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Development of therapeutic strategies for human genetic diseases caused by nucleotide repeat expansions.

Kamal Pandey / March 26, 2026

Offer Description VICE-RECTOR in Charge of the School of Natural Sciences / for Finance and Research Projects at the Adam Mickiewicz University, Poznań announces a competition for 2 positions of: Researcher Assistant at the Center for Development of Gene Therapies TREAT-EXP in the project FENG.02.01-IP.05-M038/25, TREAT-EXP: Development of therapeutic strategies for human genetic diseases caused by nucleotide repeat expansions. The FENG.02.01-IP.05-M038/25 project is carried out within the 2.1 MAB FENG call 2/2025 programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG). We are seeking a Research assistant to join the research group of dr. hab. Michał Gdula to work on leveraging epigenetics to improve the effectiveness of genetic therapies for diseases caused by nucleotide repeat expansions (including myotonic dystrophies), within the framework of the International Research Agenda (MAB) FENG grant funded by the Foundation for Polish Science (FNP). Work should aim at writing and defending a doctoral dissertation. Dr. hab. Michał Gdula’s group is one of four teams participating in the TREAT-EXP project, led by Prof. Krzysztof Sobczak and funded by FNP with PLN 30 million over four years. The overarching goal of TREAT-EXP is to build a research platform to develop therapeutic strategies and identify active compounds targeting pathogenic products of mutated genes—either toxic RNA or toxic proteins—responsible for DM, FXPAC, and ALS. The goal of Michał Gdula’s team is to increase the efficacy of therapies for DM1 and DM2 by modulating epigenetic regulation using modified antisense oligonucleotides (ASOs). DM1 is caused by a CTG expansion in the 3′UTR of the DMPK gene, while DM2 results from a CCTG expansion in an intron of the CNBP gene; the resulting toxic repeat-expanded RNA forms nuclear foci and sequesters MBNL proteins, leading to widespread alternative splicing defects and multiple multisystem symptoms. The Researcher assistant’s tasks will include characterizing the epigenetic landscape of DM-associated genes and mapping their regulatory elements in cellular models using genomic methods (e.g., ATAC-seq, CUT&RUN, Capture-C, Micro-C). Next, in collaboration with—and drawing on the expertise of—Prof. Sobczak’s group, ASOs will be designed to target selected regulatory elements in order to reduce DMPK/CNBP expression or increase the expression of MBNL genes. A brief project description can be found at: https://ibmib.web.amu.edu.pl/mab-feng-grant/ We offer a position in a well-funded, interdisciplinary environment at the Center for Development of Gene Therapies (Adam Mickiewicz University), located in the modern Center for Advanced Technologies building. Informal inquiries welcome: michal.gdula@amu.edu.pl Anticipated job starting date: May 20th, 2026 Fixed-term contract for 12 months, with the possibility of extension to 42 months Monthly salary: PLN 8 470 gross Where to apply E-mailmichal.gdula@amu.edu.pl Requirements Research FieldBiological sciencesEducation LevelMaster Degree or equivalent Skills/Qualifications The competition is open to individuals who meet the requirements specified in Article 113 of the Law on Higher Education and Science of 20 July 2018 (Journal of Laws of 2024, item 1571, Article 113 as amended) and who meet the following requirement: MSc in biological, chemical, medical, or related sciences Higher Education and Science of 20 July 2018 (Journal of Laws of 2024, item 1571, Article 113 as amended) and who meet the following requirement: MSc in biological, chemical, medical, or related sciences. Essential requirements: MSc in molecular biology/genetics or a related scientific discipline obtained before start of the project. very good skills in standard molecular biology and biochemistry techniques experience in genomic experiments (RNA-seq, ChIP-seq, WGBS and/or similar) demonstrated ability for independent thinking and project management skills high level of communication and interpersonal skills conducting research aimed at writing and defending a doctoral dissertation Desirable requirements: expierience in working with chromatin, in particular with „chromatin conformation capture” methods experience in bioinformatics microscopy and image analysis publications LanguagesENGLISHLevelGood Research FieldBiological sciences Additional Information Benefits an atmosphere of respect and cooperation; supporting employees with disabilities; flexible working hours; funding for language learning; co-financing of training and courses; additional days off for education; life insurance; pension plan; savings and investment fund; preferential loans; additional social benefits; leisure-time funding; subsidizing children’s vacations; “13th” salary; healthcare package Eligibility criteria Research experience and its relevance to the thematic scope of the research area specified in the call requirements (0–20 points); Participation in research internships, scientific workshops, and conferences (0–10 points); Scientific activity during studies, including involvement in the implementation of research projects (0–10 points). A total of 0–40 points can be awarded. Selection process Competition committee begins working no later than 14 days after the deadline for submission of documents. Formal evaluation of submitted proposals. Call to provide additional or missing documents if necessary. Selection of candidates for the interview stage. Interviews for candidates who meet the formal requirements. The chair of the competition committee announces the results and informs the candidates. This information will include justification with a reference to candidates’ strengths and weaknesses Additional comments The hired person: • will be able to develop skills and build experience in epigenetics, chromatin research, gene therapy aproaches through intensive interactions with researchers from all collaborating project groups • will expand their scientific record through publications and presentations at scientific conferences • will work in a dynamic scientific center and participate in workshops and scientific conferences, which will allow them to expand their professional network Reguired documents Application form/letter of the candidate addressed to the Vice-Rector announcing the competition; Curriculum Vitae; Doctoral diploma or certificates issued by colleges and universities attesting to education and degrees or titles held (in case of academic degrees obtained abroad – the documents must meet the equivalence criteria set out in Article 328 of the Act of 20 July 2018 Law on Higher Education and Science (Journal of Laws of 2023, item 742 Polish: Dziennik Ustaw 2024 poz. 1571 t.j.); information on the Applicant’s research and organizational achievements, including lists of: – publications, – research projects participation, – trainings and workshops participation. – conferences and seminars participation – contact details of two referring scientist Consent to the processing of personal data as follows: In accordance with Article 6 (1) (a) of the General Data Protection Regulation of 27 April 2016. (OJ EU L 119/1 of 4 May 2016) I consent to the processing of personal data other

