidence. Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages. The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.  Key dates to note The closing date for applications is 29th May 2026. Apply Now

The Opportunity: Cancer Grand Challenges – from DNA damage to the mechanisms of mutagenesis We are looking to employ a post-doctoral researcher to join the group of Professor Martin Taylor at the Institute of Genetics and Cancer (IGC), working to understand the mechanisms that drive mutagenesis. In this post you will be a key member of the international Cancer Grand Challenges CAUSE team mechanistically relating DNA damage to the mutations it generates. This is pioneering research in a highly collaborative international team embedded within a well-supported, collegiate and enthusiastic research group. This specific role is will drive the development and application of technologies to detect and map DNA damage and modifications within the human genome. You will produce DNA sequencing libraries containing known non-canonical nucleotides for training machine learning models in the decoding of primary DNA sequencing data. You will develop, refine and validate the machine learning approaches for the probabilistic detection and quantification of non-canonical nucleotides. ONT Nanopore and PacBio HiFi sequencing will be the primary initial platforms for data generation and model training. Knowledge and experience of these platforms would be an advantage. The successful candidate will have experience in molecular biology and nucleic acid manipulation, and experience in the training of machine learning models on time-series-like data. You will have ownership of your own projects and work closely with experts in biochemistry, high-accuracy mutation detection and the analysis of mass-spectrometry data. The post holder will have many opportunities for multidisciplinary collaborative working both within the IGC and with CAUSE partners based at the Sanger Institute, Hubrecht Institute, Harvard University, University of San Diego and University of Minnesota. The wider Cancer Grand Challenge community will also provide excellent opportunities for training, professional and network development. Applicants must have a PhD in molecular biology or a related discipline for appointment at Research Associate level. Applicants close to completion of their PhDs will also be considered where experience is directly relevant. Please see the job description and person specification document associated with this advert for the full list of criteria. The University of Edinburgh is a world-class organisation. We look for the best in the field across all disciplines and provide a working environment where academics can develop their careers and passion for their chosen subject area. The University isn’t just any employer. We are part of a local community and a contributor to global thinking, progress and research. In Edinburgh, you are in one of the world’s most attractive cities with active arts and social sectors, while working in a University that has made significant contributions to society, medicine, physics and teaching for over four centuries. Our people have helped create the modern world and are working on more ground-breaking technologies and practices. This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. Initially a 24-month contract is offered, with the possibility of extension. View the full job description How to apply Please include the following documents in your application: – CV – either narrative or structured. – Cover letter explaining your fit for the role, the science that excites you how you think this role could help realise your aspirations. As a valued member of our team, you can expect:  A competitive salary. An exciting, positive, creative, challenging and rewarding place to work. To be part of a diverse and vibrant international community. Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page and use our reward calculator to discover the value of your pay and benefits. Championing equality, diversity, and inclusion The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. We welcome applications from all qualified candidates and aim to make appointments only on the criteria of merit and evidence. Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages. The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.  Key dates to note The closing date for applications is 29th May 2026. Apply Now

The Opportunity: Cancer Research UK (CRUK) have awarded funding to renew the UCL-Edinburgh CRUK Glioma Brain Tumour Centre of Excellence (CoE). The CoE brings together researchers from the University of Edinburgh and University College London to develop a deeper understanding of the fundamental biology of glioma and harness this knowledge to drive new translational approaches to improve patient outcomes. The post-holder will be based at the Institute of Genetics and Cancer, University of Edinburgh or affiliated research centres within the College of Medicine and Veterinary Medicine. The mission of the Institute of Genetics and Cancer is to understand development and disease by using the latest approaches in genetic, genomic, cellular and clinical science. The postholder would benefit from world class facilities, and the combined resources and multidisciplinary skills, scientific expertise, technology and support services needed to maximise scientific discovery and provide an outstanding training environment. We are seeking transition fellows with a strong publication track record to develop an independent programme of research, relevant to the themes of the CoE. Fellows will be expected to apply for independent research funding supported by existing research programmes on brain tumours. They will receive a generous consumables budget and priority access to CoE infrastructure, including preclinical models, and will be supported by a variety of mentoring schemes. The successful candidate