Fixed-term

Research area and project description: In the Andersen lab for Biomolecular Design (andersen-lab.dk) we are experts in designing DNA, RNA and proteins to create nanoscale devices for applications in biotechnology and medicine. The lab invented the RNA origami method that allows rational design of RNA scaffolds and devices for expression in cells [1] and have recently developed RNA origami robots that can sense, compute and actuate [2], which opens new possibilities for controlling cellular function. In the recently funded RIBOTICS project, the lab aims to develop RNA origami robots for cell factories (yeast production strains) for improved synthesis of valuable proteins and biochemicals. This PhD project aims to develop biosensors based on Xenonucleic acids (XNAs), which are synthetic nucleic acids with improved chemical and biological stability. The PhD student will: Design and develop XNA sensor modules usingin vitroselection methods. Use mutational screening to develop XNA actuator modules based on fluorescent aptamers and catalytic ribozymes. Construct “XNA sensor robots” that detect chemical compounds, RNA strands, or proteins and produce fluorescent output signals. Integrate XNA sensors into microfluidic droplet systems for high-throughput screening of secretory yeast phenotypes. Apply the system for selection of optimized yeast strains for synthetic biology and bioproduction applications. The RIBOTICS project involves a team of 3 postdocs and 3 PhD students, who will work on design, characterization, and experimental verification of several RNA systems that can regulate gene expression, control enzyme proximity, sense product yields, and do molecular computations for feedback control. The PhD student will work in close collaboration with the RIBOTICS team, will receive day-to-day scientific guidance from a Postdoctoral mentor, and will be part of a vibrant research environment at the Interdisciplinary Nanoscience Center. References: [1] A single-stranded architecture for cotranscriptional folding of RNA nanostructures. Science (2014). https://doi.org/10.1126/science.1253920 [2] An RNA origami robot that traps and releases a fluorescent aptamer. Science Advances (2024). https://doi.org/10.1126/sciadv.adk1250 For technical reasons, you must upload a project description. When – as here – you apply for a specific project, please simply copy the project description above, and upload it as a PDF in the application. If you wish to, you can indicate an URL where further information can be found. Qualifications and specific competences: Required qualifications: Applicants must hold a Master’s degree or have completed at least one year of a Master’s degree in a relevant field such as: Molecular Biology, Biochemistry, Nanoscience, Biophysics or Bioengineering. Applicants should have a strong interest in RNA structural biology and a motivation to acquire expertise in relevant biophysical characterization methods. Applicants must have good communications skills and ability to work both collaboratively in an interdisciplinary team and independently. Applicants must have proficiency in English, both written and spoken Desirable skills: Hands-on experience with techniques for RNA and XNA design, synthesis, and analysis, as well as in vitro selection methods. Knowledge of or practical experience with biosensing, fluorescence-based assays, and microfluidic systems for high-throughput analysis. Place of employment and place of work: The place of employment is Aarhus University, and the place of work is Department of Molecular Biology and Genetics, Gustav Wieds Vej 14, 8000 Aarhus C  Denmark. Contacts: Applicants seeking further information for this project are invited to contact: Professor Ebbe Sloth Andersen, esa@inano.au.dk How to apply: For information about application requirements and mandatory attachments, please see the Application guide. Please read the Application guide thoroughly before applying. When ready to apply, go to https://phd.nat.au.dk/for-applicants/apply-here/ (Note, the online application system opens 1 March 2026) Choose May 2026 Call with deadline 1 May 2026 at 23:59 CEST. You will be directed to the call and must choose the programme “Molecular Biology and Genetics”. In the boxed named “Study”: In the dropdown menu, please choose: “Biosensing in biological fluids with chemically modified RNA devices (BbfcmR)” Please note: The programme committee may request further information or invite the applicant to attend an interview.

