Turbocharging T cell therapeutics for solid cancer

Details

T cell–based immunotherapies have shown promise for certain malignancies, yet multiple factors limit their effectiveness in solid tumors. This project seeks to address those limitations through a multipronged strategy that combines interventions and genetic modifications known to yield incremental improvements when used individually. Specifically, the student will explore approaches such as (1) modulating T cell subsets (e.g., T stem cell memory or naïve T cells) through small molecules and cytokines during expansion, (2) employing next-generation T cell engineering (e.g., advanced CAR constructs, CRISPR/shRNA-mediated gene edits), and (3) introducing molecular enhancements (e.g., forced expression of tumor-infiltration–promoting factors). By systematically combining these tactics, we aim to discover synergistic effects that can overcome the immunosuppressive environment of solid tumors. The project will maintain flexibility, allowing the student to adapt interventions and modifications as new insights emerge, with the overarching goal of driving T cell therapies toward more profound and durable therapeutic responses.

Eligibility 

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with experience in cell culture, molecular biology and genetic modification and mouse cancer models are encouraged to apply.

Before you Apply

Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.

How to Apply

To be considered for this project you MUST submit a formal online application form – on the application form select PhD Immunology Programme. Full details on how to apply can be found on the Website: How to apply for postgraduate research at The University of Manchester

If you have any queries regarding making an application please contact our admissions team FBMH.doctoralacademy.admissions@manchester.ac.uk

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website: Equality, diversity and inclusion (EDI | Postgraduate Research | Biology, Medicine and Health | University of Manchester

Funding Notes

Applications are invited from self-funded students. This project has a Band 3 (high) fee. Details of our different fee bands can be found on our website https://www.bmh.manchester.ac.uk/study/research/fees/