Recruitment for the position of Research Associate

TheBiologyBro Team / March 26, 2026

The University of Kassel is a dynamic university with around 21,000 students. It has an exceptionally broad profile with expertise in the fields of science, technology, culture and society. The following position is to be filled as soon as possible at the Witzenhausen location within the Department of Ecological Agricultural Sciences, specializing in Ecological Food Quality (Prof. Dr. Fabian Weber): Research Associate (m/f/d), pay grade EG 13 TV-H , fixed-term , part-time (currently 26 hours per week) Application deadline: April 10, 2026 Start date: as soon as possible Reference number: 39165 Part-time position with 65% of the regular working hours of a full-time employee. The position is initially limited until May 31, 2029, within the framework of the “GRUENKOHL” project, in accordance with Section 2 of the Academic Fixed-Term Contract Act (WissZeitVG). The opportunity to pursue a doctorate is available. Tasks: Scientific collaboration in the above project Planning and execution of sensory and chemical-analytical investigations Writing interim and final reports in German Requirements: A completed university degree in agricultural sciences, food sciences, or a related field. The required degree must be obtained no later than the start date of employment. Experience in the field of food analysis and sensory evaluation. The following are advantageous: Prior knowledge of the methods: HPLC and photometry Thorough and independent work methods A high level of organizational skills English language skills Very good German skills For further questions, please contact Prof. Dr. Fabian Weber, Tel.: +49 5542 98-1632. Our range: as an employee of the University of Kassel This opens up an interesting and diverse field of activity for you within the framework of a modern and up-and-coming university, You will become part of an interdisciplinary team with a good and collegial working atmosphere, You have the opportunity to participate in professional and interdisciplinary training measures, Your workplace is located with good access to public transport, which is currently free for you to use. Furthermore, you will benefit from the many advantages of employment in the public sector, such as: an additional company pension scheme (VBL), an optional child allowance according to TV-Hessen, a family-friendly university (including emergency childcare), an annual bonus payment in the month of November an entitlement to asset-building benefits, a promotion of voluntary engagement, cost-effective participation in university sports and the full range of fitness options within the framework of Unifit, as well as workplace health promotion. You can find more job postings at stellen.uni-kassel.de Please submit your application, including the usual supporting documents and the reference number in the subject line, via the online form. Further information can be found in our FAQs . In exceptional cases, we also accept your application documents in paper form or via the email address bewerbungen(at)uni-kassel.de , quoting the reference number. For postal applications, please submit only copies of your documents (no folders), as these cannot be returned. All documents will be destroyed in accordance with data protection regulations after the selection process is complete. The protection of your personal data is very important to us, therefore we will handle your personal data with care. By providing us with your data, you consent to its storage and use in accordance with the Hessian Data Protection and Freedom of Information Act. You may object to this at any time. Your personal data will then be deleted. Information pursuant to Article 13 GDPR regarding the collection of personal data can be found at: https://www.uni-kassel.de/uni/datenschutz Information and FAQs on applying for a job offer: https://www.uni-kassel.de/uni/universitaet/stellenangebote/hinweise-und-faq-zur-bewerbung-auf-ein-stellenangebot The University of Kassel is deeply committed to the professional satisfaction of its employees. It has been recognized as a family-friendly university and, in the spirit of equal opportunities, strives to offer everyone the same development prospects and counteract existing disadvantages. It promotes the Family Welcome Service and, for academic and research positions, the Dual Career Service. One of the University of Kassel’s strategic goals is to significantly increase the proportion of women in research and teaching. Applications from women are therefore particularly welcome. Severely disabled applicants and those with equivalent status will be given preference if equally qualified, capable, and professionally competent. Full-time positions are generally divisible (except for civil service positions). Apply Now

