Research positions Understanding spinal cord circuits in scoliosis using genetics and exercise.

Overview

Adolescent idiopathic scoliosis (AIS) is a common spinal condition that affects around 3–5 percent of young people and can lead to lifelong pain and disability. Despite its prevalence, we still don’t understand why the spine curves during adolescence. Recent research points to the nervous system – specifically the way the spinal cord senses body position (proprioception) as a key factor in scoliosis development.

In this project, you will investigate how changes in a gene linked to AIS influence the development and organisation of spinal neurons involved in proprioception. Using an innovative mouse model and advanced molecular tools, you will explore how altered neuronal pathways relate to movement and spinal curvature. You will also assess whether structured exercise influences spinal cord circuitry and behaviour.

Research aims

You will work towards:

• Mapping changes in inhibitory and excitatory neurons in the spinal cord using immunohistochemistry and image analysis
• Integrating spatial gene expression profiling with behavioural data
• Evaluating how early-life exercise alters proprioceptive circuitry and reduces scoliosis features

The project combines behavioural neuroscience, developmental genetics, and data analysis, offering an exciting interdisciplinary research experience.

Skills you will gain

• Immunohistochemistry and tissue processing
• Fluorescence/confocal microscopy
• Quantitative image analysis and statistics
• Spatial transcriptomics data interpretation
• Critical thinking in developmental neuroscience

Candidate profile

We are seeking a highly motivated student with a strong interest in:

• Neuroscience
• Anatomy
• Development
• genetics

The prospective candidate will need to be eligible for admission to the PhD programme at the University of Otago and obtain a University of Otago PhD scholarship.