Fixed-term

Professor Andrew Jones (Primary)  Professor Anni Vanhatalo Dr Jonathan Fulford Dr Matt Black Location:  Department of Public Health and Sport Sciences, St Luke’s Campus (Exeter) Maurten manufacture sports nutrition products, including a sodium bicarbonate ingestion system that serves to increase blood buffering capacity. This is important in high-intensity exercise and sports where the body generates acid during metabolism. The research project aims to evaluate the efficacy and mechanisms of action of this specific product when consumed acutely prior to bouts of continuous (e.g., 4 min treadmill time trial) and intermittent (e.g., simulated interval training session) high-intensity exercise, as well as when consumed more chronically as part of a training programme. Skeletal muscle and blood samples will be taken and other physiological and performance measurements will be made to ascertain the influence of sodium bicarbonate compared to a placebo. The research would suiit a student with an interest in exercise physiology and metabolism, causes of exercise-related fatigue, sports nutrition and athletic performance.   The University of Exeter’s Department of Public Health and Sport Sciences is inviting applications for a PhD studentship co-funded by Maurten and the University to commence on 21 September 2026 or as soon as possible thereafter.  For eligible students the studentship will cover Home tuition fees plus an annual tax-free stipend of at least £21,805 for 3.5 years full-time, or pro rata for part-time study.  The student would be based in the Faculty of Health and Life Sciences at the St Luke’s Campus in Exeter. This is a 3.5-year PhD studentship.  This is a 3.5 year PhD studentship co-funded by Maurten.   The studentship will be awarded on the basis of academic merit. Students who pay international tuition fees are eligible to apply. However, please note the following:  The award covers only part of the international tuition fee, approximately £27,000. It does not include a stipend for living expenses. International applicants will need to cover additional costs, including: Student visa fees Immigration Health Surcharge Relocation expenses associated with moving to the UK to undertake a PhD.  Applicants should ensure they have sufficient funds to meet these costs before applying.  The conditions for eligibility of home fees status are complex and you will need to seek advice if you have moved to or from the UK (or Republic of Ireland) within the past 3 years or have applied for settled status under the EU Settlement Scheme.    Entry requirements Applicants for this studentship must have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of sports science, human physiology or nutrition.   If English is not your first language you will need to meet the English language requirements and provide proof of proficiency. Click here for more information.  How to apply To apply, please click the ‘Apply Now’ below . In the application process you will be asked to upload several documents.  CV Letter of application (outlining your academic interests, prior research experience and reasons for wishing to undertake the project). Transcript(s) giving full details of subjects studied and grades/marks obtained (this should be an interim transcript if you are still studying) Two references from referees familiar with your academic work. If your referees prefer, they can email the reference direct to PGRApplicants@exeter.ac.uk quoting the studentship reference number 5865. If you are not a national of a majority English-speaking country you will need to submit evidence of your proficiency in English.  The closing date for applications is midnight on 19th June 2026.  Interviews will be held virtually or on the University of Exeter St Luke’s Campus in the week commencing 13th July 2026.   All application documents must be submitted in English. Certified translated copies of academic qualifications must also be provided.  For general information about this studentship and the application process, please contact PGRApplicants@exeter.ac.uk. Please quote reference 5865 on your application and in any correspondence about this studentship.  Project specific queries should be directed to the main supervisor. Apply Now

Position Details Department of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health Location: University of Birmingham, Edgbaston, Birmingham UK Full time starting salary is normally in the range £45,943 – £65,048 depending on ST level. Grade: Clinical Full Time, Fixed Term contract up to 3 years Closing date: 7th July Start date will ideally be 1st February 2027 Role Summary To contribute to the achievement of the Institute’s research strategy by undertaking specified research activities within an established research programme. The project is entitled: “Opportunity in Brain Tumour Diagnostics, Multi-Omics and Computational Biology.” This project addresses a major unmet clinical need: brain tumours remain the leading cause of cancer-related death in children and adults under 40, with survival outcomes still poor. Median time from surgery to tissue diagnosis is 26 days (IQR 21–36; Tessa Jowell BRAIN MATRIX interim analysis 2025). This PhD aims to develop rapid and accurate diagnostic approaches using advanced genomic technologies. The project will evaluate rapid