Postdoctoral Researcher Position in Cancer Immunology & Metabolism

TheBiologyBro Team / March 26, 2026

Johannes Gutenberg University Mainz (JGU) is one of the largest universities in Germany. Thanks to its location in the Rhine-Main science region, the university can unfold to its full potential and showcase its innovative power and dynamism. Its status as a comprehensive university allows for multidisciplinary learning and teaching and has great potential for internationally renowned, interdisciplinary research. Almost all of its institutes are located on a single campus close to the Mainz city center – creating a lively academic culture for researchers, teaching staff, and students from every continent. We are seeking a highly motivated postdoctoral researcher to join the laboratory of Dr. Anne Régnier-Vigouroux at Johannes Gutenberg University Mainz. The successful candidate will work at the interface of cancer biology, immunology, and metabolism, investigating tumor-associated microglia/macrophages (TAMs) as therapeutic targets in glioblastoma. Our research explores how inflammatory and metabolic adaptations shape TAM function during tumor progression and how targeting mitochondrial function and reactive oxygen species (ROS) signaling in tumor and immune cells can enhance anti-tumor responses. Particular emphasis is placed on cellular adaptation to physiologically relevant oxygen conditions (physioxia vs. hypoxia). The project combines patient-derived 3D tumor models, advanced molecular and metabolic analyses, and preclinical mouse glioma models. More information: Microglia in brain tumor biology (uni-mainz.de) , Welcome to GlioLighT – GlioLighT – Next Generation Glioma Treatments You will join an interdisciplinary and international research environment embedded within a vibrant biomedical campus hosting the Faculty of Biology, Faculty of Medicine, the Institute of Molecular Biology, and Max Planck research institutes. Your tasks: Collaboration in research Design and lead experimental research projects Develop innovative approaches in cancer immunometabolism Analysis of complex molecular and cellular datasets Publish findings in international peer-reviewed journals Present research at international conferences Implementation of teaching, as well as advising and supervising students Contribute to collaborative projects Your profile: Required Qualifications: A successfully completed scientific university degree in Biological Sciences or Biomedicine PhD in Biological Sciences or related discipline Strong background in immunology, molecular and cellular biology, cancer biology Advanced expertise in molecular and cellular biology techniques (ia cell culture, flow cytometry, multiplex RT-qPCR, single cell RNA-seq analysis) Experience with primary human cells and engineered cell lines Excellent English communication skills Preferred Qualifications: Experience with immunometabolism, mitochondrial biology, or oxidative stress research Experience with 3D culture systems and/or omics approaches (eg, metabolomics, proteomics) Experience in mouse models (FELASA certification or equivalent advantageous) Interested in pursuing an academic research career Communication skills in German will be helpful but are not mandatory In addition to the general requirements according to public services law, applicants must meet the recruitment requirements stipulated in § 57 of the Higher Education Act of Rhineland-Palatinate. The position is paid according to the German public sector pay scale EG 13 TV-L . The position is funded for 2 years, with possible extension of up to 1 year. JGU is diverse and welcomes qualified applications from people with varied backgrounds. We aim to increase the number of women in the field of research and teaching and therefore encourage female researchers to apply. People with severe disabilities and people with disabilities who are treated equally in accordance with Section 2 (3) SGB IX will be given preferential consideration if they are suitable. Are you ready for a new challenge and interested in this varied and responsible position? Then submit your complete application [cover letter, CV, publication list, research summary (interests and expertise; max 1 page), copy of academic degree (PhD), and contact details of two referees] by 4/10/2026 , via the “Apply now” button. You may only be employed in the civil service of the state of Rhineland-Palatinate if you can guarantee that you will uphold the free democratic basic order as defined in the Basic Law and the Constitution of Rhineland-Palatinate at all times. Apply Now