We are seeking a motivated Research Assistant to join our team in reproductive toxicology. You will support a range of experimental studies focused on how environmental chemicals affect reproductive and developmental health. Your main responsibilities will include conducting lab experiments, but you will also assist in performing literature reviews and contributing actively to research projects. The position offers an opportunity to work in a dynamic and interdisciplinary research environment with a strong focus on developmental biology, endocrine disruption, and toxicological mechanisms. Experience with laboratory animal models and histology, especially for the female reproductive system, is advantageous. Responsibilities and qualifications You will support various research projects by performing key laboratory tasks, immunohistochemistry, RNAscope, histological staining and evaluation, among others. Experience with histology is highly desirable, as you will assist with rodent toxicity studies, using methods tailored to specific projects in close collaboration with team members. While prior lab experience is beneficial, a willingness to learn new techniques and a results-driven mindset are most important. The role also includes data management and organization to support the team’s research efforts and advisory tasks. As a formal qualification, you must have a master’s degree in biotechnology, engineering, or equivalent. We offer DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. Salary and terms of employment  The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.  The period of employment is 1 year. Preferred starting date is 1 May 2026 (or according to mutual agreement). The position is a full-time position. You can read more about career paths at DTU here. Further information Further information may be obtained from Professor and Head of Research Group Terje Svingen on tesv@food.dtu.dk You can read more about the DTU National Food Institute at www.food.dtu.dk/english If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark. Application procedure  Your complete online application must be submitted no later than 17 March 2026(23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply now”, fill out the online application form, and attach all your materials in English in one PDF file. The file must include: Application (cover letter) CV Academic Diplomas (MSc) Applications received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position. Apply Now

Migraine affects over 15% of the global population and remains inadequately treated despite advances such as CGRP-targeting antibodies. Attacks involve severe head pain with nausea and sensitivity to light and sound, contributing substantially to global disability. We are launching a translational project combining generative AI-driven protein design with experimental and clinical validation. We aim to develop recombinant minibinders targeting GPCRs implicated in migraine, including receptors for adrenomedullin, amylin, and PACAP. We seek a highly motivated Postdoctoral Researcher with strong wet-lab expertise to lead the biochemical and cellular validation of these computationally designed inhibitors. Responsibilities and qualifications You will play a central role in translating computational protein designs into validated therapeutic candidates. Your responsibilities will include: De novo design of minibinders Recombinant expression and purification of AI-designed minibinders (miBds) Biochemical and biophysical characterization (e.g., binding assays, stability profiling) Cell-based GPCR signalling assays Functional validation in relevant in vitro systems Supporting in vivo pharmacological validation in rodent migraine models Close collaboration with computational protein engineers and clinical researchers Data analysis, manuscript preparation, and supervision of students where relevant The position is hybrid, but primarily laboratory-based. A strong experimental profile is essential. We are looking for a candidate who: Holds a PhD in molecular biology, biochemistry, pharmacology, protein engineering, or related field Has strong hands-on experience in recombinant protein expression and purification Has documented experience with GPCR pharmacology or receptor signalling assays Has experience with advanced biochemical methods (e.g., SPR, BLI, ELISA, fluorescence-based assays) Has experience with yeast display Has strong documentation of peer-reviewed publications Demonstrates the ability to work independently and in interdisciplinary teams It will be considered an advantage if you have: Experience with computational protein design collaborations Experience with in vivo pharmacology Experience working in translational or industry-oriented research environments As a formal qualification, you must hold a PhD degree (or equivalent). We offer DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. Salary and terms of employment The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years. Starting date is 1 May 2026, or according to mutual agreement. The