PhD position in Gene regulatory networks of lung development and regeneration

The Department of Molecular Biosciences, Wenner-Gren Institute (MBW) conducts experimental basic research in molecular cell biology, integrative biology and infection and immunobiology. The research environment is characterized by a modern and advanced methodology and has a strong international profile. MBW is one of the larger departments within the Faculty of Science at Stockholm University with just over 30 research groups and approximately 180 employees, of which 65 are doctoral students. Read more about MBW at the Department of Molecular Biosciences, Wenner-Gren Institute

Postgraduate subject 

Gene regulatory networks in lung development and regeneration

The thesis work will be carried out within the framework of a VR-funded project focusing on gene regulatory networks in lung epithelial cells during development and regeneration. The research involves multiomics analysis of mouse and human epithelial cells at single-cell resolution. snRNA sequence data and snATAC data from multiple developmental stages are initially used to predict gene regulatory networks consisting of transcription factors, enhancer elements and downstream genes. These data are integrated with multiplex in situ RNA expression data to define cellular niches and cell–cell communication patterns in the developing lung. The descriptive data are then followed by mechanistic experiments in organoids in vitro and in mice in vivo.

Eligibility requirements

To be admitted to doctoral studies, the applicant must have basic and specific eligibility requirements. The eligibility requirements must be met by the application deadline.

You have basic eligibility if you have completed a degree at advanced level, or have completed course requirements of at least 240 higher education credits (ECs), of which at least 60 ECTS credits are at advanced level, or have otherwise acquired essentially equivalent knowledge within or outside the country.

Specific eligibility requirements are described in the general curriculum for doctoral education in the subject.

Selection

Selection of applicants is made based on their ability to benefit from postgraduate education. Criteria used to assess this ability are:

• Documented knowledge and research experience in cell and molecular biology .
• Formal training in bioinformatics or statistics, as well as the ability to perform quantitative data analysis in Python and/or R.
• Good written and oral skills in English .
• Strong drive and initiative to pursue a scientific career.

Admission procedure for doctoral education at Stockholm University.

About the employment

We offer a fixed-term employment as a doctoral student in accordance with Chapter 5 of the Higher Education Ordinance (1993:100). The employment period may not be longer than the equivalent of four years of full-time doctoral education. As a doctoral student, you will primarily devote yourself to your own doctoral education, but the employment may include work with education, research and administration to a limited extent (maximum 20%).

A new appointment as a doctoral student is valid for a maximum of one year, and the appointment is then renewed for a maximum of two years at a time.

Stockholm University strives to be a workplace that is free from discrimination and provides equal rights and opportunities for everyone.

Contact

Further information is available from Professor Christos Samakovlis, christos.samakovlis@su.se .

Application

You apply for the doctoral position via Stockholm University’s recruitment system. Attach a cover letter and CV as well as the attachments requested in the application form. As an applicant, you are responsible for ensuring that the application is complete in accordance with the advertisement and that it reaches the university by the application deadline.

Instructions for applicants can be found on the website: applying for a job.

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