Website The University of Bradford
Details
Chronic wounds, particularly diabetic foot ulcers, affect millions of patients worldwide and remain one of the most difficult clinical challenges in healthcare. Current wound dressings mainly protect the wound but do little to actively stimulate tissue repair.
This PhD project will develop next-generation smart hydrogels capable of generating therapeutic electrical signals from natural body movement. By integrating piezoelectric nanomaterials into soft hydrogel systems, the project aims to create self-powered wound dressings that convert mechanical energy (such as pressure or movement) into electrical cues that stimulate tissue regeneration.
These innovative biomaterials could help enhance cell migration, improve blood vessel formation, and accelerate healing in chronic wounds without requiring external power sources or devices.
The successful candidate will work at the interface of biomaterials science, nanotechnology, and regenerative medicine, gaining hands-on experience in hydrogel engineering, nanomaterial synthesis, materials characterisation, and cell biology.
This interdisciplinary project offers an exciting opportunity to contribute to the development of smart biomaterials that actively interact with the body to promote healing. The outcomes of this research could lead to new therapeutic strategies for chronic wound care and other regenerative medicine applications.
The PhD student will join a collaborative research environment focused on advanced biomaterials and biomedical innovation, with opportunities to develop strong research skills and contribute to high-impact scientific publications.
How to apply
Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account, select ‘Postgraduate Research’ as the type of course and then use the keyword ‘pharmacy’. Applicants should then specify the project title in the ‘Research Proposal’ section.
About the University of Bradford
Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities.
Positive Action Statement
At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students.
Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level.
These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies.
Funding Notes
This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee applies, in addition to tuition fees. UK students may be able to apply for a Doctoral Loan from Student Finance for financial support.
References
1. Afeesh Rajan Unnithan, Vignesh Krishnamoorthi Kaliannagounder, Nagamalleswara Rao Alluri, Chan Hee Park, Pandiyarasan Veluswamy, Arathyram Ramachandra Kurup Sasikala, Design and Application of Piezoelectric Conductive Smart Scaffold for Non-invasive Neural Tissue Regeneration via Custom-made In vitro Mechano-Stimulator, Advanced NanoBiomed Research., 5: 2500058, 2025).
2. Arathyram Ramachandra Kurup Sasikala, Vignesh Krishnamoorthi Kaliannagounder, Nagamalleswara Rao Alluri, Sang-Jae Kim, Bishnu Kumar Shrestha, Hanene Ali-Boucetta, Chan Hee Park, Afeesh Rajan Unnithan, Remotely Actuated Self-Powered Multifunctional Piezomagnetic Nanoparticles: Proof of Concept Study for the Post-Surgical Osteosarcoma Theranogeneration, Nano Energy, 96, 107134, 2022, Senior author)
3. Sharifiaghdam, M.; Shaabani, E.; Faridi-Majidi, R.; De Smedt, S. C.; Braeckmans, K.; Fraire, J. C., Macrophages as a therapeutic target to promote diabetic wound healing. Mol Ther 2022, 30 (9), 2891-2908.
4. Mackenzie, P. Diabetes Footcare Project 1: Pathway Development; NHS UK, 2017.
5. Kerr, M.; Barron, E.; Chadwick, P.; Evans, T.; Kong, W. M.; Rayman, G.; Sutton-Smith, M.; Todd, G.; Young, B.; Jeffcoate, W. J., The cost of diabetic foot ulcers and amputations to the National Health Service in England. Diabetic Med 2019, 36 (8), 995-1002.
6. Xiong, Y.; Feng, Q.; Lu, L.; Zha, K. K.; Yu, T.; Lin, Z.; Hu, Y. Q.; Panayi, A. C.; Nosrati-Ziahmagi,
V.; Chu, X. Y.; Chen, L.; Shahbazi, M. A.; Mi, B. B.; Liu, G. H., Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer. Adv Funct Mater 2023, 33 (10).
7. Hao Wu, H. D., Zhen Tang, Yu Chen, Yichao Liu, Mo Wang, Xinghui Wei,; Ning Wang, S. B., Dongmei Yu, Zhigang Wu, Zhenda Yang, Xiaokang Li; Zheng Guo, L. S., Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promotes anti-inflammatory polarization of macrophages and bone repair via MAPK/JNK inhibition and OXPHOS activation. Biomaterials 2023, 293, 121990.
8. Koel, G.; Houghton, P. E., Electrostimulation: Current Status, Strength of Evidence Guidelines, and Meta-Analysis. Adv Wound Care (New Rochelle) 2014, 3 (2), 118-126.
9. Oliveira, K. M. C.; Barker, J. H.; Berezikov, E.; Pindur, L.; Kynigopoulos, S.; Eischen-Loges, M.; Han,Z.; Bhavsar, M. B.; Henrich, D.; Leppik, L., Electrical stimulation shifts healing/scarring towards regeneration in a
rat limb amputation model. Sci Rep-Uk 2019, 9.
10. Chen, S.; Zhu, P.; Mao, L. J.; Wu, W. C.; Lin, H.; Xu, D. L.; Lu, X. Y.; Shi, J. L., Piezocatalytic
Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications. Adv Mater 2023, 35 (25).
11. Dai, J. J.; Shao, J.; Zhang, Y.; Hang, R. Y.; Yao, X. H.; Bai, L.; Hang, R. Q., Piezoelectric dressings for advanced wound healing. J Mater Chem B 2024, 12 (8), 1973-1990.
Want fewer missed deadlines?
Follow a channel you care about (Graduate → Post-PhD).