Fixed-term

About the Project We invite applications from candidates eligible for UK student status for a PhD project investigating how mechanical forces contribute to development, and how these principles can be harnessed to inspire engineering solutions for tissue repair and regenerative medicine. Candidates with either experimental or theoretical backgrounds are encouraged to apply. The project will focus on ciliated tissues, such as those lining the airways, where microscopic hair‑like structures called cilia beat in a coordinated manner to generate fluid flow and transport mucus. While these systems are essential for physiological function, how they self‑organise during development to establish robust, large‑scale fluid flows remains poorly understood. This project will investigate how mechanical forces, fluid flow, and mechanotransduction drive the self‑organisation of ciliated tissues during development and wound healing. Together, we will combine quantitative experiments and mathematical modelling to uncover the physical principles underlying fluid transport in developing tissues, with relevance to tissue repair and regenerative medicine. Who should apply? Applicants from biology, physics, engineering, mathematics, or related disciplines are encouraged to apply. Both students with experimental and/or quantitative experience are welcome.   Ideal for students interested in: ·        bioengineering ·        biosciences ·        biophysics ·        cell mechanics ·        fluid dynamics Training includes: ·        quantitative live imaging; image analysis ·        biophysical experiments, including biophysical manipulation of Xenopus embryos ·        computational modelling ·        microfabrication and 3D printing Research environment Based at Durham University, you will join a collaborative environment spanning Engineering, Biosciences, and the Durham Biophysical Sciences Institute. You will have access to state-of-the-art imaging, fabrication, and interdisciplinary research facilities. Funding Notes This PhD studentship is for four years and is available to home students only. The funding covers a tax-free stipend at the UKRI rate and the full tuition fees at the home rate. If you are interested in applying, in the first instance contact the supervisor (Francesco Boselli, francesco.boselli@durham.ac.uk), detailing your reasons for applying for the project, as soon as possible, by no later than Friday 31st July, 2026. The position will be closed as soon as it is filled.

We are seeking a motivated and collaborative individual to join our team as a postdoctoral research associate. This role offers an exciting opportunity to contribute to the newly established NaVigate programme to develop treatment options for Alzheimer’s Disease and other small vessel diseases of the brain. The position will be initially available for 3 years, with the possibility of extending up to 5 years. The research will be carried out in the Microvascular@Manchester group (microvascularmanchester.com) under the guidance of Professor Adam Greenstein and Dr Harry Pritchard. The post will be based within the Division of Cardiovascular Sciences at the University of Manchester and the Geoffrey Jefferson Brain Research Centre. You will be responsible for: Leading research into the mechanisms underlying hypertension-related and amyloid-induced changes to cerebral small artery vascular smooth muscle cell and endothelial cell ion channel activity To prepare material for publications and conference presentations. To write reports for submission to research sponsors and partake in relevant meetings. To be an active team-member and set positive examples by showing a commitment to achieving results, encouraging and supporting junior members of the team and raising suggestions for continuous improvement. We welcome candidates who bring diverse perspectives, experiences, and approaches to their work. About You We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate: Essential Criteria: Have, or be about to obtain, a PhD (or equivalent) in biophysics and membrane biology (or similar) Extensive and up-to-date understanding of ion channel biophysics. Hands-on experience in native (freshly isolated) single cell patch clamp electrophysiology with competence in hardware and software assembly, maintenance and data analysis Experience with animal models Strong journal publication record. Desirable Criteria: Experience and understanding of cardiovascular physiology, preferably in the field of small artery biology. Cardiovascular, particularly microvascular, patch clamp expertise. Flexible approach to dealing with research problems as they arise Willingness to learn and develop Ability to assess and organise resources We value transferable skills and real-world experience as much as formal qualifications. Our benefits include:• Generous employer contribution pension• 29 days annual leave plus bank holidays, along with Christmas closure• Ride to work and EV car scheme available For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here. We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy. Enquiries about the role, shortlisting and interviews Name: Professor Adam Greenstein Email Address: adam.greenstein@manchester.ac.uk General enquiries and administrative support recruitmentservices.people@manchester.ac.uk Technical and job portal support https://jobseekersupport.jobtrain.co.uk/support/home This role is not eligible for Skilled Worker visa sponsorship. Applicants must demonstrate the right to work in the UK. Applications close at midnight on the closing date. Further particulars (with person specification) linked below. Supporting Documents Research Associate Grade 6 fps – Patch clamp (PDF, KB) Apply Now