sequencing methods alongside DNA methylation-based classifiers to accelerate tissue diagnosis. By reducing the time to diagnosis and developing new efficient techniques, this work has the potential to improve patient outcomes, enable faster access to targeted therapies and clinical trials, and reduce the psychological burden associated with diagnostic delays. We are offering an exciting fully funded clinical PhD opportunity in brain tumour diagnostics, focusing on multi-omics approaches and computational biology. This project addresses a major unmet clinical need: brain tumours remain the leading cause of cancer-related death in children and adults under 40, with survival outcomes still poor. Median time from surgery to tissue diagnosis is 26 days (IQR 21–36; Tessa Jowell BRAIN MATRIX interim analysis 2025). This PhD aims to develop rapid and accurate diagnostic approaches using advanced genomic technologies. The project will evaluate rapid sequencing methods alongside DNA methylation-based classifiers to accelerate tissue diagnosis. By reducing the time to diagnosis and developing new efficient techniques, this work has the potential to improve patient outcomes, enable faster access to targeted therapies and clinical trials, and reduce the psychological burden associated with diagnostic delays. The molecular testing will be performed mainly at the Molecular Pathology Diagnostic Service (MPDS) at UHB led by Dr Philippe Taniere, which offers access to a wide range of technologies on site (IHC, FISH, RT-PCR, NGS, long read sequencing, methylation array) as well as technical and scientifical support. The Jean Spier brain tumour tissue pipeline provides access to fresh tumour samples with appropriate clinical annotation led by Dr Victoria Wykes (academic neurosurgeon). Collaboration will also be with the Department of Cancer and Genomic Sciences – University of Birmingham, led by Professor Andrew Beggs The successful candidate (pathology /neurosurgery ST1-3 ideally with a National Training Number) will generate and analyse a richly annotated, integrated multi-omic dataset from brain tumour samples. Working at the interface of computational biology, neuro-oncology and molecular medicine, the student will apply state-of-the-art transcriptomic, proteomic and epigenomic profiling techniques. The project will also involve developing and validating novel diagnostic classifiers and establishing a testbed for genomic testing in a clinical setting. The pilot data generated will be used to apply for further fellowship funding eg.NIHR Academic Clinical Lecturer. Main Duties To plan and develop research contributions to subject area using methodologies, critical evaluations, interpretations, analyses and other appropriate techniques To analyse and interpret the results of own research and generate ideas based on outcomes To suggest and contribute to the development of research techniques, models and methods in collaboration with colleagues To contribute to writing bids for research grants To disseminate research findings using appropriate and effective media such as publication, research seminars etc To provide guidance to other staff and students on own specialist area To contribute to the production of research reports and publications To prepare papers for Steering groups and other bodies Promotes equality and values diversity acting as a role model and fostering an inclusive working culture Person Specification Medical degree, Intercalated or biomedical science degree preferable ST-1-ST3: National Training Number in Medicine or surgery (preferably pathology/neurosurgery or oncology)  Possesses sufficient breadth and depth of specialist knowledge in the discipline and or research methods and techniques to work within established research programmes. Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly. OH&DBS required The University is committed to safeguarding and we promote safe recruitment practice, therefore all associated pre-employment checks will be undertaken before any appointment is confirmed. Due to the nature of the work undertaken in this role all successful applicants will be subject to a satisfactory Occupational Health and DBS clearance prior to appointment. Further particulars can be found here Informal enquiries to Victoria Wykes, email: v.wykes@bham.ac.uk Use of AI in applications: We want to understand your genuine interest in the role and for the written elements of your application to accurately reflect your own communication style. Applications that rely too heavily on AI tools can appear generic and lack the detail we need to assess your skills and experience. Such applications will unlikely be progressed to interview. Apply Now

