Website Université Paris-Saclay
- Postdoctoral Researcher in Plant Molecular Biology
Position Identification
Research Project or Operation
As sessile organisms, plants are directly exposed to their environment. Adaptation to this environment often involves a finely regulated transcriptional response that can be triggered by changes in chromatin architecture and/or the epigenetic landscape. We are interested in specific changes to the epigenome in response to the environment, as well as the chromatic factors that trigger epigenomic responses. This project has two components: we will develop new molecular tools to better understand chromatin composition, focusing on single-locus chromatin profiling. In parallel, we will investigate how the epigenomic landscape varies throughout the year and whether these changes can provide clues about how plants adapt to their environment. For this research project, we will use a wide range of tools from genomics, molecular biology, and bioinformatics. The project is structured around two main axes. The first axis focuses on the development of a new reverse-ChIP technology aimed at identifying proteins that bind to specific genomic regions. The second axis will involve conducting epigenomic profiling experiments,
including DNA methylation profiling, small RNA sequencing (sRNA-sequencing), and Hi-C experiments, using plant tissues collected over several seasons. Given the volume of data collected, a second component of this project will consist of training the recruited individual in bioinformatics tools and their implementation.
We are offering a 12-month fixed-term postdoctoral position (M/F) within the “Nuclear Defense and 3D Genome Folding” team, led by Stefan Grob at the Institute of Plant Molecular Biology (IBMP) in Strasbourg. IBMP hosts leading research teams, has a wide range of cutting-edge technological platforms to support this project, and offers a friendly and stimulating work environment. Within our teams, we strive to create an inclusive and motivating work atmosphere where initiative,
intellectual contribution, and technical expertise are highly valued.
Hierarchical relationship:
Supervision of interns is possible.
Specific working conditions (see attached appendix):
The position may involve occasional travel for scientific conferences or collaborations. Standard laboratory-related risks are present, including handling
chemicals and biological agents, working in temperature-controlled environments, and prolonged periods of computer work. - ProfileWe are looking for a highly motivated, curious, and collaborative individual with a strong background in functional genomics. The ideal candidate will have in-depth knowledge of molecular biology and a good understanding of plant chromatin biology/epigenetics. Knowledge of genetics would be an asset.
Excellent written and spoken English is essential.
Operational skills/know-how:
Knowledge of classical molecular biology techniques, such as PCR, RT-qPCR, and cloning, and biochemical techniques such as Western blotting and immunoprecipitation. Expertise in CRISPR approaches would be an advantage.
Prior experience in bioinformatics data analysis and coding would be a plus.
Personal qualities:
Willingness to fully commit to a project. Critical thinking and the motivation to carry out demanding practical experimental work are expected. - Additional informationTo apply, please send your CV, cover letter and diploma(s)
to the attention of: Stefan Grob (stefan.grob@cnrs.fr)
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