Research Assistant (Doctoral Researcher/PhD) in “Animal Ecology”

TheBiologyBro Team / March 26, 2026

The University of Marburg, founded in 1527, offers a variety of excellent programs of study for around 22,000 students and confronts the important topics of our time through excellent research across a broad spectrum of sciences. The Department of Biology, research group “Animal Ecology” led by Prof. Dr. Anne Mupepele, is currently accepting applications for a Research Assistant (Doctoral Researcher/PhD) The position is offered with a fixed term until 2029-09-30, if no former times of qualification must be considered. The starting date is 1st of June 2026. The position is part-time (65% of regular working hours) with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 65%). The position is funded by Horizon Europe (Call: Horizon-Miss-2024-Soil-01) and part of the project “ProPollSoil” (Understanding and managing soil health impacts to protect soil-dependent pollinators). The project focuses on soil-dependent pollinators, e.g. ground-nesting bees, and their relationship to soil conditions. In collaboration with soil scientists, it will examine the extent to which land use and climatic conditions influence soil-dependent pollinators. Samples will be collected in Germany as well as European project partner countries and include sampling for chemical and physical soil properties, soil fauna, and pollinators. New methods to sample and monitor pollinators will be developed. Tasks: Development and testing of new methods (e.g. eDNA, Camera and drone imagery, deep-learning based image analyses) for monitoring soil-dependent pollinators, especially ground-nesting wild bees Application of new methods to investigate ecological research questions within the ProPollSoil project, e.g., analyzing whether ground-nesting wild bee diversity differs across land-use categories and soil types scientific services in research, including authoring and publishing peer-reviewed scientific articles and presenting research findings in team meetings and at scientific conferences The position is limited to a time period deemed adequate for the completion of a doctoral degree. As part of the assigned duties, there will be ample opportunity to conduct the independent scientific research necessary for the completion of a doctorate. The limitation complies to § 2 sec. 1 WissZeitVG. Profile: MSc degree (or equivalent) in biology, nature conservation, environmental sciences, bioinformatics or a related field Experience with, or a strong willingness to learn, computer-based data acquisition and analysis methods (e.g. statistics in R or Raspberry Pi programming) Effective team player with strong collaboration skills Excellent writing and presentation skills in English and sufficient proficiency in German, or a demonstrated willingness to learn, to manage everyday work in Germany Experience with, or a strong willingness to learn, at least one of the above-mentioned methods (eDNA, AI-based cameras, drones) Willingness to collaborate across disciplines, especially with bioinformatics and soil ecology Disposition to own scientific qualification is expected. We actively support the professional development of junior researchers by the offers of Marburg Research Academy (MARA), the International Office and the Higher Education Didactics Office. We offer: Integration into a broad research network – both at the University of Marburg and through collaboration with the 23 partners of the ProPollSoil project, especially from the LMU Munich Professional development opportunities Regular exchange with other research groups Ticket for free use of public transportation in the state Hesse, Germany German retirement plan (VBL) benefits Contact for more InformationProf. Dr. Anne Mupepele+49 6421-28 23386 mupepele@uni-marburg.de We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. As a certified family-friendly university, we support our employees in balancing family and career. A reduction of working time is possible. Applicants with a disability as discribed in SGB IX (§ 2 Abs. 2, 3) will be preferred in case of equal qualifications. Application and interview costs can not be refunded. Please apply by 2026-03-29 using the application-button below. Apply Now

