Fixed-term

About this position: We are seeking a highly motivated Postdoctoral Researcher to join our team! The research project will focus on developing fluorine NMR methodologies to unravel the nucleic acid conformational landscapes. G-quadruplexes (G4) and i-motifs (iM) are paradigmatic non-canonical nucleic acid structures that are abundant in the human genome and overrepresented in evolutionarily conserved and functionally important regions, including the telomeres, centromeres, and promoter regions of (onco)genes. They have been involved in pathobiological processes and the development of genetic instability-driven conditions, rendering them a fascinating subject within structural biology. This project will integrate ¹⁹F NMR and complementary biophysical assays on G-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand binding interactome in vitro and in the intracellular space. The outcome will provide fundamental insights into the dynamic structural interconversion of non-canonical nucleic acid systems, enabling the fine-tuning of gene expression and associated cellular dysfunctions. We are seeking a creative and independent individual with documented research experience relevant to this position. We welcome candidates from diverse backgrounds and are committed to fair hiring practices. The ideal researcher (EU Researcher Profile: R2) profile: Must-have: A PhD degree or equivalent in structural biology, Chemistry, biochemistry, biophysics, or a related field. Expertise in biomolecular NMR and a strong publication record in peer-reviewed journals Experience in the sample preparation, acquisition, processing, and resonance assignment of multidimensional solution NMR spectra for nucleic acid/ protein systems and their complexes with small ligand-like molecules. Familiarity with NMR data acquisition and analysis for characterising dynamics is advantageous. Strong scientific writing and communication skills (publications, reports, presentations) in English. Motivated to establish an independent research direction within the group’s broad interests. Nice-to-have:  Nucleic acid labelling strategies (chemical, enzymatic synthesis, click chemistry basics) Complementary expertise in other biophysical assays to monitor biomolecular interactions/binding affinities (i.e. ITC, MST, BLI, etc.) Good communication and interpersonal skills. What we provide to you: The position offers an exceptional opportunity to develop cutting-edge skills in integrative structural biology and to emerge in a highly translational research environment. Open access to CEITEC MU core facilities (https://www.ceitec.eu/core-facilities/) with state-of-the-art equipment and experienced staff members. Our group has regular access to high-field NMR spectrometers (600, 700, 850, and 950 MHz) and complementary equipment for biophysical, functional, and structural studies. Full-time contract with an attractive salary. Flexible working hours and occasional home office to support personal needs in family and career compatibility A seed funding opportunity with the possibility to apply for other prestigious grants, such as MSCA and EMBO (https://www.ceitec.eu/postdoc/t11610). Support for team members with diverse backgrounds and opportunities to collaborate across different research teams at Masaryk University/Europe. Support for further education and professional development Brno is in a great location in Central Europe with excellent quality of living (https://www.ceitec.eu/life-in-brno/t10426) Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meals and kindergarten/pension scheme, Multisport card, mental health care, sports lessons directly at the Kindergarten Elánek in Campus Support in these areas: Welcome Office service before and after arrival Grant Office support Postdoc Peer Committee CEITEC events – workshops, conferences, lectures, training, family gatherings, etc. How to apply? Application deadline: 31.03.2026 Anticipated start date: To be negotiated, the sooner the better. Applications, including a CV, a list of publications, and a motivation letter, along with contact information for at least three references, should be submitted via the online application form bellow. Any troubles with the e-application? Please contact HR – Darja Horáková (darja.horakova@ceitec.muni.cz)

About this position: We’re excited to announce an open PhD student position in Petr Tesina’s Research Group! If you’re passionate about studying human translation control, this is the perfect opportunity for you. Our research project focuses on investigating the structures of ribosomal complexes involved in this fascinating process. You’ll have access to state-of-the-art cryo-EM instruments at our local core facility, available for regular use. Plus, comprehensive training in cryo-EM techniques will be provided to the successful candidate. Our lab has recently secured substantial third-party funding, including an ERC Starting Grant and an EMBO Installation Grant, so we’re well-equipped to support your research. We’re seeking a creative, independent, and motivated individual with relevant experience in fields like structural biology, biochemistry, biophysics, or molecular biology. If you have a background in structural biology and translation, we especially encourage you to apply. The ideal candidate profile: Must-have: MSc or equivalent degree (preferably in Life Sciences) Strong interest in structural biology Experience with structural biology, biochemistry and molecular biology methods is a strong plus as well as programming skills Strong English language skills – both spoken and written Nice-to-have: Experience with human cell cultures Good communication and interpersonal skills Motivation and a collaborative mindset What we provide to you: Full-time contract with an attractive ERC-funded salary Flexible working hours EMBO support for further education and professional development: meeting grants, lab visiting fellowships, interview support, young investigator PhD course, Lindau Nobel Laureate meeting, bridging funds Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme and Multisport card, mental health care, sports lessons directly at the campus Kindergarten Elánek close to the Campus Support in these areas: Welcome Office service before and after arrival Grant Office support CEITEC PhD Committee CEITEC events – workshops, conferences, lectures, training, family gathering etc. How to apply? Application deadline: 30.06.2026 (please apply asap – candidates will be assessed in the order their applications are received) Start date: Q4 2026 / Q1 2027 (can be negotiated) Applications, including a CV, motivation letter, list of publications, and contacts for at least two references should be sent via the e-application. For any questions or issues with the e-application, please contact Lenka Divinová (lenka.divinova@ceitec.muni.cz)