PhD position in in neuroscience

The research group of Prof. Dr. Stephan Sigrist at the Institute of Biology of the Free University of Berlin is seeking a highly motivated PhD
student (m/f/d) for the ERC-funded project SynProtect. The project investigates how neuronal synapses
remain both adaptable and stable – how they enable learning and experience without
losing the precision of their signal transmission under stress, sleep deprivation, or with age.

This is what you can expect from us

This position is embedded in a research program investigating the functional organization of synaptic networks under conditions of increased neuronal stress, particularly in the context of sleep homeostasis and resilience. The focus is on a novel form of presynaptic plasticity (“PreScale”) in which structural changes in the active zone are coupled with mechanisms of intrinsic excitability. Preliminary work shows that this coupling, via Kv1/shaker-dependent potassium channels, fundamentally influences the properties of synaptic transmission, especially through frequency-dependent modulation of neurotransmitter release and short-term plasticity. The aim of this project is to functionally elucidate these relationships using a clearly electrophysiological approach.

The successful applicant will conduct a project focused on the quantitative analysis of presynaptic function. The focus will be on electrophysiological recordings at Drosophila synapses, particularly at the neuromuscular junction and – in the future – at central synapses. Parameters of synaptic transmission, such as spontaneous and evoked release events, vesicle release probability, and forms of short-term plasticity, will be systematically investigated. A particular focus will be on the functional coupling between structural changes in the active zone and the regulation of neuronal excitability, especially via Kv1/shaker channels, and their influence on action potential dynamics, Ca²⁺ influx, and synaptic signal processing. Furthermore, the project will analyze how these mechanisms affect synaptic function under different activity regimes, particularly with varying stimulation frequencies, and how they contribute to the stabilization of neuronal networks. The project integrates genetic manipulations with functional measurements and is closely linked to complementary structural and molecular approaches within the ERC project.

What you bring with you

The required qualification for employment is a completed academic university degree (Master’s / Diploma) in neuroscience, biology, biophysics or a related field. 

This is what we expect from you

A strong interest in electrophysiological questions, as well as synaptic function and neuronal signal processing, is desired. Practical experience working with Drosophila (e.g., genetics, lineage management, experimental handling) is desirable. Initial experience with electrophysiological methods is advantageous, as is knowledge of quantitative data analysis or programming (e.g., Python, MATLAB). Furthermore, an independent and structured work style, teamwork skills, and very good German and English skills are expected.

Our offer/Your benefits

Freie Universität Berlin offers an excellent, internationally oriented research environment with access to modern electrophysiological and imaging methods, as well as close ties to interdisciplinary networks such as NeuroCure and SynDiv. The position offers the opportunity for structured doctoral studies within an ERC-funded project and in-depth training in modern synaptic neurobiology.

Additional benefits:

• modern workplace in the green district of Dahlem
• Job security
• Payment according to TV-L FU including annual bonus
• Flexible working hours and mobile working by arrangement, where possible.
• the compatibility of work and family 
• 30 days of vacation with a 5-day work week
• Public holidays on December 24th and 31st.
• A diverse range of training and further education opportunities for your individual professional and personal development
• Opportunities to participate in university sports and health promotion programs
• Free parking at the building and good public transport connections.
• discounted job ticket for public transport
• Free use of the library system of the Free University
• Discounts in the cafeterias
• Employee discounts – Corporate Benefits Program

Have we sparked your interest?

We look forward to receiving your application documents. Please submit your application exclusively via our career portal by clicking the “Apply now” button. Applications submitted in paper form or by email cannot be considered.

The Free University of Berlin promotes gender equality. Applications from women are expressly encouraged. Applicants with disabilities will be given preference if equally qualified.

Further information is available from Stephan Sigrist ( stephan.sigrist@fu-berlin.de )