Fixed-term

Starting April 15, 2026 or as per agreement TheBiozentrum of the University of Baselis one of the world’s leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. The Biozentrum is establishing the Dietschy Facility for Tissue Science, a new core unit enabling systematic investigation of individual cells within intact tissues. The facility will integrate state-of-the-art methods for spatial transcriptomics, advanced microscopy, volumetric imaging, neuronal activity mapping, and multimodal data analysis, with an initial focus on neuroscience. To build this interdisciplinary platform, we invite applications for three PhD-level Research Specialists: Microscopy and Spatial Transcriptomics Specialist (this position); Image Analysis Specialist; Computational Neuroscience and Data Analysis Specialist. These positions will work closely together and will support a broad user base across the Biozentrum. Become part of our community! Your position This position will establish and operate advanced imaging and spatial transcriptomics pipelines for high-resolution molecular profiling in intact tissues. The specialist will develop and apply methods enabling large-volume processing-such as whole brain spatial transcriptomics-and integrate techniques including expansion microscopy and multiplexed FISH. Your responsibilities Operate, maintain, and expand commercial and custom-built systems for spatial transcriptomics and microfluidic tissue processing. Develop protocols for volumetric molecular imaging, including expansion microscopy and multiplexed in situ hybridization workflows. Establish whole-mount and thick-section spatial transcriptomics pipelines, ensuring tissue integrity, reproducible labeling, and high-content imaging compatibility. Build or adapt instrumentation required for large-volume sample processing and imaging. Coordinate with researchers, image analysts and data specialists to generate robust, standardized whole-brain datasets. Train and support researchers in applying facility methods to their own samples. Contribute to development of facility infrastructure for long-term whole-tissue profiling. Your profile PhD in neuroscience, bioengineering, biophysics, molecular biology, or related discipline. Expertise in advanced microscopy (light-sheet, confocal, multiphoton). Experience with spatial transcriptomics, expansion microscopy, or multiplexed FISH. Skills in instrumentation, microfluidics, or custom optical systems. Experience with tissue clearing or large fixed tissue preparations advantageous. Strong communication skills, interest in interdisciplinary work, and ability to train students and postdocs. We offer you The Biozentrum provides a highly stimulating collaborative research environment with a world-class infrastructure in a brand-new building, as well as state-of-the-art technology platforms for cutting-edge interdisciplinary research. The position is fully funded and salary is according to institutional guidelines. The position is initially for two years, with an option for extension after positive evaluation. Basel is a cosmopolitan city with people from 150 nations. Located on the border where three countries meet – Switzerland, Germany and France – it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich cultural atmosphere. Application / Contact Please apply online: https://biped.biozentrum.unibas.ch/apply/dietschy_facility_spatial-transcriptomics Your application should include: a cover letter describing relevant experience and interests a CV contact information for three referees examples of relevant work (e.g., publications, software, pipelines, imaging datasets) Application deadline: March 1, 2026 For any informal enquiries, please contact: alex.schier@unibas.ch Apply Now

The Pharmaceutical Technology Research Group led by Prof. Dr. Paola Luciani at the Department of Chemistry, Biochemistry and Pharmaceutical Sciences, Faculty of Science, of the University of Bern, Switzerland, is accepting applications for a Postdoctoral Researcher/Fellow. The position is available for six years and is financed through the European Research Council’s ERC Synergy Grant funding scheme. The starting date is 01 April 2026. Many modern biotherapeutic molecules, such as peptides and proteins, cannot reach their targets inside the cell because they cannot pass through the protective cell membrane. The ERC Synergy project “Covalent Chaotropic Membrane Transport for Biotherapeutic Delivery” (acronym: CARAMEL) will investigate a new, groundbreaking strategy to transport these impermeable molecules into cells, abandoning classical design principles in favor of a completely new approach. This will be achieved within the next 6 years through the use of superchaotropic boron clusters. The CARAMEL team will be composed of several PhD students and postdoctoral fellows from four leading European universities: the University of Bern (Department of Chemistry, Biochemistry and Pharmaceutical Sciences; Luciani lab), the University of Santiago de Compostela (Center for Research in Biological Chemistry and Molecular Materials (CiQUS), Spain; Montenegro lab), Constructor University (Bremen, Germany; Nau lab) and Marburg University (Marburg, Germany; Hantschel lab). Aim of this project, carried out in a highly multidisciplinary and international team in Bern, will be to work on the therapeutic proof-of-principle of superchaotropic boron clusters in cells, cell-derived material, and experimental models of diseases. This is a fixed-term project position. Tasks • Cooperative research in a multidisciplinary and international environment in the ERC project CARAMEL • Leveraging machine learning to predict the most efficient parameters for membrane transport • Independent planning, implementation, and evaluation of experiments on membrane transport of superchaotropic boron clusters in cells and cell-derived material • Development of experimental models of disease and in vivo evaluation of superchaotropic boron clusters • Communication of research results through publications and conference presentations • Project development, documentation, and communication with project partners Requirements • MSc-degree or equivalent and a doctorate (PhD or MD/PhD) in a life science, medical, biomedical engineering, or pharmaceutical field • Demonstrated proficiency in cell culture techniques, including independent work and oversight of cell culture activities in the laboratory. • Experience with extracellular vesicle isolation and characterization techniques • FELASA B certificate or willingness to obtain one • Familiarity with biocomputational or machine learning methods will be considered an advantage • Willingness to work in a multidisciplinary and multinational team • Very good teamwork and communication skills • Very good written and spoken English skills We offer The successful candidate would have the opportunity to undertake potential secondments in the laboratories of the other ERC Synergy PIs (Santiago, Bremen and Marburg) to gain complementary skills and access specialised facilities, subject to the project plan and mutual agreement. Prof. Dr. Paola Luciani E-mail: paola.luciani@unibe.ch To apply, interested candidates are expected to submit: • A motivation letter • Curriculum vitae, including academic certificates and up to two publications considered most relevant from the PhD work • Two reference letters Information on the selection procedure: • Deadline for applications: 1 February 2026 • Evaluation criteria: academic performance, research experience, motivation, alignment with project goals • Shortlisted candidates will be contacted for an interview

University of Bern Start of employment: 01.03.2026 or later Employment is fixed term for 36-48 months The Flück group offers multiple research opportunities for PhD candidates in the context of (pediatric) molecular endocrinology, steroid hormone (cell) biology and metabolic regulation, biochemistry and bioinformatics with translational aspects to clinical research. The offered position is based in the Department of Pediatrics and the Department of Biomedical Research at the University of Bern, Switzerland. The aim of the SNF-funded project “DSDgene” is to understand mechanisms regulating human sex development in health and disease states. With multi-omics approaches we will investigate index cases and families with genetically unresolved differences of sex development (DSD) and perform cell-based studies in order to understand underlying mechanisms. Your PhD project Genetic analysis: Perform and analyze short-read whole-exome sequencing and, where required, long-read sequencing in selected individuals and families with genetically unresolved DSD. Variant discovery: Identify, prioritize, and interpret novel candidate variants contributing to unresolved DSD cases. Data integration: Integrate genomic data with detailed clinical and phenotypic information to investigate genotype–phenotype correlations. Support and preparation of scientific reports and journal articles Requirements A Master’s degree in Genetics, Molecular Biology, Bioinformatics, or a related field. Strong interest in molecular biology, rare diseases, human development, and translational research. Experience in molecular genetics, NGS data analysis, or biostatistics is an advantage. Prior expertise or interest in programming languages (R, Python) or bioinformatics. Excellent organizational and communicational skills and the ability to work in a collaborative international research environment. We offer You will follow a highly recognized PhD training program at the GCB of the University of Bern. You will have access to state-of-the-art research equipment in bioinformatics, metabolomics and cell biology. You will work in a dynamic and interdisciplinary team. You will be involved in cross-disciplinary collaborations and have training opportunities to further develop and grow your scientific interests. Opportunity to work in close contact with other basic- and clinical-researchers within the Flück/Pandey groups at the Department of Biomedicine Research and the Department of Pediatrics. Support from experienced team members. Application and contact For subject-specific questions and information about the position, please contact Chrysanthi Kouri,chrysanthi.kouri@unibe.ch. Please address your application to Chrysanthi.Kouri,chrysanthi.kouri@unibe.chby providing a single PDF including the following documents: A) cover/motivation letter B) complete curriculum vitae C) names and email addresses of at least two referees D) PDF of publication(s). Application deadline: 20/02/2026

Offer Description Doctoral study program: Life Sciences Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Consultant: Miroslav Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation: Chronic lymphocytic leukemia (CLL) cells and indolent lymphomas are known to be dependent on diverse microenvironmental stimuli providing them signals for survival, development, proliferation, and therapy resistance. It is known that CLL cells undergo apoptosis after cultivation in vitro, and therefore it is necessary to use models of CLL microenvironment to culture CLL cells long-term and/or to study their proliferation. Several in vitro and in vivo models meet some of the characteristics of the natural microenvironment based on coculture of malignant cells with T-lymphocytes or stromal cell lines as supportive cell, but they also have specific limitations. The aim of this research is to develop and use models mimicking lymphoid microenvironment to study novel therapeutic options, e.g. drugs targeting CLL proliferation, development of resistance in long-term culture or combinatory approaches, which cannot be analysed in experiments based on conventional culture of CLL/lymphoma primary cells. This project will utilize models developed in the laboratory and will further optimize and modify them. We have recently developed a co-culture model that is allowing to induce robust proliferation of primary CLL cells, something that was virtually impossible for decades (Hoferkova et al, Leukemia, 2024). Using kinase inhibitors, the biology of CLL and responses to targeted treatment will be interrogated. The student will utilize various functional assays, RNA sequencing, genome editing, drug screening etc., with the use of primary patient’s samples and cell lines. The research might bring new insights into the microenvironmental dependencies and development of resistance to targeted therapy. Recommended literature: Hoferkova E,  et al…. Mraz M. Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs. Leukemia. 2024 Aug;38(8):1699-1711 Pavlasova G, et al…. Mraz M. Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis.  Blood. 2016 Sep 22;128(12):1609-13. doi: 10.1182/blood-2016-04-709519. Epub 2016 Aug 1. PMID: 27480113 Free PMC article Kipps et al. Chronic lymphocytic leukaemia. Nat Rev 2017 https://pubmed.ncbi.nlm.nih.gov/28102226/ Seda V, Mraz M. B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.  Eur J Haematol. 2015 Mar;94(3):193-205. doi: 10.1111/ejh.12427. Epub 2014 Sep 13. PMID: 25080849 Review. Research area: Cancer biology Keywords: lymphoma, CLL, migration, microenvironment, co-culture Funding for the PhD candidate: In the academic year 2026/27 the net income of the CEITEC PhD School student is expected to be at least CZK 29,400 (approx. EUR 1215) Part-time salary (min. 0,5 FTE) on EHA grant/AZV/GACR grants + doctoral scholarship + CEITEC PhD School scholarship. Requirements on candidates: Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have deep interest in molecular biology and cancer cell biology. Information about the supervisor: H-index 30 (citations > 3500, 50 publications with IF), currently principal investigator of 4 grants (AZV 3x, NPO, in the past ERC Starting grant). Dr. Mraz has currently 7 PhD students, with 3 finishing soon). international collaborations: University of Southampton, Univ. California- San Diego, Mayo Clinic, Dana-Farber Cancer Institute, EMBL, University of Turin (student internship available), member of EHA Comittee, reviewer in scientific journals: Blood, Leukemia, Leukemia Research; https://is.muni.cz/auth/osoba/101627; More information about the research group: http://mrazlab.ceitec.cz/ Start date: September 2026 Sign-up link: https://www.ceitec.eu/lymphoid-microenvironment-models-and-their-use-to… Where to apply Website https://www.ceitec.eu/lymphoid-microenvironment-models-and-their-use-to-study-t… Application form

Offer Description Doctoral study program: Biomedical Sciences Specialization: Molecular Medicine Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: Long non-coding RNAs (lncRNAs) in microenvironmental interactions of B cell chronic lymphocytic leukemia Annotation: Marek Mraz research group has a long-term interest in non-coding RNAs and microenvironmental interactions of malignant B cells, and this research has been supported by an ERC Starting grant (2019-2024). We have previously described novel regulators of microenvironmental interactions including short non-coding RNAs, microRNAs (Sharma et al…Mraz, Blood, 2021; Musilova et al…Mraz, Blood, 2018; Cerna et al…Mraz, Leukemia, 2019). MicroRNAs were shown to play a pivotal role in B cell functions; however, the functions of long non-coding RNAs (lncRNAs) remain unclear. We aim to decipher for the first time the role of lncRNAs in B cell receptor (BCR) signaling and B-T cell interactions. Human genome contains large numbers of lncRNAs that can regulate various physiological cellular processes or contribute to the onset or aggressiveness of cancer. We will study lncRNAs in the context of chronic lymphocytic leukemia (CLL), which is driven by aberrations in the BCR pathway and B-T interactions. Regulation of BCR pathway and B-T cell interactions by lncRNAs is likely of relevance for CLL, but is also transferable to the biology of other B cell malignancies, autoimmune diseases and normal B cells. We identified 3 candidate lncRNAs involved in microenvironmental interactions of CLL. We will decipher the molecular functions of these lncRNAs using biochemical and cellular approaches and via a novel lncRNA knock-out mouse model. We have engineered mice for genetic loss of one of these lncRNAs, and the student will analyse the phenotype of these mice and breed them with known CLL mouse models (Eu-TCL1). Detailed biochemical/molecular studies will complement these data and we will also analyze primary samples from patients with B cell malignancies. We will identify functions of lncRNAs using CRISPR interference, RNA pulldown experiments, mouse models, and molecular biology technics. Furthermore, we developed a novel co-culture model inducing robust primary CLL cell proliferation (~50%) in vitro (Hoferkova et al, Leukemia, 2024). We aim to utilize this game-changing tool to perform the first-ever CRISPR screening of lncRNAs/genes regulating primary CLL cell proliferation. This will help better understand the disease biology and possibly identify novel molecular targets for therapy. Recommended literature: Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions.  RNA Biol. 2021 May;18(5):619-632.https://pubmed.ncbi.nlm.nih.gov/33094664 Mattick JS, et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 2023 Junhttps://pubmed.ncbi.nlm.nih.gov/36596869/ Sharma et al. …Mraz. miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors. Blood 2021.https://pubmed.ncbi.nlm.nih.gov/33171493/ Musilova K, Mraz M. MicroRNAs in B-cell lymphomas: how a complex biology gets more complex. Leukemia. 2015 May;29(5):1004-17 Research area: Cancer biology Keywords: lymphoma, CLL, lncRNA, microenvironment Funding for the PhD candidate: In the academic year 2026/27 the net income of the CEITEC PhD School student is expected to be at least CZK 29,400 (approx. EUR 1215) Part-time salary (min. 0,5 FTE) on EHA grant/AZV/GACR grants + doctoral scholarship + CEITEC PhD School scholarship. Requirements on candidates: Motivated smart people that have the “drive” to work independently, but also willing to learn from other people in the lab and collaborate. Candidates should have a master’s degree in Molecular biology, Biochemistry, or similar field and have deep interest in molecular biology and cancer cell biology. Information about the supervisor: H-index 30 (citations > 3500, 50 publications with IF), currently principal investigator of 4 grants (AZV 3x, NPO, in the past ERC Starting grant). Dr. Mraz has currently 7 PhD students, with 3 finishing soon). international collaborations: University of Southampton, Univ.California- San Diego, Mayo Clinic, Dana-Farber Cancer Institute, EMBL, University of Turin (student internship available), member of EHA Comittee, reviewer in scientific journals: Blood, Leukemia, Leukemia Research; https://is.muni.cz/auth/osoba/101627; More information about the research group: http://mrazlab.ceitec.cz/ Start date: September 2026 Sign-up link: https://www.ceitec.eu/long-non-coding-rnas-lncrnas-in-microenvironmental-interactions-of-b-cell-chronic-lymphocytic-leukemia/t11430 Where to apply Website https://www.ceitec.eu/long-non-coding-rnas-lncrnas-in-microenvironmental-intera…

Offer Description The Faculty of Science, Palacký University Olomouc, invites applications for a Postdoctoral Researcherposition at the Department of Zoology. The position is primarily focused on completing independent research projects and publishing their results in international scientific journals. Key Responsibilities Conduct independent research in zoology or related biological disciplines Successfully complete research projects and prepare manuscripts Publish results in international peer-reviewed journals Contract length: One year, with the possibility of extension in the event of exceptional scientific achievements Expected starting date: 15 April 2026 Where to apply E-mail milan.vesely@upol.cz Website https://pracuj.upol.cz/nc/en/news/clanek/postdoctoral-research-fellow-with-focu… Requirements Research FieldBiological sciences » ZoologyEducation LevelPhD or equivalent Skills/Qualifications Ph.D. degree (or equivalent) in zoology, ecology, evolutionary biology, or a related field Proven publication record appropriate to career stage Ability to work independently and within an international research environment Very good command of English (written and spoken) LanguagesENGLISHLevelExcellent Additional Information Benefits https://www.prf.upol.cz/en/employees/employee-care/ Selection process https://pracuj.upol.cz/en/guide-to-the-recruitment-process/ Additional comments Documents required: Curriculum vitae, including a list of publications in international peer-reviewed journals in English Brief research and/or publication plan (1–2 pages) Contact details of two referees Applications should be submitted electronically here or as asingle PDF fileto the Head of the Department (milan.vesely@upol.cz) by15 February 2026.