We are seeking a motivated and collaborative individual to join our team as a Research Technician to provide specialist technical support for research programmes investigating the vascular mechanisms of dementia and other brain disorders. This role offers an exciting opportunity to contribute to internationally recognised research by undertaking and optimising laboratory experiments, supporting the operation of advanced research equipment, and helping generate high-quality experimental data. Working closely with researchers, students and technical colleagues, you will play an important role in supporting safe, efficient and effective laboratory-based research, within a dynamic and inclusive environment. You will be responsible for: Supporting research animal model maintenance and undertaking microdissection of arteries. Performing and optimising experimental protocols, including antibody-based imaging using confocal and super-resolution microscopy. Undertaking pressure myography and calcium imaging of small arteries, and supporting staff and students with standard laboratory protocols. Training junior technicians and PhD students in relevant laboratory techniques, including myography. Maintaining accurate records, supporting data preparation for presentations and publications, contributing to experimental design, and ensuring work is carried out in line with health and safety, data protection and University requirements. We welcome candidates who bring diverse perspectives, experiences, and approaches to their work. About You We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate: Essential Criteria: A relevant biological sciences qualification, or equivalent qualifications and substantial experience working in a research laboratory. Extensive hands-on experience of small artery physiology and immunohistochemistry in a laboratory-based dementia research setting. Strong organisational skills, with the ability to manage a complex workload, prioritise competing demands and work to deadlines without direct supervision. Excellent communication, analytical and problem-solving skills, with a high level of accuracy, attention to detail and reproducibility in laboratory work. Desirable Criteria: Experience using Word, Excel and PowerPoint, with experience of ImageJ and/or IMARIS also beneficial. A flexible approach to working hours where required to monitor procedures or experiments. We value transferable skills and real-world experience as much as formal qualifications. Our benefits include: Generous employer pension contribution Christmas closure across all departments outside of annual leave and bank holidays Purple Place employee discount platform For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here. We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy. Enquiries about the role, shortlisting and interviews Name: Adam Greenstein Email Address: adam.greenstein@manchester.ac.uk General enquiries and administrative support recruitmentservices.people@manchester.ac.uk Technical and job portal support https://jobseekersupport.jobtrain.co.uk/support/home This role is not eligible for Skilled Worker visa sponsorship. Applicants must demonstrate the right to work in the UK. Applications close at midnight on the closing date. Further particulars (with person specification) linked below. Supporting Documents BMH-031971 – Research technician – FPs (PDF, KB) Apply Now

About Us The School of Cardiovascular & Metabolic Medicine & Sciences (SCMMS) provides an outstanding multi-disciplinary environment for the pursuit of cutting-edge cardiovascular and metabolic research (https://www.kcl.ac.uk/scms).   We study the fundamental molecular, cellular, and physiological processes that underly normal and abnormal cardiovascular and metabolic function and we drive the translation of this strong basic science into advances in clinical practice to improve prevention, diagnosis and treatment.  This activity provides a high-quality research and training environment for non-clinical and clinical scientists. The School occupies facilities across the Guy’s, St Thomas’ and Denmark Hill campuses of King’s College London and comprises over 65 academic groups, hosting 400 staff and 110 PhD students.  