The Opportunity We are seeking an outstanding Research Fellow to join an ambitious translational oncology programme focused on improving precision treatment approaches for patients with gastrointestinal cancers. This funded programme brings together laboratory scientists, clinicians, and molecular researchers to develop clinically relevant approaches for understanding therapeutic response and resistance in cancer. The post offers a rare opportunity to contribute to a highly translational initiative operating at the interface of discovery science and patient care. The successful candidate will play a central role in shaping experimental strategy, generating clinically relevant biological insights, and supporting the progression of the programme towards future clinical application. This is not a conventional postdoctoral role centred on a predefined set of experiments. It is an opportunity to contribute to the development of an evolving translational research platform with clear real-world relevance. The Role The Research Fellow will contribute to the scientific and translational development of the programme, including: developing and optimising advanced experimental cancer models  leading functional studies examining therapeutic response and resistance  integrating biological and molecular data to support translational interpretation  contributing to clinically relevant reporting and communication of findings  supporting regulatory, governance, and translational preparation activities  helping shape experimental direction in collaboration with clinical and scientific investigators  The role requires a high degree of scientific independence, critical thinking, and translational judgement. What we are looking for We are seeking an individual with strong experimental expertise and an interest in clinically relevant cancer research. Essential: PhD (or equivalent) in cancer biology or a related discipline  Strong background in experimental oncology or cellular/molecular biology  Experience developing or optimising complex biological assays or model systems  Ability to interpret multifaceted biological data critically  Excellent communication and organisational skills  Evidence of scientific writing and publication  Desirable: Experience working with translational or clinically aligned research programmes  Familiarity with cancer therapeutics, resistance biology, or tumour modelling  Experience integrating molecular and functional datasets  Understanding of research governance, ethics, or regulatory frameworks  Experience working within multidisciplinary environments The Environment The successful candidate will join a collaborative multidisciplinary research environment spanning: translational cancer biology  clinical oncology and surgery  molecular profiling and computational analysis  The programme provides access to established infrastructure, high-quality clinical material, and strong translational support across Southampton and partner clinical centres. Why this role is different This position offers the opportunity to work within a genuinely translational programme designed with future clinical application in mind. You will contribute not only to experimental delivery, but also to the development of approaches capable of bridging laboratory discovery and clinical decision-making. The role is particularly suited to candidates interested in: translational cancer research  clinically impactful science  multidisciplinary programme development  future leadership in translational oncology  Career Development The post provides excellent opportunities for career progression and scientific development, including exposure to: translational programme leadership  multidisciplinary clinical–scientific collaboration  clinically aligned research strategy  future grant and fellowship development Informal enquiries For informal discussion of the role, please contact the Innovation for Translation Research Group leads: Professor Zoë Walters (Z.S.Walters@soton.ac.uk)Professor Tim Underwood (T.J.Underwood@soton.ac.uk) Apply Now

This position is subject to the satisfactory completion of required background checks. Postdoctoral Fellow Position – Cell Division and Mammary/Epithelial Cancer Biology Maxwell Lab | BC Children’s Hospital Research Institute | University of British Columbia Position Summary The Maxwell Laboratory invites applications for a highly motivated Postdoctoral Fellow with strong expertise in mammary gland biology, epithelial tissue organization, or mechanisms of cell division and mitosis, with a particular interest in cancer susceptibility and genome instability. The successful candidate will join a dynamic research team focused on understanding how errors in cell division and tissue organization contribute to hereditary and childhood cancers, with emphasis on BRCA1-associated pathways, spindle orientation, and epithelial cell fate decisions in mammary and related tissues. About the Lab The Maxwell Lab, led by Dr. Chris Maxwell at BC Children’s Hospital Research Institute and UBC, investigates how cell division is regulated at the molecular and tissue level, and how its disruption contributes to hereditary cancers and pediatric malignancies (https://bcchr.ca/maxwell-lab). Key areas include: Mechanisms of cell division fidelity, spindle orientation, and cell polarity Role of BRCA1 and associated pathways (e.g., PLK1, HMMR) in mammary epithelial biology Cellular origins of genome instability in cancer predisposition syndromes Development of in vivo and ex vivo models of pediatric and hereditary cancers Translation toward personalized medicine approaches in childhood cancer The lab has extensive expertise in: ·       Human primary mammary epithelial cell systems ·       Mouse and genetically engineered cancer models ·       High-content and live-cell imaging ·       Tumor evolution and therapeutic response modeling Research Environment The fellow will be embedded in a highly collaborative environment within: