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Department of Biochemistry and Biophysics. SciLifeLab (SciLifeLab) is a national center for molecular biosciences with a focus on research in health and the environment. The center combines leading technical expertise with advanced knowledge in translational medicine and molecular biosciences. SciLifelab is a national resource run by Karolinska Institutet, KTH, Stockholm University and Uppsala University. The center collaborates with several other universities.
Administratively, the position will be located at the Department of Biochemistry and Biophysics, Stockholm University. For more information about our operations, see our website: www.dbb.su.se.
Project description
Your doctoral studies in biochemistry will be conducted within the project “In situ cryo-EM of native glucose transporters”.
Sugar transporters play important roles in cellular metabolism and signaling, but many aspects of their mechanisms and conformational dynamics remain unresolved. Our group combines biochemical, biophysical, and structural approaches to dissect the transport cycle of key sugar transporters from human and microbial systems. This project will use state-of-the-art in situ cryo-EM to determine the native structure, composition, and regulation of GLUT transporters directly in cells or in near-native vesicular systems. The project will be part of a larger effort to study transporter function and dynamics across a variety of scales – from atomic detail to the cellular context.
Eligibility requirements
To be admitted to doctoral studies, the applicant must have basic and specific eligibility requirements. The eligibility requirements must be met at the time the applicant is admitted to the doctoral studies at the Department of Biochemistry and Biophysics.
You have basic eligibility if you have completed a degree at advanced level, or have completed course requirements of at least 240 higher education credits (credits), of which at least 60 credits at advanced level, or have otherwise acquired essentially equivalent knowledge within or outside the country.
Special eligibility requirements, to be admitted to doctoral-level education in biochemistry, the applicant must have passed courses worth at least 120 credits in chemistry/molecular life sciences (Life Science) in basic education, including a passed course at advanced level in biochemistry worth at least 15 credits and passed independent work, 30 credits, with a biochemical focus, at advanced level.
Selection
Selection of eligible applicants shall be made with regard to their ability to benefit from the education. Important assessment criteria are the following: familiarity with theory, proficiency in the subject area of the dissertation work, ability to express oneself orally and in writing in English and/or Swedish, analytical ability, creativity, initiative, independence and ability to collaborate. The basis for assessing how the applicant meets these requirements is the relevance of previous studies to the subject, grades on completed university courses (especially those at advanced level), quality and scope of the independent work, references to people who can describe the applicant’s skills and interviews.
We are looking for candidates with a strong background in enzymology and nuclear magnetic resonance (NMR). A Master’s degree (or equivalent) in biochemistry, structural biology, biophysics or related fields is required. Practical experience in cryo-EM, preferably including sample preparation, data acquisition or image processing, and knowledge of membrane proteins or transporter biology is an asset.
Admission procedure for doctoral education at Stockholm University.
About the employment
We offer a fixed-term employment as a doctoral student in accordance with Chapter 5 of the Higher Education Ordinance (1993:100). The employment period may not be longer than the equivalent of four years of full-time doctoral education. As a doctoral student, you will primarily devote yourself to your own doctoral education, but the employment may include work with education, research and administration to a limited extent (maximum 20%).
A new appointment as a doctoral student is valid for a maximum of one year, and the appointment is then renewed for a maximum of two years at a time.
Stockholm University strives to be a workplace that is free from discrimination and provides equal rights and opportunities for everyone.
Contact
Further information is available from Professor David Drew, david.drew@scilifelab.se.
General information regarding the doctoral program can be obtained from Director of Studies Andreas Barth, andreas.barth@dbb.su.se.
Application
You apply for the doctoral position via Stockholm University’s recruitment system. Attach a cover letter and CV as well as the attachments requested in the application form. As an applicant, you are responsible for ensuring that the application is complete in accordance with the advertisement and that it reaches the university by the application deadline.
Instructions for applicants can be found on the website: applying for a job.
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