position is a full-time position. You can read more about career paths at DTU here. Further information  Further information may be obtained from Associate Professor Timothy P. Jenkins (tpaje@dtu.dk) You can read more about DTU Bioengineering at www.bioengineering.dtu.dk If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark. Application procedure  Your complete online application must be submitted no later than 17 March 2026 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply now”, fill out the online application form, and attach all your materials in English in one PDF file. The file must include: Application (cover letter) CV Academic Diplomas (MSc/PhD – in English) List of publications Applications received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position. Apply Now

Are you aware that hypoxia is a common feature of human solid cancers that contributes to therapy resistance and metastasis development? In part, this is caused by communication via extracellular vesicles. In this position you will perform research at the cutting edge of an important and newly identified subpopulation of extracellular vesicles. The work performed will stretch from basal and mechanistic understanding how these EV function and contribute to cancer progression. The work will therefore stretch from basic biology to in vivo efficacy determination. PhD student on extracellular vesicles in cancer   PhD student to unravel mechanisms of action and therapeutic potential of hypoxic extracellular vesicles in cancer. Our goal: Identify the mechanism why these specific EV appear to be targeted to specific recipient cells and exploit this knowledge for potential therapeutic interventions. Your colleagues: A collaborative team at the dept. of Radiotherapy. Furthermore, as part of a Flemish-Dutch consortium, you will benefit from expertise and collaboration with Uhasselt and KULeuven. The dept. of Radiotherapy is a basic and translational research laboratory embedded within the GROW research institute of the Faculty of Health, Medicine and Life Sciences at Maastricht University. The radiotherapy lab is shared with the group “Precision Medicine’ and collectively accommodates 8 permanent scientists, 6 technicians, more than 10 PhD students and Post-Docs and is fully equipped for cell culture, molecular and cellular biology (e.g. flow cytometry, hypoxia, gene expression, proteomics and microscopy) and working with animals (optical imager, an advanced small animal irradiator with cone beam CT & gantry, MRI 7 Tesla and micro-PET). The dept of radiotherapy has set up the necessary infrastructure for controlled exposures to hypoxia and hypoxia/reoxygenation, including development of novel equipment that allows rapid and controlled changes in oxygenation. Access to expertise, equipment and resources within the much larger GROW research institute and other facilities in the University are also readily available, including the genome centre, advanced microscopy, and the animal facility. To strengthen our research activities we are looking for a Phd-student to unravel the mechanism of action of hypoxia-specific extracellular vesicles with the aim to assess its therapeutic potential. The project is part of an international consortium. An additional PhD-student will be recruited (KULeuven/UHasselt) that will focus on EV secreted by non-cancerous pathologies and setting up a platform to detect hypoxic EV in complex fluids such as plasma. The both of you will benefit from each others expertise and input. The proposed work in this vacancy will be executed at the lab of the dept. of Radiotherapy (UM, group Prof. K. Rouschop/dr. T. Keulers). A large number of techniques and collaborations with experts in the field of extracellular vesicles will be at your disposal. What you do In this position you will perform research at the cutting edge of an important and newly identified subpopulation of extracellular vesicles. The work performed will stretch from basal and mechanistic understanding how these EV function and contribute to cancer progression. The work will therefore stretch from “wet-lab” experiments to in vivo application. Are you ready to set the course for the years ahead? Then we’d love to meet you.  What you bring  We’re not looking for checkboxes; we’re interested in who you are and what you bring. Do you recognize yourself in this? Creative and ambitious– You are hard-working, creative and persistent. Strong academic foundation– You have (or will have before start) a MSc degree in Bio-medical-, bio-pharmaceutical sciences or another relevant programme. Art 9 certification to work with animals or willingness to obtain art 9 certification Collaborative mindset– You communicate clearly and contribute effectively within a research team. Fluent in English– You have strong spoken and written English skills (C1 level). What we offer  At Maastricht University, you’ll work in an international, open, and engaged environment. We offer: A 12-month contract (1.0 FTE) with the prospect of a 3 year extension. Your salary will be € 3,059 gross per month in the first year and up to a maximum of € 3,881 gross per month in the last fourth year (based on full-time employment of 38 hours per week). 