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OVERVIEW
The goal of this PhD project is to investigate how commonly used non-antibiotic drugs in combination with antibiotics can impact the evolution of antibiotic resistance in Pseudomonas aeruginosa, a high priority pathogen and leading cause of severe hospital-acquired infections.
The emergence and spread of multi-drug resistant (MDR) bacterial pathogens, virtually untreatable by antibiotics, poses a fundamental threat to human health. While it has been long-established that treating patients with antibiotics selects for resistant bacteria, recent studies have elucidated that many commonly used non-antibiotic drugs may also have unintended antimicrobial effects, and can impact the development and spread of resistance, despite this not being their intended use. The goal of this PhD project is to investigate how commonly used non-antibiotic drugs in combination with antibiotics can impact the evolution of antibiotic resistance in Pseudomonas aeruginosa, a high priority pathogen and leading cause of severe hospital-acquired infections. The PhD student will develop skills in experimental evolution, high-throughput microbiology, antimicrobial susceptibility testing, whole-genome sequencing and analysis, bacterial genetics, and fitness assays in complex environments.
Research Information
PhD Supervisors
Information on the research interests and activities of academics in Biological Sciences can be accessed via the School website and the Find a Supervisor facility.
Career Prospects
Introduction
Queen’s postgraduates reap exceptional benefits. Unique initiatives, such as the DegreePlus/Future Ready Award, bolster our commitment to employability, while innovative leadership and executive programmes alongside sterling integration with business experts helps our students gain key leadership positions both nationally and internationally. Career prospects in the biological sciences are exceptionally good. To some extent it depends on the specific topic, of course, but laboratory-based and especially quantitative skills and the proven innovation of a PhD or MPhil are highly sought after. Degrees are very much in demand, both in commercial science and public sector research and development (e.g. drug discovery and development, crop and animal improvements and welfare, sustainable agriculture and resource use, human nutrition and health, animal health, ecological management, food safety and technology, scientific communications, regulation, and many more fields).
Employment after the Course
Graduates have gone on to be professional research scientists, consultants, or hold technical and junior executive positions in commerce and government.
ENTRANCE REQUIREMENTS
Graduate
The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree in a relevant subject from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School.
International Students
For information on international qualification equivalents, please check the specific information for your country.
English Language Requirements
Evidence of an IELTS* score of 6.5, with not less than 5.5 in any component, or an equivalent qualification acceptable to the University is required (*taken within the last 2 years).
International students wishing to apply to Queen’s University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes.
For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs.
If you need to improve your English language skills before you enter this degree programme, INTO Queen’s University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree.
HOW TO APPLY
Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply.
Find a supervisor
If you’re interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions.
To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here.
You might be asked to provide a short outline of your proposal to help us identify potential supervisors.
Want fewer missed deadlines?
Follow a channel you care about (Graduate → Post-PhD).