will have a PhD degree in a relevant subject area (e.g. biology, neuroscience, biomedicine, cancer biology) and have successfully carried out a period of postdoctoral training. They should also have a proven publication record. Excellent organizational and record-keeping skills are essential. Applicants must have experience in presenting complex scientific concepts and content both in writing and verbally. They will show a strong commitment to improving outcomes for glioma patients and demonstrate excellent collaborative interpersonal skills with an ability to work co-operatively in a multidisciplinary setting. The post-holder will be expected to have the ability to assist other members of the CoE, supervise MSc and PhD students, as well as collaborate with external research groups. This post is full-time (35 hours per week); however, we are open to considering flexible working patterns. Your skills and attributes for success:  A PhD and postdoctoral experience, with demonstrated success in delivering research results relevant to the subject specialism (or near completion) Experience and achievement in the specialist area, reflected in a growing personal research portfolio Extensive experience of developing and applying theory, models, techniques and analytical methods as appropriate to the field Good understanding of the potential non-academic impacts of the research and ways of engaging in order to achieve these. Ability to work with colleagues across the organisation in a respectful manner including collegiate support of colleagues. Click to view a copy of the full job description. (opens new browser tab) Application Information  Please ensure you include the following documents in your application: CV  2-page proposal briefly outlining research interests, proposed research activities and how these align with and can contribute to the success of the Brain Tumour Centre of Excellence. As a valued member of our team you can expect: A competitive salary An exciting, positive, creative, challenging and rewarding place to work. To be part of a diverse and vibrant international community Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our staff benefits page (opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits Championing equality, diversity and inclusion: The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages (opens new browser tab) The University may be able to sponsor the employment of international workers in this role.  This will depend on a number of factors specific to the successful applicant. Key dates to note: The closing date for applications is 1 June 2026. Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone. Interview dates to be confirmed Apply Now

About us Biosciences is one of the world’s foremost centres for research and teaching in the biological sciences and one of the largest Divisions within UCL, undertaking a significant amount of research and teaching. The Division has a diverse portfolio addressing all areas of biology from protein interactions to cell function, organism development, genetics, population studies and the environment. Computational modelling approaches are frequently used alongside experimental research programmes and much of our research crosses traditional boundaries, including the relationship of biodiversity to the health of the planet. Activity is underpinned by high calibre science technology platforms and state of the art equipment. Educational activity includes a range of undergraduate programmes, an expanding number of Masters Programmes and a substantial number of postgraduate research students. This is an exciting opportunity to join the Rihel lab in the Department of Cell and Developmental Biology. The Rihel lab uses zebrafish to study mechanisms of sleep, using methods in genetics, pharmacology, behavioral neuroscience, and neuronal imaging. The lab is part of a larger community of multiple zebrafish research labs, working on many aspects of biology. About the role The main purpose of this position is to is to investigate sleep in zebrafish. The project uses a combination of molecular genetics, brain imaging, and behavioural analysis. The purpose of this job is to investigate how sleep is regulated in zebrafish. The project uses a combination of molecular genetics, brain imaging, and behavioural analysis. The successful applicant will join a highly collaborative research team involved in studying the basic mechanisms of sleep. There will be ample opportunity to present research at regular lab meetings and also local, and to the wider research community, including through publications. Successful candidates will also be supported in applying for independent funding. Interview Date(s) are scheduled for early June 2026 This is an open-ended contract with a funding end date of 05/31/2028 in the first instance. Salary will be appointed from Grade 7, spine point 34 (£48,679). Research Fellows – ‘Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (salary £34,502 – £36,348 per annum)https://www.ucl.ac.uk/human-resources/sites/human_resources/files/2023_-_24_ucl_non-clinical_grade_structure_with_spinal_points_december_2023_update_1.2.pdf with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.’ We will consider applications to work on a part-time, flexible and job share basis wherever possible. This appointment is subject to UCL Terms and Conditions of Service for Academic Staff. Please visit https://www.ucl.ac.uk/human-resources/policies/2021/jun/conditions-service-academic-staff for more information. A job description and person specification can be accessed at the bottom of this page. If you have any queries about the role, please contact Jason Rihel at j.rihel@ucl.ac.uk. If you need reasonable adjustments or a more accessible format to apply for this job online or have any queries about the application process, please contact Biosciences staffing at biosciences.staffing@ucl.ac.uk. About you The post holder is expected to test how sleep regulates synapse dynamics in the zebrafish model. The post holder will genetically and experimentally manipulate neurons and synapses in zebrafish mutants of sleep homeostasis; image brain activity and circuit function; and perform behavioural tracking experiments to follow how synapses are modulated by sleep, and vice versa. You will be expected to produce independent and original contributions to the development of causal links between sleep and neural substrates of homeostasis and to assist the team in the development, planning and delivery of the research aims. In addition to developing and conducting the research, you will communicate results as scientific papers and in scientific presentations at local, national, and international conferences. Successful post holders will also be supported in applying for independent fellowship opportunities. You must have a PhD in Neurobiology, Genetics, or a related field, and have proven knowledge of working with animals models, including molecular, genetic, and pharmacological methods. You must also have a high level of proficiency with in vivo imaging techniques to observe changes in neuronal activity and synapses such as confocal, multiphoton, or light sheet microscopy. Experience in both basic molecular biology techniques and manipulation of gene expression via mutagenesis or transgenesis in zebrafish is also required. What we offer As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: • 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) • Additional 5 days’ annual leave purchase scheme • Defined benefit career average revalued earnings pension scheme (CARE) • Cycle to work scheme and season ticket loan • Immigration loan • Relocation scheme for certain posts • On-Site nursery • On-site gym • Enhanced maternity, paternity and adoption pay • Employee assistance programme: Staff Support Service • Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more. Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality. You can read more about our commitment to Equality, Diversity and Inclusion here: https://www.ucl.ac.uk/equality-diversity-inclusion/ Available documents Attached documents are available under links. Clicking a document link will initialize its download. download: NEW JD- Research Fellow_Grade 7_Rihel_2026 May.docx Apply Now

About us UCL Respiratory is part of the Division of Medicine at University College London and is based at the Rayne Institute. The department includes approximately ten principal investigators working across a wide range of respiratory diseases, from interstitial lung disease and infection to cancer and airways disease, with a strong focus on integrating mechanistic biology with clinical and translational research. Our research focuses on understanding the mechanisms that drive chronic lung disease, particularly interstitial lung disease (ILD). A central theme of our work is how epithelial injury and repair influence immune responses and fibrotic progression. We combine mechanistic laboratory biology with analysis of human clinical samples, with the aim of identifying biologically meaningful pathways that inform patient stratification and therapeutic targeting. The group brings together clinicians, scientists, and collaborators across disciplines to address key unanswered questions in lung disease. Find out more about our work: UCL Respiratory research page About the role We are seeking a Research Fellow to join a programme investigating epithelial–immune crosstalk in chronic lung disease. The postholder will explore how epithelial injury alters cell surface signalling and regulates leukocyte recruitment, activation, and tissue remodelling in the lung. Areas of focus include epithelial signalling pathways, integrin activation, and glycosylation-dependent immune recognition (including siglecs, mucins, and glycoproteins). The role will involve a combination of cell biology, molecular biology, and in vitro functional assays, with opportunities to engage in multi-omics and translational analyses of human samples. There may also be opportunities for in vivo work depending on project direction. The successful candidate will: design and deliver experimental studies analyse and interpret complex datasets contribute to manuscripts and grant applications supervise junior researchers and students work within a collaborative multidisciplinary research environment The postholder will be expected to work with a high degree of independence while contributing to the broader activities of the research team. This role is eligible for UCL sponsorship. About you You will have a PhD in a relevant discipline such as cell biology, immunology, respiratory biology, or glycobiology, and evidence of independent research through publications or equivalent experience. You will have strong expertise in cell and molecular biology techniques and experience of managing research projects. You will be able to work independently and as part of a multidisciplinary team, with excellent organisational, analytical, and communication skills. Desirable experience includes: • epithelial biology and/ or glycosylation • multi-omics approaches (e.g. transcriptomics, proteomics) • working with human samples or translational datasets You will demonstrate a commitment to high-quality, rigorous research and collaborative working. What we offer This is an exciting opportunity to join a multidisciplinary team working across the Division of Medicine. As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: • 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) • Additional 5 days’ annual leave purchase scheme • Defined benefit career average revalued earnings pension scheme (CARE) • Cycle to work scheme and season ticket loan • Immigration loan • Relocation scheme for certain posts • On-Site nursery • On-site gym • Enhanced maternity, paternity and adoption pay • Employee assistance programme: Staff Support Service • Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more. Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosterscreativity and innovation, and we want our community to represent the diversityof the world’s talent. We are committed to equality of opportunity, to beingfair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications fromcandidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minoritybackgrounds; disabled people; LGBTQI+ people Our department holds an Athena SWAN Silver award, inrecognition of our commitment and demonstrable impact in advancing genderequality. Available documents Attached documents are available under links. Clicking a document link will initialize its download. download: Research Felow job_description.docx Apply Now

