Fixed-term

What if cardiometabolic and autoimmune diseases share a root cause? Join a cutting-edge collaboration uncovering how post-translational protein modifications ignite chronic inflammation and how we can intervene. For our Zon-MW funded project we invite 2 enthusiastic PhD candidates, one based at the Maastricht University and one at the Leiden University Medical Centre. This vacancy is for the position at Maastricht University, offering a stimulating research setting and close collaboration within the project team. PhD Candidate: The vicious circle of protein modification-induced chronic inflammation Our goal: In this project, you will explore how post-translationally modified proteins and their antibodies contribute to chronic (low grade) inflammation and the development of cardiometabolic diseases. By studying complement activation and is association with (sub)clinical phenotypes using data from The Maastricht Study, you will help clarify their relevance in the etiology of disease. Your colleagues: You will be embedded in a collaborative research environment at Maastricht University, working closely with researchers within the local team. You will also collaborate with researchers and a fellow PhD candidate at Leiden University Medical Centre in the research group of Prof Dr L.T. Trouw, with regular joint meetings and exchange visits as an integral part of the PhD programme. The PhD candidate based in Leiden will focus on the experimental and translational components of the project thereby complementing the human data analyses performed in Maastricht. Post-translationally modified proteins (PTMs) and their antibodies have been long-implicated in the etiology of auto-immune disease. Notably, PTMs and anti-PTMS are also found in other non-communicable diseases, but their pathophysiological relevance needs to be firmly established. In this PhD project, you will explore how activation of the complement system by PTMs contributes to systemic low-grade inflammation and to the development of cardiometabolic diseases. The complement system is part of our innate immune defence against infections and can trigger inflammation. You will use data and biobanked samples of The Maastricht Study (www.themaastrichtstudy.nl), a large and deeply-phenotyped observational cohort, as well as interventions cohorts. You will design and perform assays to measure several post-translationally modified proteins (PTMs) such as malondialdehyde-acetaldehyde adducted proteins, advanced glycation endproducts, and carbamylated proteins and their antibodies in this cohort. You will combine these data with the available in-depth (pre)clinical phenotypes to address the contribution PTM-activated complement activation contributes to the development of cardiometabolic diseases. What you doAs a PhD candidate you will: Design and perform in ELISA-based measurements of PTMs, anti-PTMs and complement in human samples (observation and interventional).   Perform data-analyses to relate these data to clinical outcomes. Perform cluster analyses to uncover underlying (patho)physiological phenotypes. Collaborate with the LUMC-team to integrate the human findings and preclinical experimental data. Publish your results, present at international conferences, and contribute to departmental teaching activities. Are you eager to uncover how ubiquitous protein modifications, via complement activation and proinflammatory effects, form a shared root cause in the etiology of cardiometabolic and autoimmune diseases? Then we’d love to meet you! What you bring We’re not looking for checkboxes; we’re interested in who you are and what you bring. Do you recognize yourself in this? You are interested in interdisciplinary research that explores the full translational axis, this is your place to be. Our ideal candidate holds accuracy and precision in high regards, possesses strong analytical and critical thinking skills and excellent communication skills. Collaboration, good time management and organizational skills are vital for properly balancing a PhD project. Additionally, adaptability and a proactive learning attitude are key to successfully completing a PhD track. Furthermore, you bring: MSc in Biomedical Sciences, Epidemiology, Medicine, Biology, Health Sciences, or a related field. Good laboratory skills, preferably including experience with analytical laboratory assays such as ELISA. Experience and affinity with statistical analyses in large datasets (regression, mediation, moderation). Experience in working in interdisciplinary teams or a strong desire to do so. Excellent Proficiency in scientific English (speaking, reading, and writing), at C1 level or higher. Proficiency in use SPSS and/or R or willingness to learn. A keen and demonstratable interest in the etiology behind the development of cardiovascular diseases and related comorbidities. What we offer At Maastricht University, you’ll work in an international, open, and engaged environment. We offer:  A 12-month contract (1,0 FTE) with the prospect of a 3 year extension based on mutual satisfaction. A gross monthly salary between € 3.059 and € 3.881 (based on full-time employment of 38 hours per week). 8% holiday allowance and an 8.3% year-end bonus.  29 vacation days (based on full-time), four additional days off (Carnival Monday and Tuesday, Good Friday, and Liberation Day), and the possibility to accrue up to 12 extra days through compensation hours.Freedom and space to shape your work independently and develop your ideas.  A close-knit community of colleagues to collaborate and grow with.  A solid pension plan via ABP, company fitness schemes, and access to various university sports facilities.  An inspiring work environment in the heart of Europe.  About the Faculty of Health, Medicine and Life Sciences (FHML)FHML is committed to health in the broadest sense: from molecule to human, and from healthcare to prevention. We train healthcare professionals and researchers through innovative educational programmes and conduct groundbreaking research in health and well-being. As part of Maastricht UMC+ (MUMC+), our international and interdisciplinary community forms a unique collaboration between university and academic hospital, where education, research, and care come together. Interested?Want to know more about this position or what it’s like to work at our university? Reach out to Dr. Marleen van Greevenbroek at m.vangreevenbroek@maastrichtuniversity.nl. The end date of the publication is 2 August 2026. If you want to apply, please submit the following: CV Motivationletter which you clearly explain why you are the most suitable candidate for this position Academic Transcripts Contactdetails of two referees Please note that only complete applications will be considered. The first round of interviews will take place between 11 and 14 August 2026. In the second interview round candidates will be asked to prepare and deliver a presentation. Apply now via the button below. We look forward to getting to know you! Apply Now

We are seeking to recruit a Postdoctoral Research Associate within the Centre for Preclinical Imaging (CPI) at the University of Liverpool (UoL). This 30-month position is available from 1 July 2026 to work on a study to characterise biodistribution, dissipation and efficacy of long-acting drugs. Funded by a multi-million-pound EPSRC grant to establish a world leading UK Hub for Advanced Long-acting Therapeutics (HALo) this work will involve multimodal imaging including MRI and MPI in rodent models to assess long-acting drugs. We are seeking a dynamic and motivated candidate with expertise in mammalian cell culture, small animal (rodent) imaging to support data acquisition and qualitative analysis of the imaging studies. In this highly collaborative project, you will be working with internationally leading scientists and researchers with expertise in chemistry, pharmacology, cancer biology and imaging. The focus of our group is to develop cutting-edge translational imaging biomarkers. You will also support the integrated analysis of imaging findings with chemical analysis and other wet lab assays towards characterising the long-acting drugs for various biological applications. Essential criteria include a PhD in Biological Sciences or a related field, with experience mammalian cell culture and small animal in vivo imaging. Excellent communication, team working, and organisational skills are essential. Experience using state-of-the-art imaging software, image processing using Matlab or similar image processing platforms is desirable. A personal license by the Home Office to work on animals in UK would be an asset but not essential as training can be provided for candidates who do not have a licence. For preliminary enquiries and specific application details, contact Professor Harish Poptani Harish.Poptani@liverpool.ac.uk or Dr Marco Giardiello magia@liverpool.ac.uk. If you are still awaiting your PhD to be awarded you will be appointed at Grade 6, spine point 30. Upon written confirmation that you have been awarded your PhD, your salary will be increased to Grade 7, spine point 31 Our commitment to Equality, Diversity and Inclusion. We are committed to enhancing a workforce as diverse as our community and particularly encourage applicants who are of minoritised genders and ethnic backgrounds, living with a disability, and/or are members of the LGBTQIA+ community. Click on the link below to view the full Job Description Job description   Apply Now