8% holiday allowance and an 8.3% year-end bonus. 29 vacation days (based on full-time), four additional days off (Carnival Monday and Tuesday, Good Friday, and Liberation Day), and the possibility to accrue up to 12 extra days through compensation hours. Flexible working hours, a home office allowance, and the option to work from home. Freedom and space to shape your work independently and develop your ideas. A close-knit community of colleagues to collaborate and grow with. A solid pension plan via ABP, company fitness schemes, and access to various university sports facilities. An inspiring work environment in the heart of Europe. About the Faculty of Health, Medicine and Life Sciences (FHML) FHML is committed to health in the broadest sense: from molecule to human, and from healthcare to prevention. We train healthcare professionals and researchers through innovative educational programmes and conduct groundbreaking research in health and well-being. As part of Maastricht UMC+ (MUMC+), our international and interdisciplinary community forms a unique collaboration between university and academic hospital, where education, research, and care come together. Interested?  Want to know more about this position or what it’s like to work at our university? Reach out to Kasper Rouschop at Kasper.rouschop@maastrichtuniversity.nl. The end date of the publication is 15 March 2026. Please upload your CV, motivation letter and contact information of 2 referees. The interviews for this position will take place mid-April 2026. The preferred start date is June 2026. The vacancy is open for internal and external candidates. In case of equal qualifications, internal candidates will be prioritized. Apply now via the button below. We look forward to getting to know you! Apply Now

Do you want to be trained to develop multi-level thrombosis risk prediction models by integrating insights from the cellular, thrombus, and organ levels? Would you like to be part of a prestigious doctoral network working to revolutionize personalized medicine by using cutting-edge in silico, in vitro, and in vivo technologies to understand, predict and treat thrombosis? This is your chance!! Our goal:Develop multi-level thrombosis risk prediction models that integrate cellular, thrombus, and organ-level insights. Your colleagues:An international team of researchers within the ThromboRisk consortium, collaborating across 10 partner universities. Job Description At the faculty of Health, Medicine and Life Sciences at Maastricht University,a PhD-position is available within the ThromboRisk project,which is funded by the EU’s Marie Sklodowska-Curie Actions (MSCA) Doctoral Network.The position will last 36 months and recruitment will open in May 2026. It will be hosted by Maastricht University, and will involve close collaboration with Eindhoven University of Technology (the Netherlands), as well as a 3-month secondment at University of Bern (Switzerland). Research program description ThromboRisk will develop an integrated platform to advance our understanding of thrombosis across biological scales, combining mechanobiology, biochemistry, pathophysiology, and computational modelling. Together with your fellow doctoral candidates you will make a unique contribution to the multi-level thrombosis risk prediction framework, addressing specific aspects of thrombus formation, growth, rupture, and clinical impact. This hands-on training will be supplemented by several scientific and professional development courses as well as an immersive training programme, in which doctoral candidates will have the opportunity to hone their skills for the jobs of tomorrow, while addressing the societal challenges of the ThromboRisk program. The ThromboRisk consortium is funded by the European Unionunder Grant Agreement No. 101227706. It comprises 10 partner universities: Eindhoven University of Technology (NL), Maastricht University (NL), University of Amsterdam (NL), Catholic University Leuven (BE), Charité – Universitätsmedizin Berlin (DE), University College London (UK), Transylvania University of Brasov (RO), SANO Centre for Computational Personalized Medicine (PL), University of Leeds (UK), and University of Bern (CH). Doctoral candidate project Personalized hemodynamic modelling of iliofemoral vein thrombosis for prediction of residual obstruction, recurrent thrombosis, and post-thrombotic syndrome Post-thrombotic syndrome (PTS) is a chronic complication following deep vein thrombosis (DVT), particularly in patients with iliofemoral DVT or recurrent thrombosis. Understanding flow-related mechanisms underlying residual obstruction could improve treatment strategies and lead to new interventions. In this project, you will develop personalized in silico and in vitro hemodynamic models of venous thrombosis to predict residual obstruction, recurrence, and PTS. In silicomodels will use duplex ultrasound, MRI (acute and