Role of the extracellular matrix in skeletal muscle stem cell function

Details

The regenerative capacity of skeletal muscle stem cells, also called satellite cells, is essential for muscle homeostasis and to maintain healthy muscles throughout the lifespan. The micro-environment of satellite cells plays a critical role in ensuring that the stem cells remain quiescent when not needed and in controlling the balance between differentiation and self-renewal when satellite cells are activated. The extracellular matrix is an important player in this micro-environment. We have previously demonstrated that one component of the extracellular matrix, Laminin-111, is remodelled in a dynamic manner during the activation and differentiation of skeletal muscle stem cells. This project aims at deciphering further how different extracellular matrix components contribute to regulating different effects in skeletal muscle stem cells using mouse genetic models as well as human iPSC-derived skeletal muscle organoids.

Candidates applying to this project should have a minimum 2.1 undergraduate honours degree (or equivalent) and/or MSc degree with Merit in a relevant science subject. It will be an advantage if candidates have a previous research experience in stem cell biology.

For more details on the entry requirements and research at the University of Sheffield, and how to apply visit our school’s webpages at https://www.sheffield.ac.uk/biosciences/postgraduate/phd

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more.

Please apply for this project using this link: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying

Funding Notes

Note that this project is for self-funded students only. Applicants should enquire about registration fees before applying.

First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University’s application form using the following link:

https://www.sheffield.ac.uk/postgraduate/phd/apply/applying

References

SS Rayagiri, D Ranaldi , A Raven, NIF Mohamad Azhar, O Lefebvre, PS Zammit, AG Borycki. 2018. Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nat Commun 9(1):1075. doi: 10.1038/s41467-018-03425-3