BC Children’s Hospital Research Institute, UBC Department of Pediatrics, and the Michael Cuccione Childhood Cancer Research Program. The lab also actively collaborates with national and international partners in the fields of: Hereditary cancer biology; Oriented cell division mechanisms; Pediatric leukemia and breast cancer modeling; and, Precision oncology initiatives Project Focus (Representative Areas) and Responsibilities Applicants may contribute to one or more of the following: 1. Mammary epithelial cell fate and division orientation Mechanisms controlling symmetric vs asymmetric division Role of spindle orientation in differentiation and tumor initiation 2. Genome instability in hereditary cancer syndromes Role of spindle orientation in differentiation and tumor initiation ·       Interaction between mitotic machinery and DNA damage responses 3. Cell division regulation in epithelial tissue architecture 4. Translational cancer modeling ·       Patient-derived mammary epithelial systems ·       In vivo modeling of cancer predisposition states The fellow will be responsible for conducting basic/translational research in one or more of the above research focus areas, design and execute research plans and perform data analyses, contribute to writing manuscripts and grants, present research findings in internal and external meetings, and/or mentor junior trainees in the laboratory. Required qualifications 1.       PhD in Cell Biology, Cancer Biology, Developmental Biology, Biochemistry, or related field 2.       Strong expertise in at least one of: Mammary epithelial biology or organoid systems; Cell division / mitosis / spindle dynamics; Genome instability or DNA damage responses 3.       Proven record of first-author publications in high-impact journals 4.       Experience with at least one of: Live-cell imaging or advanced microscopy; Mouse models or genetically engineered systems; Primary cell culture or organoid systems; Molecular perturbation (CRISPR, RNAi, etc.)  Preferred qualifications Background in BRCA1, HMMR, PLK1, or related mitotic regulators Experience in epithelial polarity or tissue architecture Quantitative or systems biology approaches (imaging analytics, proteomics, or genomics) Demonstrated ability to lead projects independently Experience in epithelial polarity or tissue architecture Willingness to respect diverse perspectives, including perspectives in conflict with one’s own. Demonstrates a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion. What We Offer Opportunity to work on fundamentally important questions in cell division and cancer biology Access to human tissue models and state-of-the-art imaging platforms Strong mentorship toward academic independence or research scientist careers Integration into a collaborative translational pediatric, adolescent and young adult oncology network The expected salary for this position is $60,000 per annum. The Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate. Application procedure To apply, please submit the following as one PDF file via https://ubc.wd10.myworkdayjobs.com/ubcfacultyjobs (JR#): ·       Curriculum Vitae (including publication list) ·       Cover letter describing research interests, career goals, and a brief summary of prior research accomplishments (1–2 pages) ·       Contact information for three referees Should you have any queries around this position, please contact Brenda Tse at brenda.tse@ubc.ca Applications will be reviewed on a rolling basis and will continue until the position is filled. The start date for this position will be a date to be mutually agreed. We invite applications from qualified candidates who share our commitment to employment equity and inclusive excellence, and we welcome applications from candidates belonging to historically, persistently, or systemically marginalized groups: Indigenous (First Nation, Métis, Inuit) Peoples, racialized persons, persons with disabilities, women, 2SLGBTQIA+ people, and trans and non-binary people. The University is committed to creating and maintaining an inclusive and equitable work environment for all members of its workforce. An inclusive work environment presumes an environment where differences are appreciated, recognized, and integrated into current structures, planning, and decision-making modes. Within this hiring process we are committed to creating an inclusive and equitable process for all candidates (including but not limited to people with disabilities).  Confidential accommodations are available on request. Please contact Brenda Tse via email at Brenda.tse@ubc.ca. If you have any questions regarding accommodations or accessibility during the recruitment and hiring process or for more information and support, please visit UBC’s Centre for Workplace Accessibility website at https://hr.ubc.ca/health-and-wellbeing/workplace-accessibility/centre-workplace-accessibility or contact the Centre at workplace.accessibility@ubc.ca. With gratitude, we acknowledge that the University of British Columbia Faculty of Medicine and its distributed programs, which include four university academic campuses, are located on traditional, ancestral and unceded territories of First Nations Peoples and communities around the province. Our Vision: To Transform Health for Everyone. Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a