follow-up), biomarkers, and thrombus characteristics. In vitromicrofluidic models will use disease-specific flow conditions and blood samples from DVT patients. Your work will ultimately contribute to a risk prediction tool for recurrent DVT and PTS, ready for evaluation in clinical trials. What you bring It’s not about ticking boxes – it’s about your perspective, ideas, and drive. Does this sound like you? Creative and ambitious– You’re hard-working, persistent, and eager to push boundaries. Strong academic foundation– You have (or will have before 01-09-2026) a MSc degree in Biomedical Engineering or a related field. Interdisciplinary interest– You bring knowledge of, or interest in, clinical medicine and data science or biochemistry. Collaborative mindset– You communicate clearly and contribute positively to a research team. Fluent in English– You have strong spoken and written English skills (C1 level). Eligibility criteria (MSCA regulations) You mustnothold a doctoral degree at the time of recruitment. You must comply with the MSCA mobility rule: you must not have resided or carried out your main activity (work, studies, etc.) in the Netherlands for more than 12 months in the 36 months prior to the recruitment date. (Exceptions apply for certain types of residency, e.g., refugee procedure.) What we offer At Maastricht University, you’ll work in an international, open, and engaged environment. We offer: A 36-month employment contract (1.0 FTE) with an intermediate evaluation after 12 months. A salary in scale P (UFO profile Promovendus) ranging from €3,059 to €3,881 gross per month (full-time, 38 hours). 8% holiday allowance and an 8.3% year-end bonus. 29 vacation days (full-time), four additional public holidays, and the option to gain 12 extra days through compensation hours. Flexible working hours, hybrid working options (role-dependent), commuting and internet allowances. Opportunities to shape your personal and professional development through a broad range of training programmes and university-wide initiatives such as Acknowledge & Appreciate. Excellent secondary employment benefits, including a strong pension scheme (ABP), company fitness, and access to extensive UM sports facilities. About the Faculty of Health, Medicine and Life Sciences (FHML) At FHML, everything revolves around healthy living. Our research and education focus on prevention, health preservation, and health promotion — contributing to the well-being of individuals and society. FHML collaborates closely with the academic hospital in Maastricht, together forming the Maastricht University Medical Center (MUMC+). As UM’s largest faculty, FHML brings together an international community of staff and students. We offer a wide range of Dutch- and English-taught bachelor’s and master’s programmes, grounded in innovative educational concepts and strong links to practice. Our multidisciplinary research covers carefully selected themes, ranging from fundamental insights to applied innovations. Research activities are organized across six graduate schools and two research institutes. Interested? Do you have questions about this position? Feel free to contact Dr. Arina ten Cate: arina.tencate@maastrichtuniversity.nlorarina.cate@mumc.nl Applying? If you are ready to join us, please apply now! Applications will be reviewed on a rolling basis until the position is filled. Promising candidates will be contacted by email. Apply Now

Welcome to Maastricht University! Do you want to be trained to develop multi-level thrombosis risk prediction models by integrating insights from the cellular, thrombus, and organ levels? Would you like to be part of a prestigious doctoral network working to revolutionise personalized medicine by using cutting-edge in silico, in vitro, and in vivo technologies to understand, predict and treat thrombosis? This is your chance!! Our goal: Develop multi-level thrombosis risk prediction models by integrating insights from the cellular, thrombus, and organ levels. Your colleagues: A collaborative, international network of researchers within the ThromboRisk consortium. Job Description At the faculty of Health, Medicine and Life Sciences at Maastricht University, a PhD-position is available within the ThromboRisk project, which is funded by the EU’s Marie Sklodowska-Curie Actions (MSCA) Doctoral Network. The position will last 36 months and recruitment will open in May 2026. It will be hosted by Maastricht University, and will involve close collaboration with Eindhoven University of Technology (the Netherlands), as well as 3-month secondments at Siemens (Romania) and Charité (Germany). Research program description ThromboRisk will develop an integrated platform to advance our understanding of thrombosis across biological scales, combining mechanobiology, biochemistry, pathophysiology, and computational modelling. Together with your fellow doctoral candidates you will make a unique contribution to the multi-level thrombosis risk prediction framework, addressing specific aspects of thrombus formation, growth, rupture, and clinical