About us Within the Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, the laboratory of Doctor Salih is dedicated to investigating the interplay between the immune system and cognitive function in the ageing brain focusing on neurodegenerative diseases like Alzheimer’s disease. We study genetic variations in the human population and their effects on neurodegenerative diseases using techniques such as GWAS, transcriptomics, and epigenetics. Our interdisciplinary approach integrates molecular biology, biochemistry, cell biology, and advanced genomic methods to advance our understanding and treatment of dementia and age-related disorders. Our team is committed to translating our research findings into practical applications. By integrating GWAS data with transcriptomic (bulk, single-cell, long-read and spatial), proteomic and epigenetic analyses from human and model systems, we identify new risk genes and pathways involved in dementia and ageing. Through our efforts, we strive to develop new therapeutic approaches and diagnostic tools. About the role We are recruiting a Research Fellow to contribute a leading role to a project to identify the genetic, epigenetic, and cellular mechanisms by which oligodendrocytes and GWAS variants coordinate ageing and neurodegeneration by cross-talk with neurons and microglia. You will analyse newly generated H3K27ac datasets (ChIP-seq and CUT&Tag) and integrate them with new single-nucleus multiome data, and existing transcriptome data (bulk, single-cell, long-read and spatial), GWAS data, proteomics, and data from induced pluripotent stem cells (iPSCs)-oligodendrocytes and other iPSC cultures using a wide range of bioinformatics approaches to dissect the mode of action by which epigenetic and genetic factors coordinate oligodendrocytic funtion and cell type cross-talk in ageing, resilience and disease. This specific role is supported by a larger UK DRI Key Question Stage II grant and is jointly supervised by Dr Dervis Salih and Dr Sarah Marzi (KCL). You will be based at UCL for one year, then will spend two years at King’s College London to lead the bioinformatic analysis and data integration between collaborators. You will be responsible for planning, execution and report of bioinformatics experiments and contribution to the formulation and submission of research publications as well as management and direction of this challenging project as opportunities allow. The overarching goal of the project is to understand how epigenetic and genetic factors come together to control oligodendrocyte function via transcriptome, proteome and cell-type cross-talk to impact ageing, neurodegeneration and resilience. The post is available immediately and is funded by the UK Dementia Research Institute Ltd for 12 months at UCL. After completing 12 months at UCL, the post will then move to King’s College London for a further 24 months. If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team (ion.hradmin@ucl.ac.uk). Informal enquiries regarding the role can be addressed to Dr Dervis Salih (dervis.salih@ucl.ac.uk). A full job description and person specification for this role can be accessed below. To apply, please upload a current CV, complete the online application form, and use the supporting statement section or upload a cover letter to outline how you meet the essential and desirable criteria for the role. Please do not upload any additional attachments as these will not be considered by the selection panel. About you You’ll have a PhD (or be close to completion) in Neuroscience, Cell Biology, Immunology, Biochemistry, Molecular Biology, or a related discipline, coupled with knowledge of epigenetics and transcriptomics analyses, multiomics and/or data integration, and cellular, molecular, or biochemical mechanisms of neurodegenerative diseases and aging. Demonstrable experience in performing high-quality research, of working in a laboratory in an interdisciplinary research environment, and the demonstrable ability to execute a programme of experiments through the design and improvement phase to data curation and publication is also essential for this role. This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa. What we offer Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £39,148 – £41,833 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis. As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below: 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) Additional 5 days’ annual leave purchase scheme Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan Immigration loan On-site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more. We will consider applications to work on a part-time, flexible, and job share basis wherever possible. This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit https://www.ucl.ac.uk/human-resources/conditions-service-research-teaching-and-professional-services-staff for more information. Our commitment to Equality, Diversity and Inclusion The Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Gold award, in recognition of our commitment and demonstrable impact in advancing gender equality. As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles,