PhD position for Synthetic Biology-Inspired Therapies

Project background

Advancing the Frontiers of Cell-based therapies and Synthetic Biology

Our group applies state-of-the-art synthetic biology principles to engineer human cells and create next-generation cell-based therapies targeting cancer as well as metabolic, neurodegenerative, autoimmune and infectious diseases. Leveraging innovative platforms such as novel biosensors, gene switches, genetic closed-loop circuits, and chemical structures that interface with and actuate cellular activities, we design programmable cellular implants and devices for therapeutic applications. By integrating fundamental discoveries with translational development, we aim to shape the future of biomedical innovation.

Job description

• PhD projects will combine molecular engineering, cell programming, and chemical–biological interfacing to engineer human cells using synthetic gene circuits and biosensing platforms, develop novel biosensing systems for real-time monitoring of cellular states, create genetic architectures for precise therapeutic protein regulation, and translate these research advances into programmable cellular implant prototypes
• Projects will be highly interdisciplinary, fostering close collaboration with molecular biologists, bioengineers, and clinical researchers to accelerate translation into clinically relevant therapies

Profile

• We are seeking highly motivated applicants eager to bridge basic and translational research in cell biology and synthetic biology
• Candidates should have strong skills in molecular and cell biology techniques, including cultivation and engineering of primary human cells and mammalian cell lines
• Experience with in vivo techniques, as well as completion of an accredited course in laboratory animal science (FELASA / LTK or equivalent), would be an asset
• We welcome applicants with an outstanding academic record and who are enthusiastic about building a career in academia, industrial R&D, or biotechnology entrepreneurship

We offer

• Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society
• We are actively committed to a sustainable and climate-neutral university
• You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits

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