impact. This hands-on training will be supplemented by several scientific and professional development courses as well as an immersive training programme, in which doctoral candidates will have the opportunity to hone their skills for the jobs of tomorrow, while addressing the societal challenges of the ThromboRisk program. The ThromboRisk consortium is funded by the European Union under Grant Agreement No. 101227706. It comprises 10 partner universities: Eindhoven University of Technology (NL), Maastricht University (NL), University of Amsterdam (NL), Catholic University Leuven (BE), Charité – Universitätsmedizin Berlin (DE), University College London (UK), Transylvania University of Brasov (RO), SANO Centre for Computational Personalized Medicine (PL), University of Leeds (UK), and University of Bern (CH). Your PhD project Personalized hemodynamic modelling of arteriovenous grafts for prediction of vascular access stenosis and thrombosis Thrombosis is a common complication of arteriovenous grafts for hemodialysis, often accompanied by venous outflow stenosis due to intimal hyperplasia from disturbed flow. Understanding which venous outflow stenoses progress and lead to graft thrombosis is crucial. In this project, you will develop personalized in silico and in vitro hemodynamic models to predict graft thrombosis in hemodialysis patients. Your work will involve: Developing in silico models using computational fluid dynamics combined with macroscopic thrombus formation modelling. Creating in vitro microfluidic or bench-top models using disease-specific flow conditions and blood from hemodialysis patients. The project will ultimately deliver a tool for vascular access surveillance to predict patient-specific stenosis progression and thrombosis risk, ready for evaluation in clinical trials. What you bring It’s not about ticking boxes – it’s about your perspective, ideas, and drive. Does this sound like you? Creative and ambitious– You are hard-working and persistent. Strong academic foundation– You have (or will have before 01-09-2026) a MSc degree in Biomedical Engineering or another relevant programme. Interdisciplinary interest– You bring knowledge of, or interest in, vascular imaging and artificial intelligence. Collaborative mindset– You communicate clearly and contribute effectively within a research team. Fluent in English– You have strong spoken and written English skills (C1 level). Eligibility criteria (MSCA regulations) You must not already hold a doctoral degree at the date of recruitment. You must comply with the MSCA mobility rule: you must not have resided or carried out your main activity (work, studies, etc.) in the Netherlands for more than 12 months in the 36 months preceding recruitment. (Exceptions apply for compulsory service, holidays, or refugee-status procedures.) What we offer At Maastricht University, you’ll work in an international, open, and engaged environment. We offer: A 36-month employment contract (1.0 FTE) with an intermediate go/no-go evaluation after 12 months. A salary graded in scale P (UFO profile Promovendus) ranging from €3,059 to €3,881 gross per month (full-time, 38 hours). 8% holiday allowance and an 8.3% year-end bonus. 29 vacation days (full-time), four additional public holidays, and the possibility to accrue 12 extra days through compensation hours. Flexible working hours and the option to work partly from home (dependent on job requirements), including commuting and internet allowances. A wide range of training programmes and development opportunities, including UM initiatives such as Acknowledge & Appreciate. Excellent secondary employment conditions, including a strong pension scheme (ABP), company fitness, and access to extensive UM sports facilities. The terms of employment at Maastricht University are largely set out in the Collective Labour Agreement of Dutch Universities, supplemented by local UM provisions. About the Faculty of Health, Medicine and Life Sciences (FHML) At FHML, everything revolves around healthy living. Our research and education place a strong emphasis on prevention, health preservation, and health promotion. We aim to contribute to the well-being of individuals as well as society. FHML works closely with the academic hospital in Maastricht, forming Maastricht University Medical Center (MUMC+). As UM’s largest faculty, FHML brings together an international community of staff and students. We offer a wide range of Dutch- and English-taught programmes grounded in innovative educational concepts and strong connections to practice. Our multidisciplinary research focuses on selected themes spanning fundamental science to applied innovations. Research activities are organized into six graduate schools and two research institutes. Interested? Do you have questions about this position? Feel free to contact Dr. Maarten Snoeijs at maarten.snoeijs@mumc.nl. Applying? If you’re ready to join us, apply now! Applications will be reviewed as they are received and will continue until the position is filled. Promising candidates will be contacted by email.