PhD student in Prof. Maciej Cieśla group (Sonata20 – Vladyslava Liudkovska project) 06/2026

Offer Description

Our lab studies how RNA metabolism and pre-mRNA splicing shape the molecular identity of stem cells during the earliest stages of development. In this project, we ask how the spliceosome – one of the most complex cellular machineries – is dynamically regulated in C. elegans germ stem cells, and how changes in its composition influence cell fate.

The project has three aims:

1. Map the dynamics of splicing factors and alternative splicing events across different regions of the germline, and identify the events critical for germline regulation.
2. Determine how individual splicing factors regulate germ cell fate, using genome and protein-level perturbation approaches to generate worms with altered splicing factor levels and characterise the resulting phenotypes.
3. Identify genes that undergo alternative splicing during germline specification and assess the physiological relevance of these events.

Beyond its fundamental significance, this work may inform future approaches to reproductive disorders and germ cell-derived cancers.

Your Role:

You will design and carry out experiments combining molecular biology, genetics, microscopy, and biochemistry, working both independently and in close collaboration with the team. You will also contribute to experimental planning, data interpretation, basic bioinformatic analysis, and the preparation of publications.

We are looking for

Essential:

– MSc (or equivalent) in molecular biology, biochemistry, genetics, developmental biology, or a related life science

– Strong foundational knowledge of molecular biology, genetics, and cell biology

– Hands-on experience with standard molecular and genetic techniques (e.g., PCR, cloning, gel electrophoresis, microscopy, Western blotting)

– Excellent written and spoken English

– A solid scientific track record relative to career stage

– Ability to work independently and as part of a team

Desirable:

– Prior experience with C. elegans (training will be provided if not)

– Familiarity with RNA biology, gene expression regulation, or stem cell and developmental biology

– Experience with CRISPR/Cas9, transcriptomics or proteomics, confocal microscopy, or basic bioinformatics (e.g., RNA-seq or MS data analysis)

We offer:

– Job type (employment contract/stipend): Full-time position, fixed-term contract, up to 48 months,

– Remuneration/month: 5.000 PLN net/month,

– The position starts on the 1st of October 2026 or as soon as possible,

– Work in an active team in an excellent scientific environment,

– Comprehensive training in molecular biology, genetics, transcriptomics, proteomics, and biochemistry,

– Access to the state-of-the-art equipment and facilities,

– Participation in courses and conferences,

– Medical package and social benefits (sports card, holiday bonus, 36 days of paid holiday per year).

Required documents (in English):

– Cover letter,

– CV,

– List of publications (if applicable),

– Reference contacts (please do not send generic letters, contact details only).

If you think you are the person we are looking for, please apply by filling in this form: https://forms.gle/Exoy7iw4U8cYLL9C6