Postdoctoral position in Computational Biology

TheBiologyBro Team / March 26, 2026

Research Associate for the field of Molecular Pharmacology

TheBiologyBro Team / March 26, 2026

Founded in 1607, Justus Liebig University Giessen (JLU) is a research university steeped in tradition. Inspired by a curiosity for the unknown, we enable around 25,000 students and 5,800 staff members to advance science for the benefit of society. Join us in exploring new paths and writing success stories – your own and those of the university. Join us from July 1st, 2026 on a part-time basis (50%) as Research Associate (m/f/d) for the field of Molecular Pharmacology The position, in accordance with Section 2 of the Academic Fixed-Term Contract Act (WissZeitVG) and Section 72 of the Hessian Higher Education Act (HessHG), is a fixed-term appointment with the opportunity for further academic qualification at the Institute of Pharmacology and Toxicology within the Department of Veterinary Medicine. Remuneration will be based on pay grade 13 of the TV-H collective agreement, provided the necessary qualifications are met. Provided the maximum permissible duration of a fixed-term employment contract is not exceeded, they will generally be employed for an initial period of 3 years. An extension of up to a further 2 years is possible under the aforementioned conditions. Your tasks at a glance • Independent scientific and university teaching qualification, scientific services in research and teaching in accordance with § 72 HessHG ( Higher Education Act) • Assumption of teaching duties in accordance with the teaching load regulations of the State of Hesse; this includes lectures, seminars, and exercises in the veterinary medicine degree program as well as the instruction of students in the application of scientific methods and scientific equipment • Participation in externally funded projects of the research group and regular presentation and publication of research results • Working with hazardous substances, biological agents, and radioisotopes • Laboratory administrative tasks and maintenance of scientific equipment Your qualifications and skills • Completed university degree in veterinary medicine • Interest in learning about new scientific tasks/questions • Teamwork skills and dedicated collaboration with partners • Excellent written and spoken English skills and good German skills are required • Proficient computer skills • Due to the constantly changing and diverse experimental approaches, a high degree of flexibility and independence is essential • Practical experience and theoretical knowledge in cell biological, pharmacological, biochemical, and bioinformatic methods Our offer to you • A varied role with flexible working hours • Free use of public transport (Hesse State Ticket) • More than 100 seminars, workshops, and e-learning opportunities per year for personal development, as well as a wide range of health and sports programs • Remuneration according to the TV-H collective agreement, company pension scheme, child allowance, and special payments • Excellent work-life balance (certified as a “family-friendly university” audit) For further questions, please contact Prof. Dr. Joachim Geyer by email ( Joachim.M.Geyer ). JLU welcomes qualified applications regardless of biological or social gender, disability, nationality, ethnic or social origin, religion, worldview, age, or sexual orientation and identity. In accordance with its gender equality plan, JLU aims to increase the proportion of women on its staff; therefore, qualified women are strongly encouraged to apply. JLU is a certified family-friendly university. Applications from severely disabled persons will be given preference if they are equally qualified. Do you want to explore new paths with us? Apply via our online form by April 1, 2026 , quoting reference number 183/10. We look forward to receiving your application.