Project description Crohn’s disease is an incurable inflammatory condition of the gut associated with high morbidity, poor quality of life and significant healthcare costs. The current treatment options for Crohn’s disease include nutrition and immunosuppressant drug-based therapies. Up to 60% of patients will initially respond to these therapies; however around 20% of them will lose response every subsequent year. Hence, there is a need to develop novel combination and andjuct therapies for more effective and long-lasting disease control. Within a multicentre clinical trial, the PhD student will test nutritional therapies as an adjuvant to biological drug therapies to optimise treatment effectiveness, reduce disease activity and improve inflammatory markers in children with active Crohn’s disease. This PhD will also explore the effect of this novel combination therapy approach on host immune responses and the mediating role of habitual diet. This project may lead to the development of new, more potent and personalised, dietary therapies for children with Crohn’s disease. This PhD opportunity is a collaboration between academics in the University of Glasgow, clinicians from 6 children hospitals across Scotland and Nestle Health Sciences, a major industrial partner specialised in the production of proprietary nutritional therapies for the management of Crohn’s Disease. The student will be working in collaboration with another laboratory PhD student who will focus on the role of the gut microbiome in predicting responses to nutrition and drug-based therapies. The two students will be working in parallel, each with distinct individual objectives. Candidates should have a 2:1, preferably with relevant experience in dietetics/nutrition (preferably clinical nutrition), nursing or another healthcare profession. During the course of the PhD, the student will receive training in conducting and co-ordinating clinical trials, dietary assessment, clinical nutrition and dietetics, and clinical medicine. The student will work in partnership with the National Health Service. Dietary assessment will be performed using both conventional and novel dietary assessment methods. A panel of pro-inflammatory and anti-inflammatory cytokines will be measured and a comprehensive immunophenotype of peripheral blood mononuclear cells will be performed. The student will gain experience in cutting-edge research within a multidisciplinary team (School of Medicine, Dentistry and Nursing) working at the interface of clinical medicine, nutrition, dietetics, food science, bioinformatics and laboratory based research. The student will also be in close interaction with the industrial partner involved in this study and will exchange knowledge with them regularly, offering a unique industrial slant to this research post. NOTE: Once you apply through the online portal, please forward your application reference number and CV to Konstantinos.gerasimidis@glasgow.ac.uk. Funding Notes This prestigious studentship covers tuition fees, an annual stipend in excess of the UKRI rate at £24,000 per year for 3.5 years of studies and a generous budget for study running costs. This studentship offers only Home fees for UK students or students who are eligible for Home fees (e.g. those with settled status or of Irish citizenship). Suitable students should have as a minimum an upper second-class honours BSc. Apply Now

About the Project We invite applications from candidates eligible for UK student status for a PhD project investigating how mechanical forces contribute to development, and how these principles can be harnessed to inspire engineering solutions for tissue repair and regenerative medicine. Candidates with either experimental or theoretical backgrounds are encouraged to apply. The project will focus on ciliated tissues, such as those lining the airways, where microscopic hair‑like structures called cilia beat in a coordinated manner to generate fluid flow and transport mucus. While these systems are essential for physiological function, how they self‑organise during development to establish robust, large‑scale fluid flows remains poorly understood. This project will investigate how mechanical forces, fluid flow, and mechanotransduction drive the self‑organisation of ciliated tissues during development and wound healing. Together, we will combine quantitative experiments and mathematical modelling to uncover the physical principles underlying fluid transport in developing tissues, with relevance to tissue repair and regenerative medicine. Who should apply? Applicants from biology, physics, engineering, mathematics, or related disciplines are encouraged to apply. Both students with experimental and/or quantitative experience are welcome.   Ideal for students interested in: ·        bioengineering ·        biosciences ·        biophysics ·        cell mechanics ·        fluid dynamics Training includes: ·        quantitative live imaging; image analysis ·        biophysical experiments, including biophysical manipulation of Xenopus embryos ·        computational modelling ·        microfabrication and 3D printing Research environment Based at Durham University, you will join a collaborative environment spanning Engineering, Biosciences, and the Durham Biophysical Sciences Institute. You will have access to state-of-the-art imaging, fabrication, and interdisciplinary research facilities. Funding Notes This PhD studentship is for four years and is available to home students only. The funding covers a tax-free stipend at the UKRI rate and the full tuition fees at the home rate. If you are interested in applying, in the first instance contact the supervisor (Francesco Boselli, francesco.boselli@durham.ac.uk), detailing your reasons for applying for the project, as soon as possible, by no later than Friday 31st July, 2026. The position will be closed as soon as it is filled.