Our community of world-renowned researchers and educators have access to a state-of-the art core facilities and expertise, including for high-throughput screening, multimodality in vivo imaging, proteomics, integrative physiology and viral & non-viral vector production. As part of King’s Health Partners, we have an excellent environment for basic-clinical interaction and a strong focus on mentoring and career development.  The School is a partner of the NIHR Biomedical Research Centre at Guy’s and St. Thomas’, which offers world class facilities for translational studies and phase I/II clinical trials. The post is based within the School of Cardiovascular and Metabolic Medicine & Sciences at the Southbank Campus.  The School and these Centres provide an outstanding highly multidisciplinary environment with state-of-the-art equipment, facilities and technical support for both laboratory work and animal studies.  About The Role A position is available for a Cardiovascular Research Fellow (Cardiac Physiologist / Clinical Scientist) within the School of Cardiovascular and Metabolic Medicine & Sciences at King’s College London. This jointly funded post between King’s College London and Guy’s and St Thomas’ NHS Foundation Trust is embedded within one of the UK’s leading echocardiography research groups. The role offers a unique combination of clinical service delivery and academic research, providing an excellent opportunity for both professional and academic development. The successful candidate will perform and independently report clinical echocardiography examinations to British Society of Echocardiography (BSE) standards. They will lead research clinics jointly overseen by the Echocardiography Department at Guy’s and St Thomas’ NHS Foundation Trust (clinical governance) and the Department of Clinical Pharmacology at King’s College London (academic governance), including but not limited to Cardiac Resynchronisation Therapy (CRT) Optimisation and Inherited Cardiac Conditions clinics. The post holder will also undertake vascular and other physiological assessments in accordance with research study protocols. BSE Adult Transthoracic Echocardiography Accreditation (or an equivalent qualification) is an essential requirement for this role. Working under the supervision of Dr Haotian Gu (Principal Investigator), the post holder will contribute to the NIHR-funded EFFECT-CRT study, the British Heart Foundation-funded EF1 in CRT study, and other research projects led by the Guy’s and St Thomas’ Cardiovascular Research & Development team. Academic responsibilities will include supporting study coordination, data management and analysis, and the preparation of reports, presentations, and scientific publications. The post will be primarily based at the Clinical Research Facility, St Thomas’ Hospital, London, with travel to other study sites required as part of the research programme. This is a full-time post (40 hours per week), and you will be offered a fixed term contract for two years from start of contract. About You To be successful in this role, we are looking for candidates to have the following skills and experience:  Essential criteria BSc or equivalent in a subject relevant to cardiovascular research   British Society of Echocardiography Adult Transthoracic Echocardiography Accreditation or equivalent   Clinical echocardiographic experience – equivalent to NHS Band 7  Knowledge of cardiovascular physiology   Good written and presentation skills  Good IT skills  Desirable criteria Post-graduate qualification or PhD in a subject relevant to cardiovascular research  Experience in cardiovascular research management  Experience in grant application   Experience in conference presentation  Experience in research publication  Downloading a copy of our Job Description Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process.   Further Information At King’s, we believe that the diversity of our community and a culture that is welcoming, open, inclusive and collaborative, are great strengths of the university. The Equality Act of 2010 protects the rights of our students and staff and provides a framework to fulfil our duties to eliminate unlawful discrimination, harassment and victimisation and in addition, to advance equality of opportunity and foster good relations between those who share a protected characteristic and those who do not. At times, this will include balancing rights and beliefs that can feel in tension. We are committed to free speech and to academic freedom, believing that our foundational purpose as a university, is to create spaces where a wide range of ideas, including ideas that are controversial, can be discussed and debated, and where members of our community can express lawful views without fear of intimidation, harassment or discrimination. When engaging in the robust exchange of ideas, we ask that our community is mindful of our Dignity at King’s guidance. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the person specification section of the job description. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible. To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages. Apply Now