Development of therapeutic strategies for human genetic diseases caused by nucleotide repeat expansion.

Kamal Pandey / March 26, 2026

Offer Description We are looking for people for the position: Chief Specialist – Scientific and technical Specialist (F/M) In the project: FENG.02.01-IP.05-M038/25, TREAT-EXP: Development of therapeutic strategies for human genetic diseases caused by nucleotide repeat expansion. The FENG.02.01-IP.05-M038/25 project is carried out under Measure 2.1 MAB FENG, call 2/2025 of the Foundation for Polish Science, co-financed by the European Union from the funds of Priority 2 of the European Funds for Modern Economy 2021-2027 Programme (FENG). Place of work: TREAT-EXP Gene Therapy Development Center in the building of the Center for Advanced Technologies of Adam Mickiewicz University (Morasko) We are seeking a supportive Scientific and technical Specialist to join the research groups of Michał Gdula and dr Rajani Gudipatti to work on the improvement of the effectiveness of genetic therapies for diseases caused by nucleotide repeat expansions (including myotonic dystrophies), within the framework of the International Research Agenda (MAB) FENG grant funded by the Foundation for Polish Science (FNP). Both Michal Gdula and Rajani Gudipatti head two independent research groups out of four teams participating in the TREAT-EXP project, led by Prof. Krzysztof Sobczak and funded by FNP with PLN 30 million over four years. The overarching goal of TREAT-EXP is to build a research platform to develop therapeutic strategies and identify active compounds targeting pathogenic products of mutated genes—either toxic RNA or toxic proteins—responsible for DM, FXPAC, and ALS. Scope of duties: expression of proteins needed for the project (restriction enzymes, proteases, LIF, enzymatic complex subunits) cell culture; providing general lab support for both groups (dr hab. Michał Gdula and dr Rajani Gudipatti) in their daily activities Where to apply Websitehttps://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=c81133d62… Requirements Research FieldBiological sciencesEducation LevelMaster Degree or equivalent Skills/Qualifications Essential requirements: MSc in molecular biology/genetics or a related scientific discipline obtained before start of the project. very good skills in standard molecular biology and biochemistry techniques experience in protein expression high level of communication and interpersonal skills significant experience in wet-lab research advanced knowledge of English, both spoken and written Desirable requirements: experience in genomic methods experience in C.elegans culture experience in bioinformatics microscopy and image analysis co-authorship of the publication LanguagesENGLISHLevelGood Additional Information Benefits We offer: stable employment based on an employment contract for a period of 12 months with the possibility of extension until 31 December 2029; will be able to develop further skills and be trained in broad range of methods used by both groups: for example build experience in epigenetics, C.elegans model, gene therapy approaches through intensive interactions with researchers from all collaborating project groups will expand their scientific record through publications may develop its own project basic salary: 10 784 zł gross an atmosphere of respect and cooperation. Additional comments We would like to kindly inform you that we only respond to selected offers GDPR information clause (for current and future recruitment purposes) The Controller of your personal data is: Adam Mickiewicz University in Poznań, with its registered office at 1 H. Wieniawskiego Street, 61-712 Poznań, NIP 777 00 06 350, REGON 000001293, hereinafter referred to as the Controller. The Controller processes your personal data. Contact details of the Data Protection Officer: iod@amu.edu.pl Your personal data will be processed for the purpose of: conducting and participating in the recruitment process for the position indicated in the advertisement, conducting and participating in subsequent recruitment processes for the same position or a position corresponding to your qualifications or experience, establishing, pursuing or defending against claims. 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