We are seeking a motivated and collaborative individual to join our team as a postdoctoral research associate. This role offers an exciting opportunity to contribute to the newly established NaVigate programme to develop treatment options for Alzheimer’s Disease and other small vessel diseases of the brain. The position will be initially available for 3 years, with the possibility of extending up to 5 years. The research will be carried out in the Microvascular@Manchester group (microvascularmanchester.com) under the guidance of Professor Adam Greenstein and Dr Harry Pritchard. The post will be based within the Division of Cardiovascular Sciences at the University of Manchester and the Geoffrey Jefferson Brain Research Centre. You will be responsible for: Leading research into the mechanisms underlying hypertension-related and amyloid-induced changes to cerebral small artery vascular smooth muscle cell and endothelial cell ion channel activity To prepare material for publications and conference presentations. To write reports for submission to research sponsors and partake in relevant meetings. To be an active team-member and set positive examples by showing a commitment to achieving results, encouraging and supporting junior members of the team and raising suggestions for continuous improvement. We welcome candidates who bring diverse perspectives, experiences, and approaches to their work. About You We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate: Essential Criteria: Have, or be about to obtain, a PhD (or equivalent) in biophysics and membrane biology (or similar) Extensive and up-to-date understanding of ion channel biophysics. Hands-on experience in native (freshly isolated) single cell patch clamp electrophysiology with competence in hardware and software assembly, maintenance and data analysis Experience with animal models Strong journal publication record. Desirable Criteria: Experience and understanding of cardiovascular physiology, preferably in the field of small artery biology. Cardiovascular, particularly microvascular, patch clamp expertise. Flexible approach to dealing with research problems as they arise Willingness to learn and develop Ability to assess and organise resources We value transferable skills and real-world experience as much as formal qualifications. Our benefits include:• Generous employer contribution pension• 29 days annual leave plus bank holidays, along with Christmas closure• Ride to work and EV car scheme available For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here. We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy. Enquiries about the role, shortlisting and interviews Name: Professor Adam Greenstein Email Address: adam.greenstein@manchester.ac.uk General enquiries and administrative support recruitmentservices.people@manchester.ac.uk Technical and job portal support https://jobseekersupport.jobtrain.co.uk/support/home This role is not eligible for Skilled Worker visa sponsorship. Applicants must demonstrate the right to work in the UK. Applications close at midnight on the closing date. Further particulars (with person specification) linked below. Supporting Documents Research Associate Grade 6 fps – Patch clamp (PDF, KB) Apply Now

We are seeking a motivated and collaborative individual to join our team as a Research Technician to provide specialist technical support for research programmes investigating the vascular mechanisms of dementia and other brain disorders. This role offers an exciting opportunity to contribute to internationally recognised research by undertaking and optimising laboratory experiments, supporting the operation of advanced research equipment, and helping generate high-quality experimental data. Working closely with researchers, students and technical colleagues, you will play an important role in supporting safe, efficient and effective laboratory-based research, within a dynamic and inclusive environment. You will be responsible for: Supporting research animal model maintenance and undertaking microdissection of arteries. Performing and optimising experimental protocols, including antibody-based imaging using confocal and super-resolution microscopy. Undertaking pressure myography and calcium imaging of small arteries, and supporting staff and students with standard laboratory protocols. Training junior technicians and PhD students in relevant laboratory techniques, including myography. Maintaining accurate records, supporting data preparation for presentations and publications, contributing to experimental design, and ensuring work is carried out in line with health and safety, data protection and University requirements. We welcome candidates who bring diverse perspectives, experiences, and approaches to their work. About You We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate: Essential Criteria: A relevant biological sciences qualification, or equivalent qualifications and substantial experience working in a research laboratory. Extensive hands-on experience of small artery physiology and immunohistochemistry in a laboratory-based dementia research setting. Strong organisational skills, with the ability to manage a complex workload, prioritise competing demands and work to deadlines without direct supervision. Excellent communication, analytical and problem-solving skills, with a high level of accuracy, attention to detail and reproducibility in laboratory work. Desirable Criteria: Experience using Word, Excel and PowerPoint, with experience of ImageJ and/or IMARIS also beneficial. A flexible approach to working hours where required to monitor procedures or experiments. We value transferable skills and real-world experience as much as formal qualifications. Our benefits include: Generous employer pension contribution Christmas closure across all departments outside of annual leave and bank holidays Purple Place employee discount platform For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here. We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy. Enquiries about the role, shortlisting and interviews Name: Adam Greenstein Email Address: adam.greenstein@manchester.ac.uk General enquiries and administrative support recruitmentservices.people@manchester.ac.uk Technical and job portal support https://jobseekersupport.jobtrain.co.uk/support/home This role is not eligible for Skilled Worker visa sponsorship. Applicants must demonstrate the right to work in the UK. Applications close at midnight on the closing date. Further particulars (with person specification) linked below. Supporting Documents BMH-031971 – Research technician – FPs (PDF, KB) Apply Now

