Post Doc in mechanisms underpinning DNA damage and cancerogenesis

Postdoc Position

Department of Genome Biology

We investigate the mechanisms underpinning DNA damage and cancerogenesis, with a focus on:

• Replication Stress & Genome Instability: How oxidative stress in cancer cells leads to formation of genotoxic R-loops and conflicts between transcription and replication complexes (TRCs).
• Molecular mechanisms of prevention, signaling, and resolution of replication stress associated with TRCs.
• Exploiting Stress Tolerance: Studying replication stress tolerance pathways to find ways to increase cancer therapy effectiveness.

What we offer:

• The position is funded by a prestigious 5-year Junior Star Grant from the Czech Science Foundation.
• A full-time, fixed-term employment contract for 2 years, with possible extension.
• Attractive salary, employment benefits, and 5 weeks of vacation per year + 5 sick days.
• A collaborative scientific environment supported by state-of-the-art facilities.
• Opportunities for training and specialized courses to expand a skillset.
• Support to pursue independent funding.

Who we’re looking for:

• A PhD in molecular biology, genetics, biochemistry, or a related field.
• Proactive drive, collaborative spirit, a problem-solving mindset.
• Willingness to contribute to the foundational setup of the lab.
• Proficient in both written and spoken English.

Not required, but beneficial:

• Expertise in the field of DNA repair, replication, or transcription of DNA.
• Experience with advanced technologies, including light microscopy, CRISPR, omics approaches (Chip-seq, proteomics), or bioinformatics.

How to apply:

• Cover letter: your motivation to apply for this position and description of your research interests.
• CV: Highlight your skills, experience, and scientific achievements.
• References: Provide contact details for two referees.
• Send your application to hedvika.vlastnikova@iem.cas.cz
• Application deadline: until February 28th, 2026, or until the position is filled.

More information about the Institute of Experimental Medicine of the Czech Academy of Sciences can be found at www.iem.cas.cz.

The Institute of Experimental Medicine of the CAS, v. v. i., reserves the right to invite only selected candidates for a personal or online interview and the right not to select any of the candidates.

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