Details The UCL Cancer Institute is the hub for cancer research at University College London, one of the world’s leading universities. We bring together a large community of scientists working to translate fundamental discoveries in cancer biology into kinder and more effective therapies for patients. This studentship is part of the UCL–Edinburgh CRUK Glioma Brain Tumour Centre of Excellence, an interdisciplinary research network dedicated to understanding glioma biology and developing new translational approaches for children and young people affected by brain tumours. About the role We are seeking a highly motivated PhD student to join an exciting Cancer Research UK-funded project investigating how paediatric glioma cells interact with the neurovascular microenvironment during tumour growth, invasion and response to treatment. The project will focus on diffuse midline glioma (DMG), one of the most challenging childhood brain cancers. Working under the supervision of Professor Simona Parrinello and Dr Ivan Bassi, you will develop and apply zebrafish models to study tumour–neurovascular interactions in vivo. The project combines advanced live imaging, quantitative image analysis, molecular and cell biology techniques, genetic manipulation, and analysis of single-cell and spatial transcriptomic datasets to identify mechanisms driving tumour progression and therapy resistance. The successful candidate will contribute to generating new insights into paediatric glioma biology and identifying potential therapeutic vulnerabilities. How to Apply Submit the following by 28th July 2026 (using the apply button): CV including: Contact details of two referees (one academic). A short statement explaining how your experience aligns with the project and person specification. Academic transcripts and certificates (PDF format). Include official English translations if applicable. Please note that UK students start date is October 2026 and International student will be February 2027. About you You will have, or be expecting to obtain, a UK Master’s degree or a First or Upper Second Class Bachelor’s degree (or overseas equivalent) in biological sciences, biomedical sciences, neuroscience, cancer biology, developmental biology, or a related discipline. You will possess a strong interest in cancer research, paediatric brain tumours, developmental biology, vascular biology, neuroscience, or related fields. You should have experience of laboratory-based research and an understanding of molecular and/or cell biology principles. We are looking for someone with excellent organisational and communication skills, strong attention to detail, and the ability to work both independently and collaboratively within a multidisciplinary research environment. Experience in areas such as cell culture, fluorescence microscopy, quantitative image analysis, zebrafish models, cancer biology or neuroscience would be advantageous but is not essential. What we offer This is a full time fully funded 4 year PhD studentship funded by Cancer Research UK, successful candidates will receive a non-taxable annual stipend of £24,643 covering tuition fees and meet UCL PhD admissions criteria. Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people. Our division holds an Athena SWAN Gold award, in recognition of our commitment to advancing gender equality. You can read more about our commitment to Equality, Diversity and Inclusion here: https://www.ucl.ac.uk/equality-diversity-inclusion/ APPLY HERE

About us A three-year PhD studentship funded by Cure DHDDS is available from 1 October 2026, in the Translational Omics Research Group at the UCL Great Ormond Street Institute of Child Health. This project will be under the supervision of Professor Kevin Mills, Dr Jenny Hällqvist, Dr Wendy Heywood and Professor Philippa Mills. This project will define how impaired dolichol biosynthesis disrupts glycosylation, protein handling and cellular quality control in DHDDS deficiency. By measuring these processes dynamically with stable isotope tracers and mass spectrometry, the study aims to convert a poorly understood rare disease into a measurable pathway for biomarker discovery, functional diagnostics and therapeutic target identification. The student will use cutting edge stable isotope tracing, proteomics, lipidomics and state of the art mass spectrometry to build a dynamic cellular model of DHDDS deficiency. This model will track dolichol metabolism, lipid flux, glycoprotein synthesis, protein folding and cellular quality control in real time. During a PhD we aim to create a platform for disease mechanism discovery, new biomarker development, functional diagnostics and future therapeutic testing. The student will work at the interface of rare disease biology, neuronal cell models, iPSC derived organoids, translational omics and therapeutic discovery. The project will be based in a highly active translational omics