About Us The School of Cardiovascular & Metabolic Medicine & Sciences (SCMMS) provides an outstanding multi-disciplinary environment for the pursuit of cutting-edge cardiovascular and metabolic research (https://www.kcl.ac.uk/scms).   We study the fundamental molecular, cellular, and physiological processes that underly normal and abnormal cardiovascular and metabolic function and we drive the translation of this strong basic science into advances in clinical practice to improve prevention, diagnosis and treatment.  This activity provides a high-quality research and training environment for non-clinical and clinical scientists. The School occupies facilities across the Guy’s, St Thomas’ and Denmark Hill campuses of King’s College London and comprises over 65 academic groups, hosting 400 staff and 110 PhD students.  Our community of world-renowned researchers and educators have access to a state-of-the art core facilities and expertise, including for high-throughput screening, multimodality in vivo imaging, proteomics, integrative physiology and viral & non-viral vector production. As part of King’s Health Partners, we have an excellent environment for basic-clinical interaction and a strong focus on mentoring and career development.  The School is a partner of the NIHR Biomedical Research Centre at Guy’s and St. Thomas’, which offers world class facilities for translational studies and phase I/II clinical trials. The post is based within the School of Cardiovascular and Metabolic Medicine & Sciences at the Southbank Campus.  The School and these Centres provide an outstanding highly multidisciplinary environment with state-of-the-art equipment, facilities and technical support for both laboratory work and animal studies.  About The Role A position is available for a Cardiovascular Research Fellow (Cardiac Physiologist / Clinical Scientist) within the School of Cardiovascular and Metabolic Medicine & Sciences at King’s College London. This jointly funded post between King’s College London and Guy’s and St Thomas’ NHS Foundation Trust is embedded within one of the UK’s leading echocardiography research groups. The role offers a unique combination of clinical service delivery and academic research, providing an excellent opportunity for both professional and academic development. The successful candidate will perform and independently report clinical echocardiography examinations to British Society of Echocardiography (BSE) standards. They will lead research clinics jointly overseen by the Echocardiography Department at Guy’s and St Thomas’ NHS Foundation Trust (clinical governance) and the Department of Clinical Pharmacology at King’s College London (academic governance), including but not limited to Cardiac Resynchronisation Therapy (CRT) Optimisation and Inherited Cardiac Conditions clinics. The post holder will also undertake vascular and other physiological assessments in accordance with research study protocols. BSE Adult Transthoracic Echocardiography Accreditation (or an equivalent qualification) is an essential requirement for this role. Working under the supervision of Dr Haotian Gu (Principal Investigator), the post holder will contribute to the NIHR-funded EFFECT-CRT study, the British Heart Foundation-funded EF1 in CRT study, and other research projects led by the Guy’s and St Thomas’ Cardiovascular Research & Development team. Academic responsibilities will include supporting study coordination, data management and analysis, and the preparation of reports, presentations, and scientific publications. The post will be primarily based at the Clinical Research Facility, St Thomas’ Hospital, London, with travel to other study sites required as part of the research programme. This is a full-time post (40 hours per week), and you will be offered a fixed term contract for two years from start of contract. About You To be successful in this role, we are looking for candidates to have the following skills and experience:  Essential criteria BSc or equivalent in a subject relevant to cardiovascular research   British Society of Echocardiography Adult Transthoracic Echocardiography Accreditation or equivalent   Clinical echocardiographic experience – equivalent to NHS Band 7  Knowledge of cardiovascular physiology   Good written and presentation skills  Good IT skills  Desirable criteria Post-graduate qualification or PhD in a subject relevant to cardiovascular research  Experience in cardiovascular research management  Experience in grant application   Experience in conference presentation  Experience in research publication  Downloading a copy of our Job Description Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process.   Further Information At King’s, we believe that the diversity of our community and a culture that is welcoming, open, inclusive and collaborative, are great strengths of the university. The Equality Act of 2010 protects the rights of our students and staff and provides a framework to fulfil our duties to eliminate unlawful discrimination, harassment and victimisation and in addition, to advance equality of opportunity and foster good relations between those who share a protected characteristic and those who do not. At times, this will include balancing rights and beliefs that can feel in tension. We are committed to free speech and to academic freedom, believing that our foundational purpose as a university, is to create spaces where a wide range of ideas, including ideas that are controversial, can be discussed and debated, and where members of our community can express lawful views without fear of intimidation, harassment or discrimination. When engaging in the robust exchange of ideas, we ask that our community is mindful of our Dignity at King’s guidance. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the person specification section of the job description. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible. To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages. Apply Now