Website The University of Westminster
We are seeking a highly motivated PhD candidate to pioneer a simplified approach to non-invasive prenatal testing (NIPT) for fetal chromosomal abnormalities. This innovative project investigates alternative sources of DNA, such as blood spot samples, that could potentially replace blood plasma for accurate detection of common trisomies (Down’s, Edwards’, and Patau syndromes), potentially revolutionising prenatal screening accessibility worldwide.
You will develop and validate a novel NIPT assay using cutting-edge molecular techniques, including next-generation sequencing (NGS), cell-free DNA (cfDNA) extraction, and fetal fraction quantification. This combined wet-lab and dry-lab project offers hands-on experience with advanced genomic technologies while conducting a comprehensive cost-effectiveness analysis to assess the feasibility of implementing blood-spot screening in clinical settings. The research addresses a critical healthcare challenge: current plasma-based NIPT requires specialised equipment, trained phlebotomists, and cold-chain transport, limiting accessibility in resource-constrained settings. Your work could enable self-collection, reduce NHS costs, and democratize access to gold-standard prenatal screening globally.
Requirements
Undergraduate degree (or equivalent) in molecular biology, genetics, bioinformatics, or related biomedical sciences. Strong organizational skills and meticulous attention to detail. Commitment to completing mandatory Human Tissue Act (HTA) training. Enthusiasm for collaborative research with clinical partners.
Desirable skills
Experience in omics technologies or bioinformatics data analysis. Knowledge of prenatal diagnostics or reproductive health. Statistical analysis experience. Note: Training in NGS, cfDNA analysis, and data interpretation will be provided during Year 1.
This research directly contributes to UN Sustainable Development Goals (SDG 3: Good Health and Well-being, SDG 5: Gender Equality, SDG 10: Reduced Inequalities) by developing accessible diagnostic tools that empower women to make informed reproductive decisions. By simplifying prenatal screening, you will help eliminate healthcare disparities and improve maternal-fetal outcomes in underserved communities. Join us in transforming women’s health through innovative biomedical research that bridges laboratory science and real-world clinical impact. This is your opportunity to develop expertise in advanced molecular diagnostics while addressing a critical global healthcare need.
Please contact Dr Maria Neofytou to discuss: m.neofytou@westminster.ac.uk.
Entry requirements and how to apply
Candidates should have a minimum classification of 2.1 in their Bachelor’s degree or equivalent, and preferably a Master’s degree. Applicants whose secondary level education has not been conducted in the medium of English should also demonstrate evidence of appropriate English language proficiency normally defined as IELTS: 6.5 (overall score with not less than 6.0 in any of the individual elements).
Read more about:
- Our entry requirements
- How to apply
- What should be in a PhD research proposal
- Our Graduate School and the support they provide
To make an application: Visit the School of Life Sciences page to apply for the programme most appropriate to your research.
Application deadline: Applications should be submitted by 5pm on Friday 15 May 2026.
Interviews will take place in June.
You must include the code and title of the studentship you are applying for in your application header, ie “SLS-1 Studentship”.
For queries about any aspect of the application process or informal enquiries, contact our Doctoral Coordinator, Dr Polly Hayes at p.hayes@westminster.ac.uk.
* Minimum full-time enrolment before submission is 33 months. Fee waivers and maintenance are in place for the three-year studentship. Following that, there is a six-month no-fee period for writing up. If a doctoral research student has not submitted by the end of the no-fee period, a £1,500 fee applies.
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