laboratory of around 25 researchers with expertise in mass spectrometry, proteomics, metabolomics, lipidomics, rare disease diagnostics and biomarker translation. The group has helped deliver major translational programmes including mass spectrometry testing during the COVID 19 pandemic and the development of the first blood test for Parkinson’s disease. About the role Background DHDDS deficiency is a rare and devastating congenital disorder of glycosylation. It affects dolichol biosynthesis, a core biochemical pathway required for normal protein glycosylation. Despite this, patients often do not show the classical transferrin isoelectric focusing pattern that usually reveals defective glycoprotein synthesis in CDG. This creates a major biological and clinical puzzle. The disease is clearly driven by a defect in glycosylation biology yet the standard diagnostic readout can appear relatively normal. This suggests that DHDDS deficiency may cause a more subtle, neuronal specific and dynamic failure of glycosylation, protein folding, trafficking and degradation. These hidden defects may be largely invisible in plasma but highly damaging in neuronal cells. This PhD will tackle that problem directly. By combining stable isotope tracers with high resolution omics and advanced cellular models, the student will measure the movement of metabolites, lipids and proteins through the pathway rather than relying only on static measurements. This will allow the disease process to be watched as it happens. Hypothesis and aims We hypothesise that DHDDS deficiency causes a dynamic failure of dolichol driven glycosylation and protein quality control that is not fully captured by conventional CDG testing. The project will test whether impaired dolichol metabolism disrupts glycoprotein synthesis, protein folding, trafficking and degradation in neuronal and hepatic cell systems. The student will use stable isotope tracers to quantify pathway flux in real time and define the biochemical signature of DHDDS deficiency. The aims are to build a functional cellular model of DHDDS deficiency, identify disease relevant biomarkers, define the hidden mechanisms linking DHDDS dysfunction to neuronal injury and create a platform for testing candidate therapeutic strategies. Research outputs The project will deliver a stable isotope based cellular model of DHDDS deficiency that can measure dolichol flux, glycoprotein synthesis, protein folding, trafficking and degradation in real time. It will generate new mechanistic insight into why DHDDS patients lack the classical CDG isoelectric focusing pattern and will identify biochemical markers that better reflect disease activity. The work will also create a platform for testing candidate therapies in neuronal, hepatic and iPSC derived organoid systems. Expected outputs include targeted mass spectrometry assays, lipidomic and proteomic datasets, mechanistic pathway models, PhD publications, conference presentations and a translational workflow that could be developed into a future functional diagnostic test.   Policy-outputs The policy output is a new model for how ultra rare genetic diseases should be moved beyond diagnosis by sequencing alone. This work could support a shift toward functional biochemical testing in CDG, helping clinicians measure disease activity, monitor treatment response and design biomarker driven trials. In the longer term it could inform NHS rare disease pathways, trial readiness frameworks and orphan therapy development by showing how a hidden cellular defect can be converted into a measurable diagnostic and therapeutic readout. About you Applicants should have a keen research interest in metabolism and neurodegeneration but especially in the omic techniques of proteomics and lipidomics. Applicants should have a minimum of an upper second-class UK Bachelor’s degree and/or a Master’s degree (preferably with a merit or distinction) in a biological sciences preferably biochemistry. What we offer This studentship provides a starting stipend of £23,805 per annum and covers the cost of Home and Overseas tuition fees. The studentship does not cover the costs of the Student Visa application and Immigration Health Surcharge. Funding is not provided for paid parental and medical leave. Unpaid interruptions can be requested and may be supported. How to apply Enquiries regarding the post can be made to Enquiries regarding the post can be made to Professor Kevin Mills (kevin.mills@ucl.ac.uk) To apply, please send a current CV including the contact details of two professional referees as well as a 1-sided A4 cover letter to Professor Kevin Mills (kevin.mills@ucl.ac.uk) Closing date for applications: 28 July 2026. Interview date: 10 August 2026 Applications that are submitted without following the correct application process will not be considered. The successful applicant will then be required to apply to and register on the Child Health research degree to take up the studentship. Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.