Astrocyte-Neuron Interactions in Neural Circuit Function and Dementia

Details

The brain’s complexity has long been framed through the lens of neurons, yet another class of cells – astrocytes – quietly shapes the very circuits that underlie thought, memory, and disease. Despite comprising up to 40% of brain cells and being recognized since the earliest anatomical studies, astrocytes remained understudied for decades due to the technical challenges of probing their function. This gap is now closing. Advances in optical and genetic tools have opened a new frontier in neuroscience, revealing astrocytes as dynamic regulators of neural activity rather than passive support cells. The Khakh Laboratory has spent nearly 20 years developing methods to understand how astrocytes influence neuronal circuits and behavior.

Now relocating from UCLA to the UK Dementia Research Institute (UK DRI) at Cardiff, the lab is launching an ambitious new research programme focused on uncovering how astrocytes contribute to brain function and, critically, to the development and progression of dementia. This move represents more than a change in geography – it marks the beginning of a new phase of discovery within one of the UK’s most vibrant and collaborative neuroscience environments. The lab’s long-standing record of innovation, continuous competitive funding, and high-quality publications provides a strong foundation for tackling pressing questions in neurodegeneration.

A PhD student joining this programme will enter a deeply immersive and supportive training environment. The lab will combine molecular genetics, advanced imaging, electrophysiology, and translational neuroscience to interrogate astrocyte biology across multiple systems, from in vivo mouse models to human stem cell-derived astrocytes. This integrative approach allows trainees to develop a broad and versatile technical skillset while addressing mechanistic questions at the cutting edge of the field. The PhD project will explore how astrocytes shape neural circuit dynamics and drive pathological processes in dementia, with the goal of identifying new therapeutic strategies.

Training in the Khakh Laboratory extends beyond experimental work. Students are mentored in data analysis, scientific writing, and presentation, preparing them for leadership roles in academia and beyond. The lab’s track record has been solid: all trainees who pursued academic careers have successfully secured faculty positions. This success reflects not only rigorous scientific training but also a culture that values curiosity, independence, and collaboration. The group itself is internationally diverse, bringing together talented scientists with varied perspectives united by a shared commitment to discovery.

Importantly, the lab maintains a hands-on ethos. With active experimental engagement from Khakh and a collaborative atmosphere, students benefit from close mentorship and direct involvement in shaping their research projects. This creates an environment where ideas move quickly from concept to experiment, fostering both creativity and scientific rigor.

For a prospective PhD student, this is an opportunity to join a leading lab at a pivotal moment – both in its relocation and in the broader changes within neuroscience. By contributing to a deeper understanding of astrocytes, students will help understand brain function and open new avenues for treating dementia and related disorders.

Funding Notes

This is a fully funded PhD project.

Please contact Baljit Khakh with initial inquiries and kindly include a full CV with the names of two referees.