Offer Description Workplace: Department of Experimental Biology, Faculty of Science, Masaryk University in Brno, Czech Republic Type of Contract: temporary position with 3-year contract (with possible extension), academic Working Hours: 0,3 FTE (part-time employment of 12 hours per week) Expected Start Date: 1.3.2026 or negotiable with respect to immigration timelines for non EU candidates Number of Open Positions: 1 Application Deadline: 12.2.2026                                         EU Researcher Profile:R2 About the Workplace Masaryk University is modern, dynamic and the most attractive university in the Czech Republic with ten faculties, more than 7 000 staff and 33 000 students, a wide range of research areas and a strong international position. We are the largest academic employer in the South Moravian Region. Faculty of Science MU, a holder of the HR Excellence in Research Award by the European Commission, is a research-oriented faculty, offering university education (Bachelor’s, Master’s, and Doctoral degree programs) closely linked to both primary and applied research and high school teaching of the following sciences: Mathematics, Physics, Chemistry, Biology, and Earth sciences. We are the most productive scientific unit of the Masaryk University generating around 40 % of MU research results. The Department of Experimental Biology, Section of Animal Physiology and Immunology at the Faculty of Science of MU is a modern, fully equipped workplace where individual research groups are engaged in research at all levels – from molecules and cells to invertebrates and humans; from basic research to the application of results in human and veterinary medicine. Job Description Key Duties: Active participation in the preparation and implementation of education in immunology for students in bachelor, master and doctoral degree programmes at the Faculty of Science Creation of texts for educational purposes Participation in the dissemination of knowledge in the field of experimental biology to the general public Skills and Qualifications The applicant must have: Completed university education in a doctoral programme (Ph.D.) in animal physiology or a related field Ability to perform independent teaching and experimental activities Excellent command of the English language, both written and spoken Excellent knowledge of the Czech language, both written and spoken, at C2 level; in the case of non-native speakers, it must be evidenced by a certificate or a high school graduation certificate in Czech language Active cooperation with Czech and foreign experts in the field Practical experience with in vivo experiments using mice – from preparation of animal protocols to inducing various types of inflammation, fibrosis, tumors, and isolating primary cells Knowledge of experimental work with extracellular vesicles Practical knowledge of flow cytometry methods Active attitude, initiative and willingness to continue professional growth Organisational skills Ability to work as part of a team Civic and moral integrity, responsibility Informal inquiries about the position can be sent to: doc. RNDr. Martin Vácha, email vacha@sci.muni.cz, phone no +420 549 497 877. We Offer An interesting job in a dynamically-expanding university area Participation in teaching immunological methods, the opportunity to pass on your expertise to students in an inspiring academic environment Opportunity to supervise bachelor, master and doctoral theses Use of state-of-the-art instrumentation at the Institute of Experimental Biology Flexible working hours and occasional home office to support personal needs in family and career compatibility Employee benefits such as 8 weeks of paid vacation per year, pension insurance contribution or nursery/children´s group allowance, Multisport card, vaccinations free of charge, discounted language courses, exclusive mobile tariff offer by Vodafone, childcare groups at Campus and Komenského náměstí) Opportunity to work and live in a modern and dynamic city (for more information on costs of living, you can refer to Numbeo) Welcome Office provides support with your relocation to Brno Application Process The application shall be submitted online by 12.2.2026 via an e-application https://www.muni.cz/en/about-us/careers/vacancies/80308 The candidate shall provide following: CV Cover letter describing candidate’s research interest and experience with experimental methods in immunology Names and contact details of at least 2 references After submitting your application successfully, you will receive an automatic confirmation email from jobs.muni.cz. Selection Process Received applications will be considered carefully in line with principles of the EU Charter and Code for Researchers. Selection criteria: (i) meeting qualification requirements described above, (ii) all required documents provided. Shortlisted candidates will be invited for a personal or online interview. The Faculty Recruitment Policy (OTM-R) can be seen here. Faculty of Science, Masaryk University is an equal opportunity employer. We support diversity and are committed to creating an inclusive environment for all employees. Visit our Career page. We are looking forward to hearing from you! Where to apply Website https://www.muni.cz/en/about-us/careers/vacancies/80308